Table 3 Association of HPA-1, HPA-3 and factor XIII genotypes/alleles between recurrent miscarriage cases and controls
103 Cases N(%) | 113 Controls N (%) | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
P-value | OR (95%CI) | P-value | OR (95%CI) | |||
HPA-1 | ||||||
A/A | 82 (79.6) | 109 (96.5) | - | 1 (reference) | - | 1 (reference) |
A/B | 3 (2.9) | 3 (2.7) | 0.34 | 1.33 (0.26–6.76) | 0.608 | 1.53 (0.30–7.83) |
B/B | 18 (17.5) | 1 (0.9) | 0.002* | 23.93 (3.13–1.82.90) | 0.002* | 24.13 (3.13-186.15) |
Allele A | 83 (80.6) | 111 (98.2) | 0.001* | 10.3 (3.98–26.76) | ||
Allele B | 20 (19.4) | 2 (1.8) | ||||
HPA-3 | ||||||
A/A A/B | 93 (90.3) 0 (0) | 113 (100) 0 (0) | 0.001* - | - - | - - | - - |
B/B | 10 (9.7) | 0 | - | - | - | |
Allele A | 93 (90.3) | 113 (100) | 0.001* | - | - | - |
Allele B | 10 (9.7) | 0 | - | - | - | |
Factor XIII | ||||||
Val/Val | 91 (88.3) | 102 (90.3) | - | 1(reference) | - | 1(reference) |
Val/Leu | 10 (9.7) | 9 (8.0) | 0.649 | 1.25 (0.48–3.20) | 0.530 | 1.38 (0.51–3.73) |
Leu/Leu | 2 (1.9) | 2 (1.8) | 0.910 | 1.12 (0.15–8.12) | 0.673 | 1.53 (0.21–11.16) |