Variables | Hazard ratio [CI 95%] | p |
---|---|---|
Number of PTC-Ca | < 0.001 | |
1 | 1 | |
2 | 7.296 [3.180–16.739] | |
≥ 3 | 15.509 [5.185–46.396] | |
Female sex | 1.763 [0.992–3.133] | 0.053 |
Liver disease | 0.720 | |
Biliary atresia | 1 | |
Fulminant hepatitis | 0.691 [0.272–1.758] | |
Other | 0.884 [0.450–1.734] | |
Type of LT | 0.630 | |
Left lateral segment (organ donation) | 1 | |
Left lobe | 1.226 [0.542–2.771] | |
Left lateral segment (living donation) | 1.517 [0.799–2.878] | |
Whole liver | 1.488 [0.442–5.010] | |
Cold ischemia time > 600 min | 1.184 [0.664–2.110] | 0.570 |
Number of bile ducts anastomosis = 2 | 1.283 [0.656–2.511] | 0.470 |
Bilio-biliary anastomosis | 0.386 [0.053–2.795] | 0.350 |
Number of arteries = 2 | 1.689 [0.524–5.447] | 0.380 |
Hepatic artery status at 1 month | 0.014 | |
No arterial issues | 1 | |
Thrombosis | 2.292 [1.261–4.166] | |
Stenosis | 0.426 [0.058–3.122] | |
Acute rejection | 0.812 [0.465–1.416] | 0.460 |
Cholangitis at first PTC-C | 1.410 [0.799–2.488] | 0.240 |
Cytolysis at first PTC-C | 1.074 [0.562–2.055] | 0.830 |
Cholestasis at first PTC-C | 1.729 [0.622–4.807] | 0.290 |
Age at first PTC-Cb | 1.001 [0.919–1.089] | 0.990 |
Time between LT and first PTC-Cb | 1.000 [0.987–1.013] | 0.990 |
Intrahepatic stenosis at first PTC-C | 1.873 [1.088–3.222] | 0.023 |
Extrahepatic stenosis at first PTC-C | 0.876 [0.349–2.200] | 0.770 |
Anastomotic stenosis at first PTC-C | 0.454 [0.257–0.801] | 0.006 |
Lithiasis at first PTC-C | 2.352 [1.092–5.067] | 0.028 |
Drain type after first PTC-C | 0.260 | |
External drain | 1 | |
External drain + internal–external drain | 2.071 [0.871–4.923] | |
Internal–external drain | 1.165 [0.458–2.964] | |
Duration of the first drainb | 1.191 [0.813–1.746] | 0.370 |
Complications after first PTC-C | 0.270 | |
No complication | 1 | |
Minimal hemobilia | 1.660 [0.653–4.220] | |
Important hemobilia | 0.755 [0.182–3.129] | |
Cholangitis | 0.358 [0.110–1.160] | |
Sepsis | 0.612 [0.189–1.984] | |
Multivariate analysis | ||
PTC-C Nr. 2 (ref.1) | 6.764 [2.957–15.571] | < .0001 |
PTC-C Nr. 3 or more (ref.1) | 15.511 [5.157–46.650] | < .0001 |
Anastomotic stenosis 1 (ref none) | 0.489 [0.276–0.865] | 0.014 |