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Table 2 Univariate and multivariate analysis of risk factors for primary percutaneous transhepatic cholangiography with balloon cholangioplasty (PTC-C) group treatment failure. LT: Liver transplantation

From: Long-term outcome of combined radiologic and surgical strategy for the management of biliary complications after pediatric liver transplantation

Variables

Hazard ratio [CI 95%]

p

Number of PTC-Ca

 

 < 0.001

          1

1

 

          2

7.296 [3.180–16.739]

 

           ≥ 3

15.509 [5.185–46.396]

 

Female sex

1.763 [0.9923.133]

0.053

Liver disease

 

0.720

          Biliary atresia

1

 

          Fulminant hepatitis

0.691 [0.272–1.758]

 

          Other

0.884 [0.450–1.734]

 

Type of LT

 

0.630

          Left lateral segment (organ donation)

1

 

          Left lobe

1.226 [0.542–2.771]

 

          Left lateral segment (living donation)

1.517 [0.799–2.878]

 

          Whole liver

1.488 [0.442–5.010]

 

Cold ischemia time > 600 min

1.184 [0.664–2.110]

0.570

Number of bile ducts anastomosis = 2

1.283 [0.656–2.511]

0.470

Bilio-biliary anastomosis

0.386 [0.053–2.795]

0.350

Number of arteries = 2

1.689 [0.524–5.447]

0.380

Hepatic artery status at 1 month

 

0.014

          No arterial issues

1

 

          Thrombosis

2.292 [1.261–4.166]

 

          Stenosis

0.426 [0.058–3.122]

 

Acute rejection

0.812 [0.465–1.416]

0.460

Cholangitis at first PTC-C

1.410 [0.799–2.488]

0.240

Cytolysis at first PTC-C

1.074 [0.562–2.055]

0.830

Cholestasis at first PTC-C

1.729 [0.622–4.807]

0.290

Age at first PTC-Cb

1.001 [0.919–1.089]

0.990

Time between LT and first PTC-Cb

1.000 [0.987–1.013]

0.990

Intrahepatic stenosis at first PTC-C

1.873 [1.088–3.222]

0.023

Extrahepatic stenosis at first PTC-C

0.876 [0.349–2.200]

0.770

Anastomotic stenosis at first PTC-C

0.454 [0.2570.801]

0.006

Lithiasis at first PTC-C

2.352 [1.0925.067]

0.028

Drain type after first PTC-C

 

0.260

          External drain

1

 

          External drain + internal–external drain

2.071 [0.871–4.923]

 

          Internal–external drain

1.165 [0.458–2.964]

 

Duration of the first drainb

1.191 [0.813–1.746]

0.370

Complications after first PTC-C

 

0.270

          No complication

1

 

          Minimal hemobilia

1.660 [0.653–4.220]

 

          Important hemobilia

0.755 [0.182–3.129]

 

          Cholangitis

0.358 [0.110–1.160]

 

          Sepsis

0.612 [0.189–1.984]

 

Multivariate analysis

  

PTC-C Nr. 2 (ref.1)

6.764 [2.957–15.571]

 < .0001

PTC-C Nr. 3 or more (ref.1)

15.511 [5.157–46.650]

 < .0001

Anastomotic stenosis 1 (ref none)

0.489 [0.276–0.865]

0.014

  1. Bold was used for statistically significant values
  2. aAnalyzed as a time-dependent variable
  3. bContinuous variables