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  1. Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder that is more frequent in males than females. Several genes on the X chromosome have been studied as cand...

    Authors: Xiaohui Xu, Keeley Brookes, Bo Sun, Nicholas Ilott and Philip Asherson
    Citation: BMC Research Notes 2009 2:71
  2. Apart from simple steatosis, the non-alcoholic steatohepatitis (NASH) can progress into liver fibrosis and cirrhosis. To date, however, no widely accepted therapeutic modalities have been established against N...

    Authors: Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Masaharu Yamazaki, Tatsuhiro Tsujimoto, Hideto Kawaratani, Takemi Akahane, Yosuke Aihara and Hiroshi Fukui
    Citation: BMC Research Notes 2009 2:70
  3. It can be seen from the available mollusk mitogenomes that the family Pectinidae exhibits the most variation in genome organization. In this study, comparative mitogenomic analyses were performed for three sca...

    Authors: Xiangyun Wu, Xiaodong Xu, Ziniu Yu and Xiaoyu Kong
    Citation: BMC Research Notes 2009 2:69
  4. Oxygenases belong to the oxidoreductive group of enzymes (E.C. Class 1), which oxidize the substrates by transferring oxygen from molecular oxygen (O2) and utilize FAD/NADH/NADPH as the co-substrate. Oxygenases c...

    Authors: Pankaj K Arora, Manish Kumar, Archana Chauhan, Gajendra PS Raghava and Rakesh K Jain
    Citation: BMC Research Notes 2009 2:67
  5. Activating mutations in the PIK3CA gene have been identified in a variety of human malignancies and are commonly detected in hotspot codons located in the helical and kinase domains in exons 9 and 20. Existing me...

    Authors: Carolyn D Hurst, Tahlita CM Zuiverloon, Christian Hafner, Ellen C Zwarthoff and Margaret A Knowles
    Citation: BMC Research Notes 2009 2:66
  6. Cell-specific expression of a subset of Enhancer of split (E(spl)-C) genes in proneural clusters is mediated by synergistic interactions between bHLH A (b asic H elix-L oop-H elix A ctivator) and Notch-signalling...

    Authors: John W Cave, Li Xia and Michael A Caudy
    Citation: BMC Research Notes 2009 2:65
  7. Baculovirus expression vector system (BEVS) has become a standard in recombinant protein production and virus-like particle preparation for numerous applications.

    Authors: Hanna-Riikka Kärkkäinen, Hanna P Lesch, Antti I Määttä, Pyry I Toivanen, Anssi J Mähönen, Miia M Roschier, Kari J Airenne, Olli H Laitinen and Seppo Ylä-Herttuala
    Citation: BMC Research Notes 2009 2:63
  8. The purpose of this report is to assess the safety and efficacy of single lower pole access for multiple and branched renal calculi. A prospective non randomized clinical study included 26 patients with comple...

    Authors: Mahmoud M Shalaby, Medhat A Abdalla, Hassan A Aboul-Ella, Abdel-Monem A El-haggagy and Alaa A Abd-Elsayed
    Citation: BMC Research Notes 2009 2:62
  9. Dermatophytes are a group of closely related keratinophilic fungi that can invade keratinized humans and animals tissues such as skin, hair and nails causing dermatophytosis. They are an important cause of sup...

    Authors: Jaya Garg, Ragini Tilak, Atul Garg, Pradyot Prakash, Anil Kumar Gulati and Gopal Nath
    Citation: BMC Research Notes 2009 2:60
  10. The Runt DNA binding domain (Runx) defines a metazoan family of sequence-specific transcription factors with essential roles in animal ontogeny and stem cell based development. Depending on cis-regulatory context...

    Authors: Anthony J Robertson, Claire Larroux, Bernard M Degnan and James A Coffman
    Citation: BMC Research Notes 2009 2:59
  11. Fluorescent proteins such as GFP (Green Fluorescent Protein) and DsRED (Discosoma sp.Red Fluorescent Protein) are often used as reporter molecules for transgene expression in Drosophila and other species. We h...

    Authors: Dhruv Grover, Junsheng Yang, Daniel Ford, Simon Tavaré and John Tower
    Citation: BMC Research Notes 2009 2:58
  12. We analyzed the use of RefSNP (rs) numbers to identify genetic variants in abstracts of human genetic association studies published from 2001 through 2007. The proportion of abstracts reporting rs numbers incr...

    Authors: Wei Yu, Renée Ned, Anja Wulf, Tiebin Liu, Muin J Khoury and Marta Gwinn
    Citation: BMC Research Notes 2009 2:56
  13. Asthma is a complex phenotype that is influenced by both genetic and environmental factors. Genome-wide linkage and association studies have been performed to identify susceptibility genes for asthma. These st...

    Authors: Yoshiko Imada, Masaya Fujimoto, Kenji Hirata, Tomomitsu Hirota, Yoichi Suzuki, Hirohisa Saito, Kenji Matsumoto, Akira Akazawa, Toshio Katsunuma, Shigemi Yoshihara, Motohiro Ebisawa, Masanao Shibasaki, Tadao Arinami, Mayumi Tamari and Emiko Noguchi
    Citation: BMC Research Notes 2009 2:54
  14. The nucleotide-binding oligomerization domain containing 1 (NOD1) gene encodes a pattern recognition receptor that senses pathogens, leading to downstream responses characteristic of innate immunity. We investiga...

    Authors: Claudia Huebner, Lynnette R Ferguson, Dug Yeo Han, Martin Philpott, Murray L Barclay, Richard B Gearry, Alan McCulloch, Pieter S Demmers and Brian L Browning
    Citation: BMC Research Notes 2009 2:52
  15. Free-living amoebae serve as a natural reservoir for some bacteria that have evolved into «amoeba-resistant» bacteria. Among these, some are strictly intra-amoebal, such as Candidatus "Protochlamydia amoebophila"...

    Authors: Claire Moliner, Didier Raoult and Pierre-Edouard Fournier
    Citation: BMC Research Notes 2009 2:51
  16. Antimicrobial resistance is fast becoming a global concern with rapid increases in multidrug-resistant Gram negative organisms. The prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isol...

    Authors: Stephen E Mshana, Erasmus Kamugisha, Mariam Mirambo, Trinad Chakraborty and Eligius F Lyamuya
    Citation: BMC Research Notes 2009 2:49
  17. Whole genome amplification (WGA) is a practical solution to eliminate molecular analysis limitations associated with genomic DNA (gDNA) quantity. Different methods have been developed to amplify the whole geno...

    Authors: Osama Alsmadi, Fadi Alkayal, Dorota Monies and Brian F Meyer
    Citation: BMC Research Notes 2009 2:48
  18. The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes Human African Trypanosomiasis. Its cell cycle is complex and not fully understood at the molecular level. The T. brucei genome co...

    Authors: Séverine Monnerat, Caroline Clucas, Elaine Brown, Jeremy C Mottram and Tansy C Hammarton
    Citation: BMC Research Notes 2009 2:46
  19. Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as ...

    Authors: Nermeen SA Abdel Fattah, Hanan E Hassan, Zenab A Galal and El Sayed E El Okda
    Citation: BMC Research Notes 2009 2:44
  20. Warfarin is an oral anticoagulant (OAT) that needs active management to ensure therapeutic range. Initial management is often carried out as an inpatient, though not requiring inpatient facilities. This mismat...

    Authors: Dónall Forde, Mortimer B O'Connor and Oonagh Gilligan
    Citation: BMC Research Notes 2009 2:41
  21. Nemaline myopathy is a neuromuscular disorder characterized by the presence of nemaline bodies in patient muscles. 20% of the cases are associated with α-skeletal muscle actin mutations. We previously showed t...

    Authors: Drieke Vandamme, Ellen Lambert, Davy Waterschoot, Davina Tondeleir, Joël Vandekerckhove, Laura M Machesky, Bruno Constantin, Heidi Rommelaere and Christophe Ampe
    Citation: BMC Research Notes 2009 2:40
  22. Currently one of the largest online repositories for human and mouse stem cell gene expression data, StemBase was first designed as a simple web-interface to DNA microarray data generated by the Canadian Stem ...

    Authors: Reatha Sandie, Gareth A Palidwor, Matthew R Huska, Christopher J Porter, Paul M Krzyzanowski, Enrique M Muro, Carolina Perez-Iratxeta and Miguel A Andrade-Navarro
    Citation: BMC Research Notes 2009 2:39
  23. Achromobacter sp. AO22 (formerly Alcaligenes sp. AO22), a bacterial strain isolated from a lead-contaminated industrial site in Australia, was previously found to be resistant to moderate to high levels of mercur...

    Authors: Shee Ping Ng, Belinda Davis, Enzo A Palombo and Mrinal Bhave
    Citation: BMC Research Notes 2009 2:38
  24. Citrus Huanglongbing (HLB) is one of the most devastating diseases on citrus and is associated with Candidatus Liberibacter spp.. The pathogens are phloem limited and have not been cultured in vitro. The current ...

    Authors: Jeong-soon Kim and Nian Wang
    Citation: BMC Research Notes 2009 2:37
  25. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine implicated in the pathogenesis of a number of human diseases including inflammatory neurological diseases. Its role in the pathogenesi...

    Authors: Vidhan Jain, Shannon McClintock, Avinash C Nagpal, Aditya P Dash, Jonathan K Stiles, Venkatachalam Udhayakumar, Neeru Singh and Naomi W Lucchi
    Citation: BMC Research Notes 2009 2:36
  26. Tetanus is an infectious disease caused by the contamination of wounds from bacteria that live in soil. The tetanus mortality rate remains high in developing countries affected by natural disasters. Whether th...

    Authors: Agung Budi Sutiono, Andri Qiantori, Hirohiko Suwa and Toshizumi Ohta
    Citation: BMC Research Notes 2009 2:34
  27. Sequence information on the 16S-23S rDNA internal spacer region (ISR) exhibits a large degree of sequence and length variation at both the genus and species levels. A primer pair for the amplification of 16S-2...

    Authors: Akihiro Tazumi, Shinji Ono, Tsuyoshi Sekizuka, John E Moore, B Cherie Millar and Motoo Matsuda
    Citation: BMC Research Notes 2009 2:33
  28. The cytokines interleukin-1 and tumor necrosis factor (TNF), and the cytokine blocker interleukin-1 receptor antagonist, all have been demonstrated to enter the cerebrospinal fluid (CSF) following peripheral a...

    Authors: Edward L Tobinick, Kai Chen and Xiaoyuan Chen
    Citation: BMC Research Notes 2009 2:28
  29. Yusho an intoxication caused by oral dioxins and polychlorinated biphenyls occurred in 1968. Patients suffered from various systemic symptoms, including general fatigue, nausea, muscular and articular pain, ac...

    Authors: Tomoaki Imamura, Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Soichi Koike, Bunichi Tajima, Shiro Matsuya, Hiroshi Uchi, Satoko Shibata and Masutaka Furue
    Citation: BMC Research Notes 2009 2:27
  30. Discriminating taxa with the nuclear marker, amplified fragment length polymorphism (AFLP) has been accomplished for various organisms in economic, ecological, and evolutionary studies. The protocol available ...

    Authors: Jessica A Wooten and Lori R Tolley-Jordan
    Citation: BMC Research Notes 2009 2:26
  31. Acute aortic dissection (AAD) is a life-threatening condition requiring immediate assessment and therapy. A patient suffering from AAD often presents with an insignificant or irrelevant medical history, giving...

    Authors: Irene Asouhidou and Theodora Asteri
    Citation: BMC Research Notes 2009 2:25
  32. Genetic transformation of the malaria mosquito Anopheles gambiae has been successfully achieved in recent years, and represents a potentially powerful tool for researchers. Tissue-, stage- and sex-specific promot...

    Authors: Fabrizio Lombardo, Gareth J Lycett, Alessandra Lanfrancotti, Mario Coluzzi and Bruno Arcà
    Citation: BMC Research Notes 2009 2:24

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