|
Positions of residues in substrate (Donor: c-Kit)
|
Position of residues in Ligand (Acceptor: Shp-1)
|
Distance of H-bonds in A°
|
|---|
|
649:ND2
|
192:O
|
2.54
|
|
649:ND2
|
193:O
|
1.12
|
|
650:N
|
192:O
|
2.03
|
|
650:ND1
|
195:OE1
|
2.11
|
|
650:ND1
|
195:OE2
|
2.07
|
|
650:NE2
|
195:OE2
|
2.98
|
|
652:N
|
195:OE1
|
1.44
|
|
652:N
|
195:OE2
|
2.64
|
|
653:N
|
195:OE1
|
2.56
|
|
655:N
|
200:OD1
|
2.04
|
|
656:N
|
200:OD1
|
2.86
|
|
671:OE2
|
196:O
|
2.27
|
|
671:OE2
|
199:O
|
2.66
|
|
775:NE2
|
213:O
|
2.18
|
|
782:N
|
3:OG
|
2.12
|
|
785:OG
|
3:OG
|
2.52
|
|
785:OG
|
103:OD1
|
2.89
|
|
802:N
|
211:OE1
|
2.27
|
|
803:N
|
211:O
|
2.68
|
|
807:NZ
|
197:O
|
2.51
|
|
807:NZ
|
198:O
|
2.53
|
|
818:NZ
|
28:OG
|
2.51
|
|
818:NZ
|
100:O
|
2.83
|
|
819:ND2
|
100:OH
|
2.50
|
|
820:O
|
85:NE2
|
2.92
|
|
821:OG
|
82:O
|
2.03
|
|
847:OG1
|
83:OE1
|
2.83
|
|
847:OG1
|
83:OE2
|
2.09
|
|
848:N
|
83:OE2
|
2.84
|
|
849:N
|
83:OE2
|
2.19
|
|
849:OE2
|
79:O
|
2.58
|
|
849:OE2
|
83:OE1
|
2.49
|
|
849:OE2
|
83:OE2
|
1.91
|
|
915:N
|
76:OE2
|
2.49
|
|
916:OG1
|
75:O
|
2.71
|
- A: Represents hydrogen bonds between activation loop residues and N-sh2 domain residues B: Shows kinase lobe residues preceding c-terminal tail of c-Kit and N-sh2 domain residues
