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Table 2 Hydrogen bonds detected between Kit kinase & SH2 domains

From: The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An in silico analysis

Positions of residues in substrate (Donor: c-Kit) Position of residues in Ligand (Acceptor: Shp-1) Distance of H-bonds in A°
649:ND2 192:O 2.54
649:ND2 193:O 1.12
650:N 192:O 2.03
650:ND1 195:OE1 2.11
650:ND1 195:OE2 2.07
650:NE2 195:OE2 2.98
652:N 195:OE1 1.44
652:N 195:OE2 2.64
653:N 195:OE1 2.56
655:N 200:OD1 2.04
656:N 200:OD1 2.86
671:OE2 196:O 2.27
671:OE2 199:O 2.66
775:NE2 213:O 2.18
782:N 3:OG 2.12
785:OG 3:OG 2.52
785:OG 103:OD1 2.89
802:N 211:OE1 2.27
803:N 211:O 2.68
807:NZ 197:O 2.51
807:NZ 198:O 2.53
818:NZ 28:OG 2.51
818:NZ 100:O 2.83
819:ND2 100:OH 2.50
820:O 85:NE2 2.92
821:OG 82:O 2.03
847:OG1 83:OE1 2.83
847:OG1 83:OE2 2.09
848:N 83:OE2 2.84
849:N 83:OE2 2.19
849:OE2 79:O 2.58
849:OE2 83:OE1 2.49
849:OE2 83:OE2 1.91
915:N 76:OE2 2.49
916:OG1 75:O 2.71
  1. A: Represents hydrogen bonds between activation loop residues and N-sh2 domain residues B: Shows kinase lobe residues preceding c-terminal tail of c-Kit and N-sh2 domain residues