Surgical management of Diabetic foot ulcers: A Tanzanian university teaching hospital experience
- Phillipo L Chalya1Email author,
- Joseph B Mabula†1,
- Ramesh M Dass†2,
- Rodrick Kabangila†3,
- Hyasinta Jaka†3,
- Mabula D Mchembe†4,
- Johannes B Kataraihya†3,
- Nkinda Mbelenge†2 and
- Japhet M Gilyoma†1
© Chalya et al; licensee BioMed Central Ltd. 2011
Received: 22 February 2011
Accepted: 24 September 2011
Published: 24 September 2011
Diabetic foot ulcers (DFUs) pose a therapeutic challenge to surgeons, especially in developing countries where health care resources are limited and the vast majority of patients present to health facilities late with advanced foot ulcers. A prospective descriptive study was done at Bugando Medical Centre from February 2008 to January 2010 to describe our experience in the surgical management of DFUs in our local environment and compare with what is known in the literature.
Of the total 4238 diabetic patients seen at BMC during the period under study, 136 (3.2%) patients had DFUs. Males outnumbered females by the ratio of 1.2:1. Their mean age was 54.32 years (ranged 21-72years). Thirty-eight (27.9%) patients were newly diagnosed diabetic patients. The majority of patients (95.5%) had type 2 diabetes mellitus. The mean duration of diabetes was 8.2 years while the duration of DFUs was 18.34 weeks. Fourteen (10.3%) patients had previous history of foot ulcers and six (4.4%) patients had previous amputations. The forefoot was commonly affected in 60.3% of cases. Neuropathic ulcers were the most common type of DFUs in 57.4% of cases. Wagner's stage 4 and 5 ulcers were the most prevalent at 29.4% and 23.5% respectively. The majority of patients (72.1%) were treated surgically. Lower limb amputation was the most common surgical procedure performed in 56.7% of cases. The complication rate was (33.5%) and surgical site infection was the most common complication (18.8%). Bacterial profile revealed polymicrobial pattern and Staphylococcus aureus was the most frequent microorganism isolated. All the microorganisms isolated showed high resistance to commonly used antibiotics except for Meropenem and imipenem, which were 100% sensitive each respectively. The mean hospital stay was 36.24 ± 12.62 days (ranged 18-128 days). Mortality rate was 13.2%.
Diabetic foot ulceration constitutes a major source of morbidity and mortality among patients with diabetes mellitus at Bugando Medical Centre and is the leading cause of non-traumatic lower limb amputation. A multidisciplinary team approach targeting at good glycaemic control, education on foot care and appropriate footware, control of infection and early surgical intervention is required in order to reduce the morbidity and mortality associated with DFUs. Due to polymicrobial infection and antibiotic resistance, surgical intervention must be concerned.
Diabetic foot ulcers (DFUs) pose a major public health problem worldwide and contribute significantly to morbidity and mortality of patients with diabetes . It is estimated that 15% to 20% of patients with diabetes will develop an ulcer on their foot at some point, and for many of these cases, the most appropriate treatment results in some form of surgery .
Diabetic foot ulcers are the most common cause of non-traumatic lower limb amputations in developing countries, and the risk of lower extremity amputation is 15 to 46 times higher in diabetics than in persons who do not have diabetes mellitus .
The prevalence of diabetic foot ulcers ranged between 1.0% and 4.1% in the United States, 4.6% in Kenya, and 20.4% in Netherlands [4–6]. Similarly, numerous hospital-based studies in Nigeria demonstrated that the prevalence of limb ulcerations was between 11.7% and 19.1% among individuals with diabetes in Nigeria [7, 8]. The prevalence of DFUs among hospitalized patients with diabetes in Iran was 20% .
The burden of diabetic foot ulceration is heaviest in the resource-poor parts of the world where the incidence is high but sophisticated and efficient diagnostic, therapeutic and rehabilitative facilities are sparse. The challenge of management of DFUs in developing countries is that most patients with DFUs present to healthcare facilities late with advanced foot ulcers. The reasons for the late presentation include poor economic capabilities in cost shared healthcare systems, inadequate knowledge of self-care, socio-cultural reasons and poor and inadequate diabetes healthcare . Studies in Tanzania have shown that surgical intervention of DFUs after the onset of gangrene may be too late to prevent death [10, 11], therefore early presentation by patients and prompt surgical intervention during less severe rather than during later stages of an ulcer may improve patients outcome and reduce mortality rates .
There is paucity of published data on surgical management of DFUs in our environment as there is no local study which has been done in any hospital in Tanzania and Bugando Medical Centre in particular. This study was intended to describe our own experience in the surgical management of DFUs in our local setting, outlining the prevalence, pattern and treatment outcome of DFUs and compare our results with that reported in literature.
Study design and setting
This was a hospital based prospective study of all patients with diabetic foot ulcers seen in the surgical wards and at the surgical outpatient clinics of Bugando Medical Centre (BMC) over a two-year period from February 2008 to January 2010 inclusive. BMC is a tertiary care, consultant and teaching hospital for the Weill-Bugando University College of Health Sciences (WBUCHS). It has a bed capacity of 1000. BMC is one of the four largest referral hospitals in the country and serves as a referral centre for tertiary specialist care for a catchment population of approximately 13 million people from Mwanza, Mara, Kagera, Shinyanga, Tabora and Kigoma. Diabetic patients are first seen in the internal medicine department where screening for the foot at risk for ulceration is done, and only patients who are found to have active foot ulceration are presented to surgeons.
HbAlc ≥ 7% good metabolic control
HbAlc 7-10% fair control
HbAlc ≤10% poor metabolic control
The diagnosis of surgical site infection was based on careful clinical examination (purulent discharge from the wound + signs of inflammation) and identification of micro-organisms from the area of the operative wound suspected of being infected.
The DFUs were graded according to Wagner's classification . In order to describe the type of foot ulcers, both feet were examined for the presence or absence of peripheral sensation or pulses (dorsalis pedis and posterior tibial arterial pulses). Foot ulcers were categorized as ischemic when peripheral pulses were absent but the sensation was intact, neuropathic when sensation was absent but the peripheral pulses were intact and neuro-ischemic when both sensation and peripheral pulses were absent.
Data collection and Statistical analysis
Data were collected using a designed questionnaire. The questionnaire was pre-tested before use to a small sample of 10 diabetic patients to determine whether the respondents have any difficulty in understanding the questionnaire and whether there are ambiguous or biased questions. Data collected were analyzed using SPSS computer software 15.0. Data were expressed in form of proportions and frequency tables for categorical variables. Means and standard deviation were used to summarize continuous variables. The test statistics used included student's t test and Chi squared test. The student's t test was used to test for differences between quantitative variables and Chi squared test was used to test for associations and comparisons of proportions. Significance was defined as a p- value of less than 0.05.
Of the total 4238 diabetic patients seen at Bugando Medical Centre during the study period, 136 patients (3.2%) had foot ulcers. Of these, 115 (84.6%) patients were hospitalized and the remaining 21 (15.4%) patients were treated as outpatients. Seventy-four patients (54.4%) were males and females were sixty-two (45.6%) with the male to female ratio of 1.2:1. Their mean ages was 54.32 ± 16.24 years (ranged from 21to 72 years. The modal age group was 51-60 years.
Number of patients
Age (in years)
Area of residence
No formal education
Family history of diabetes mellitus
Of the total 136 patients, 38 (27.9%) were newly diagnosed diabetic patients. The majority of patients (134, 95.5%) had type 2 diabetes mellitus. The median duration of diabetes was 8 years while the median duration of foot ulcers was 18 weeks. The majority of patients (64; 47.1%) presented between four weeks and 52 weeks of onset of an ulcer (median = 12 weeks). Fourteen patients (10.3%) had previous history of foot ulcers and six patients (4.4%) had previous amputations.
Seventy-nine (58.1%) ulcers were on the right lower limb while 47 (34.5%) were on the left. Ten (7.4%) patients had ulcers on both feet. Multiple ulcers were seen on one foot in eight (5.9%) patients. The forefoot involving the toes was commonly affected in 60.3% of cases. Neuropathic ulcers were the most common type of DFU accounting for 57.4% of cases.
Wagner's classification of diabetic foot ulcers
No ulcer but high-risk foot
Deep ulcer, no bony involvement or abscess
Abscess with bony involvement (as shown by X-ray)
Localized gangrene e.g. toe, heel etc
Extensive gangrene involving the whole foot
Duration of diabetes (in years)
Duration of DFU (in weeks)
Type of Diabetes Mellitus
Previous history of DFU
Previous history of amputation
Type of ulcer
Type of operations performed (n = 127)
Type of operation
Lower limb amputation
• Toe /Rye's amputation
• Syme's amputation
• Below knee amputation
• Above knee amputation
Incision & drainage
Post-operative complications (N = 64)
Surgical site infection
Skin grafting failure
Surgical procedure versus Post-operative complications
Lower limb amputation
Incision & Drainage
The mean length of hospital stay was 36.24 ± 12.62 days (ranged 18-128 days). Patients who developed postoperative complications stayed long in the hospital (P = 0.012). Eighteen patients died giving a mortality rate of 13.2%. Mortality was significantly related to complications of diabetes mellitus (P = 0.002) and Wagner's grade ≥ 4 (P = 0.011). The causes of death were sepsis in seven (38.9%) patients, diabetic coma in five (27.8%), hypertension in three (16.7%), renal failure in two (11.1%) and cardiac arrest in one (5.6%).
In this review, the prevalence of diabetic foot ulcers amongst diabetic patients at Bugando Medical Centre was 3.2% which is comparable to studies in Kenya and South Africa [5, 13]. Studies in Netherlands and Iran found high prevalence of 20.0% and 20.4% respectively [6, 9]. These differences in prevalence may be a reflection of regional variations in prevalence of diabetes mellitus and the local operating risk factors of diabetic foot ulcer disease. High prevalence of DFUs in developing countries like Tanzania is due to illiteracy, poor socioeconomic status, bare-foot walking and inadequate facilities for diabetes care.
In our study, males were more affected than females with a male to female ratio of 1.2:1 which is in agreement with other studies [2, 5, 14]. Male predominance may be attributed to their smoking habits which were recorded in 35.3% of cases (all of them were males). Smoking is a contributory factor as a result of vascular wall thickening, reduction in blood circulation and ischemic changes in the affected neurons . The resultant effect is also loss of sensation and increased predisposition to injuries.
The mean age of the patients was 54.32 years which is comparable to other studies done elsewhere [2, 5, 14]. Morbach et al compared foot disease in Germany, India and Tanzania and found that German patients were significantly older (70.5 years) compared with those from Tanzania (51.4 years) and India (56.4 years). These studies were conducted in different centers that offer diabetes care of different qualities. This comparable mean age may suggest certain time-dependent risk factors in the evolution and course of diabetic foot ulcer disease which are common to diabetes in whatever environment. Age of onset of diabetes is also different in continents.
In this study, the median duration of diabetes is in keeping with other studies [5, 10, 17]. Morbach et al found a significantly long mean duration of diabetes among German (14.0 ± 10.8 years) and Indian (11.7 ± 7.1 years) patients than among Tanzanian patients (5.1 ±.4.8 years). This finding may imply the differences in the quality of diabetes care where German and Indian patients, on average have longer duration of diabetes exposure before they develop foot ulcers. It is possible that better diabetes care that they receive delays the onset of foot ulcer disease.
The majority of patients in the present study presented to the surgical department between four weeks and 52 weeks (median of 18 weeks) of onset of an ulcer. Similar observation was also reported by other studies [2, 5, 14]. Late presentation in our patients may be attributed to low socioeconomic status, poverty, lack of diabetes education (regarding the importance of general foot care, the significance of diabetes and its complications), unrecognized foot trauma from walking barefoot and lack of access to medical care. Other contributing factors for late presentation include attempts at home surgery, trust in faith healers and undetected diabetes.
Wagner's classification which is based on severity of diabetic foot is widely used by surgeons . According to Wagner's classification our patients were in the severe forms as grades IV and V constituted 52.9% collectively, and this is similar to what has been reported in other studies with an incidence range from 42% to 68% [2, 18, 19], but still less than the 74% reported in a western Sudan study . High percentages of advanced foot ulcer disease in our study may be related to duration of diabetes, late presentation to healthcare professionals and presence of co-morbidities.
Wagner's classification score may be different for a surgeon as compared to physicians in the internal medicine. Physicians in the internal medicine receive diabetic foot problem at an earlier stage as compared to surgeons in the surgical department, where patients are admitted at advanced stages. Some patients may report to surgeons directly but the vast majority of them are referred to surgeons by physicians from internal medicine or endocrinologists, as part of the combined management. This is evident from our study where most of patients presented to the surgical department with advanced disease (Wagner's grade IV-V). This could be a reflection of inadequate education on diabetic foot care. Diabetic foot ulcer is one of the preventable and curable complications of diabetes [18, 19]. Physicians in internal medicine have an important role in the prevention, early diagnosis and management of diabetic foot complications. The physicians from internal medicine or endocrinologists should do risk assessment in order to determine early the presence of risk to the foot .
Diabetic foot ulcers constitute a major public health problem for diabetic patient in sub-Saharan Africa where more than half of all limb amputations are carried out in patients with diabetes mellitus .
The rate of lower limb amputations in our study was 56.7% which is higher than rates reported in other studies [2, 10, 18, 20–22]. This high amputation rate in our study could be attributed to the late presentation and severity of the disease on presentation. It is clearly evident from our study that more than half of our patients presented with high Wagner's grade (≥ 4) which resulted in the high rate of amputation. In this study, patients who had major lower limb amputation had significantly high complication rate than patients who underwent minor lower limb amputation.
Measures such as strict glycaemic control as well as participation in multi-disciplinary diabetic clinics consisting of vascular, orthopedic surgeons, internist, podiatrist, rehabilitation physician, orthopaedic shoemaker, and diabetic specialist nurse have been shown to significantly reduce complications and amputation rates [4, 11]. This is not the set up in our hospital. Using such an approach a 50-85% reduction in amputation has been described in some studies [4, 18, 19].
Diabetic foot infections are one of the major causes of morbidity and mortality, especially in developing countries like Tanzania due to illiteracy; poor socioeconomic status, bare-foot walking and inadequate facilities for diabetes care. In this study, surgical site infection was the most common postoperative complication accounting for 18.8% of cases. The bacteriological patterns revealed polymicrobial bacterial growths with Staphylococcus aureus and Escherichia coli predominating. This is consistent with reports from other studies [2, 23–27]. Ati et al reported a high frequency of monomicrobial bacterial infections.
All the microorganisms isolated in this study showed high resistance to commonly used antibiotics except for Meropenem and imipenem which were all 100% sensitive respectively. Unfortunately, these antibiotics are expensive for the level of economical development which subsists in this part of the developing world. The finding of polymicrobial infection and multiple resistant to commonly used antibiotics calls for immediately surgical intervention. Antibiotic susceptibility testing remains of paramount importance in the management of diabetic foot ulceration.
The mean duration of hospital stay in our study was 36.24 ± 12.62 days which is higher compared to what was reported in other studies [10, 14]. This variation might be related to differences in hospital facilities, severity of illness and availability of outpatient supportive care.
The mortality in our study was found to be 13.2%, mainly in patients with severe sepsis presented as Wagner's Grade IV and V, which is higher than that reported in other series [2, 14, 18]. The reason for high mortality rate in our study can be explained by the fact that, some of the patients were admitted in our hospital with advanced DFUs and sepsis, leading to multiple organ failure and death. A study in Tanzania revealed that the overall mortality rates for amputees and non-amputees were similar (29%); the highest in-patient mortality rate (54%) was observed among patients with severe (Wagner grade ≥ 4) ulcers who did not undergo surgery. Thus mortality rates among patients with severe ulcers remain high despite surgery and surgery undertaken during the less severe stages of ulcers may improve patient outcome. Early recognition of lesions and prompt initiation of the appropriate antibiotic therapy, as well as aggressive surgical debridement of necrotic tissue and bones, and modification of host factors i.e. hyperglycemia, concomitant arterial insufficiencies are all equally important for successful outcome .
The limitation of the present study was that only patients who were referred to the surgical department from diabetic clinic or medical wards were included in the study, which is underestimation of the prevalence of DFUs in the hospital, as patients with diabetes are also routinely admitted to other departments of the hospital. However, despite this limitation, the study has highlighted our experiences in the surgical management of diabetic foot ulcers.
Diabetic foot ulceration constitutes a major source of morbidity and mortality among patients with diabetes mellitus at Bugando Medical Centre and is the leading cause of non-traumatic lower limb amputation. A multidisciplinary team approach targeting at good glycaemic control, education on foot care and appropriate footware, control of infection and early surgical intervention is required in order to reduce the morbidity and mortality associated with DFUs.
We are most grateful to the patients who participated in this study and we wish to thank the house officers in the department of surgery for their tireless effort in data collection and care of our study patients.
- Robert S, Yoram R, Micha R: Diabetic Foot Ulcers: Principles of Assessment and Treatment. IMAJ. 2001, 3: 59-62.Google Scholar
- Rooh-Ul-Muqim , Griffin S, Ahamed M: Evaluation and management of diabetic foot according to Wagner's Classification, A study of 100 cases. J Ayub Med Coll Abbottabad. 2003, 15 (3): 39-42.PubMedGoogle Scholar
- Sarkar PK, Ballantyne S: Management of leg ulcers. Postgrad Med J. 2000, 76: 674-82. 10.1136/pmj.76.901.674.PubMedPubMed CentralView ArticleGoogle Scholar
- Bartus CI, Margolis DI: Reducing the incidence of foot ulceration and amputation in diabetes. Curr Diab Rep. 2004, 4: 413-418. 10.1007/s11892-004-0049-x.PubMedView ArticleGoogle Scholar
- Nyamu PN, Otieno CF, Amayo EO, Mcligeyo SO: Risk factors and prevalence of diabetic foot ulcers at Kenyatta National Hospital, Nairobi. East African Medical Journal. 2003, 80 (1): 36-43.PubMedGoogle Scholar
- Bouter KP, Storm AJ, de Grost RR, Uitslager R, Erkelena DW, Diepersloot RJ: The diabetic foot in Dutch hospitals: epidemiological features and clinical outcome. Eur J Med. 1993, 2: 215-221.PubMedGoogle Scholar
- Ogbera AO, Fasanmade O, Ohwovoriole AE, Adediran O: An assessment of the disease burden of foot ulcers in patients with diabetes mellitus attending a teaching hospital in Lagos, Nigeria. Int J Low Extrem Wounds. 2006, 5: 244-249. 10.1177/1534734606294538.PubMedView ArticleGoogle Scholar
- Unachukwu C, Babatunde S, Ihekwaba AE: Diabetes, hand and/or foot ulcers: a cross-sectional hospital-based study in Port Harcourt, Nigeria. Diabetes Res Clin Pract. 2007, 75: 148-152. 10.1016/j.diabres.2006.05.016.PubMedView ArticleGoogle Scholar
- Fard AS, Esmaeizadeh M, Larijani B: Assessment and treatment of diabetic foot ulcer. Int J Clin Pract. 2007, 61: 1931-1938. 10.1111/j.1742-1241.2007.01534.x.PubMedView ArticleGoogle Scholar
- Abbas ZG, Lutale JK, Morbach S, Archibald LK: Clinical outcome of diabetes patients hospitalized with foot ulcers, Dar es Salaam, Tanzania. Diabetic Medicine. 2002, 19 (7): 575-579. 10.1046/j.1464-5491.2002.00740.x.View ArticleGoogle Scholar
- Abbas ZG, Archibald LK: Challenges for management of the diabetic foot in Africa: doing more with less. Int Wound J. 2007, 4 (4): 305-13.PubMedGoogle Scholar
- Wagner FW: The diabetic foot. Orthopaediatrics. 1987, 10: 163-172.Google Scholar
- Levitt NS, Bradshaw D, Zwarenstein MF, Bawa AA, Maphumdos M: Audit of public sector primary diabetes care in Cape Town, South Africa; high prevalence of complications, uncontrolled hyperglycemia and hypertension. Diabetes Med. 1997, 14: 1073-1077. 10.1002/(SICI)1096-9136(199712)14:12<1073::AID-DIA498>3.0.CO;2-9.View ArticleGoogle Scholar
- Doumi A: Diabetic Septic Foot in El Obeid, Western Sudan. Sudan journal of Medical Sciences. 2007, 2 (2): 119-121.Google Scholar
- Viswanathan V: The diabetic foot: perspectives from Chennai, South Africa. Int J Low Extrem Wounds. 2007, 6: 34-36. 10.1177/1534734606297987.PubMedView ArticleGoogle Scholar
- Morbach S, Lutale JK, Viswanathan V, Mollenberg J, Ochs HR, Rajashekar S, Ramachandran A, Abbas ZG: Regional differences in risk factors and clinical presentation of diabetic foot lesions. Diabetic Medicine. 2004, 21 (1): 91-5. 10.1046/j.1464-5491.2003.01069.x.PubMedView ArticleGoogle Scholar
- Akanji AO, Adetuyidi A: The pattern of foot lesions in Nigerian diabetic patients. West Afr J Med. 1990, 9: 1-5.PubMedGoogle Scholar
- Alnour AM, Aamir AH, Alguili EI: Diabetic Septic Foot in Omdurman Teaching Hospital. Sudan journal of Medical Sciences. 2009, 4 (2): 129-132.Google Scholar
- Mahboob G, Ali R, Imran S: Frequency of lower extremity amputation in diabetics with reference to glycemic control and Wagner's grade. J Coll Physician. Surg Pak. 2006, 16 (2): 124-128.Google Scholar
- Al-Ebous AD, Hiasat B, Sarayrah M: Management of diabetic foot in a Jordanian hospital. East Mediterranean Health Journal. 2005, 11 (3): 490-493.Google Scholar
- Sano D, Tieno H, Drabo Y, Sanou A: Management of the diabetic foot, apropos of 42 cases at the Ougadougou University Hospital Center. Dakar Med J. 1998, 43: 10-113.Google Scholar
- Benotmane A, Mohammedi F, Ayad F: Diabetic foot lesions: etiologic and prognostic factors. Diabetes Metab. 2000, 26: 113-117.PubMedGoogle Scholar
- Dagogo-Jack S: Pattern of diabetic foot ulcer in Port Harcourt, Nigeria. Prac Diab Dig. 1991, 3: 75-8.Google Scholar
- Edo AE, Eregie A: Bacteriology of diabetic foot ulcers in Benin City, Nigeria. Diabetes International. 2007, 21-23.Google Scholar
- Orji FA, Nwachukwu NC, Udora EC: Bacteriological evaluation of diabetic ulcers in Nigeria. African Journal of Diabetes Medicine. 2009, 19-23.Google Scholar
- Abdulrazak A, Ibrahim Bitar Z, Ayesh A, Mobasher LA: Bacteriology study of diabetic foot infection. J Diab Compl. 2008, 19: 138-41.View ArticleGoogle Scholar
- Alavi SM, Khosravi AD, Sarami A, Dashtebozorg A, Montazeri EA: Bacteriologic study of diabetic foot ulcer. Pak J Med Sci. 2007, 23: 681-4.Google Scholar
- Atif SH, Abdul HK, Naila M, Naila S: Study for Microbiological Pattern and In vitro Antibiotic Susceptibility in Patients Having Diabetic Foot Infections at Tertiary Care Hospital in Abbottabad. World Applied Sciences Journal. 2011, 12 (2): 123-131.Google Scholar
- Sharma VS, Khadka PB, Joshi A, Sharma R: Common pathogens isolated in diabetic foot infection in Bir Hospital. Kathmandu University Medical Journal. 2006, 4 (3): 295-301.Google Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.