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Table 1 Characteristics of patients with unfavorable cancer of unknown primary site (n = 179)

From: Evaluation of prognostic factors and the role of chemotherapy in unfavorable carcinoma of unknown primary site: a 10-year cohort study

Characteristic No. of patients %
Median age at diagnosis, year (range, IQR) 73 (30-98, 58-80)  
Gender   
   Male 128 71.5
   Female 51 28.5
Histology   
   Carcinoma, unclassifiable 83 46.4
   Adenocarcinoma 71 39.7
   Squamous cell carcinoma 6 3.4
   Neuroendocrine carcinoma 12 6.7
   Others 7 3.9
Histologic grade   
   Poorly differentiated or Undifferentiated 31 17.3
   Unspecified 148 82.7
Performance status   
   0 19 10.6
   1 67 37.4
   2 44 24.6
   3 27 15.1
   4 22 12.3
Initial site at diagnosis   
   Liver 38 21.2
   Lung 23 12.8
   Bone 47 26.3
   Central nervous system 7 3.9
   Peritoneum 18 10.1
   Lymph nodes 43 24
   Others 3 1.7
Sites of disease involvement   
   Liver 80 44.7
   Lung and pleural 87 48.6
   Bone 74 41.3
   Central nervous system 14 7.8
   Lymph nodes 107 59.8
No. of metastatic organs   
   1 40 22.3
   2 52 29.1
   > 2 87 48.6
Treatment   
   Chemotherapy 118 66.0
   Radiotherapy 52 29.1
   Tyrosine kinase inhibitors 2 1.1
Chemotherapy regimens   
   Cisplatin-based 89 75.4
   5-FU-based 51 43.2
   Etoposide-based 45 38.1
   Gemcitabine-based 17 14.4
   Taxane-based 13 11.0
   Oxaliplatin-based 11 9.3
  1. IQR, inter-quartile range.