Array data extractor (ADE): a LabVIEW program to extract and merge gene array data

BMC Research Notes

Table 1 Class A GPCRs significantly regulated in human heart disease

Gene	p-value	+/-	Gene	p-value	+/-	Gene	p-value	+/-
P2RY13	0.00E + 00	+	NPBWR1	7.37E-08	-	GPR78	3.46E-05	-
P2RY14	0.00E + 00	+	PTGER2	7.82E-08	-	HCRTR2	5.29E-05	+
S1PR3	9.04E-52	-	P2RY12	7.98E-08	+	S1PR2	6.57E-05	-
GPR4	2.80E-31	-	GPR3	9.09E-08	-	OPN3	7.01E-05	-
P2RY2	3.08E-30	-	CMKLR1	1.07E-07	+	F2RL1	1.07E-04	-
ADRB1	7.41E-21	-	LPAR3	1.50E-07	-	HTR7	1.37E-04	-
MRGPRF	5.41E-19	-	P2RY11	1.68E-07	-	S1PR4	1.50E-04	-
C5AR1	3.34E-14	-	TAAR1	1.21E-06	-	GPR171	1.93E-04	+
PTGER3	3.91E-13	-	GPR84	1.25E-06	-	MRGPRX2	2.40E-04	-
GPR34	1.94E-12	+	GALR2	1.64E-06	-	GPR37L1	4.36E-04	-
CXCR4	1.77E-11	+	GPR161	2.88E-06	-	HRH2	4.47E-04	-
DARC	3.48E-10	-	RXFP3	3.60E-06	-	CCR2	7.51E-04	-
LTB4R	2.98E-09	-	TSHR	5.54E-06	-	BDKRB1	7.96E-04	-
FPR2	6.92E-09	-	ADRA1B	7.49E-06	-
HTR2B	3.19E-08	+	P2RY6	8.14E-06	-

47 of 288 class A GPCRs are differentially expressed in heart disease (p < 0.001). List of receptors was derived from the website of the International Union of Basic and Clinical Pharmacology (http://www.iuphar-db.org). Data was combined from 12 studies, containing 25 groups and 14 different cardiomyopathies: human arrhythmogenic right ventricular cardiomyopathy (ARVC, 1 group, 12 samples, 12 controls), dilated cardiomyopathy (DCM, 13 groups, 241 samples, 127 controls), doxorubicin induced cardiomyopathy (DOX, 1 group, 7 samples, 8 controls), fetal cardiomyopathy (FCM, 1 group, 5 samples, 5 controls), valvular cardiomyopathy (VCM, 1 group, 7 samples, 11 controls), hypertrophic cardiomyopathy (HCM, 3 groups, 119 samples, 55 controls), and ischemic cardiomyopathy (ICM, 5 groups, 166 samples, 52 controls). p-value represents combined p-values using Stouffer’s Z-transform method. +/- indicates up- or down-regulation reported by > 75% of the studies.

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