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Table 1 Class A GPCRs significantly regulated in human heart disease

From: Array data extractor (ADE): a LabVIEW program to extract and merge gene array data

Gene p-value +/- Gene p-value +/- Gene p-value +/-
P2RY13 0.00E + 00 + NPBWR1 7.37E-08 - GPR78 3.46E-05 -
P2RY14 0.00E + 00 + PTGER2 7.82E-08 - HCRTR2 5.29E-05 +
S1PR3 9.04E-52 - P2RY12 7.98E-08 + S1PR2 6.57E-05 -
GPR4 2.80E-31 - GPR3 9.09E-08 - OPN3 7.01E-05 -
P2RY2 3.08E-30 - CMKLR1 1.07E-07 + F2RL1 1.07E-04 -
ADRB1 7.41E-21 - LPAR3 1.50E-07 - HTR7 1.37E-04 -
MRGPRF 5.41E-19 - P2RY11 1.68E-07 - S1PR4 1.50E-04 -
C5AR1 3.34E-14 - TAAR1 1.21E-06 - GPR171 1.93E-04 +
PTGER3 3.91E-13 - GPR84 1.25E-06 - MRGPRX2 2.40E-04 -
GPR34 1.94E-12 + GALR2 1.64E-06 - GPR37L1 4.36E-04 -
CXCR4 1.77E-11 + GPR161 2.88E-06 - HRH2 4.47E-04 -
DARC 3.48E-10 - RXFP3 3.60E-06 - CCR2 7.51E-04 -
LTB4R 2.98E-09 - TSHR 5.54E-06 - BDKRB1 7.96E-04 -
FPR2 6.92E-09 - ADRA1B 7.49E-06 -    
HTR2B 3.19E-08 + P2RY6 8.14E-06 -    
  1. 47 of 288 class A GPCRs are differentially expressed in heart disease (p < 0.001). List of receptors was derived from the website of the International Union of Basic and Clinical Pharmacology (http://www.iuphar-db.org). Data was combined from 12 studies, containing 25 groups and 14 different cardiomyopathies: human arrhythmogenic right ventricular cardiomyopathy (ARVC, 1 group, 12 samples, 12 controls), dilated cardiomyopathy (DCM, 13 groups, 241 samples, 127 controls), doxorubicin induced cardiomyopathy (DOX, 1 group, 7 samples, 8 controls), fetal cardiomyopathy (FCM, 1 group, 5 samples, 5 controls), valvular cardiomyopathy (VCM, 1 group, 7 samples, 11 controls), hypertrophic cardiomyopathy (HCM, 3 groups, 119 samples, 55 controls), and ischemic cardiomyopathy (ICM, 5 groups, 166 samples, 52 controls). p-value represents combined p-values using Stouffer’s Z-transform method. +/- indicates up- or down-regulation reported by > 75% of the studies.
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