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Eosinophilic myocarditis: two case reports and review of the literature
BMC Research Notes volume 6, Article number: 538 (2013)
Eosinophilic myocarditis is a rare and often under-diagnosed subtype of myocarditis with only around 30 cases published in the medical literature. In this article we present two patients with eosinophilic myocarditis with the aim to demonstrate the often elusive nature of the disease and present the current scientific literature on this topic.
A 76 years old Caucasian gentleman and a 36 years old Aboriginal gentleman both presenting with heart failure symptoms were eventually diagnosed with eosinophilic myocarditis after extensive evaluation. Their presentation, assessment, and medical management is explored in this article.
Eosinophilic myocarditis remains a rare and likely under-diagnosed subtype of myocarditis. The key features of this disease include myocardial injury in the setting of non-contributory coronary artery disease. Endomyocardial biopsy remains the definitive gold standard for diagnosis of noninfectious eosinophilic myocarditis. Non-invasive cardiac imaging in the setting of peripheral eosinophilia can be strongly suggestive of eosinophilic myocarditis with potential for earlier diagnosis. Failure to diagnose eosinophilic myocarditis and the delay of therapy may lead to irreversible myocardial injury. Therapies for this disease have yet to be validated in large prospective studies.
Myocarditis refers to heart muscle inflammation secondary to direct external antigen exposure such as viruses, bacteria, parasites, and drugs or to autoimmune activation against self-antigens. Traditionally the diagnosis of myocarditis was based on the histological Dallas criteria on endomyocardial biopsy which mandates the visualization of inflammatory cells and myocardial necrosis on the same microscopic section; if concomitant necrosis is not detected the diagnosis of myocarditis is considered borderline. Given the limitations of endomyocardial biopsies, in particular its low sensitivity from the often patchy nature of the disease and potential procedural risks, more recent and broader definitions of myocarditis were introduced. These encompass a hybrid of clinical, laboratory, and imaging criteria that may help secure the diagnosis and forgo the need for a biopsy in all cases .
The prevalence of myocarditis in general is not well established given the lack of consensus on its diagnostic criteria in the scientific community. As such, among unselected autopsy series, its prevalence is as high as 1 to 5% . The most common causes of myocarditis include infectious and autoimmune etiologies . Eosinophilic myocarditis (EM) is a rare subtype of myocarditis characterized by focal or diffuse myocardial inflammation with infiltrating eosinophils and is often associated with peripheral blood eosinophilia [2, 3]. To date there are less than 30 published case reports of EM and include patients ranging from 2 to 83 years of age . Given the rarity of this form of myocarditis, it is often under-recognized and first discovered on postmortem examination . EM was observed in 0.5% of unselected autopsy series and in more than 20% of explanted hearts from heart transplant recipients secondary to drug-induced hypersensitivity .
In this review article we present two cases of eosinophilic myocarditis and outline the current scientific literature on this topic including its pathophysiology, diagnosis, and recommended therapy.
A 76-year-old Caucasian gentleman with a history of hypertension and asthma presents with history of sharp and pleuritic chest pain radiating to the shoulders with associated dyspnea with gradual deterioration of functional status to New York heart Association (NYHA) functional class III. Laboratory investigations revealed a normal creatine kinase (CK), elevated troponin T at 2.74 ug/L, C– reactive protein (CRP) at 140 mg/L (normal: 0–8), and eosinophilia at 3.92×105/L. The initial presumptive diagnosis was acute coronary syndrome however coronary angiography revealed no significant coronary artery disease. The patient was found to have global reduction in left ventricular systolic function, ejection fraction (EF) 30-35%, along with mildly impaired right ventricular dysfunction on echocardiography. In addition, an uninfused computed tomography (CT) scan of the chest revealed a small right pleural effusion and multiple small centrilobar nodules in the lungs bilaterally with upper lung zone predominance and ground glass attenuation consistent with pulmonary eosinophilia. Magnetic resonance imaging (MRI) identified mild subendocardial delayed enhancement with a near circumferential distribution raising the possibility of eosinophilic myocarditis (Figures 1, 2). There were no suggestions of underlying infection and stool for ova and parasites as well as serology for trypanosome and strongyloides were negative. A vasculitis screen including anti-neutrophil cytoplasmic antibodies (ANCAs) was negative. There were no recently started medications to suggest a drug induced hypersensitivity reactions and physical exam and history were negative for malignancy.
Given this presentation, a diagnosis of clinically suspected eosinophilc myocarditis, idiopathic hypereosinophilic syndrome subtype (HES) in particular, with possible pulmonary involvement was made. The patient declined to undergo a confirmatory endomyocardial biopsy. In addition to the standard medical management of heart failure he was started on oral prednisone at 60 mg per day with 10 mg tapering doses per week to a baseline maintenance dose of 10 mg per day. Unfortunately he showed little to no recovery in cardiac function and is currently being treated medically for his heart failure and followed as an out-patient in the heart failure clinic.
A 36-year-old male presents with a two-month history of shortness of breath on exertion progressing to NYHA class III symptoms. His history and physical examination were otherwise unremarkable aside from this new onset heart failure. Laboratory investigations revealed mildly elevated white blood cell (WBC) count with mild elevation in the absolute eosinophil count (1.7×105/L; normal range 0.0-0.4×105/L). Echocardiography demonstrated severe biventricular dysfunction with left ventricular EF <20% and subendocardial delayed enhancement was identified on cardiac MRI consistent with myocarditis. Coronary angiography was unremarkable and endomyocardial biopsy demonstrated active myocarditis with intact and degranulating interstitial eosinophils; greater then 5–8 cells per biopsy specimen (Figure 3). Since there was no evidence of infection, vasculitis, malignancy, or drug induced hypersensitivity reactions the diagnosis of idiopathic eosinophilic myocarditis was established. In addition to standard heart failure treatment, 1 g/day of IV methylprednisolone was initiated for three days followed by two weeks of oral prednisone at 50 mg/day with slow taper. The maintenance dose of steroids was unfortunately discontinued prematurely secondary to corticosteroid-induced psychosis and the development of a concurrent cellulitis and suspicion of pneumonia precluded alternative immunosuppressive treatment. Only mild improvement in cardiac function was observed; the patient is currently being treated medically for his heart failure and followed as an out-patient at the heart failure clinic.
When the diagnosis of myocarditis is strongly suspected confirming the etiology as eosinophilic in nature may be challenging short of endomyocardial biopsy given the rarity of the disease and its vague clinical presentation. Patients with EM may indeed present with various signs and symptoms including fever, chills, malaise, weight loss, acute coronary syndrome-like features, heart failure, tachy- or brady-type arrhythmias, and sudden death [4–6]. To date there are no universally accepted guidelines for the diagnosis of EM but as the disease becomes better recognized so will its characterization. The Japanese Circulation Society Task Force Committee on Acute and Chronic Myocarditis published helpful guidelines for the diagnosis and treatment of EM ; essential diagnostic features include eosinophilia > 500/μL, cardiac symptoms, elevated cardiac enzymes, electrocardiogram (ECG) changes, and cardiac dysfunction on ultrasonography, especially in the setting of unremarkable coronary angiography. Definitive diagnosis requires an endomyocardial biopsy .
In EM, the eosinophils may be associated with myocardial inflammation in three distinct forms . The first is a hypersensitivity reaction to a foreign antigen known as allergic esosinophilic myocarditis and is often drug induced . Myocardial inflammation may also be triggered in association with systemic eosinophilc disorders such as Churg-Strauss. Lastly, EM may present in the form of fulminant necrotic myocarditis of unclear etiology . Clinical disorders that may result in both hypereosinophilia and endomyocardial injury include idiopathic hypereosinophilic syndrome, malignancies, parasitic infections, vasculitic and granulomatous diseases, tropical endomyocardial diseases, drug reactions, and transplant rejections . A paramount diagnostic feature of EM on endomyocardial biopsy includes the detection of myocardial eosinophils; these inflammatory cells are rarely detected in normal myocardial interstitium thus their presence is considered pathologic for EM . Regardless of the underlying etiology of EM, whether related to the HES or a parasitic infection, eosinophil-mediated cardiac injury occurs in a similar fashion and ranges from early necrosis to subsequent thrombosis and fibrosis . On a macroscopic level this type of myocardial injury can translate into variable degrees of focal or diffuse structural abnormalities including systolic or diastolic dysfunction, mural thrombi, micro-abscesses, ventricular wall aneurysms, and rupture [10, 12, 13]. The sensitivity of endomyocardial biopsy based on autopsy specimens was estimated to be around 54% given the often patchy nature of the disease and this is likely even lower in the beating heart due to the technical difficulties of the biopsy procedure . A minimum of 5 right ventricular samples should be obtained, however this is based on transplant rejection data for which endomyocardial biopsy is very sensitive and is not standardized for the detection of myocarditis . Additionally, studies have shown significant interobserver variability in the interpretation of endomyocardial biopsy specimens in diagnosis of myocarditis . Although life-threatening complications such as right ventricular perforation are reported to be less than 1%, the overall complication rate including tricuspid regurgitation, occult pulmonary embolism, transient arrhythmias and access site hematoma is as high as 6% .
The presence of peripheral eosinophilia may heighten the suspicion for EM but relying solely on this laboratory parameter to diagnose EM and judge treatment response may be misleading. In essence, some patients with sustained eosinophilia never develop cardiac disease and others with biopsy confirmed EM never develop eosinophilia throughout the course of their disease [4, 11]. The detection of eosinophil cationic protein (ECP), one of several toxic proteins derived from the degranulation of eosinophils, may be an adjunct to the diagnostic potential of peripheral eosinophilia . Arima and colleagues were the first to report the utility of serum levels of ECP in the diagnosis and treatment response of five patients with EM showing normalization of ECP levels with disease regression . These observations suggest that ECP may in part be responsible for the pathophysiology of EM and that the number of myocardial degranulated eosinophils rather than the total number of eosinophils may be of greater diagnostic significance .
Non-invasive cardiac imaging in myocarditis, such as echocardiography, nuclear imaging with gallium67- or indium111-labeled antimyosin antibodies, and MRI can be useful in assessing myocardial dysfunction although there are no specific features that help establish the diagnosis of EM with certainty as is the case with endomyocardial biopsy . Echocardiography is usually the most readily available imaging modality in most institutions. Common findings on 2D echocardiography include left ventricular dysfunction in up to 69% of cases as evidenced by segmental wall motion abnormalities. Reversible left ventricular hypertrophy can also be observed in 15% of cases while left ventricular cavity dilatation is usually minimal or absent. In addition, only 23% will have right ventricular involvement .
Nuclear imaging can be highly sensitive in detecting evidence of myocarditis, such as myocyte necrosis (sen 83%), and although its specificity is only moderate at an estimated 53% it has a high negative predictive value of 92% . Limitations of nuclear imaging include limited tracer availability, poor spatial resolution, and radiation exposure to the patients and staff .
Cardiac MRI is a good non-invasive diagnostic imaging alternative, in particular when it comes to its safety, reproducibility, and ability to accurately evaluate cardiac anatomy and function . MRI can nicely depict the common abnormalities noted in myocarditis which include ventricular dysfunction, transient increase in wall thickness and chamber dimensions, pericardial effusion, and inflammatory tissue changes such as edema, capillary leakage, hyperemia, cellular necrosis, and fibrosis . Myocardial edema can be detected using T2-weighted imaging while delayed enhancement imaging allows for the visualization of myocardial fibrosis and inflammation. Esosinophilic myocarditis is typically characterized by extensive myocardial hyperintensity on T-2 weighted imaging along with subendocardial delayed enhancement; mesocardial and epicardial delayed enhancement have also been reported and the extend of delayed enhancement is inversely proportional to LV EF . Subendocardial enhancement can also be identified in the setting of myocardial infarction which should be excluded in the evaluation of a suspect case of myocarditis. The good diagnostic accuracy of MRI in myocarditis was highlighted in pooled controlled trials with a sensitivity and specificity of 67 and 91% respectively along with positive and negative predictive values of 91 and 69% respectively .
The initial treatment goal in patients with EM is to ensure hemodynamic stability. Depending on the severity of heart failure and extent of multi-organ involvement patients may require anywhere from intermittent diuresis and analgesia to full cardio-pulmonary support. In addition, reversible and readily treatable etiologies, such as therapy of an underlying parasitic infection or discontinuation of an offending drug, should be identified and addressed as soon as possible. Given the underlying inflammatory nature of EM, therapy with corticosteroids has been successfully documented in various case reports [2–5, 9]; it is important to rule out active infection on endomyocardial biopsy prior to initiation of immunosuppression, using viral PCR for instance, to avoid worsening burden of disease . A recent retrospective case series by Kawano and colleagues 20112 was the first to propose initiation and maintenance doses of prednisolone based on disease severity; initial 1 g methylprednisolone pulse dose was reserved for patients with pre-cardiac tamponade, cardiogenic shock, and pulmonary edema as compared to 1 mg/kg/day of prednisolone for more stable patients; a 5-10 mg/day dose of prednisolone was subsequently given to prevent relapse. Not all patients with EM require corticosteroid therapy, especially if the disease severity is very mild [2, 21]. There remains little consensus in the use, dose, or duration of corticosteroids in the setting of EM and the need for maintenance therapy remains to be validated in large well-designed studies . A similar conundrum exists for the use of other immunosuppressive agents, such as azathioprine, mycophenolate, and intravenous gammaglobulins, which have been used in conjunction with corticosteroids in the treatment of EM [22–24].
In our two patients, the first patient likely had a subtype of EM known as idiopathic hypereosinophilic syndrome (HES). This syndrome is characterized by absolute eosinophil count greater than 1.5×105/L lasting for more than six months in the absence of any known cause of hypereosinophilia and with evidence of multi-organ involvement directly attributable to the eosinophilia or otherwise unexplained in the clinical setting [4, 13, 25]. In our second case presentation, the patient did not have a sustained level of peripheral eosinophilia during all of his medical encounters as such it remains unclear whether he had an undifferentiated form EM or HES. Similar case presentations of EM without significant levels of peripheral eosinophils have been documented in few cases across the medical literature [26–29]. The underlying mechanism of HES is postulated to be a primary disorder of myelopoiesis or an overproduction of eosinophilopoietic cytokines by lymphocytes . The most common clinical manifestations include dermatologic, pulmonary, and gastrointestinal features with predominant pruritis, dermatitis, asthma, cough, dyspnea, abdominal pain, vomiting, and diarrhea . However some case series report cardiac involvement in up to 40-50% of patients with HES . Corticosteroid therapy in HES has been successfully documented in published case reports with induced complete or partial responses at 1 month in 85% of patients following monotherapy; most patients remained on maintenance doses with a median of 10 mg prednisone equivalent daily dose for 2 months to 20 years [4, 30, 32]. It remains uncertain however why our patients failed to respond to the proposed therapy. One possible explanation includes the late initiation of therapy secondary to the elusive diagnosis of EM and by which time myocardial injury maybe irreversible. In addition, sub-therapeutic initiation and or maintenance doses, or treatment resistant fulminant eosinophilic myocarditis may have been key factors in the observed treatment response. In our second case presentation, poor tolerance to corticosteroids and a lack of maintenance therapy were key factor as well.
EM remains a rare and likely under-diagnosed subtype of myocarditis. The key features of this disease include myocardial injury in the setting of non-contributory coronary artery disease. Endomyocardial biopsy remains the definitive gold standard for diagnosis of noninfectious EM . Non-invasive cardiac imaging in the setting of peripheral eosinophilia can be strongly suggestive of EM with potential for earlier diagnosis. Failure to diagnose EM and the delay of therapy may lead to irreversible myocardial injury. The therapies of EM have yet to be validated in large prospective studies.
Written informed consent was obtained from both patients for publication of this case report and any accompanying images. Copies of the written consent are available for review by the Editor-in-Chief of this journal.
Anti-neutrophil cytoplasmic antibody
Eosinophil cationic protein
Magnetic resonance imaging
- NYHA class:
New York Heart Association Classification
White blood cell.
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The authors declare that they have no competing interests.
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Rizkallah, J., Desautels, A., Malik, A. et al. Eosinophilic myocarditis: two case reports and review of the literature. BMC Res Notes 6, 538 (2013). https://doi.org/10.1186/1756-0500-6-538