Skip to main content

Undesirable effect of cosmetic lip augmentation with autologous fat tissue



Facial cosmetic procedures are commonplace nowadays, especially techniques that aim to increase lip volume. Full lips provide a youthful, healthy, feminine and sensual appearance. There are many techniques and materials used to recover the loss of contour that occurs with age.

Case presentation

An unusual case of fat tissue accumulation following cosmetic upper lip augmentation in a 61 year-old female was reported. Surgical treatment was performed for esthetic concerns. Microscopically, the tissue removed was composed of muscle fibers and mature adipocytes.


Undesirable effects of esthetic treatment can occur and the clinician should be familiar with such complications to diagnose and manage them.


Full and well-defined lips represent beauty, attractiveness and sensuality [1, 2]. Gravity, maxillomandibular bone resorption, teeth and soft tissue loss, sun exposure and smoking contribute to signs of aging on the lip [2, 3]. Several types of treatment are described to restore a youthful appearance, ranging from surgical methods to filler materials, such as collagen, hyaluronic acid, polymethylmethacrylate (PMMA), synthetic hydrogels, calcium hydroxyapatite, silicone, expanded polytetrafluoroethylene and autologous fat graft [3]. This report discusses an unusual case of fat tissue accumulation following cosmetic lip augmentation.

Case report

A 61 year-old female was attended at our department complaining about an unesthetic “fold” on her upper lip when smiling and talking. During anamnesis, she reported having type 2 diabetes, hypertension and a history of cosmetic augmentation of the upper lip. Twelve years ago, she was submitted to an injection of autologous fat tissue in her upper lip; however, she did not know any details about the procedure.

Physical examination revealed bilateral submucosal enlargement of the upper lip, which was soft on palpation, especially on the left side, and showed no color alteration of the mucosa (Figure 1). She was submitted to surgery based on the diagnostic hypotheses of dislocation of fat graft or double lip. The incision was made on the fold, revealing that the fat tissue was well demarcated, and was easily removed (Figure 2). Microscopically, the specimen was composed of muscle fibers and mature adipocytes (Figure 3). After 30 days of follow-up, she was satisfied with clinical result (Figure 4).

Figure 1
figure 1

Initial clinical photograph of the enlargement on the upper lip.

Figure 2
figure 2

Photograph of surgery showing removal of the autologous fat graft.

Figure 3
figure 3

Photomicrography exhibiting mature adipocytes (HE staining).

Figure 4
figure 4

Final clinical appearance.


Autologous fat transplantation is indicated for the correction of wrinkles, depressed or atrophic areas in the face [1] and volume loss in the aging process [4]. Fat injections are more successful in facial areas due to the availability of a richer vascular supply [1]. Autologous fat implant is readily available, inexpensive, host compatible and can be harvested easily and repeatedly when needed, without promoting allergies or foreign body reactions [4]. However, the disadvantages of using this material are its high viscosity and lower rates of success, especially when used for changes that occur due to aging [1].

Longevity of the correction is unpredictable, depending on the harvesting and transfer techniques of the fat [5]. Undesired dislocation of the prosthetic material to more superficial parts of the lips could be attributed to frequent movement in this area [3, 6] and ptosis induced by gravity. The lipofilling used in facial sites shows a very high risk of developing nodules of adipose tissue and other visible irregularities [4] that cause undesirable cosmetic effects, as occurred in this case. The amount of fat transferred can play a role in the degree of volume retention and in the onset of contour problems [7]. In addition, fat has an unpredictable resorption rate in the perioral region [2, 3, 7].

Differential diagnosis of this case was unsatisfactory esthetic treatment and double lip. Double lip is a rare oral abnormality, characterized by a deformity of the lip, in which a fold of labial mucosa is evident at rest or smiling [8]. Double lip, blepharochalasis and thyroid enlargement are features of Ascher Syndrome [9]. Microscopically, it presents as hyperplasia of the salivary gland and of squamous epithelium [8]. In this study, the patient only presented the appearance of “double lip”. Monhian et al. [10] have reported inflammatory response and fibrotic tissue without the presence of adipocytes in biopsies from local implantation of autologous fat graft. In this report, mature adipocytes and muscle fibers were observed. The final diagnosis was based on clinical exam and microscopic evidence.

Surgical treatment was performed for esthetic concerns. However, the treatment of patients with similar clinical appearance could be necessary due to alterations in phonetics, mastication and difficulty in wearing a prosthesis [8]. The patient decided not to perform surgery on the contralateral side and she was satisfied with the outcome.


Nowadays, esthetic treatments are widely performed, especially in the perioral area. In some cases, undesirable effects can occur and the clinician should be familiar with such complications in order to diagnose and manage them correctly.

Consent information

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.


  1. Dastoor SF, Misch CE, Wang HL: Dermal fillers for facial soft tissue augmentation. J Oral Implantol. 2007, 33: 191-204. 10.1563/1548-1336(2007)33[191:DFFFST]2.0.CO;2.

    Article  PubMed  Google Scholar 

  2. Sarnoff DS, Saini R, Gotkin RH: Comparison of filling agents for lip augmentation. Aesthet Surg J. 2008, 28: 556-563. 10.1016/j.asj.2008.07.001.

    Article  PubMed  Google Scholar 

  3. Ali MJ, Ende K, Maas CS: Perioral rejuvenation and lip augmentation. Facial Plast Surg Clin North Am. 2007, 15: 491-500. 10.1016/j.fsc.2007.08.008. Review

    Article  PubMed  Google Scholar 

  4. Botti G, Pascali M, Botti C, Bodog F, Cervelli V: A clinical trial in facial fat grafting: filtered and washed versus centrifuged fat. Plast Reconstr Surg. 2011, 127: 2464-2473. 10.1097/PRS.0b013e3182131d5d.

    Article  PubMed  CAS  Google Scholar 

  5. Kuran I, Tumerdem B: A new simple method used to prepare fat for injection. Aesthetic Plast Surg. 2005, 29: 18-23. 10.1007/s00266-004-0059-8.

    Article  PubMed  Google Scholar 

  6. Hoffmann C, Schuller-Petrovic S, Soyer HP, Kerl H: Adverse reactions after cosmetic lip augmentation with permanent biologically inert implant materials. J Am Acad Dermatol. 1999, 40: 100-102. 10.1016/S0190-9622(99)70536-0.

    Article  PubMed  CAS  Google Scholar 

  7. Glasgold RA, Lam SM, Glasgold MJ: Facial fat grafting: the new paradigm. Arch Facial Plast Surg. 2008, 10: 417-418. 10.1001/archfaci.10.6.417.

    Article  PubMed  Google Scholar 

  8. Palma MC, Taub DI: Recurrent double lip: literature review and report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009, 107: e20-e23. 10.1016/j.tripleo.2008.11.016.

    Article  PubMed  Google Scholar 

  9. Ascher KW: Das syndrom blepharochalasis, struma, and doppellippe. Klin Wochenschr. 1922, 1: 2287-8. 10.1007/BF01716885. Apud in: Palma MC, Taub DI. Recurrent double lip: literature review and report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009, 107:e20–e23

    Article  Google Scholar 

  10. Monhian N, Ahn MS, Maas CS:Injectable and implantable materials for facial wrinkles. Facial plastic and reconstructive surgery. 2002, New York: Thieme Medical Publishers, 247-262. 2,

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Estela Kaminagakura.

Additional information

Competing interests

The authors declare that there are no conflicts of interest.

Authors’ contributions

EK, JAR and JDA were involved in clinical attendance and drafting the manuscript. YRC performed the microscopic analyse. All authors read and approved the final manuscript.

Authors’ original submitted files for images

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Kaminagakura, E., Rosa, J.A., Carvalho, Y.R. et al. Undesirable effect of cosmetic lip augmentation with autologous fat tissue. BMC Res Notes 6, 79 (2013).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: