Neck swelling from a retropharyngeal abscess caused by penicillin-resistant Streptococcus pneumoniae: a case report
© Hyo et al.; licensee BioMed Central Ltd. 2014
Received: 13 August 2013
Accepted: 28 April 2014
Published: 10 May 2014
In small children, retropharyngeal abscesses usually occur after upper respiratory tract infections. Unlike in adults, these abscesses are difficult to diagnose in small children, and can rapidly develop into deep neck or mediastinal abscesses.
A 2-year-old Japanese boy recently presented to our department with a chief complaint of neck swelling. Physical examination revealed bilateral tonsillitis and swelling of the left posterior pharyngeal wall. Emergency neck computed tomography angiography showed a contrast-enhanced abscess cavity posterior to the left retropharyngeal space, and a low-density area surrounded by an area without contrast enhancement in the posterior neck. The latter was suspected to be a deep neck infection secondary to a retropharyngeal abscess. After surgery, the patient was diagnosed with a retropharyngeal abscess and concurrent cystic lymphangioma. The lesions improved after intraoral incision and drainage, and administration of antibiotics.
Lymphangiomas and retropharyngeal abscesses are both known to be more common in children than in adults. However, we found no other reports of concomitant presentation of lymphangioma and retropharyngeal abscess in the literature.
KeywordsRetropharyngeal abscess Cystic lymphangioma Penicillin-resistant Streptococcus pneumoniae
Retropharyngeal abscesses occur more often in children than in adults, and are not rare . Although the first-line treatment is usually surgical incision and drainage , a few recent case studies reported successful treatment with antimicrobial agents only . Retropharyngeal abscesses have been reported to cause deep neck and mediastinal abscesses in some cases. In children, the symptoms of retropharyngeal abscesses are less specific than in adults, and physical examination is less likely to reveal definitive findings, which can cause delayed diagnosis. We recently encountered a patient who presented with a chief complaint of neck swelling, and was subsequently found to have a retropharyngeal abscess caused by drug-resistant pneumococcal infection, with a concurrent cervical tumour. We report here our surgical and medical treatment of concomitant retropharyngeal abscess and cystic lymphangioma, and review the relevant literature.
Retropharyngeal infection most commonly occurs in children aged younger than 6 years. Early detection of a developing retropharyngeal abscess can alleviate the need for surgical drainage. Infections originate in the lymphatic chains that drain the upper airway and pharynx. By 3 to 4 years of age, the retropharyngeal lymph node system begins to atrophy, and the risks of inflammation and infection subsequently decrease .
Although retropharyngeal abscesses have few specific symptoms, 50% of patients experience fever, stiff neck, neck pain, and difficulty swallowing . However, retropharyngeal abscesses often occur after upper respiratory tract infections, and these symptoms are not specific to the development of an abscess. Previous studies reported that the most common symptoms at presentation were decreased oral intake (92%), neck pain (89%), and neck swelling or mass (79–83%) . Although it is not uncommon for patients with retropharyngeal abscesses to present with a main complaint of neck swelling, this is often associated with enlarged lymph nodes or a deep neck abscess, and none of the previously reported cases had a cystic lymphangioma.
CT angiography is an effective diagnostic imaging modality for the detection of retropharyngeal abscesses . Contrast-enhanced CT is the radiological modality of choice for evaluating retropharyngeal abscesses, and is highly sensitive but not very specific. MRI is better than CT for imaging soft tissue masses such as cystic lymphangiomas. We believe that CT angiography is also useful for the investigation of retropharyngeal abscesses.
Because retropharyngeal abscesses are often accompanied by upper respiratory tract infections, the microorganisms isolated from these abscesses are often similar to those isolated from patients with upper respiratory tract infections. In a study by Hoffmann et al.,  the bacteria isolated from retropharyngeal abscesses included Streptococcus spp. (72%), S. pyogenes (41%), Staphylococcus aureus (13%), Candida (6%), and Haemophilus influenzae (3%). The proportion of cases with S. aureus infection was particularly high in children aged less than 1 year. The rates of detection of methicillin-resistant S. aureus are increasing. Many patients have also been shown to have mixed infections. Brook  performed needle aspirations on 14 paediatric patients with retropharyngeal abscesses and found that 12 had mixed anaerobic and aerobic infections, including Streptococcus spp., S. aureus, and H. influenzae. Studies by Asmar  and Craig et al. had similar findings. However, antibiotic-resistant bacteria were rarely isolated in these studies, suggesting that isolation of PRSP in the current patient can be attributed to the high prevalence of antibiotic-resistant bacteria in Japan .
Lymphangiomas are uncommon lesions of the lymphatic channels, and are often present at birth and usually diagnosed during childhood, mostly before the age of 2 years. Diagnosis is by MRI and fine-needle aspiration cytology findings . In the past, surgery was the treatment of choice for lymphangiomas. However, because of surgical complications including nerve injury, cyst recurrence, and cosmetic problems, OK-432 therapy has recently become the treatment of choice. Injection of OK-432 into the cyst produces inflammation [14, 15], and induction of cytokines in the cells of the cyst wall results in fibrotic adhesions in the cyst with resolution of fluid accumulation. In the present case, we hypothesize that inflammation arising from the retropharyngeal abscess also caused inflammation of the congenital lymphangioma. The cystic lymphangioma then remained inflamed after resolution of the retropharyngeal abscess, but resolved after OK-432 therapy.
Lymphangiomas and retropharyngeal abscesses are both known to be more common in children than in adults. However, we found no other reports of concomitant presentation of lymphangioma and retropharyngeal abscess in the literature. Concomitant occurrence of these conditions may increase with increasing age.
We reported here a case of retropharyngeal abscess caused by PRSP in a young child who presented with neck swelling. Investigation revealed a retropharyngeal abscess and an enlarged cystic lymphangioma secondary to the abscess. After intraoral surgical incision and drainage and administration of antibiotics, the patient recovered uneventfully.
Written informed consent was obtained from the patient’s parents for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (23791947,26861424), and a research project grant from Kawasaki Medical School (23S-2).
- Page NC, Bauer EM, Lieu JE: Clinical features and treatment of retropharyngeal abscess in children. Otolaryngol Head Neck Surg. 2008, 138: 300-306. 10.1016/j.otohns.2007.11.033.PubMedView ArticleGoogle Scholar
- Kirse DJ, Roberson DW: Surgical management of retropharyngeal space infections in children. Laryngoscope. 2001, 111: 1413-1422. 10.1097/00005537-200108000-00018.PubMedView ArticleGoogle Scholar
- Yamasaki Y, Nishi J, Nishikawa T, Tatsumoto C, Kasano F, Sano N, Kawano Y, Kawakami K: Descending necrotizing mediastinitis secondary to retropharyngeal abscess in a child. J Infect Chemother. 2008, 14: 255-257. 10.1007/s10156-008-0606-3.PubMedView ArticleGoogle Scholar
- Millan SB, Cumming WA: Supraglottic airway infections. Prim Care. 1996, 23: 741-758. 10.1016/S0095-4543(05)70360-2.PubMedView ArticleGoogle Scholar
- Philpott CM, Selvadurai D, Banerjee AR: Pediatric retropharyngeal abscess. J Laryngol Otol. 2004, 118: 919-926.PubMedView ArticleGoogle Scholar
- Grisaru-Soen G, Komisar O, Aizenstein O, Soudack M, Schwartz D, Paret G: Retropharyngeal and parapharyngeal abscess in children–epidemiology, clinical features and treatment. Int J Pediatr Otorhinolaryngol. 2010, 74: 1016-1020. 10.1016/j.ijporl.2010.05.030.PubMedView ArticleGoogle Scholar
- Stone ME, Walner DL, Koch BL, Egelhoff JC, Myer CM: Correlation between computed tomography and surgical findings in retropharyngeal inflammatory processes in children. Int J Pediatr Otorhinolaryngol. 1999, 49: 121-125. 10.1016/S0165-5876(99)00108-1.PubMedView ArticleGoogle Scholar
- Hoffmann C, Pierrot S, Contencin P, Morisseau-Durand MP, Manach Y, Couloigner V: Retropharyngeal infections in children. Treatment strategies and outcomes. Int J Pediatr Otorhinolaryngol. 2011, 75: 1099-1103. 10.1016/j.ijporl.2011.05.024.PubMedView ArticleGoogle Scholar
- Brook I: Microbiology of retropharyngeal abscesses in children. Am J Dis Child. 1987, 141: 202-204.PubMedGoogle Scholar
- Asmar BI: Bacteriology of retropharyngeal abscess in children. Pediatr Infect Dis J. 1990, 9: 595-597. 10.1097/00006454-199008000-00017.PubMedView ArticleGoogle Scholar
- Craig FW, Schunk JE: Retropharyngeal abscess in children: clinical presentation, utility of imaging, and current management. Pediatrics. 2003, 111: 1394-1398. 10.1542/peds.111.6.1394.PubMedView ArticleGoogle Scholar
- Watanabe A, Yanagihara K, Matsumoto T, Kohno S, Aoki N, Oguri T, Sato J, Muratani T, Yagisawa M, Ogasawara K, Koashi N, Kozuki T, Komoto A, Takahashi Y, Tsuji T, Terada M, Nakanishi K, Hattori R, Hirako Y, Maruo A, Minamitani S, Morita K, Wakamura T, Sunakawa K, Hanaki H, Ohsaki Y, Honda Y, Sasaoka S, Takeda H, Ikeda H, et al: Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009: general view of the pathogens’ antibacterial susceptibility. J Infect Chemother. 2012, 18: 609-620. 10.1007/s10156-012-0434-3.PubMedView ArticleGoogle Scholar
- Orvidas LJ, Kasperbauer JL: Pediatric lymphangiomas of the head and neck. Ann Otol Rhinol Laryngol. 2000, 109: 411-421.PubMedView ArticleGoogle Scholar
- Laranne J, Keski-Nisula L, Rautio R, Rautiainen M, Airaksinen M: OK-432 (Picibanil) therapy for lymphangiomas in children. Eur Arch Otorhinolaryngol. 2002, 259: 274-278. 10.1007/s00405-001-0438-6.PubMedView ArticleGoogle Scholar
- Ohta N, Fukase S, Watanabe T, Ito T, Aoyagi M: Effects and mechanism of OK-432 therapy in various neck cystic lesions. Acta Otolaryngol. 2010, 130: 1287-1292. 10.3109/00016489.2010.483480.PubMedView ArticleGoogle Scholar
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