- Short Report
- Open Access
Metabolic syndrome improvement in depression six months after prescribing simple hygienic-dietary recommendations
© Garcia-Toro et al.; licensee BioMed Central Ltd. 2014
- Received: 18 November 2013
- Accepted: 2 June 2014
- Published: 5 June 2014
Changes in diet and exercise have been separately demonstrated to improve Depression, although scientific evidence available is scarce. In a previously published controlled study, just recommending these and other lifestyle measures (sleep restriction and sunlight exposure) in combination once, patients experienced improvements in their depressive symptoms six months later. In this sample, one in three depressive patients had metabolic syndrome (MetS) at baseline. First line treatment of MetS condition is hygienic-dietetic, being Mediterranean diet and exercise especially important. Therefore we analyzed if lifestyle recommendations also improved their metabolic profile.
During the sixth month evaluation, a smaller number of patients from the group receiving hygienic-dietary recommendations met MetS criteria comparing with the control group.
This study suggests that costless lifestyle recommendations, such as exercise and Mediterranean diet, have the capacity to promote both mental and physical health in a significant proportion of depressive patients. Further research is needed to confirm or discard these preliminary findings.
- Metabolic syndrome
- Lifestyle recommendations
Depression is a high prevalent disorder, prone to chronicity, and associated with a large burden in terms of suffering, disability, and healthcare costs[1, 2]. One of the most common factors associated with depression is the presence of somatic disorders. Metabolic syndrome (MetS) is a combination of risk factors (abdominal obesity, hypertension, dyslipidemia, and glucose intolerance) that are predictive of progression to coronary artery disease, type 2 diabetes, asthma and certain cancers[4, 5]. MetS worsens with age and is rapidly growing in adults and adolescents[6, 7]. The prevalence of MetS in depression vary from 25 to 41% and depression increases the risk of MetS from 1.7 to 2.8 times[8, 9]. A complex bidirectional interrelationship between depression and MetSyn has been suggested[8–10]. Patients with Depression and other mental disorders may be especially predisposed to MetS since it has been proved it is triggered by psychopharmacologic drug-induced adverse effects, sedentary lifestyle, poor dietary habits, increased substance abuse and possible limited access to health care[11, 12]. There are other biological mechanisms underlying the association between metabolic syndrome and depression, but are not clearly established. Biological links that include increased pro-inflammatory cytokines, stress-induced hyperactivity of the hypothalamic pituitary axis (HPA), changes in homeostasis between the sympathetic and parasympathetic nervous systems and cerebral small vessel and circulation disease have been proposed[14, 15, 8, 9]. Pathophysiology overlap of depression and MetS could offers new possibilities for simultaneous prevention and treatment. Modification of risk factors should be considered a primary target.
First line treatment of MetS should be based on lifestyle change, including exercise and nutrition therapy, such as Mediterranean diet[6, 7, 11, 16]. A Mediterranean dietary pattern has been defined as comprising at least two of the following components: high monounsaturated/saturated fat ratio, low to moderate red wine consumption, high consumption of legumes, high consumption of grains and cereals, high consumption of fruits and vegetables, low consumption of meat and meat products and increased consumption of fish, and moderate consumption of milk and dairy products. Diet and exercise have been suggested able to normalize immune and metabolic dysregulation in persons with MetS. Diet and exercise interventions have been also demonstrated to improve depression although the evidence is still scarce. However, to our knowledge, no previous research was specifically aimed to determine the impact of exercise and diet recommendations on patients with Depression and MetS.
We hypothesized that hygienic-dietary recommendations can change the metabolic profile of patients with Depression and MetSyn sixth months later.
Eighty outpatients with a depressive episode were recruited for a randomized clinical trial that was designed to test the effectiveness of lifestyle recommendations in Depression[19, 20]. The inclusion criteria were male and female patients over 18 years; experiencing a depressive episode according to DSM-IV diagnostic criteria for Major Depressive Disorder, Dysthymic Disorder or Bipolar Disorder; receiving antidepressant treatment; patients who have the ability to communicate in Spanish and give informed written consent and women of childbearing age practicing safe contraceptive methods. Exclusion criteria were: any other severe disease that affects the CNS; uncontrolled or potentially interfering medical condition; delusions or hallucinations at the time of the study; significant risk of suicide and pregnancy or lactation.
Complete analytic parameters (basal and six month’s data) were available for fifty-one of those patients who finished the study. Reasons for non-completion included patient decision, protocol violation or appearance of a severe, uncontrolled, or potentially interfering medical condition. The study protocol was approved by the local ethical board (CEIC: Comité Ético y de Investigación Clínica de las Islas Baleares), and was registered (Trial registration: Current Controlled Trials ISRCTN59506583) and published elsewhere.
Go to bed when sleepy and not before 11 p.m. Use your bed and bedroom only for sleep and sex (do not read, watch TV or lie on the bed during the day). If you do not fall asleep after 15 or 20 minutes, get up and start an activity until you feel sleepy enough to go back to bed. Get up early, never later than 9 a.m., no matter how well you have slept the night before. Do not lie down or take a nap during the day.
Walk at least 1 hour a day, at a good pace but without becoming short of breath or being unable to talk while walking. If you think you have a medical problem which makes walking difficult or uncomfortable consult your doctor. Use appropriate footwear for walking and have a shower or a bath afterwards.
Expose yourself to sunlight at least 2 hours per day, taking precautions to avoid sunburn or sunstroke (sunscreen, hat, etc.).
Try to eat a healthy and balanced diet. Eat at regular hours without snacking between meals. Avoid especially sweet or sugary drinks. Eat fish at least three times per week, plus fruit, cereals, nuts and vegetables daily.
Sleep the hours that you feel your body needs.
Adapt the pace of daily physical activity that meets your needs.
If exposed to sunlight take precautions to avoid sunburn or sunstroke (sunscreen, hat, etc.).
Try to eat a healthy and balanced diet.
The Mini International Neuropsychiatric Interview (MINI), the Hamilton rating scale for depression (HAM-D) 17-item version, the 21-item Beck Depression Inventory, and the Clinical Global Impression scale (CGI) were used. After the sixth month intervention tests were again administered by blind raters. During this time the patients were taking antidepressants, and continued to be treated by their GP or psychiatrist without any interference from the research team. Analytical determinations, blood pressure and weight were measured at baseline and after six months. The “International Diabetes Federation” (IDF) criteria were used to define MetS in the patients: They must have central obesity, defined as excessive waist circumference, with sex and ethnic specific values (≥94 cm for European men) or BMI > 30 kg/m2 plus two or more of the following four factors; raised triglycerides level: ≥ 150 mg/dl or specific treatment for this lipid abnormality; reduced concentration of high density lipoprotein (HDL): < 40 mg/dl in men and < 50 mg/dl in women or specific treatment for this lipid abnormality; raised blood pressure: systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg or treatment of previously diagnosed hypertension; raised fasting plasma glucose concentration ≥ 100 mg/dl or previously diagnosed type 2 diabetes.
We conducted a statistical analysis using Fisher’s exact test for categorical variables and U Man-Whitney test for continuous variables.
Demographic and clinical results
Active n = 25
Control n = 26
Female sex, N°
Age y, Mean (SD)
Major Depression, N°
- 8.80 (8.9)
- 5.57 (4.9)
- 8.64 (9.2)
- 4.25 (6.3)
- 1.72 (1.3)
- 0.69 (1.0)
- 0.11 (1.5)
- 2.33 (15.7)
- 2.04 (16.9)
- 1.76 (15.0)
Serum glucose increment
- 3.9 (20.7)
- 0.6 (21.3)
Total Cholesterol increment
- 3.92 (21.9)
LDL Cholesterol increment
- 7.00 (19.5)
HDL Cholesterol increment
- 0.15 (8.1)
Metabolic Syndrome pre, N°
Metabolic Syndrome post, N°
The main finding of this study is that MetS was lower in those patients receiving the active hygienic-dietary recommendations compared to the control group. Perhaps due to lack of statistical power, our study has not found differences among any of the variables included in MetS definition. Nevertheless, it has been suggested that it is more important the association of Depression with the construct of MetS rather than with its components.
Seasonality of serum lipids and weight/body mass index may affect MetS prevalence raising their development in the winter. Changes of plasma volume linked to seasonal variations in temperature and/or physical activity could be responsible of this fact. However, these findings cannot explain our results, since patients were assessed throughout the year and assigned randomly to both groups.
Depressed people are more prone to eat highly palatable and caloric food, rich in cholesterol and carbohydrate and low in fish, vegetable and cereals. This diet does not ensure an adequate intake of B vitamins, folic acids, and essential fatty acids for vascular, inflammatory and metabolic balance, and may induce MetS. Depression, when in comorbidity with MetS, shows worse course, more severe clinical picture and a higher tendency to chronicity and suicidality besides lower social functioning. It has been proposed the concept of “metabolic depression” to identify a chronic subtype of depression more frequent in late-life, with metabolic abnormalities and a protracted course[10, 21]. Our preliminary data could indicate that this situation can be faced better when combining antidepressant treatment with dietary hygienic measures.
Our study has some weaknesses that need to be acknowledged for proper interpretation. The main limitations of this study are the small sample size and the short follow-up period. However, the small sample size would not explain our positive findings but makes the type I statistical error more probable. Although the vast majority of patients met criteria for Major Depression, we also had patients with Dysthymic and Bipolar Disorder. Due to the limited sample we could not carry out a separate analysis of these patients to determine if they have the same behavior against lifestyle recommendations.
Depression has been associated with poor adherence to diet and exercise regimens[14, 18]. There is no measure of adherence in this study. This is a clear limitation because low adherence to the study recommendations cannot be ruled out and this reinforces the fact that these findings may simply be chance. Nevertheless we demonstrated in a pilot study with a small part of these patients using actigraphs, that they did change their lifestyle habits, at least in a short-term period. It would have been interesting to dispose of objective adherence measures from all the patients during the follow-up. Unfortunately, it could not be put into practice due to logistical limitations.
The benefits of lifestyle changes for patients experiencing a depressive episode and Metabolic Syndrome could be achieved by using a simple combination of hygienic-dietary recommendations on a written piece of paper. These benefits applied to metabolic profile are a key factor for patients’ future cardiovascular health which also constitutes a key factor for their Mental Health evolution[1, 24–26]. The improvement of the metabolic profile found in this study would be an extra-motivation for patients in order to maintain these lifestyle changes in the long-term.
We thank the Instituto de Salud Carlos III of the Spanish Ministry of Health for funding the study (FIS n° PI07 0544 and n° PI11/01392).
- Gutierrez-Fraile M, Garcia-Calvo C, Prieto R, Gutierrez-Garitano I: Mental disorders in psychiatric outpatients in spain. Actas Esp Psiquiatr. 2011, 39: 349-355.PubMedGoogle Scholar
- Rubio JM, Markowitz JC, Alegria A, Pérez-Fuentes G, Liu SM, Lin KH, Blanco C: Epidemiology of chronic and nonchronic major depressive disorder: results from the national epidemiologic survey on alcohol and related conditions. Depress Anxiety. 2011, 28: 622-631. 10.1002/da.20864.PubMedPubMed CentralView ArticleGoogle Scholar
- Garcia-Toro M, Rubio JM, Gili M, Roca M, Jin CJ, Liu SM, Bastianoni C, Blanco C: Persistence of chronic major depression: a national prospective study. J Affect Disord. 2013, 151: 306-312. 10.1016/j.jad.2013.06.013.PubMedView ArticleGoogle Scholar
- Kahl KG, Greggersen W, Schweiger U, Cordes J, Balijepalli C, Lösch C, Moebus S: Prevalence of the metabolic syndrome in unipolar major depression. Eur Arch Psychiatry Clin Neurosci. 2012, 262: 313-320. 10.1007/s00406-011-0277-4.PubMedView ArticleGoogle Scholar
- Jin H, Lanouette NM, Mudaliar S, Henry R, Folsom DP, Khandrika S, Glorioso DK, Jeste DV: Association of posttraumatic stress disorder with increased prevalence of metabolic syndrome. J Clin Psychopharmacol. 2009, 29: 210-215. 10.1097/JCP.0b013e3181a45ed0.PubMedPubMed CentralView ArticleGoogle Scholar
- Rubenfire M, Mollo L, Krishnan S, Finkel S, Weintraub M, Gracik T, Kohn D, Oral EA: The metabolic fitness program: lifestyle modification for the metabolic syndrome using the resources of cardiac rehabilitation. J Cardiopulm Rehabil Prev. 2011, 31: 282-289. 10.1097/HCR.0b013e318220a7eb.PubMedView ArticleGoogle Scholar
- Garcia-Toro M, Roca M, Monzon S, Vives M, Oliván B, Vicens E, Salva J, Gili M: Hygienic-dietary recommendations for major depression treatment: study protocol of a randomized controlled trial. BMC Psychiatry. 2012, 12: 201-10.1186/1471-244X-12-201.PubMedPubMed CentralView ArticleGoogle Scholar
- Suttajit S, Pilakanta S: Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia. Neuropsychiatr Dis Treat. 2013, 9: 941-946.PubMedPubMed CentralView ArticleGoogle Scholar
- Grover S, Nebhinani N, Chakrabarti S, Avasthi A, Kulhara P: Metabolic syndrome in drug-naive patients with depressive disorders. Indian J Psychol Med. 2013, 35: 167-173. 10.4103/0253-7176.116247.PubMedPubMed CentralView ArticleGoogle Scholar
- Marazziti D, Rutigliano G, Baroni S, Landi P, Dell'osso L: Metabolic syndrome and major depression. CNS Spectr. 2013, 8: 1-12.Google Scholar
- Pan A, Keum N, Okereke OI, Sun Q, Kivimaki M, Rubin RR, Hu FB: Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care. 2012, 35: 1171-1180. 10.2337/dc11-2055.PubMedPubMed CentralView ArticleGoogle Scholar
- Hidaka BH: Depression as a disease of modernity: explanations for increasing prevalence. J Affect Disord. 2012, 140: 205-214. 10.1016/j.jad.2011.12.036.PubMedPubMed CentralView ArticleGoogle Scholar
- Hamer M, Batty GD, Kivimaki M: Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing. Mol Psychiatry. 2012, 17: 940-945. 10.1038/mp.2012.30.PubMedPubMed CentralView ArticleGoogle Scholar
- Alvarez A, Faccioli J, Guinzbourg M, Castex MM, Bayón C, Masson W, Bluro I, Kozak A, Sorroche P, Capurro L, Grosembacher L, Proietti A, Finkelsztein C, Costa L, Fainstein Day P, Cagide A, Litwak LE, Golden SH: Endocrine and inflammatory profiles in type 2 diabetic patients with and without major depressive disorder. BMC Res Notes. 2013, 6: 61-10.1186/1756-0500-6-61.PubMedPubMed CentralView ArticleGoogle Scholar
- Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y: Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study. BMC Public Health. 2013, 13: 862-10.1186/1471-2458-13-862.PubMedPubMed CentralView ArticleGoogle Scholar
- Toobert DJ, Glasgow RE, Strycker LA, Barrera M, Ritzwoller DP, Weidner G: Long-term effects of the Mediterranean lifestyle program: a randomized clinical trial for postmenopausal women with type 2 diabetes. Int J Behav Nutr Phys Act. 2007, 4: 1-10.1186/1479-5868-4-1.PubMedPubMed CentralView ArticleGoogle Scholar
- Rees K, Hartley L, Flowers N, Clarke A, Hooper L, Thorogood M, Stranges S: 'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013, 8: CD009825-PubMedGoogle Scholar
- Penninx BW, Milaneschi Y, Lamers F, Vogelzangs N: Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med. 2013, 11: 129-10.1186/1741-7015-11-129.PubMedPubMed CentralView ArticleGoogle Scholar
- Garcia-Toro M, Ibarra O, Gili M, Salva J, Monzón S, Vives M, Serrano MJ, Garcia-Campayo J, Roca M: Effectiveness of hygienic-dietary recommendations as enhancers of antidepressant treatment in patients with depression: study protocol of a randomized controlled trial. BMC Public Health. 2010, 10: 404-10.1186/1471-2458-10-404.PubMedPubMed CentralView ArticleGoogle Scholar
- Garcia-Toro M, Ibarra O, Gili M, Serrano MJ, Oliván B, Vicens E, Roca M: Four hygienic-dietary recommendations as add-on treatment in depression: a randomized-controlled trial. J Affect Disord. 2012, 140: 200-203. 10.1016/j.jad.2012.03.031.PubMedView ArticleGoogle Scholar
- Marijnissen RM, Smits JE, Schoevers RA, van den Brink RH, Holewijn S, Franke B, de Graaf J, Oude Voshaar RC: Association between metabolic syndrome and depressive symptom profiles-sex-specific?. J Affect Disord. 2013, 151: 1138-1142. 10.1016/j.jad.2013.07.029.PubMedView ArticleGoogle Scholar
- Altinbas K, Guloksuz S, Oral ET: Metabolic syndrome prevalence in different affective temperament profiles in bipolar-I disorder. Rev Bras Psiquiatr. 2013, 35: 131-135. 10.1590/1516-4446-2011-0746.PubMedView ArticleGoogle Scholar
- García-Toro M, Ibarra O, Gili M, Serrano MJ, Vives M, Monzón S, Bauzá N, Oliván B, Vicens E, Roca M: Adherence to lifestyle recommendations by patients with depression. Rev Psiquiatr Salud Ment. 2012, 5: 236-40. 10.1016/j.rpsm.2012.04.003.PubMedView ArticleGoogle Scholar
- Gans RO: The metabolic syndrome, depression, and cardiovascular disease: Interrelated conditions that share pathophysiologic mechanisms. Med Clin North Am. 2006, 90: 573-591. 10.1016/j.mcna.2006.05.002.PubMedView ArticleGoogle Scholar
- Sanchez-Villegas A, Delgado-Rodriguez M, Alonso A, Schlatter J, Lahortiga F, Serra Majem L, Martínez-González MA: Association of the mediterranean dietary pattern with the incidence of depression: The seguimiento universidad de Navarra/University of navarra follow-up (SUN) cohort. Arch Gen Psychiatry. 2009, 66: 1090-1098. 10.1001/archgenpsychiatry.2009.129.PubMedView ArticleGoogle Scholar
- Salvi V, Albert U, Chiarle A, Soreca I, Bogetto F, Maina G: Metabolic syndrome in italian patients with bipolar disorder. Gen Hosp Psychiatry. 2008, 30: 318-323. 10.1016/j.genhosppsych.2008.04.009.PubMedView ArticleGoogle Scholar
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