Impaired quality of life in patients with systemic sclerosis compared to the general population and chronic dermatoses
© Bretterklieber et al.; licensee BioMed Central Ltd. 2014
Received: 27 January 2014
Accepted: 30 July 2014
Published: 2 September 2014
Systemic sclerosis (SSc) is a rare and potentially life threatening autoimmune disorder. The burden of disease compared to other dermatoses is unknown. The purpose of this study was to assess both the quality of life in patients with SSc and the variables that are associated with poor quality of life. Forty-one patients with systemic sclerosis (29 limited, 2 diffuse, 10 undifferentiated forms) were assessed with respect to their health status and compared to published data for the normal population, SSc patients from other studies, and patients with chronic skin diseases.
For the most part, our SSc patients had better outcomes in all 8 dimensions of the SF-36 than SSc patients from other studies, and poorer scores than the healthy population and those with occupational contact dermatitis, ichthyosis, non-melanoma skin cancer, contact dermatitis, atopic eczema, chronic nail disease, vitiligo, health care workers with work-related disease, and those with other chronic skin diseases, but significantly better scores for mental health than those with nail disease, vitiligo, and health-care workers. Patients with atopic dermatitis, psoriasis and pemphigus had significantly poorer mean scores in social function and mental health than SSc patients. Patients with pemphigus were also significantly impaired in their physical and emotional roles. Patients with systemic lupus erythematosus (SLE) had the significantly poorest mean scores for QoL in all 8 domains except bodily pain and emotional role.
Besides SLE, SSc is one of the most severe chronic dermatologic diseases in terms of reduced QoL. Since SSc cannot be cured, treatment strategies should include therapeutic interventions such as psychotherapy, social support, physiotherapy, and spiritual care. Their beneficial effects could be studied in future.
Systemic sclerosis (SSc) is a rare and potentially life threatening autoimmune disorder accompanied by fibrosis of the skin and/or internal organs, vascular lesions, and specific antibodies . The clinical appearance of the disease is polymorphous. SSc generally starts with Raynaud’s phenomenon (RP) and proceeds to limited or diffuse sclerosis of the skin. The undifferentiated form (uSSc) is diagnosed when a patient does not fulfil the American College of Rheumatology (ACR) criteria . Disease progression may vary considerably and is unforeseeable. The impact of this complex disease on quality of life (QoL) and its variables has received substantial attention in recent years , and quality of life questionnaires to assess it have become important instruments to validate outcomes in patients treated with new modalities, such as biologics .
One of the most widely used instruments to assess QoL is the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). It is a general health status questionnaire, measuring patient-centered rather than biological or disease-centered outcomes. It also measures physical and mental health constructs [5, 6]. SF-36 has been used to assess QoL in rheumatic disease, and has been validated in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus .
Several studies have investigated QoL in SSc in- and outpatients in various age groups with diverse organ involvement [3, 7–13]. Twelve datasets, comprising 1127 SSc patients, were included in a systematic review to investigate health-related QoL. The latter was reduced in patients with SSc: their pooled SF-36 Physical Component Summary (PCS) scores were more than 1 standard deviation (SD) below the general population .
Similar to SSc, dermatoses such as psoriasis, atopic dermatitis, pemphigus, or lupus erythematosus also follow a chronic incurable course with impaired QoL. Our research question was whether patients with SSc might have a higher disease burden than those with other dermatoses. To our knowledge, such a comparison has not yet been published. Here, we compared SSc data from the SF-36 questionnaire with published data from healthy persons, SSc patients, and patients with chronic dermatoses, and analyzed clinical factors that contribute to the impairment of QoL.
QoL in different types of SSc compared to healthy persons and to other studies on QoL in SSc
Comparison of SF-36 items in patients with SSc and those with other dermatoses
Number of patients
Mean age (years)
Median disease duration (years)
Our SSc patients
58 ± 13
8 (2 – 40)
66 ± 27
66 ± 43
59 ± 26
54 ± 24
54 ± 23
77 ± 25
73 ± 42
72 ± 17
Better or similar in all dimensions
Normal population without chronic disease 
Patients with occupational contact dermatitis 
Patients with ichthyosis 
Patients with non-melanoma cervicofacial skin cancer 
Patients with contact eczema 
Patients with atopic eczema 
Poorer only in mental health
Patients with nail disorders ( >1a) 
Patients with vitiligo in China 
Health care workers with work-related skin diseases 
Chronic skin diseases 
Poorer in social function and mental health
Patients with atopic dermatitis 
Patients with different types of psoriasis < 10 years 
Psoriasis ≥ 10 years 
Poorer or similar in all dimensions
Patients with pemphigus vulgaris 
Patients with systemic lupus erythematosus 
Demographics and SF-36 scores in SSc patients according to the ACR-criteria classification
All SSc patients
Limited or diffuse SSc
Number of patients
90 % (28/31)
Mean age (min-max)
Mean duration of SSc, years (min-max)
Mean duration of Raynaud, years (min-max)
Karnofski index (min-max)
Rodnan score (min-max)
SF-36 scores mean (min-max)
Relevant findings in SSc compared to other dermatoses
Comparing SSc to other dermatoses, subscale scores for SSc in all dimensions were significantly poorer than or comparable to patients with occupational contact dermatitis , ichthyosis , non-melanoma skin cancer , and contact eczema  (Table 1). SSc patients had better results in mental health compared to patients with long-standing nail disease , vitiligo , chronic skin diseases , and health care workers with work related disease , The SF-36 scores in patients with atopic dermatitis vary and can be better or worse than in SSc [19, 23].
In comparison to SSc patients, those with psoriasis and pemphigus were significantly impaired in mental health and social function; with pemphigus this was also true for physical and emotional roles compared to SSc patients [24, 25].
Patients with SLE had lower mean scores than SSc patients for QoL in all 8 domains except bodily pain and emotional role, and poorer QoL in all 8 domains than age-matched samples from the normal female population in the US .
In this study, SSc patients were impaired in their QoL compared to healthy persons, but had better SF-36 outcome compared to SSc patients from other studies. But as in other studies, the domains of the SF-36 were too insensitive to find a significant difference in QoL between patients with uSSc and with manifest SSc [7, 10].
A very recent study from Naples determined QoL with the SF-36 in early SSc, a group comparable with our uSSc. Compared to this study, physical function and physical role were poorer in our patient cohort . This may be due to the colder climate in Austria, with more severe RP during the winter and summer rainy periods. Even primary RP can lead to a significant reduction in QoL compared to controls with respect to both the physical and the mental component scores .
The group most comparable to our study comprised patients with limited SSc in the study by Johnson et al., in which vitality (51.1 vs. 44.6, p = 0.014), social function (76.6 vs. 64.8, p = 0.005), and mental health (80.0 vs. 63.6, p = 0.005) were significantly poorer than in our SSc patients, whereas physical function and bodily pain scores were not significantly different (Figure 1) . They also studied patients with diffuse SSc, who were similar to our patients only in mental health but worse in the other dimensions. Also in the study by Perrot et al., pain dimension scores are significantly lower than in ours . A neuropathic component is associated with a higher pain score.
In a recent cross-sectional survey of 381 SSc patients that was focused on anxiety and depression, 40.3% of them had diffuse cutaneous SSc, 50.5% limited cutaneous SSc and 9.2% limited SSc (uSSC in our definition) . Poorer mental health was significantly associated with anxiety and depression. This was based on a poorer physical component score and related to disabilities, especially of the hands, and aesthetic impairment and not to organ involvement . We did not investigate depression and anxiety. Our patients had impaired median physical function compared to the normal population (65.8 vs. 97), but better physical function compared to Nguyen’s study involving the hands on the basis of digital ulcers (15 vs. 45.3%), pitting scars (29 vs. 58.8%) and calcinosis (22 vs. 33.7%).
All the other SSc studies using the SF-36 scales revealed significantly poorer scores in QoL than in our study (Figure 1) [3, 8, 10, 13]. Most of our patients attended the day clinic once a month for one-day infusion therapy with iloprost; they also received paraffin baths and physiotherapy. SF-36 scores poorer than those of our SSc patients were found in a study in which the majority of patients were outpatients and members of patient associations . This might have been due to the higher percentage of diffuse SSc (36%) in that study. Rannou et al. also reported a large percentage of diffuse SSc (46%) in 50 SSc patients in the French patient association who did not differ substantially in terms of their SF-36 items from the study by Mestre-Stanislas et al. with more than 50% diffuse SSc, but also had a poorer QoL scores than ours in all parameters . In comparison to our patient group, 80% vs. 15% of those patients had arthralgia and 86% vs. 37% gastrointestinal involvement.
Hudson et al. compiled SF-36 scores for 504 SSc patients . The SF-36 subscale and summary scores for SSc were significantly poorer than those for the general US population, except for mental health and the mental component summary score. In all, their scores were worse than those of our patients. The patients were similar to ours as regards the percentage of women (86% vs. 88%) and mean age (56 vs. 58 years). However, 44% patients had diffuse SSc, compared to 5% of patients in our group.
In a cross-sectional multicenter study consisting of 416 patients from the Canadian Scleroderma Research Group Registry, the authors evaluated the patients’ self-reported physical health . Thirty-five percent had diffuse SSc. Their mean Rodnan score was 10.6, compared to 6.7 in our group. Additionally, shortness of breath, gastrointestinal problems, and swollen joints were significant clinical predictors of impaired QoL. In our study, 41% of patients had lung involvement and 85% had skin involvement. Dysphagia and gastrointestinal disease were seen in 37% of our patients.
Differences in control populations and variations in QoL from country to country could also explain why all the other QoL studies on SSc produced poorer SF-36 scores than ours. Our control group, the healthy German population (mean age 47.7 years), showed better subscale scores in all dimensions but in physical role compared to a healthy control group in Naples . In the US control population norms (women aged 45-54 years), all SF-36 scales were substantially poorer than in our controls .
SSc patients have significantly higher subscale scores in mental health and social function than those with other chronic inflammatory dermatoses. Since the majority of patients with SSc have progressive disease, they are unlikely to experience an improvement in QoL. SSc patients might be able to cope better with the disease and so have better scores in the mental components. Besides, SSc as a chronic condition might be better tolerated than a disease like atopic dermatitis, which can feature stress-induced flares.
In SLE, QoL was even poorer than in patients with hypertension, diabetes or myocardial infarction . SSc and SLE have a similar course of disease and are more common in younger or middle-aged women. In patients with non-melanoma skin cancer, QoL correlated significantly with the patients’ coexisting illnesses and medical risk factors . Stigmatization because of rash in SLE, and sclerosis of the face and hands in SSc, the uncertain course of the disease, fatigue, environmental factors (such as sun exposure in SLE and cold in SSc), and reduced life expectancy are some of the factors that influence QoL. Besides the parameters evaluated on the SF-36 questionnaire in SSc, disease burden , body appearance, stigmatization  and impaired hand function are of similar magnitude as in patients with rheumatoid arthritis . As indicated by Nguyen, the aesthetic appearance is important in all dermatologic diseases with visible skin lesions such as in SSc ; but chronic eczema on the face, psoriasis, ichthyosis, pemphigus, nail disease, or vitiligo can also invoke negative emotions and result in reduced self-esteem [21, 33]. Moreover, chronic diseases such as SSc may cause frequent absences from work, as is also the case in those diseases that feature itching, skin rash flares, pains or fatigue (contact eczema, atopic dermatitis, arthralgia/arthritis in psoriasis, lupus erythematosus).
Limitations of the study were the low prevalence of diffuse SSc compared to other studies, which impeded an exact comparison of data. This was not caused by selection bias since we investigated consecutive SSc patients. The fact is that we mostly care for patients who have limited SSc or uSSc since patients with diffuse SSc might more often be seen at the rheumatology department. But we have clearly shown that dyspnoea or different hand disabilities impair QoL. Another limitation was the small number of patients and that fact that we only used the SF-36 questionnaire to determine QoL, although there are other instruments that measure disability such as the scleroderma Health Assessment Questionnaire HAQ , the Cochin Hand Function Scale (CHFS)  and the Scleroderma Assessment Questionnaire (SAQ) . We could not include all the studies using the SF-36 in diverse dermatologic diseases that are available from PubMed but we showed examples to underscore disease burden in the different dermatologic diseases.
SF- 36, as a patient self-assessment instrument, cannot distinguish between the different SSc subtypes but does reflect organ involvement that can cause disabilities affecting the SF-36 subscales. Clinical factors such as digital ulcers, dysphagia, or dyspnoea can be measured by laboratory or clinical methods. Non measurable factors are burden of disease, degree of stigmatization, or hand disability, which represent the sum of physical and psychological factors that all contribute to the empirical dimension we call quality of life.
Our results indicate that SSc has high disease burden as compared to the general population and to patients with more common skin diseases. Since SSc is a rare disease, there is a lack of awareness on the part of health care providers and policy makers. This is unfortunate for the sufferers since their QoL is much lower than that of patients with more common chronic conditions such as heart disease or diabetes .
Unlike psoriasis, atopic dermatitis, pemphigus, or SLE, remission cannot be achieved with SSc. Patients can adapt well to their slowly progressing disease so that social factors and disease coping may contribute to relatively better mental health than in other dermatoses. More therapeutic emphasis should therefore be placed on techniques for coping with the disease and biopsycho-social support [35, 36]. When it is an option for the patient, spiritual care can improve mental health scores by helping to alleviate depression or pain [37, 38]. Clinical practice should feature an interdisciplinary approach to SSc patients, involving physicians, physical and occupational therapists, psychologists, social workers and spiritual advisers. The influence of biopsycho-social-spiritual supportive interventions could be an area for fruitful future study.
In 2012, 45 consecutive patients with SSc who had regular outpatient or day clinic appointments were enrolled at the Department of Dermatology for complete medical workup; the detailed clinical data were to be the basis of a diploma thesis (Painsi C. Dermatologic markers of systemic sclerosis in pulmonary hypertension, 2009-2010). This study was approved by the Ethics Committee of the Medical University of Graz.
Forty-one patients agreed to fill out the SF-36 questionnaire. This was part of data acquisition program for the German Network of Systemic Sclerosis (DNSS). Based on ACR criteria, the patients were classified into 29 with limited cutaneous SSc, 2 with diffuse SSc, and 10 with uSSc . USSc was diagnosed in patients who did not fulfill the ACR criteria but suffered from early SSc, defined by a positive Raynaud’s phenomenon (RP) and at least one further feature of SSc: positive nail fold capillary alterations, puffy fingers, or detectable scleroderma-associated autoantibodies [2, 39].
The patient’s history was taken, including duration of RP and skin sclerosis. Pulmonary function was determined with diffusing capacity of the lung for carbon monoxide (DLCO); stress echocardiography and right heart catheterization were performed to diagnose or rule out pulmonary hypertension (PAH). Oesophagus dysmotility was shown by barium swallow, kidney function by serum creatinine levels and urinalysis. Patients were examined for the extent of skin sclerosis, digital ulcers, scars and calcinosis, and queried for arthralgia and arthritis. The Rodnan score and Karnofski index were documented.
In 2012 we searched PubMed for studies on QoL in SSc and in chronic skin diseases measured by the SF-36 questionnaire and used their data, when appropriate, for comparison.
QoL assessment and function measures
The SF-36 questionnaire comprises eight scales: physical function, physical role, bodily pain, general health, vitality, social function, emotional role, and mental health. For each scale, the score ranges from 0 (poor) to 100 (excellent) to define health status. Scores are also summarized into two global scores, i.e. the physical component score (PCS) and the mental component score (MCS) .
For global assessment, these 8 scales were evaluated in all 41 SSc patients and were compared with published data obtained from the normal population , patients with SSc [3, 7, 8, 10, 13], patients with occupational contact dermatitis , ichthyosis , non-melanoma skin cancer , eczema depending on the body site , atopic dermatitis [19, 23], nail disease , vitiligo , work-related skin diseases in health care workers , psoriasis , pemphigus , systemic lupus erythematosus (SLE) , and other chronic skin disease .
Data are presented as mean and standard deviations. For statistical analysis a two-sided one-sample t-test was used to determine significant differences between our patients’ mean values and published mean values from other SSc patient groups, other skin diseases, and the normal population without chronic diseases. When a normal distribution could not be assumed, nonparametric tests were performed. To analyse clinical factors that could influence QoL, we used the chi square or Fisher’s exact test for categorical data and Spearman rank correlation for continuous data. No multiple testing p-value adjustment was made since this was an exploratory analysis . A p-value less than 0.05 was considered statistically significant. Data were analyzed using the statistical software IBM SPSS Statistics (Release 20.0.0. 2011. Chicago (IL), USA: SPSS Inc., an IBM Company).
Data acquisition was approved by the Ethics Committee of the Medical University of Graz.
- Gabrielli A, Avvedimento EV, Krieg T: Scleroderma. N Engl J Med. 2009, 360: 1989-2003. 10.1056/NEJMra0806188.PubMedView ArticleGoogle Scholar
- Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommetee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Commettee. Arthritis Rheum. 1980, 23: 581-590. 10.1002/art.1780230510.Google Scholar
- Hudson M, Thombs BD, Steele R, Panopalis P, Newton E, Baron M: Quality of life in patients with systemic sclerosis compared to the general population and patients with other chronic conditions. J Rheumatol. 2009, 36: 768-772. 10.3899/jrheum.080281.PubMedView ArticleGoogle Scholar
- Baker EL, Coleman CI, Reinhart KM, Phung OJ, Kugelman L, Chen W, White CM, Mamolo CM, Cappelleri JC, Baker WL: Effect of Biologic Agents on Non-PASI Outcomes in Moderate-to-Severe Plaque Psoriasis: Systematic Review and Meta-Analyses. Dermatol Ther (Heidelb). 2012, 2: 9-View ArticleGoogle Scholar
- McHorney CA, Ware JE, Raczek AE: The MOS 36-Item Short-Form Health Survey (SF-36): II. Psychometric and clinical tests of validity in measuring physical and mental health constructs. Med Care. 1993, 31: 247-263. 10.1097/00005650-199303000-00006.PubMedView ArticleGoogle Scholar
- Ware JE, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.PubMedView ArticleGoogle Scholar
- Johnson SR, Glaman DD, Schentag CT, Lee P: Quality of life and functional status in systemic sclerosis compared to other rheumatic diseases. J Rheumatol. 2006, 33: 1117-1122.PubMedGoogle Scholar
- Hudson M, Steele R, Lu Y, Thombs BD, Panopalis P, Baron M: Clinical correlates of self-reported physical health status in systemic sclerosis. J Rheumatol. 2009, 36: 1226-1229. 10.3899/jrheum.081057.PubMedView ArticleGoogle Scholar
- Hudson M, Thombs BD, Steele R, Panopalis P, Newton E, Baron M: Health-related quality of life in systemic sclerosis: a systematic review. Arthritis Rheum. 2009, 61: 1112-1120. 10.1002/art.24676.PubMedView ArticleGoogle Scholar
- Rannou F, Poiraudeau S, Berezne A, Baubet T, Le-Guern V, Cabane J, Guillevin L, Revel M, Fermanian J, Mouthon L: Assessing disability and quality of life in systemic sclerosis: construct validities of the Cochin Hand Function Scale, Health Assessment Questionnaire (HAQ), Systemic Sclerosis HAQ, and Medical Outcomes Study 36-Item Short Form Health Survey. Arthritis Rheum. 2007, 57: 94-102. 10.1002/art.22468.PubMedView ArticleGoogle Scholar
- Ostojic P, Damjanov N: The scleroderma Assessment Questionnaire (SAQ). A new self-assessment questionnaire for evaluation of disease status in patients with systemic sclerosis. Z Rheumatol. 2006, 65: 168-175. 10.1007/s00393-006-0050-7.PubMedView ArticleGoogle Scholar
- Iudici M, Cuomo G, Vettori S, Avellino M, Valentini G: Quality of life as measured by the short-form 36 (SF-36) questionnaire in patients with early systemic sclerosis and undifferentiated connective tissue disease. Health Qual Life Outcomes. 2013, 11: 23-10.1186/1477-7525-11-23.PubMedPubMed CentralView ArticleGoogle Scholar
- Mestre-Stanislas C, Poiraudeau S, Berezne A, Rannou F, Pagnoux C, Revel M, Guillevin L, Mouthon L: Differences in patients with systemic sclerosis recruited from associations and tertiary care settings. Presse Med. 2010, 39: e205-e209. 10.1016/j.lpm.2010.02.038.PubMedView ArticleGoogle Scholar
- Bullinger MKI: SF-36 Fragebogen zum Gesundheitszustand. 1998, Göttingen, Bern, Toronto, Seattle: Hogrefe-Verlag GmbH & Co, Verlag für PsychologieGoogle Scholar
- Lau MY, Matheson MC, Burgess JA, Dharmage SC, Nixon R: Disease severity and quality of life in a follow-up study of patients with occupational contact dermatitis. Contact Dermatitis. 2011, 65: 138-145. 10.1111/j.1600-0536.2011.01896.x.PubMedView ArticleGoogle Scholar
- Ganemo A, Sjoden PO, Johansson E, Vahlquist A, Lindberg M: Health-related quality of life among patients with ichthyosis. Eur J Dermatol. 2004, 14: 61-66.PubMedGoogle Scholar
- Rhee JS, Loberiza FR, Matthews BA, Neuburg M, Smith TL, Burzynski M: Quality of life assessment in nonmelanoma cervicofacial skin cancer. Laryngoscope. 2003, 113: 215-220. 10.1097/00005537-200302000-00004.PubMedView ArticleGoogle Scholar
- Thomson KF, Wilkinson SM, Sommer S, Pollock B: Eczema: quality of life by body site and the effect of patch testing. Br J Dermatol. 2002, 146: 627-630. 10.1046/j.1365-2133.2002.04692.x.PubMedView ArticleGoogle Scholar
- Holm EA, Wulf HC, Stegmann H, Jemec GB: Life quality assessment among patients with atopic eczema. Br J Dermatol. 2006, 154: 719-725. 10.1111/j.1365-2133.2005.07050.x.PubMedView ArticleGoogle Scholar
- Tabolli S, Alessandroni L, Gaido J, Sampogna F, Di Pietro C, Abeni D: Health-related quality of life and nail disorders. Acta Derm Venereol. 2007, 87: 255-259.PubMedGoogle Scholar
- Wang KY, Wang KH, Zhang ZP: Health-related quality of life and marital quality of vitiligo patients in China. J Eur Acad Dermatol Venereol. 2011, 25: 429-435. 10.1111/j.1468-3083.2010.03808.x.PubMedView ArticleGoogle Scholar
- Matterne U, Apfelbacher CJ, Soder S, Diepgen TL, Weisshaar E: Health-related quality of life in health care workers with work-related skin diseases. Contact Dermatitis. 2009, 61: 145-151. 10.1111/j.1600-0536.2009.01592.x.PubMedView ArticleGoogle Scholar
- Maksimovic N, Jankovic S, Marinkovic J, Sekulovic LK, Zivkovic Z, Spiric VT: Health-related quality of life in patients with atopic dermatitis. J Dermatol. 2012, 39: 42-47. 10.1111/j.1346-8138.2011.01295.x.PubMedView ArticleGoogle Scholar
- Sampogna F, Tabolli S, Soderfeldt B, Axtelius B, Aparo U, Abeni D: Measuring quality of life of patients with different clinical types of psoriasis using the SF-36. Br J Dermatol. 2006, 154: 844-849. 10.1111/j.1365-2133.2005.07071.x.PubMedView ArticleGoogle Scholar
- Tabolli S, Mozzetta A, Antinone V, Alfani S, Cianchini G, Abeni D: The health impact of pemphigus vulgaris and pemphigus foliaceus assessed using the Medical Outcomes Study 36-item short form health survey questionnaire. Br J Dermatol. 2008, 158: 1029-1034. 10.1111/j.1365-2133.2008.08481.x.PubMedView ArticleGoogle Scholar
- Jolly M: How does quality of life of patients with systemic lupus erythematosus compare with that of other common chronic illnesses?. J Rheumatol. 2005, 32: 1706-1708.PubMedGoogle Scholar
- De Angelis R, Salaffi F, Grassi W: Health-related quality of life in primary Raynaud phenomenon. J Clin Rheumatol. 2008, 14: 206-210. 10.1097/RHU.0b013e31817a2485.PubMedView ArticleGoogle Scholar
- Perrot S, Dieude P, Perocheau D, Allanore Y: Comparison of pain, pain burden, coping strategies, and attitudes between patients with systemic sclerosis and patients with rheumatoid arthritis: a cross-sectional study. Pain Med. 2013, 14: 1776-1785. 10.1111/pme.12213.PubMedView ArticleGoogle Scholar
- Nguyen C, Ranque B, Baubet T, Berezne A, Mestre-Stanislas C, Rannou F, Papelard A, Morell-Dubois S, Revel M, Moro MR, Guillevin L, Poiraudeau S, Mouthon L, Groupe Français de Recherche sur la Sclérodermie: Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey. PLoS One. 2014, 9: e90484-10.1371/journal.pone.0090484.PubMedPubMed CentralView ArticleGoogle Scholar
- Suarez-Almazor ME, Kallen MA, Roundtree AK, Mayes M: Disease and symptom burden in systemic sclerosis: a patient perspective. J Rheumatol. 2007, 34: 1718-1726.PubMedGoogle Scholar
- Joachim G, Acorn S: Life with a rare chronic disease: the scleroderma experience. J Adv Nurs. 2003, 42: 598-606. 10.1046/j.1365-2648.2003.02663.x.PubMedView ArticleGoogle Scholar
- Stamm TA, Mattsson M, Mihai C, Stocker J, Binder A, Bauernfeind B, Stummvoll G, Gard G, Hesselstrand R, Sandqvist G, Draghicescu O, Gherghe AM, Voicu M, Machold KP, Distler O, Smolen JS, Boström C: Concepts of functioning and health important to people with systemic sclerosis: a qualitative study in four European countries. Ann Rheum Dis. 2011, 70: 1074-1079. 10.1136/ard.2010.148767.PubMedPubMed CentralView ArticleGoogle Scholar
- Ginsburg IH: The psychosocial impact of skin disease. An overview. Dermatol Clin. 1996, 14: 473-484. 10.1016/S0733-8635(05)70375-2.PubMedView ArticleGoogle Scholar
- Duruoz MT, Poiraudeau S, Fermanian J, Menkes CJ, Amor B, Dougados M, Revel M: Development and validation of a rheumatoid hand functional disability scale that assesses functional handicap. J Rheumatol. 1996, 23: 1167-1172.PubMedGoogle Scholar
- Kwakkenbos L, Bluyssen SJ, Vonk MC, van Helmond AF, van den Ende CH, van den Hoogen FH, van Lankveld WG: Addressing patient health care demands in systemic sclerosis: pre-post assessment of a psycho-educational group programme. Clin Exp Rheumatol. 2011, 29: S60-S65.PubMedGoogle Scholar
- Mozzetta A, Antinone V, Alfani S, Neri P, Foglio Bonda PG, Pasquini P, Puddu P, Picardi A: Mental health in patients with systemic sclerosis: a controlled investigation. J Eur Acad Dermatol Venereol. 2008, 22: 336-340. 10.1111/j.1468-3083.2007.02426.x.PubMedView ArticleGoogle Scholar
- Reynolds N, Mrug S, Hensler M, Guion K, Madan-Swain A: Spiritual Coping and Adjustment in Adolescents With Chronic Illness: A 2-Year Prospective Study. J Pediatr Psychol. 2014, 39: 542-551. 10.1093/jpepsy/jsu011.PubMedView ArticleGoogle Scholar
- Bussing A, Janko A, Baumann K, Hvidt NC, Kopf A: Spiritual needs among patients with chronic pain diseases and cancer living in a secular society. Pain Med. 2013, 14: 1362-1373. 10.1111/pme.12198.PubMedView ArticleGoogle Scholar
- Koenig M, Joyal F, Fritzler MJ, Roussin A, Abrahamowicz M, Boire G, Goulet JR, Rich E, Grodzicky T, Raymond Y, Senecal JL: Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud’s phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis. Arthritis Rheum. 2008, 58: 3902-3912. 10.1002/art.24038.PubMedView ArticleGoogle Scholar
- Bender R, Lange S: Adjusting for multiple testing–when and how?. J Clin Epidemiol. 2001, 54: 343-349. 10.1016/S0895-4356(00)00314-0.PubMedView ArticleGoogle Scholar
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