This is the first study to examine the measurement of maternal triglycerides in late pregnancy using the Roche Accutrend® Plus. The Accutrend® Plus has previously been examined in two studies in the non-pregnant population. Both studies reported acceptable agreement between methods [11, 12]. The mean bias found in the current study (−0.01 mmol/L (−0.5%)) was smaller than that found in either of the previous two studies using the Accutrend® Plus (8.8% ; 0.26 mmol/L ). While the mean bias measured in the current study was low, the 95% confidence intervals of the bias was broad but not dis-similar to those found in previous studies of this meter [11, 12]. This may be contributed to by person to person variability in the difference between methods or by the formal venous triglycerides being measured in the clinical run rather than in a single batch. Performing the formal triglycerides in the clinical run may have introduced more error than otherwise would have been found but is more reflective of a potential “real use” situation.
A concern raised by Scafoglieri  was that the Accutrend® Plus should not be used for diagnosis of hypertriglyceridemia. Given this, in addition to method comparison, it would be useful to undertake practicability analyses. These have yet to be performed for the Accutrend® Plus in pregnancy. In the current study, the correlation between the two capillary measures taken by study staff was high.
It needs to be borne in mind that the purpose of measuring triglyceride levels in the pregnancy setting is not for the diagnosis of maternal hypertriglyceridemia but to potentially allow assessment of the variation in triglycerides throughout the day. This would provide for a detailed assessment of the association of postprandial triglycerides with pregnancy outcomes. Further, the triglyceride meter could be utilized for self-monitoring of postprandial triglycerides as glucose meters are currently used in diabetes in pregnancy, providing feedback on the effects of food choices. Given we have demonstrated that this meter has low bias, it would be possible to use this device in the research setting to examine maternal triglycerides in pregnancy. In the non-pregnancy setting, the Accutrend® GCT meter has been used for home monitoring [13, 14] and was found to be useful.
The primary limitation of the current study is that it has not assessed the ease of use of the meter. In comparison to glucose meters which have been specifically designed for use by the non-clinician, the Accutrend® Plus meter has been designed more as a point of care meter for use in clinical settings. Prior to using the meter on a broader scale, the practicality and reliability of the non-clinician using the meter at home need to be assessed.