- Case Report
- Open Access
Hemoperitoneum in a patient with spontaneous rupture of the posterior wall of an unscarred uterus in the second trimester of pregnancy
© Abdalla et al. 2015
- Received: 7 March 2015
- Accepted: 12 October 2015
- Published: 24 October 2015
Hemoperitoneum resulting from a rupture of an unscarred uterus is a rare condition. Uterine rupture in patients without evident risk factors is associated with non-specific signs and symptoms that can delay the diagnosis. This is a report of spontaneous rupture of posterior wall of the uterus in the second trimester of pregnancy presented as intra-abdominal bleeding.
Here, we report the case of a 31-year-old Caucasian multiparous female (gravida 3, para 1) who had a sudden onset of abdominal pain at 28 weeks of gestation. The patient had no history of caesarean section. Exploratory laparotomy was performed due to deterioration of the patient’s clinical condition, and ultrasound results were suspicious for hemoperitoneum. Uterine rupture in the posterior wall with active bleeding from the defect was confirmed. A caesarean section was performed, and a live female infant weighing 1000 g, with an Apgar score of three, was delivered. A hysterectomy was performed during the caesarean section.
Diagnostic difficulties arise from the rarity of the disease, a nonspecific clinical picture and the absence of the main risk factors. Uterine rupture should be considered in the differential diagnosis of hemoperitoneum in patients with an unscarred uterus.
- Caesarean section
- Uterine rupture
There are no precise diagnostic criteria of uterine rupture during pregnancy and labor. Due to the different clinical presentations of uterine rupture, many cases (e.g., asymptomatic uterine rupture) have been excluded from population-based studies . According to a systematic review of maternal morbidity and mortality by the World Health Organization in 2005, the median incidence of uterine rupture is 5.3 per 10,000 deliveries. A history of caesarean section is the most important risk factor for uterine rupture in developed countries . Most reported cases of uterine rupture are associated with previous scarring of the uterus, multiparity, a short length of time (less than 18 months) since the last caesarean section, the number of previous caesarean sections, single-layer closure instead of two-layer closure, placenta previa and the use of prostaglandins or oxytocin for labor induction or augmentation [2–5]. Fetal heart rate abnormality, most commonly bradycardia, is the most common presentation of uterine rupture. Uterine rupture can also present as abdominal pain, vaginal bleeding, and altered uterine contractions. More rarely, it can present as hypotension, shock, hematuria, shoulder tip pain and scar tenderness. The most common combination of these symptoms is an abnormal fetal heart rate with abdominal pain. Uterine rupture can be an accidental finding during a caesarean section . Maternal tachycardia is an alarming sign that can, along with another medical signs, alert the physician to the possibility of uterine rupture . It was thought that loss of uterine contraction is a typical sign of uterine rupture; however, normal uterine contraction patterns or hyperstimulation of the uterus may also be noted . In the differential diagnosis of uterine rupture, placental abruption, placenta previa, uterine inversion, cervical tear, vaginal tear, coagulopathy, uterine atony and uterine artery rupture may be considered . Intra-abdominal bleeding is rare after the first trimester of pregnancy. In the first trimester of pregnancy, most cases of intra-abdominal bleeding are related to extrauterine pregnancy . Hemoperitoneum in the second trimester can be attributed to both obstetric and non-obstetric causes. A literature review revealed few reports of cases of hemoperitoneum due to obstetric causes other than ectopic pregnancy . The causes of these cases can be divided into placental, uterine and vascular causes. Placenta percreta is a rare placental abnormality that can cause severe complications, such as hemoperitoneum . Placental abruption is not a cause of hemoperitoneum in the absence of uterine rupture. However, during pregnancy, the clinical features of hemoperitoneum can trigger a suspicion of placental abruption because these conditions share similar clinical features, and these similarities can cause diagnostic difficulties . Uterine anomalies are a reported cause of rupture of the unscarred uterus in the first trimester in patients with uterine anomalies . Endometriosis can cause erosion of the utero-ovarian vessels, resulting in severe hemorrhage .
In this case, no risk factor for uterine rupture was evident. There might be unrecognized uterine perforation during curettage and there was no diagnostic laparoscopy after this procedure to exclude this injury. Uterine curettage have been reported as a cause of uterine rupture during next pregnancy . Previous injury of the uterus is not likely to have caused uterine rupture in this case because the second pregnancy was uneventful. On the other hand this possible mild unrecognized injury might be further worsened by the second pregnancy and labor. For this reason possible unrecognized uterine injury should be considered as a cause of the uterine rupture in this case. A careful obstetric history did not suggest the presence of endometriosis. Moreover, no evidence of endometriosis was found during the laparotomy, and adenomyosis was excluded by histopathological examination of the excised uterus. In this case, the placenta was located in the anterior abdominal wall; thus, a relationship between the placenta and the defect can easily be excluded . The patient is generally healthy, and her family history is negative for muscle diseases. A rupture of unscarred uterus is rare . The ultrasound exam was beneficial in this case because it revealed the presence of free fluid inside the abdominal cavity. The results of the fetal non-stress test were reactive, which led us initially to exclude uterine rupture in the differential diagnosis and delayed the decision to perform an emergency caesarean section. An emergency exploratory laparotomy was performed to determine the site of bleeding, which could have been obstetric or non-obstetric. Difficulties in the diagnosis of uterine rupture can be attributed to several factors. First, uterine rupture is rare. A scarred uterus is the main risk factor for uterine rupture. In patients with atypical histories, the diagnosis may be delayed or may even be established at the time of laparotomy, thereby increasing maternal and fetal morbidity and mortality. Rupture of the uterus should be considered in pregnant women with hemoperitoneum, even when caesarean section is absent from the obstetric history.
Written, informed consent was obtained from the patient for publication of this Case Report and accompanying images.
All authors participated in designing and developing the study, as well as in preparing the manuscript. SR and BM initially assessed the medical condition. RM and AN did the exploratory laparotomy. SW and CK managed the postoperative period. All authors read and approved the final manuscript.
Timorek-Lemieszczuk Agnieszka provided editing assistance in preparing the manuscript.
The authors declare that they have no competing interests.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Hofmeyr GJ, Say L, Gülmezoglu AM. WHO systematic review of maternal mortality and morbidity: the prevalence of uterine rupture. BJOG. 2005;112:1221–8.View ArticlePubMedGoogle Scholar
- Veena P, Habeebullah S, Chaturvedula L. A review of 93 cases of ruptured uterus over a period of 2 years in a tertiary care hospital in South India. J Obstet Gynaecol. 2012;32:260–3.View ArticlePubMedGoogle Scholar
- Fitzpatrick KE, Kurinczuk JJ, Alfirevic Z. Uterine rupture by intended mode of delivery in the UK: a national case-control study. PLoS Med. 2012;9:e1001184.PubMed CentralView ArticlePubMedGoogle Scholar
- Bujold E, Goyet M, Marcoux S, et al. The role of uterine closure in the risk of uterine rupture. Obstet Gynecol. 2010;116:43–50.View ArticlePubMedGoogle Scholar
- Hagneré P, Denoual I, Souissi A, Deswarte S. Spontaneous uterine rupture after myomectomy. Case report and review of the literature. J Gynecol Obstet Biol Reprod. 2011;40:162–5.View ArticleGoogle Scholar
- Sweeten KM, Graves WK, Athanassiou A. Spontaneous rupture of the unscarred uterus. Am J Obstet Gynecol. 1995;172:1851–5.View ArticlePubMedGoogle Scholar
- Rodriguez MH, Masaki DI, Phelan JP, Diaz FG. Uterine rupture: are intrauterine pressure catheters useful in the diagnosis? Am J Obstet Gynecol. 1989;161:666–9.View ArticlePubMedGoogle Scholar
- Mazzone ME, Woolever J. Uterine rupture in a patient with an unscarred uterus: a case study. WMJ. 2006;105:64–6.PubMedGoogle Scholar
- Agdi M, Tulandi T. Surgical treatment of ectopic pregnancy. Best Pract Res Clin Obstet Gynaecol. 2009;23:519–27.View ArticlePubMedGoogle Scholar
- Salama S, Nizard J, Camus E, Ville Y. Spontaneous haemoperitoneum after the second trimester of pregnancy. Diagnosis and management. Eur J Obstet Gynecol Reprod Biol. 2009;142:82–3.View ArticlePubMedGoogle Scholar
- Blé RK, Adjoussou S, Doukoure B, et al. Placenta percreta: a rare etiology of spontaneous uterine perforation in the second trimester of pregnancy. Gynecol Obstet Fertil. 2011;39:e11–4.View ArticlePubMedGoogle Scholar
- Vyjayanthi S, Rajesh U, Bloomfield TH. Haemoperitoneum due to placenta percreta in the third trimester mimicking placental abruption. J Obstet Gynaecol. 2002;22:690–1.View ArticlePubMedGoogle Scholar
- Tola EN. First trimester spontaneous uterine rupture in a young woman with uterine anomaly. Case Rep Obstet Gynecol. 2014;2014:967386.PubMed CentralPubMedGoogle Scholar
- Williamson H, Indusekhar R, Clark A, Hassan IM. Spontaneous severe haemoperitoneum in the third trimester leading to intrauterine death: case report. Case Rep Obstet Gynecol. 2011;2011:173097.PubMed CentralPubMedGoogle Scholar
- Nkwabong E, Kouam L, Takang W. Spontaneous uterine rupture during pregnancy: case repoert and review of literature. Afr J Reprod Health. 2007;11(2):98–103.View ArticleGoogle Scholar
- Sun HD, Su WH, Chang WH, Wen L, Huang BS, Wang PH. Rupture of a pregnant unscarred uterus in an early secondary trimester: a case report and brief review. J Obstet Gynaecol Res. 2012;38:442–5.View ArticlePubMedGoogle Scholar