Dramatic response to alectinib in a patient of ALK-rearranged lung cancer with poor performance status
BMC Research Notes volume 9, Article number: 173 (2016)
Lung cancers with anaplastic lymphoma kinase rearrangements are highly sensitive to anaplastic lymphoma kinase tyrosine kinase inhibition, underscoring the notion that such cancers are addicted to anaplastic lymphoma kinase activity. Several anaplastic lymphoma kinase inhibitors have been identified and are being evaluated in clinical trials. However patients with poor performance status (3 or 4) were not involved in these clinical trials, it has been unclear to use anaplastic lymphoma kinase–tyrosine kinase inhibitors for these patients. Here, we report an anaplastic lymphoma kinase-positive non small cell lung cancer patient with performance status 4, who was successfully treated with alectinib.
We report on a 52-year-old patient diagnosed as non small cell lung cancer harboring echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene. His performance status was 4 because of severe respiratory failure. We treated this patient with alectinib as the first line therapy. Dramatic response was obtained and his performance status improved from 4 to 1 without severe adverse events.
Alectinib is a therapeutic option for the anaplastic lymphoma kinase positive patients with poor performance status.
Non small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Platinum-based chemotherapy is the standard therapy for patients with metastatic or recurrent disease. However, platinum-based chemotherapy is not recommended for patients with poor performance status (PS) of 3 or 4. Recently oncogenic drivers have been identified to play essential roles in the tumorigenesis, survival and proliferation in lung cancer. The National Comprehensive Cancer Network recommends epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) as a salvage treatment option for NSCLC patients with poor PS. While there has been a study looking at crizotinib versus chemotherapy in anaplastic lymphoma kinase (ALK) positive NSCLC , there is no prospective clinical evidence that indicates the efficacy of ALK TKIs for ALK positive patients with poor PS.
A 52-year-old man who was a smoker presented with severe respiratory failure. There was no special family history. A chest computed tomography (CT) showed a tumor in the right lower lung with atelectasis and multiple lung metastases in bilateral lung fields (Fig. 1a). Bone scintigraphy showed a hot spot on his lumber vertebrate, and thus clinical stage was IV (cT4N3M1b). As for his breathing state, SpO2 was around 90 % under the conditions of an oxygen flow rate 10 L/min with reservoir bag mask. His performance status (PS) was 4. Best supportive care seemed to be a proper choice. His medical history was unremarkable, and he had taken no medications. He had smoked 34 pack-years. The serum carcinoembryonic antigen (CEA) level was 8.6 ng/mL (normal range, 0–5.0 ng/mL). We conducted bronchoscopy by using high-flow nasal cannulae to make a pathological diagnosis and to assess molecular status. The diagnosis was adenocarcinoma, and moreover molecular analysis revealed that ALK protein was positive by immunohistochemical staining and ALK rearrangement was positive by reverse transcription polymerase chain reaction (RT-PCR). Fluorescence in situ hybridization (FISH) test was indeterminate.
Therefore, we treated the patient with alectinib at 300 mg twice daily. In 3 weeks, chest CT showed dramatic shrinkage of the primary tumor in the right lower lobe and bilateral multiple lung metastases (Fig. 1b). Bronchoscopic study also showed dramatic improvement in right lower bronchus (Fig. 2a, b). The only adverse event was grade 1 elevation of alanine aminotransferase (ALT). The ALT level was 19 U/L before treatment, the maximum ALT level was 59 U/L during treatment. This adverse event was manageable. His PS improved from 4 to 1, the Karnofsy Performance Scale (KPS) improved from 10 to 90 %, and he discharged in 4 weeks his PS improved from 4 to 1 and he discharged in 4 weeks.
The echinoderm microtubule-associated protein-like 4 (EML4)-ALK, a fusion gene first described in 2007, possesses oncogenic activity that can be blocked by ALK inhibitor , and Rikova et al.  described two ALK fusion partners. Alectinib is a novel, highly selective oral ALK inhibitor [4, 5]. Seto et al. reported the efficacy and safety of alectinib in ALK inhibitor-naive patients with ALK-rearranged lung cancer in a phase 1–2 study. The overall response rate in the phase 2 part of the study was 93.5 %. The mean duration of treatment was 14.8 months, and at 1 year of follow-up, the median PFS had not been reached. The adverse events of alectinib were less than crizotinib . There were no treatment-related grade 4 adverse events or deaths. Therefore, we chose alectinib for our patient. At present, crizotinib and alectinib are available as ALK inhibitors in Japan. The phase 3 studies (JapicCTI-132316, NCT02075840) comparing alectinib with crizotinib in the patients with chemo-naive, advanced ALK-rearranged lung cancer are ongoing. The superiority between the two drugs is not clear until the results of these trials come out. It should be pointed out that these clinical trials do not involve the patients with poor PS such as PS 3 or 4. In crizotinib, there are a few reports indicate the efficacy of crizotinib therapy for the patients with poor PS. Tamai et al.  reported a patient with ALK positive lung adenocarcinoma who was administered crizotinib via nasogastric and percutaneous endoscopic gastrostomy tubes. Ahn et al.  reported in the case of EGFR-mutated patients with poor PS, gefitinib is recommended as a first-line treatment. Inoue et al.  reported that the efficacy and feasibility of gefitinib for patients with poor PS and EGFR mutations. The objective tumor response rate was 66 % and toxicities were comparable to that observed in patients with PS 0–2. In the patients of an oncogene addicted lung cancer with poor PS, cytotoxic chemotherapy is not applicable, however, molecular target therapy might be feasible. Now, we can use two ALK-TKIs (crizotinib and alectinib) in Japan however, these ALK-TKIs have not been recommended in Japanese guideline because of no clinical evidence for such poor PS. To the best of our knowledge, this is the first case report of dramatic response to alectinib in an ALK-rearranged lung adenocarcinoma patient with PS 4.
This case suggests alectinib could be a therapeutic option for such patients. Obviously, further study is necessary (UMIN000015094).
Written informed consent was obtained from the patient for publication of this case report and accompanying images.
anaplastic lymphoma kinase
reverse transcription polymerase chain reaction
fluorescence in situ hybridization
epidermal growth factor receptor
Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;20(368):2385–94.
Soda M, Choi YL, Enomoto M, Takada S, Takada Y, Ishikawa Ishikawa, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561–6.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131:1190–203.
Latif M, Saeed A, Kim SH. Journey of the ALK-inhibitor CH5424802 to phase II clinical trial. Arch Pharm Res. 2013;36:1051–4.
Yang JC. A selective ALK inhibitor in ALK-rearranged patients. Lancet Oncol. 2013;14:564–5.
Seto T, Kiura K, Nishio M, Nakagawa K, Maemondo M, Inoue A, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol. 2013;14:590–8.
Tamai K, Nagata K, Otsuka K, Nakagawa A, Tachikawa R, Otsuka K, et al. Crizotinib administered via nasogastric and percutaneous endoscopic gastrostomy tubes for the successful treatment of ALK-rearranged lung cancer in a patient with poor performance status. Respir Investig. 2013;51:46–8.
Ahn HK, Jeon K, Yoo H, Han B, Lee SJ, Park H, et al. Successful treatment with crizotinib in mechanically ventilated patients with ALK positive non-small-cell lung cancer. J Thorac Oncol. 2013;8:250–3.
Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, et al. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol. 2009;27:1394–400.
HT prepared the manuscript and the literature search. KT conducted bronchofiberscopy. TM reviewed and edited the manuscript. YTcorrected and revised the manuscript. MI and KN treated and observed the patient. ST performed the histopathological examinations. KO reviewed the manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
About this article
Cite this article
Tanaka, H., Taima, K., Morimoto, T. et al. Dramatic response to alectinib in a patient of ALK-rearranged lung cancer with poor performance status. BMC Res Notes 9, 173 (2016). https://doi.org/10.1186/s13104-016-1983-9