A cross-sectional, facility based study of comorbid non-communicable diseases among adults living with HIV infection in Zimbabwe

The successful rollout of highly active antiretroviral therapy (HAART) has resulted in increased life expectancy of HIV infected people. However, new clinical and public health problems are emerging. Opportunistic infections and AIDS-defining cancers (ADC) which characterised the pre-HAART era have given way to the new challenges of comorbid non-communicable diseases (NCD) in those living and aging with HIV [1]. The health and life quality gains made against HIV/AIDS are now under threat from heart disease, diabetes, stroke, kidney and liver disease, (non-AIDS defining) cancers, and mental health problems which are increasingly prevalent and documented among the HIV positive [2]. For example, cardiovascular disease has emerged as the leading cause of morbidity and mortality in HIV infected persons in developed country settings [3].

Inevitable age-related degenerative changes (possibly accelerated in HIV infection), cumulative exposure to antiretroviral drug toxicities, effects of ongoing inflammation, progressive immune dysfunction, and long-term infection by the virus itself are postulated to drive these NCDs in HIV [4–6]. Much of what is known about HIV-NCD comorbidities has emerged from studies in high income countries (HICs) [7–11]. However, the available sparse evidence suggests similar trends of increasingly prevalent NCDs among HIV infected populations in low- and middle-income countries (LMICs), including sub-Saharan Africa [12, 13].

Zimbabwe's disease terrain, similar to most SSA countries, was until recently dominated by HIV/AIDS. There is growing recognition, however, of the contribution of NCDs to the morbidity and mortality burden in the general population. Available limited data indicate that hypertension accounts for at least 40 % of all hospital out-patient consultations [14], while cardiovascular diseases are the fourth leading cause of in-patient hospital mortality [15].

The only nationally representative survey [16] to date (2005), based on the WHO STEPwise Approach, reported modest prevalence of modifiable NCD risk factors. Hypertension and diabetes mellitus rates, for example, stood at 18 and 3.7 %, respectively. With regards to the HIV infected population, the burden of comorbid NCDs remains unknown. This is despite the fact that HIV prevalence currently stands at 15 % in a population of 14 million [17].

Lack of data notwithstanding, the potential impact of NCD comorbidity in HIV is likely to be profound in the LMICs, particularly sub-Saharan Africa (SSA), which is home to 80 % of the global 35 million people living and aging with HIV [18]. There remain huge knowledge gaps about the epidemiology, diagnosis thresholds and optimal clinical management strategies of comorbid NCDs in HIV infection in the LMIC context. Similarly, there is little data on models of care appropriate to this phenomenon of colliding epidemics—NCDs and infections—occurring against the backdrop of fragile health systems and severe resource constraints [19]. Consequently, the evidence base to critically inform interventions and strategies to effectively meet these new and rapidly growing challenges in SSA is thin. Understanding the NCD burden among those living and ageing with HIV is critical if the gains already made in the fight against HIV are to be maintained.

As an initial step in mapping the NCD-HIV comorbidity terrain in low income, high HIV burden settings, the study sought to describe the prevalence and patterns of non-communicable disease among adults living with HIV infection in Zimbabwe. Additionally, the study investigated potential associations between prevalence and patterns of comorbidities with patient characteristics like HIV disease severity markers and exposure to different ART drug classes.

The study set out to describe the prevalence of comorbidity and multi-morbidity in a population of adults living with HIV infection and receiving care at a public sector facility in Zimbabwe. This was an initial step in understanding the emergent challenges of NCD comorbidity in HIV infection. The occurrence of these comorbidities and multi-morbidities was further described according to patient demographic and clinical characteristics. It is anticipated that any observed associations with these characteristics may help in the formulation of risk stratification algorithms.

In our study, we had more female than male participants, with females presenting at a younger age and with less severe and/or less advanced HIV disease compared to their male counterparts. These findings are in keeping with sub-Saharan Africa's HIV epidemic, where transmission is largely heterosexual coupled with increased infection vulnerability of women [18], on one hand, and their better health-seeking behavior [20], on the other. We found that women were more likely to have both comorbidities and multi-morbidities, compared to men. Similarly, this pattern was observed for individual NCDs, notably more women had both hypertension and asthma, compared to men. Women also had a higher prevalence of T2DM than men though this relationship did not reach statistical significance. Though pregnant women were excluded from the study, the possible contribution of previous pregnancies to prevalent hypertension or diabetes mellitus was not investigated.

Meaningful comparisons across studies are precluded by differences in case ascertainment and the actual definitions of comorbidity. Other than findings reported from cohorts treated in high income countries [10, 11], the study by Oni et al. [21] is, to our knowledge, the only one from SSA that sought to address a similar research question as ours. In a primary care facility-based study in a peri-urban South African setting, they reported gender- and age-stratified prevalence rates of comorbidity in HIV. Amongst males, comorbidity rates were 17 % (18–34 years), 28 % (36–45 years), 34 % (46–55 years) and 20 % (>55 years). The corresponding rates among females were 28, 30, 30 and 10 %, respectively; meaning that only in the younger subjects (18–45 years) was comorbidity higher in females than males.

Within each respective gender group, our study did not further stratify comorbidity according to age groups because of very limited events. Though this limits comparison with the South African findings, our study undoubtedly suggests lower overall prevalence of HIV-related comorbidity. Noteworthy is the fact Oni et al. included only hypertension, diabetes mellitus and TB in their definition of comorbidity. They reported hypertension as the commonest comorbid condition. We had similar findings, with overall prevalence of hypertension in our study at 10.2 % (95 % CI 8.4–12.3).

To date, reported hypertension prevalence rates among HIV positive persons in SSA range from 11 % in Kenya [22] to 28 % in Uganda [23]. A recent systematic review [24] on hypertension prevalence in HIV infection and with a broader population focus reported rates ranging from 8.7 to 45.9 % in low- and middle-income countries (LMICs). Although we did not include an HIV negative comparison group in our study, our reported prevalence of 10.2 % is less than the previously reported Zimbabwean national average rate of 17.9 % in the general population [16]. Hypertension is largely asymptomatic and coupled with the clinic's lack of active screening for hypertension, it may be speculated that our reported low prevalence, relative to the general population, may represent under-diagnosis.

The literature on hypertension in HIV infected persons in SSA is sparse and methodological differences aside, findings are equivocal: some studies report higher hypertension rates in the HIV positive versus the uninfected [25] while others suggest lower prevalence or no differences [26, 27]. Evidence from a systematic review including predominantly non-African subjects concluded that the risk of hypertension among HV positive persons was higher in the ART experienced versus the ART-naïve. The review did not compare hypertension to the general population [28]. Interestingly, and in contrast to our findings, men have been reported as being disproportionately affected [21].

Our study also found type 2 diabetes mellitus (T2DM) prevalence of 2.1 % with a higher but statistically insignificant rate in females (2.2 vs. 1.9 %; p = 0.731) compared to males. We could not ascertain how the diagnosis of T2DM was made in each patient. Rates of T2DM in HIV higher than what we found have been reported elsewhere in SSA: 16 % in Kenya [29] and 23.5 % [30] in South Africa. A nationally representative survey of the general adult Zimbabwean population found T2DM prevalence of 3.7 % in 2005 [16]. This estimate (reported in 2005) is most likely outdated and unrepresentative of the current situation. Unpublished findings from an urban general population community-based survey (2012) found combined rates of self-reported prevalent T2DM and previously undiagnosed hyperglycemia (random venous blood glucose ≥11.1 mmol/l) of nearly 9 %. A more recent estimate from the WHO (2014) places T2DM (fasting glucose ≥7.0 mmol/l or on medication) prevalence at 7.8 % (95 % CI 3.0–15.9) among adults in the general population [31].

The relationship between HIV/ART and diabetes is the subject of ongoing controversy. Observations of both increased risk and no difference have been noted in high income countries [32–34]. Elevated risks are linked to, among other factors, duration of and exposure to certain ARV drugs like stavudine, efavirenz and protease inhibitors [30, 34, 35]. A systemic review (2013) of the association between HIV/ART and development of T2DM in SSA subjects implied protective effects as judged by reduced HbA1c levels [12]. Notwithstanding lack of an HIV negative comparator group within our study, and taking into consideration sample variation, our finding of a 2.1 % T2DM prevalence maybe difficult to reconcile with, firstly, the much higher background T2DM prevalence in the general population, and secondly, the high frequency of stavudine (60.4 %), efavirenz (>60 %) and protease inhibitor (4.7 %) use among study participants.

In the general population hypertension and T2DM have similar risk factors: tobacco use, unhealthy diets, physical inactivity and harmful use of alcohol. These have all been documented to be highly prevalent in some HIV positive populations [36], though they were not measured in this study. ARV drug toxicities including lipodystrophy and dyslipidemias, chronic systemic inflammation, endothelial dysfunction, coagulation disorders and the virus itself are additional risk factors peculiar to HIV disease [37].

Another finding of note was the relatively high occurrence of asthma in our study population. We report a prevalence of 4.3 % (95 % CI 3.1–5.8 %). The asthma burden in the Zimbabwean general population is estimated at 2.3 % [38]. Female study participants had higher rates than their male peers (5.3 vs. 2.2 %; p = 0.026). Though not within the scope of the study to ascertain each included diagnosis, review of some patient case notes indicated that the diagnosis of asthma in some patients was based on adult-onset wheezing, effort dyspnoea and persistent coughing. HIV trained nurses provided the bulk of on-going care including initial patient assessments. Pulmonary function testing was not available either.

Consequently, argument can be made to refer to this class of condition broadly as obstructive lung disease (OLD) [39], which includes chronic bronchitis, fixed airway obstruction, bronchial hyper-responsiveness as well as asthma. OLD has recently come to the fore as the number of persons ageing with HIV continues to grow. Known risk factors for OLD include HIV infection, pulmonary TB, tobacco smoking and indoor pollution from biomass fuel exposure [40–42]. The latter disproportionately affects women in LMICs, especially SSA. Our study only assessed history of pulmonary TB, which stood at 61 % among participants, and we did not measure the burden of the other risk factors. Asthma prevalence among HIV-infected persons is reported to be increased with possibility of a different risk factor profile from the uninfected population [43].

The study's primary outcome of HIV with any comorbid NCD has some drawbacks. From an epidemiological or health systems perspective, where the concern might be burden of care and health resources allocation, the study's end-point has currency. However, from a pathogenesis-clinical standpoint in the given contest of HIV and ART exposure, the prominent limitation is that this end-point is potentially heterogeneous. This is because whereas cardiometabolic diseases like diabetes mellitus and hypertension may have common risk factors, other NCDs like asthma arguably have a different risk factor profile, as outlined above.

Other co-variables of study interest were ART exposure, age and HIV disease severity. Overall, the study population had considerable ART experience with at least half the participants having been on treatment for at least 5 years. However, we found no significant relationships between either ARV drug class or duration of exposure with risk of comorbidity. This is in contrast with the accumulated evidence linking, for example, PIs with diabetes and cardiovascular events, or NRTIs with cardiac disease [12, 27, 28, 30]. CD4+ cell counts (baseline and latest) and baseline WHO stage had no demonstrated significant associations with comorbidity risk. Similarly, duration of (known) HIV sero-positive state was insignificant after multi-variate analysis. All these factors have been previously linked with comorbidity development [44]. Our study may have been underpowered to detect these effects because of its relatively small sample size.

Lastly, the HIV epidemic in SAA is maturing with ever growing numbers of adults ageing with HIV, notwithstanding the observation from this study of a relatively small proportion (13 %) being aged 55 years or more. In the general population, NCD risks are known to be considerably increased in this age (50+ years old) group. Indeed, our findings point to age as being an important risk factor for both comorbidity and multi-morbidity in the HIV infected population. In multi-variate analysis adjusting for gender, duration of HIV sero-positive state, ART regimens received, and baseline WHO HIV disease stage and CD4 + cell counts, each additional year of age was associated with a 6 % increased risk of comorbidity (adjusted OR 1.06; 95 % CI 1.04–1.08).

In the light of these, as well as findings from other studies within and without SSA, it is strongly recommended that a policy of active screening for NCDs, especially hypertension and T2DM, be adopted as part of routine HIV care. Due to severe resource constraints in most SSA care settings, targeted screening, guided by age and gender for example, may be proposed. As the HIV epidemic increasingly overlaps with the growing problem of NCDs, demands for life-long care will multiply in SSA. It is high time to consider how the infrastructure that developed as a response to HIV—voluntary testing and point-of-care testing technologies, decentralization of treatment to primary care, public engagement and resource mobilisation, behavior change and social marketing strategies, among others—can be adapted and simultaneously deployed in the fight against NCDs.

Task shifting of HIV care in SSA from doctors to nurses and other less skilled cadres allowed the rapid scaling of treatment delivery in the face of severe human capacity constraints. The successes notwithstanding, the training needs of these front line cadres may not have kept pace with an evolving epidemic and its emerging problems. Beyond the burden of NCDs in HIV, huge gaps exist in our knowledge of diagnosis, treatment and outcomes of these comorbidities within the SSA context. This is in turn presents urgent priorities for research.

We have shown that, in keeping with reports from HICs, NCD comorbidities are emerging as a significant and growing challenge in HIV care in SSA. The first from Zimbabwe, a high HIV burden country, our report contributes to this growing body of knowledge of HIV and non-communicable diseases comorbidity. We also highlighted the knowledge gaps peculiar to our sub-Saharan African setting requiring research. Lastly, if the gains made in the fight against HIV are to be preserved, there is an urgent need to integrate NCD screening and care into HIV programmes.