Tuberculous monoarthritis of the wrist in a patient with systemic lupus erythematosus: a case report

Tuberculosis (TB) still causes a significant burden on modern healthcare all around the world, particularly in the developing world. In 2015, there were an estimated 10.4 million new (incident) TB cases worldwide, of which 5.9 million were men, 3.5 million were women and 1 million were children [1]. TB is an endemic infection in Sri Lanka. Although Sri Lanka is considered a low prevalent country in the South-East Asia region [2] around 9000 new TB cases are notified every year [3]. Nearly 60% of these are smear-positive, pulmonary TB cases [3].

Studies have shown tuberculosis to be common in patients with systemic lupus erythematosus (SLE), compared to the general population [4]. Higher cumulative dose of steroids and lupus nephritis have been shown to be important risk factors for TB [5].

Unusual presentations of tuberculosis among these patients may lead to delay in diagnosis and initiation of treatment. A high degree of suspicion is needed in assessing patients on immunosuppressive drugs and non-specific features and prolonged febrile illness. We present a patient with tuberculous arthritis of the left wrist, who was on immuno-suppressive therapy for SLE.

Skeletal involvement is seen in 1–3% of patients with TB [6]. The commonest site of involvement in bone and joint TB is the spine [7]. Weight-bearing large joints are the next to be affected, particularly hip, knee and ankle [6]. Involvement of wrist in TB is rare, though the exact prevalence is unknown. In a case series of bone and joint TB in the United Kingdom 14 out of 203 cases (6%) had wrist involvement [7].

Tuberculosis involving the wrist can be classified as cutaneous lesions, tenosynovitis, bursitis, osteomyelitis, arthritis, and tuberculous hypersensitivity reactions [8]. In a case series published in 1984, 11 cases of Mycobacterium tuberculosis of the hand and wrist were described [9]. This series highlighted the considerable delay between the onset of symptoms and the time of correct diagnosis. Many patients had a diagnosis of rheumatoid arthritis or nonspecific synovitis prior to the diagnosis of tuberculosis. Most patients lacked pulmonary symptoms. Only two patients had a prior history of tuberculosis and only one had significant pulmonary involvement. Most had tenosynovitis involving the flexors or extensors. Three had tenosynovitis and arthritis whereas one had only tuberculous arthritis. Two patients had carpal tunnel syndrome as a result of carpal canal involvement. Ten patients had apparent cures of tuberculosis following surgical debridement and antituberculous therapy.

A recently published study which reviewed 44 cases of wrist TB in a pediatric population highlighted the considerable delay in diagnosis despite advancement of diagnostic techniques, owing to minimal initial symptoms and rarity of the lesion. A considerable number of patients eventually developed chronic wrist pain. This study highlighted that early imaging with MRI and synovial biopsy were key to diagnosis and the most important determinant of treatment success was early initiation of antituberculous chemotherapy [10].

Our patient did not have evidence of past tuberculosis or evidence of tuberculosis at other sites. The diagnostic delay occurred as the presentation was thought to be SLE related arthritis initially, as she did not have any significant systemic symptoms or high inflammatory markers. A case series published on wrist TB in 2003 highlighted the presence of normal ESR in a significant proportion of patients [11]. Alternate diagnoses were considered as increasing immunosuppression and symptomatic treatment did not work, but there was a significant delay in diagnosis owing to the non-specific clinical features.

Our patient did not have a contact history of tuberculosis. However living in a TB endemic region, reactivation of latent tuberculosis by immunosuppression was the likely cause of the current presentation.

Diagnosis of wrist TB is often challenging. Radiographs may not show significant changes and magnetic resonance imaging is superior to radiography and CT for the diagnosis of wrist TB [9]. X-ray changes in wrist TB include bone atrophy, bone or joint destruction with discrete periostitis, and the presence of the typical spina ventosa [12, 13]. Presence of these changes in radiographs should warrant histological assessment for diagnosis of TB. Lozano et al. reported a case of TB wrist presenting with chronic wrist pain presumed to be post traumatic, but histologically evaluated due to radiological appearance of wrist bone destruction [14].

Our patient did not have significant abnormalities on serial X-rays. Magnetic resonance imaging of the wrist joint was not done due to the limited resources. MRI scanning is a good modality to demonstrate soft tissue abnormalities and provides greater detail on the extent of joint involvement, though it is not diagnostic [15]. There should be a lower threshold for advanced imaging in immune compromised patients who are more vulnerable to unusual infections.

Infections are an important cause of morbidity and mortality among SLE patients leading to premature deaths, particularly in developing countries. Tuberculosis is a leading infection among this group [16].

Studies have shown that tuberculosis is more prevalent among SLE patients [17–19] with a statistically significant increase in osteo articular TB compared to the normal population [18]. The exact prevalence of tuberculosis among SLE patients is not known; however, it varies depending on local prevalence of TB.

Uncontrolled hyperactivity of the immune system gives rise to an immuno-compromised state in SLE. Defects in cell mediated immunity caused by the disease as well as medication increases the risk of TB in the SLE patient [20]. Studies have described TB to be associated with SLE flares in some patients. It had been postulated that antibodies generated against TB may cross react with cellular antigens, which might increase flares in SLE patients and precipitate SLE in certain patients [19, 20].

As discussed above diagnosis of TB can be difficult in SLE patients due to overlapping features of the two diseases and atypical presentations [21]. Diagnosis can be made even more difficult when SLE flares coexist with tuberculosis. Pulmonary TB commonly presents without chest radiographic evidence of cavitation [22], while extra-pulmonary TB presents with fever, weight loss and skin nodules [20].

In our centre, SLE patients are not routinely screened for latent tuberculosis before starting treatment. However patients who are to be started on TNF-alpha blockers are screened for latent TB and treated. There are multiple studies evaluating the use of prophylactic anti-TB treatment in SLE patients on immunosuppressives; however, clear evidence of benefit is lacking in this regard [23].

With treatment our patient’s pain improved in severity but persisted. She was functionally disabled with disuse atrophy of small muscles of the hand.

There is limited literature on cases of wrist TB and treatment outcome. In a recent study of thirty cases of hand and wrist TB, a good outcome to anti-TB treatment was noted [24]. However, many studies have demonstrated that tuberculosis among SLE patients has high relapse rates and more complications compared to the normal population [25, 26].

In conclusion, tuberculous arthritis should be considered in the differential diagnosis in patients with chronic arthritis presenting with worsening symptoms. The onset and progression could be insidious with normal inflammatory markers, which can cause diagnostic confusion. MRI scan of the joint could facilitate early diagnosis. Though advanced imaging facilities are not freely available in resource poor settings patients with immunosuppression should be given priority, with a low threshold for imaging. Joint fluid analysis and synovial biopsy are generally helpful in the diagnosis, and should be done in patients with joint effusions whenever possible, carefully balancing the benefits and procedure related risks.