Skip to content

Advertisement

BMC Research Notes

Research Article
Open Access

Assessment of inhaled corticosteroids use and associated factors among asthmatic patients attending Tikur Anbessa Specialized Hospital, Ethiopia

BMC Research Notes201710:314

https://doi.org/10.1186/s13104-017-2645-2

©  The Author(s) 2017

Received: 28 January 2017

Accepted: 21 July 2017

Published: 25 July 2017

Abstract

Background

Inhaled corticosteroids (ICSs) are cornerstone therapy for persistent asthma. However, underutilization of ICSs is common and little is known about factors contributing toward this undesirable use.

Methods

A cross-sectional study was conducted through interview and chart review among persistent asthmatic patients attending chest clinic of Tikur Anbessa Specialized Hospital from 1 May to 31 September 2014. A total of 131 eligible patients who attended the clinic during study period were included in the study. A multivariate logistic regression was used to examine the association between independent and dependent variables.

Results

Overall, extent of underutilization of ICSs was found to be 68%. Monthly income, comorbidity and types of ICSs products prescribed showed significant association with reported underutilization. Patients’ reported reasons for underutilization includes; unaffordability (44%), using only when symptoms exacerbate (21%), fear of side effects (10%), practitioners’ recommendation (10%) and unavailability of ICSs in the local market (7%). Physicians also stated unaffordability, fear of side effects and dependency, lack of local guideline for asthma management and unavailability of ICSs as the contributing factors.

Conclusion

In this setting, extent of underutilization of ICSs was found to be high and seems the result of complex interaction of various factors. Financial problem combined with inconsistent availability of ICSs in the local market, patients’ poor knowledge of asthma and ICSs, negative attitude toward ICSs, absence of local guidelines for asthma management are found to be essential elements dictating an extent of ICSs use.

Keywords

AsthmaPersistentInhaled corticosteroidsUnderutilization

Background

The incidence of asthma has increased dramatically in the past few decades. According to Global Asthma Network report [Global Initiative for Asthma (GINA)], approximately 334 million people worldwide have asthma with high burden of disability [1]. The historic perception of associating asthma with developed countries no longer exist as rapidly increasing number of people are being affected by the disease in developing countries. The mean prevalence of diagnosed asthma was highest in the richest countries (9.4%) followed closely by the poorest countries (8.2%). The middle-income countries had the lowest prevalence (5.2%) [2].

Airway inflammations are a major factor in the pathophysiology of asthma and remain as a principal target of treatment. Although asthma cannot be cured, appropriate management can ensure adequate control of the disease, reverse and even prevent disease process and enable people to have good quality of life [3].

Pharmacological therapy is a key part of asthma management. Generally, asthma drugs can be classified as relievers and controller. There are two groups of controllers; those with anti-inflammatory action including corticosteroids and leukotriene modifiers, and those with a sustained bronchodilator action including long acting β-agonists (LABAs) and slow-releasing theophylline [3, 4]. Medications with anti-inflammatory activity are recommended for all patients with persistent asthma. Inhaled corticosteroids (ICSs) are the most effective medications for long-term control of persistent asthma across all age groups and in most of the therapy care steps [5]. However, studies done in different part of the world indicate low utilization of these key medications, developing countries suffering the most [6–9]. Given the importance of this medication, it would be crucial to determine causes of such underuse. Therefore, the aim of this study was to identify the factors associated with underutilization of ICS among persistent asthma patients in Tikur Anbessa Specialized Hospital (TASH).

Methods

A prospective cross-sectional study was conducted at the chest clinic of TASH from 1 May to 31 September 2014. TASH is located in Addis Ababa, the capital of Ethiopia, and it is the largest hospital in the country providing a tertiary level care.

All patients with persistent asthma of duration greater than 1 year were included. Patients were excluded if they were <18 years of age or had one or more of the following comorbidities: congestive heart failure, other lung disease [including but not limited to chronic obstructive pulmonary diseases (COPDs), cystic fibrosis, and interstitial lung disease], or other medical conditions, such as severe anemia or malignancy, that could have made categorization of asthma severity difficult.

All asthmatic patients who attended the clinic for their regular follow-up during study period and fulfilled inclusion criteria were included in the study summing up a total of 131 patients. Eight physicians (four fellows and four residents) working at the chest clinic were requested to fill semi-structured questionnaires for qualitative data.

Data were collected through patient interview using a semi-structured questionnaire comprising socio-demographic characteristics, disease characteristics, ICS use, and knowledge and attitude towards asthma and ICS. The questionnaires were adapted from previous studies and appropriate modifications were made to serve our purposes [10, 11]. In addition, the charts of the patients were also reviewed particularly to generate information pertaining to medication history. Data from physicians was collected by using self-administered semi-structured questionnaire focusing their perspectives and experiences on patients’ ICS use. Severity of asthma was determined by using GINA criteria [2] such as frequency of symptoms in a week, frequency of nighttime awakening symptoms in a past month, interference with normal activity, the use short acting β2 agonist and lung function. Accordingly, mild persistent asthma was defined as occurrence of symptoms >2 days/week but not daily or occurrence of nighttime awakening symptoms three to four times a month or the use of short acting β2 agonist >2 days/week but not daily, and not more than 1× on any day with minor limitation and forced expiratory volume in 1 s (FEV1) >80% predicted. Moderate persistent asthma was defined as occurrence of symptoms daily or occurrence of nighttime awakening symptoms >1×/week but not nightly or the use of short acting β2 agonist daily with some limitation and FEV1 >60% but <80% predicted. Severe persistent asthma was defined as occurrence of symptoms throughout the day or occurrence of nighttime awakening symptoms nightly or the use of short acting β2 agonist several times per day with extreme limitation and FEV1 <60% predicted.

The regimen of ICS recommended for the patient is reviewed from the chart prior to the interview. Patients were also requested to report the regimen they have been using with the type of product prescribed. The extent of underutilization of ICS was calculated considering the appropriateness of ICS regimen (the dose and frequency of ICS) the patients have been using for given asthma category compared against recommendation of GINA guideline for the specific step of asthma management [1]. In addition, patients who were eligible for ICS but without prescription for ICS, patients who were prescribed ICS but not using then were counted under category of inadequate ICS use. Asthma and ICS knowledge was dichotomized into good and poor by computing sum of questionnaires assessing knowledge for each patient and taking median score as cut-off point. Similarly, attitude toward asthma and ICS were dichotomized into positive and negative attitude by computing sum of the questionnaires assessing attitude for each patient and taking the median score as cut-off point.

The data was entered into epi info version 7 and analyzed using Statistical Package for Social Science (SPSS) for windows version 20. Each variable was evaluated independently in a bivariate analysis and association was determined using cross tabulation and crude odds ratio (COR) with 95% CI. All variables associated with the underutilization of ICS at a probability level of less than or equal to 0.25 on the bivariate analysis were entered into a multivariate logistic regression analysis to control for confounders. The covariates tested includes; educational status, types of ICS products prescribed, monthly income, duration of asthma, comorbidity, severity of asthma, asthma knowledge and ICS knowledge. The final model was selected by using Wald criterion and Hosmer and Lemeshow test to determine variables that were independently associated with underutilization of ICS at a probability level of less than 0.05 and presented using adjusted odds ratio (AOR).

Operational definition

Inhaled corticosteroids

Asthma medication products containing either corticosteroid alone or in combination with LABAs.

Underutilization of inhaled corticosteroids

The use of suboptimal regimen compared against the recommendation by GINA guideline for the specific step of asthma management or primary non-adherence or discontinuation in all or not having prescription for ICSs in case of persistent asthma patients.

Primary non-adherence

Patients who were prescribed ICSs but never filled the prescription.

Results

Socio-demographic characteristics of participants

A total of 131 subjects were included in the final analysis. The mean age of the study subjects was 52.29. Significant proportions of study population were women (64%) and considerable (65%) numbers of the participants were married. With regards to educational status, a sizable proportion (34.4%) of the patients had college diploma and above, while 25.2% of the participants were not fortunate enough to have formal education. The majority (73%) of study subjects were earning less than 1200 Ethiopian Birr (ETB) which is equivalent to $53.5 on monthly basis considering all sources of their income.

Disease characteristics of the asthmatic patients

The mean duration of asthma for this study group during study period was 20.9 years and more than half (52%) of study participants had asthma of greater than 21 years duration. The severity category of asthma was found to be distributed roughly equal among all categories: 34.4, 33.6 and 32.1% of the participants had mild persistent asthma, moderate persistent asthma and severe persistent asthma, respectively. About 59% of the respondents had one or more comorbid condition and under half (43.5%) of the study population were on one or more medications other than anti-asthmatics. The common comorbidities reported in these participants were gastro-esophageal reflux disorder (20.7%), hypertension (19%), diabetes mellitus (12%), allergic rhinitis (10%) and mental illness (10%). Other comorbidities such as sinusitis, heart failure and osteoarthritis were also reported.

Inhaled corticosteroids use

As it can be seen from Table 1, ICS were prescribed in 90.8% of the cases; out of which corticosteroid products prescribed alone was accounted for about 74% of the cases. The remaining received combination product, corticosteroids with LABA. Among the patients prescribed with ICS, 61.3% had been taking ICS, 23.5% discontinued, and 15.1% were primary non-adherent. From those who had been taking ICS, about 42% of the patients were on suboptimal regimen. Overall underutilization of ICS was found to be 68%.
Table 1

Inhaled corticosteroids use in TASH chest clinic from 1 May to 31 September 2014 (n = 131)

ICS use

Number (%)

ICS prescribed

 Yes

119 (90.8)

 No

12 (9.2)

Types of ICS products prescribed

 ICS alone

88 (73.9)

 ICS with LABA

31 (26.1)

ICS prescribed patients (n = 119)

 Patients using ICS

73 (61.3)

 Patients who discontinued using ICS

28 (23.5)

 Primary non-adherence

18 (15.1)

Patients who were using ICS (n = 73)

 Patients on optimal regimen

42 (57.5)

 Patients on suboptimal regimen

31 (42.5)

Underutilization of ICS

 Yes

89 (68)

 No

42 (32)

TASH Tikur Anbessa Specialized Hospital

Patients’ knowledge and attitude toward asthma and Inhaled corticosteroids

Table 2 shows that more than half (61.4%) of the ICS users had good asthma knowledge, while most of them (90.1%) had positive attitude towards asthma. Approximately 46% of the ICS users had good knowledge of ICS and only 54.5% of the ICS users displayed positive attitude toward ICS.
Table 2

Patients’ knowledge and attitude toward asthma and inhaled corticosteroids in TASH chest clinic from 1 May to 31 September 2014 (n = 131)

Knowledge and attitude toward asthma and ICS

Number (%)

Asthma knowledge

 Good

77 (61.4)

 Poor

54 (38.6)

Attitude towards asthma

 Positive

106 (90.1)

 Negative

25 (9.9)

ICS knowledge (n = 119)a

 Good

55 (45.5)

 Poor

64 (54.5)

Attitude toward ICS (n = 119)

 Positive

64 (54.5)

 Negative

55 (45.5)

TASH Tikur Anbessa Specialized Hospital

aPatients filled with ICS only were assessed for ICS knowledge and attitude

Factors associated with underutilization of inhaled corticosteroids

Table 3 illustrates a result of multivariate logistic regression analysis of factors associated with underutilization of ICS among study subjects. It shows that patients who earned monthly income less than or equal to 1200 ETB were about five times more likely to underutilize ICS than those earned greater than 2500 ETB [95% CI 1.10–22.16]. Patients with comorbidity were about three times more likely to underutilize ICS than those with no comorbidity [95% CI 1.11–8.69]. The model also indicated 4.4 times increased odds of underutilization among patients who had been prescribed with ICS alone compared to patients who had been filled with combination products [95% CI 1.49–12.92].
Table 3

Multivariate analysis of factors associated with underutilization of inhaled corticosteroids in TASH chest clinic from 1 May to 31 September 2014 (n = 131)

Variables

Underutilization of ICS

COR (95% CI)

AOR

Yes n (%)

No n (%)

Monthly income in ETB (=120)a

 ≤1200

56 (78.3)

17 (21.7)

8.10 (2.19–30.00) a

5.35 (1.10–22.16)

 1201–2500

15 (51.9)

13 (48.1)

2.42 (0.59–9.82)

1.46 (0.29–7.22)

 >2500

10 (30.8)

9 (69.2)

1.01

1.00

Duration of asthma in years

 ≤21

36 (56.9)

28 (43.1)

1.00

1.00

 >21

47 (72.1)

20 (27.9)

1.96 (0.91–4.21)

1.49 (0.54–4.15)

Comorbidity

 Yes

54 (71.8)

23 (28.2)

2.15 (1.001–4.65) a

3.10 (1.11–8.69) a

 No

29 (54.2)

25 (45.2)

1.00

1.00

Types of ICS products prescribed

 ICS alone

68 (73.9)

26 (26.1)

4.44 (1.88–10.62) a

4.39 (1.49–12.92) a

 ICS with LABA

15 (38.7)

21 (61.3)

1.00

1.00

Severity of asthma

 Mild

28 (61.9)

18 (38.1)

1.00

1.00

 Moderate

23 (52.5)

21 (47.5)

0.68 (0.28–1.64)

0.545 (0.16–1.87)

 Severe

32 (81.1)

9 (18.9)

2.63 (0.94–7.40)

3.17 (0.86–11.75)

Variables with significant association are indicated in italics

TASH Tikur Anbessa Specialized Hospital, CI confidence interval, COR crude odds ratio, AOR adjusted odds ratio

a Remaining subjects were non respondents, Ethiopian per capita income is $590, price of beclate (beclomethasone) 200 μg in Ethiopia is 110 ETB

Patients’ reasons for reported underutilization of inhaled corticosteroids

Patients (89) who deemed as under utilizers of ICS were asked about the factors contributing for underutilization and considerable portion (44%) mentioned unaffordability. In addition, about 21% of the patients tended to decrease the dose or change the dose frequency of the drug when they felt symptom free leading to use of suboptimal regimen, while about 10% of patients claimed that they were told to so by the practitioners themselves. Patients also referred side effects (10%) and unavailability of ICS (8%). Forgetfulness, lack of effect, not liking the drug, and fear of dependence are other reasons cited by the remaining respondents for reported underutilization.

Physicians’ reported reasons for patients’ underutilization of inhaled corticosteroids

Eight physicians working in chest clinic during data collection period were requested to fill questionnaires regarding to adequacy of ICS utilization from patients’ side, almost all of the physicians participated in the study responded ‘no’ and cited different reasons for the problem. However, most of them (75%) stated cost of ICS as a major barrier. Physicians also pointed out patients’ perceptions such as fear of side effects (62.5%) and dependence (50%) as causes for underutilization. Some of the physicians (25%) also mentioned lack of standard of practice such as local guideline as a stumbling block for appropriate use of ICS.

Physicians were also probed if there were any circumstances in which they prescribed other drugs than ICS, all of them said ‘yes’ revealing the use of either oral steroids or theophedrine for uncontrolled asthma (75%). Fifty percent of physicians also pointed out other reason like unavailability of ICS in the local market and patients’ inability to afford ICS as a driving force in the drug selection process.

Discussion

The primary objective of this study was to assess factors associated with underutilization of ICS among persistent asthma patients under regular follow up at the chest unit of TASH. In the present study, high prevalence of underutilization of ICS was found from patients’ perspective. Significant association was found between underutilization of ICS and patients with monthly income of less than 1200 ETB, comorbidity, and types of ICS prescribed. Commonly cited reasons for underutilization of ICS were increased cost, use only when symptoms appear, patients perception towards ICS and inconsistent availability.

Overall, in this study, underutilization of ICS was found to be 68%. The finding is in agreement with a study done in the US where 65% of the patients were using a dose of ICS below that recommended in the National Heart, Lung, and Blood Institute guideline for asthma diagnosis and management [12]. However, the major difference between these two studies is that in the later study, most of the underutilization appeared to represent physicians’ recommendations. This is not the case in this study where underutilization of ICS was primarily due to primary non-adherence, discontinuation, and suboptimal regimen use.

Generally, it is well understood that cost of medications affects utilization pattern of patients adversely. The problem is critical when it comes to asthma drugs, particularly ICS, which is the mainstay therapy of asthma. In the current study, monthly income of participants was significantly associated with underutilization of ICS. Though it is difficult to compare income pattern of different countries hence its association with underutilization of ICS, our finding is in agreement with studies done in elsewhere [13–15].

The present study also showed significant association between underutilization of ICS and comorbidity. Similar finding is reported form Canadian study [16]. Increased odds of underutilization of ICS among patients with one or more comorbidity could be due to different reasons. Patients with comorbidity are more likely to use other medications than ICS which may lead to increased financial burden. Relatedly, taking medications other than asthma medications can result in complicated and burdensome medication regimens often leading to forgetfulness.

In the present study, types of ICS product prescribed, whether corticosteroids were prescribed alone or in combination with LABA, was significantly associated with ICS underutilization. According to the guideline when corticosteroids alone is used, increasing the dose from low to moderate or high is recommended depending on the steps of management or severity of the disease. However, sometimes physicians fail to do so and tend to recommend similar dose across most steps of asthma management [17]. This malpractice could be associated with absence of local clinical guideline for management of asthma as it was mentioned by some of the practitioners in the setting. On the other hand, in spite of having prescription for combination therapy, patients tend to use corticosteroids alone mostly due to increased cost of combination therapy which might be inadequate (in terms of dose and frequency) for the given step of management.

With respect to patients’ reported reasons for underutilization of ICS, unaffordability of ICS was found to have big influence on ICS use (44%). This finding is in line with reports from elsewhere [16–20]. In addition, unavailability of ICS in the study setting was reported from both patients and care providers as one of the factors contributing for underutilization of ICS.

Another frequently stated reason in association with underutilization of ICS was use of ICS when only symptoms appear (21%). Although there was no significant association found between ICS underutilization and knowledge of ICS and asthma, in this study, only 45.5 and 64.1% of the patients had good knowledge of ICS and asthma, respectively. This finding supplements the idea that patients’ tendency to use ICS when symptoms appears is because of lack of understanding about the nature of the disease, and exact role ICS in asthma therapy as well as the necessity for their continuous use as it is indicated in other studies [21, 22].

In this study, about 9% of patients with persistent asthma had not received prescription for ICS which is in consistent with other studies [21, 23]. Aforementioned under prescription could be attributed to different reasons. Firstly, physician may prescribe other drug than ICS intentionally when the patients fail to afford ICS as it was reported by some of the physicians. Secondly, physicians also tend to use drugs from other class for uncontrolled/refractory asthma management which might have contributed for reported under prescribing.

Finally, in this study, absence of local protocol for management of asthma was shown to have negative impact on the proper utilization of ICS from physicians’ side. Although physicians are expected to use international guidelines in this situation, inconsistent prescribing pattern and failure to adhere to such guidelines might occur [23].

Conclusion

In the present study, extent of underutilization of ICS was found to be high amid various factors. Financial problem combined with inconsistent availability of ICS in the local market, poor patients’ knowledge of asthma and ICS, negative attitude toward ICS, absence of local guidelines for asthma management are shown to be major contributing factors for the reported underutilization of ICS. Therefore, concerned bodies should ensure consistent availability and affordability of ICS. It is also very essential to increase awareness of the patients on asthma and ICS and to prepare local guideline for management of asthma.

Limitation of the study

Since it is a cross-sectional design, it was not possible to find temporal relationship between cause and effect. The present study had also limitation regarding its generalizability. First, the study was not multi-centered, hence did not address different population of asthma. Secondly, due to poor patients flow during study period it was not possible to attain maximum sample size. Therefore, this result should be extrapolated cautiously.

Abbreviations

AOR: 

adjusted odds ratio

AAU: 

Addis Ababa University

COPD: 

chronic obstructive pulmonary diseases

COR: 

crude odds ratio

ETB: 

Ethiopian Birr

FEV1 : 

forced expiratory volume in 1 s

GINA: 

Global Initiative for Asthma

ICS: 

inhaled corticosteroids

LABA: 

long acting β2-agonists

TASH: 

Tikur Anbessa Specialized Hospital

SPSS: 

Statistical Package for Social Science

Declarations

Authors’ contributions

Yohanes Ayele is principal author responsible for the conception of the research idea, designing the study, data collection and analysis, interpretation of findings, and authoring the manuscript. Ephrem Engidawork and Tola Bayisa reviewed the research and draft manuscript. All authors have read and agreed to the final manuscript.

Acknowledgements

We would like to acknowledge Addis Ababa University for all the support and funding extended to complete this study. We also extend our heartfelt thanks to all Staff Members of the Chest Clinic of TASH. Our appreciation also goes to the data collectors who showed the utmost effort in acquiring appropriate information.

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

The data collection tools are attached as an additional supporting file. The datasets are available from the corresponding author on reasonable request.

Ethical approval and consent to participate

This study was approved by the Institutional Review Board of Addis Ababa University. Data collectors explained the purpose, benefit and risk of the study to each participant in order to obtain verbal consent from study participants prior to data collection. The questionnaires and others tools were coded; no references were made in oral or written reports that could link participants to the research.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia
(2)
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
(3)
Department of Internal Medicine, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

References

  1. Global Asthma Network. The global asthma report. Auckland: Global Asthma Network. http://www.globalasthmareport.org (2014). Accessed 20 Jan 2015.
  2. The global asthma report 2011. Paris: The International Union Against Tuberculosis and Lung Disease. http://www.isaac.auckland.ac.nz/Global_Asthma_Report_2011.pdf (2011). Accessed 20 Jan 2015.
  3. National Institute of Health. Expert Panel report-3: guideline for the diagnosis and management of asthma. National Heart, Lung and Blood Institute. http://www.nhlbi.nih.gov/files/docs/guidelines (2007). Accessed 15 Dec 2015.
  4. Global Initiative for Asthma. Global strategy for asthma management and prevention. http://www.ginasthma.org (2012). Accessed 10 Dec 2014.
  5. Barnes PJ. Inhaled corticosteroids. Pharmaceuticals. 2010;3(3):514–40.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Zemedkun K, Woldemichael K, Tefera G. Assessing control of asthma in Jush, Jimma, south west Ethiopia. Ethiop J Health Sci. 2014;24(1):49–58.View ArticlePubMedPubMed CentralGoogle Scholar
  7. Bårnes CB, Ulrik CS. Asthma and adherence to inhaled corticosteroids: current status and future perspectives. Respir Care. 2015;60(3):455–68.View ArticlePubMedGoogle Scholar
  8. Laforest L, Van Ganse É, Devouassoux G, Chatte G, Tamberou C, Belhassen M, Chamba G. Deliberate interruptions and changes of dose of inhaled corticosteroids by asthma patients: “a community pharmacy study”. Rev Mal Respir. 2015;32(1):8–17.View ArticlePubMedGoogle Scholar
  9. Yuksel N, Ginther S, Man P, Tsuyuki RT. Underuse of inhaled corticosteroids in adults with asthma. Pharmacotherapy. 2000;20(4):387–93.View ArticlePubMedGoogle Scholar
  10. Boulet LP. Perception of the role and potential side effects of inhaled corticosteroids among asthmatic patients. Chest. 1998;113(3):587–92.View ArticlePubMedGoogle Scholar
  11. Chambers CV, Markson L, Diamond JJ, Lasch L, Berger M. Health beliefs and compliance with inhaled corticosteroids by asthmatic patients in primary care practices. Respir Med. 1999;93(2):88–94.View ArticlePubMedGoogle Scholar
  12. Liou A, Grubb JR, Schechtman KB, Hamilos DL. Causative and contributive factors to asthma severity and patterns of medication use in patients seeking specialized asthma care. Chest. 2003;124(5):1781–8.View ArticlePubMedGoogle Scholar
  13. Apter AJ, Boston RC, George M, Norfleet AL, Tenhave T, Coyne JC, Birck K, Reisine ST, Cucchiara AJ, Feldman HI. Modifiable barriers to adherence to inhaled steroids among adults with asthma: it’s not just black and white. J Allergy Clin Immunol. 2003;111(6):1219–26.View ArticlePubMedGoogle Scholar
  14. Jobin M-S, Moisan J, Bolduc Y, Dorval E, Boulet L-P, Grégoire J-P. Factors associated with the appropriate use of asthma drugs. Can Respir J. 2011;18(2):97–104.View ArticlePubMedPubMed CentralGoogle Scholar
  15. Vaidya V, Holiday-Goodman M, Pinto S. Demographic disparities in patient-reported use of inhaled corticosteroids among patients with persistent asthma. J Asthma Allergy. 2010;3:101–6.View ArticlePubMedPubMed CentralGoogle Scholar
  16. Sin DD, Tu JV. Underuse of inhaled steroid therapy in elderly patients with asthma. Chest. 2001;119(3):720–5.View ArticlePubMedGoogle Scholar
  17. Kelly HW. What is new with the β2-agonists: issues in the management of asthma. Ann Pharmacother. 2005;39(5):931–8.View ArticlePubMedGoogle Scholar
  18. Ait-Khaled N, Enarson DA, Bissell K, Billo NE. Access to inhaled corticosteroids is key to improving quality of care for asthma in developing countries. Allergy. 2007;62(3):230–6.View ArticlePubMedGoogle Scholar
  19. Braman SS. The global burden of asthma. Chest. 2006;130(1 Suppl):4S–12S.View ArticlePubMedGoogle Scholar
  20. Onyedum C, Ukwaja K, Desalu O, Ezeudo C. Challenges in the management of bronchial asthma among adults in Nigeria: a systematic review. Ann Med Health Sci Res. 2013;3(3):324–9.View ArticlePubMedPubMed CentralGoogle Scholar
  21. Al-Jahdali HH, Al-Zahrani AI, Al-Otaibi ST, Hassan IS, Al-Moamary MS, Al-Duhaim AS, Al-Shimemeri AA, Al-Dawood AS. Perception of the role of inhaled corticosteroids and factors affecting compliance among asthmatic adult patients. Saudi Med J. 2007;28(4):569–73.PubMedGoogle Scholar
  22. Mosnaim G, Li H, Martin M, Richardson D, Belice PJ, Avery E, Ryan N, Bender B, Powell L. Factors associated with levels of adherence to inhaled corticosteroids in minority adolescents with asthma. Ann Allergy Asthma Immunol. 2014;112(2):116–20.View ArticlePubMedGoogle Scholar
  23. Hasford J, Uricher J, Tauscher M, Bramlage P, Virchow JC. Persistence with asthma treatment is low in Germany especially for controller medication—a population based study of 483,051 patients. Allergy. 2010;65(3):347–54.View ArticlePubMedGoogle Scholar

Copyright

© The Author(s) 2017

Advertisement

BMC Research Notes

ISSN: 1756-0500

Contact us