Perceived causes and risk factors of Buruli ulcer among patients at Agogo Presbyterian hospital in Ashanti Region of Ghana
BMC Research Notes volume 11, Article number: 64 (2018)
The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Data was collected using a structured questionnaire and analysed using SPSS version 16.0.
Buruli ulcer was perceived as a disease caused by witchcraft (38%), enemies (15%), as well as not pouring libation or praying (16%). Also, increased appetite (30%), oedema or swelling on the skin (29%) and over weight (23%) was perceived as signs and symptoms of Buruli ulcer and a section of the respondents (53%) did not know any risk factor. The age of respondents, gender and level of education were found to determine knowledge of Buruli ulcer (P ≤ .05). Public Educations and campaigns should focus on causes and risk factors to ensure that there is adequate knowledge among the general public on Buruli ulcer.
Buruli ulcer dehydrates its victims economically, disfigures one physically and may influence social stigma .
Buruli ulcer is caused by Mycobacterium ulcerans the bacteria that cause tuberculosis and leprosy . How it is transmitted is still being investigated  but the risk factors include proximity to stagnant or slow-flowing bodies of water, poor wound care and not wearing protective clothing . It starts as a painless swelling (nodule) which can ulcerate within 4 weeks causing gross deformities if left untreated .
The West African sub region has been mostly affected with Cote d’Ivoire recording 24,000 cases from 1978 to 2006 . About 7000 cases were also reported from 1989 to 2006 in Benin and 51 cases have been confirmed in Nigeria since its discovery .
More than 11,000 cases have been reported in Ghana since 1993 with Asante-Akim North, Amansie West District as well as the coastal areas of Ga West District been some of the most endemic areas . In spite of the incidence of the disease in the country, people do not know about it and perceive it as God inflicted disease or caused by drinking from ponds, swimming in rivers, wading in swampy areas, witchcraft and curses [6,7,8].
Loss of productivity caused by lengthy hospital stay is a concern, as well as the disabling outcomes that frequently occur as a result of Buruli ulcer .
Even though Asante-Akim North has the second highest prevalence rate of the disease (prevalence 131.5/100,000) in Ghana , various studies conducted on Buruli ulcer knowledge were carried out in Ga West Municipality or Amansie West District [7, 8, 10, 11]. However, a study conducted in Asante-Akim North District on behavioral sanitation impact on Mycobacterium ulcerans infection focused mainly on assessing hygienic behaviours among a relatively smaller proportion of respondents . This study differs in terms of its location, study aim and sample size and improves upon previous work on Buruli ulcer in the study area by exploring knowledge on signs, symptoms and prevention of Buruli ulcer that were not explored.
Also, Records at the Agogo hospital indicate that Buruli ulcer cases are mostly reported at the hospital but most cases are presented late which complicates the conditions of patients.
Adequate knowledge about the disease is important in order to increase early detection that may reduce the trauma, pain and cost that comes with late treatment .
This study was therefore conducted to determine the perceived causes and risk factors of Buruli ulcer among patients of Presbyterian hospital, Agogo in Asante-Akim North District in the Ashanti region of Ghana.
This study used descriptive design through quantitative approach which was carried out from November 2015 to May 2016.
The study site was the Presbyterian hospital, in Agogo Asante which is a Municipal hospital in Ashanti-Akim North. It is one of the largest healthcare facilities in Ashanti Region of Ghana and serves as a referral centre for many hospitals. The study site was selected because the Hospital serves as a Training Centre for Buruli ulcer Treatment in Ghana and as Collaborating Centre for the University Of Ghana School Of Public Health. The District is known to be one of the most endemic areas in Ghana when it comes to Buruli ulcer cases .
Inclusion was based on individuals’ status as Buruli ulcer patient and the non-Buruli ulcer patients were selected based on only those who visited the hospital for various reasons. They were selected from both outpatient and inpatient units.
Sample size and sampling
A simple random sampling technique was employed to select 400 respondents whose knowledge on the causes and risk factors of Buruli ulcer were assessed using a structured questionnaire. ‘Yes’ and ‘No’ was written on pieces of papers and those who selected the ‘Yes’ were selected for the study. In each particular day and at each particular time that data was collected, patients who were at the hospital were approached and after explaining the purpose of the study to them and obtaining their consent were asked to select one of the papers that had either ‘Yes’ or ‘No’ written in them. Respondents who selected papers that had ‘Yes’ written on it were selected for the study.
The sample size for the study was determined using Yamane  formula. For this study, 95% confidence level and the level of precision (P = .05) were used adopting the Equation;
The symbol n in the equation represents the sample size; N represents the population size while e represents the level of precision. Agogo Hospital was estimated to have provided services to about 4000 patients with confirmed and suspicious Buruli ulcer cases within the previous 3 years. Using this formula,
A 10% non-respondent rate was assumed and therefore 36 were added to 364 to give us a sample size of 400. Data was collected within a period of 3 months and two research assistants were employed.
Instrument for data collection and analysis
A structured questionnaire (Additional file 1) was used which was divided into five (5) subsections that includes Demographic information, Knowledge on Buruli ulcer, Knowledge on causes, Knowledge on risk factors and Prevention. The questionnaire was designed based on the objectives that guided the study and was not taken from any previous study.
A pre-test of the questionnaires was conducted at Manso Nkwanta in Amansie West District which is a Buruli ulcer endemic area. The results of the pre-test helped in reshaping the questionnaire for the actual study. SPSS software version 16.0 was used to analyse the data and results were presented using frequency tables.
Demographic characteristics of respondents
Table 1 show that participants were youthful in nature because all of them were between the ages of 15–39 years. Again, 48% were married while 44–8% were single and widowed respectively. More females (51%) than males (49%) took part in the study and 18% of the respondents had no formal education, while 82% had completed at least primary education.
Causes and risk factors of Buruli ulcer
The causes and risk factors of Buruli ulcer according to the respondents are as shown in Table 2. From the table, 38% said Buruli ulcer is caused by witchcraft, 15% said enemies, 10% said Mycobacterium ulcerans, 7% mentioned ancestors while 30% did not know what causes Buruli ulcer. It can also be observed that more than half of respondents (53%) said they did not know any risk factors of Buruli ulcer, 16% mentioned not pouring libation or praying (offending the gods) 17% believed that having multiple sexual partners is a risk factor, 8% indicated poor personal hygiene 5% said swimming or wading in ponds and while1% mentioned drinking non-potable water as risk factors.
Signs, symptoms and prevention of Buruli ulcer
Signs, symptoms and prevention of Buruli ulcer are presented in Table 3 which shows that 30% mentioned an increased appetite as a sign and symptom of Buruli ulcer, 29% mentioned oedema or swelling on the skin, 23% said over weight and 6% mentioned painless plaque of a well-demarcated lesion while 12% said they do not know any sign or symptom.
In terms of prevention, 40% said Buruli ulcer can be prevented through clean water usage, 25% mentioned avoiding swimming in rivers, 10% mentioned education on personal hygiene and 25% had no idea.
The study revealed that tradition and superstition played significant role in explaining what causes Buruli ulcer as most of the respondents believed that Witchcraft, enemies, offending the gods can cause Buruli ulcer. The results implies that majority of the respondents view Buruli ulcer from cultural and traditional perspectives in terms of what causes it and had no idea of the actual causes. There is the potential of increased risk for Buruli ulcer since causes are not known. The effect of this is that people are likely to engage in behaviours that may expose them to possibility of contracting Buruli ulcer without them knowing. The findings on the causes of Buruli ulcer is similar to that of Owusu–Sekyere et al.  who also found that in most communities affected by Buruli ulcer in Ghana, witchcraft can be used to inflict others with Buruli ulcer. Similar beliefs have been reported by Adobea and Adamba  that people thought Buruli ulcer is caused by their own adversaries, including witches as well as Stienstra et al.  study that reported witchcraft as a major cause of the disease perceived by study participants. Also, witchcraft as the cause of the disease was reported by Renzaho et al.  with 5.2% of respondents suggesting so. These findings are not surprising since both studies were conducted in the same country (Ghana) where tradition, superstition and culture permeate all aspect of the lives of the people. In terms of risk factors, majority did not know of any risk factor for Buruli ulcer.
The poor knowledge on the risk factors means that the people may indulge in behaviors that may put them at higher risk of contracting the disease. This calls for serious public health education and promotion in order to bring the disease under control. The poor knowledge is similar to the study of Kamga et al.  who reported low level of knowledge in his study.
The results indicate that a good number of respondents 30% mentioned an increased appetite as a sign of Buruli ulcer. This finding reveals that respondents had poor knowledge and understanding of the disease. The implication is that early detection and treatment is unlikely. This has the potential of worsening health conditions of individuals which could have been managed if diseases are detected earlier. Despite the cultural and traditional perspectives of viewing Buruli ulcer, a good number of the respondents still believe that good practices at the community level can prevent the spread of Buruli ulcer in the community. The implication is that people may not report to the hospital for appropriate intervention and those who will report are likely to delay and may also be based on wrong assumptions.
Greater proportion of respondents also believed that Buruli ulcer can be prevented when residents are provided with clean water. This suggests that, respondents believed that government has a major role to play in the prevention of the spread of Buruli ulcer in Ghana and in communities such as Agogo. The irony of their suggestion is that, most of them explained the cause of the disease from spiritual perspective yet believed that provision of clean and potable water can help prevent the disease. Since Agogo is an endemic zone for Buruli ulcer, it was expected that at least majority of the respondents would have had a fair idea of how to prevent the disease just like as revealed in a study of Tia et al.  where 83% were familiar with the disease.
Buruli ulcer was perceived as a disease caused by witchcraft (38%), enemies (15%), as well as not pouring libation or praying (16%). Also, increased appetite (30%), oedema or swelling on the skin (29%) and over weight (23%) was perceived as signs and symptoms of Buruli ulcer and a section of the respondents (53%) did not know any risk factor. The attribution to witchcraft and enemies and not knowing the signs and symptoms and risk factors may affect early detection and treatment as most of them will not report signs at a healthcare facility which may worsen their condition. The Age of respondents, Gender and Level of Education were found to determine knowledge of Buruli ulcer (P ≤ .05).
The Ministry of health, in collaboration with the National Commission on Civic Education should embark on public education and campaigns in endemic areas with special focus on causes and risk factors to improve awareness among the general public on Buruli ulcer.
The government must also collaborate with the various communication networks in the country to send frequent messages on Buruli ulcer to the general public.
The Department of Public Health of the Ghana Health Service must develop Buruli ulcer sensitization programmes, hand out brochures and leaflets to inform people and use the various media outlets to improve public knowledge on Buruli ulcer.
Limitation of the study
The study was limited to one hospital and therefore the findings cannot be generalised. However, the quality of data gathered was not affected in any way by this limitation.
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Collection of data was assigned to the fourth author (ES) and all the data was collected by him. The secondary data compilation, review of the study, data analysis and manuscript drafting was done by the first author (RA). EA (second author) provided methodological guidance as well as supervised the analysis and participated in drafting the manuscript and the third author (WKM) provided methodological guidance. Each and every author played a key role in the analysis of data as well as the designing and preparation of the manuscript. All authors have agreed to the submission of this manuscript for publication. All authors read and approved the final manuscript.
Our sincere and profound gratitude goes out to the management and staff of the School of Nursing, Garden City University College and Presbyterian hospital in Agogo Ashanti as well as all patients who participated in this study. We further wish to thank all whose works on Buruli ulcer helped us in putting this work together.
The authors declare that they have no competing interests.
Availability of data materials
A complete document of this study and its findings can be found at the Library of Garden City University College, Kumasi.
Consent for publication
All authors have approved the submission and publication of this manuscript.
Ethics approval and consent to participate
The ethical standards in the selected institution were adhered to. An introductory letter was sent to the institutions to ask for permission to conduct the study in the institution before using the facility. The Committee on Ethics, Publication and Research at the Garden City University College approved the study.
Consent was obtained from all respondents verbally and parents of respondents who were minors were also contacted to obtain their consent to include respondents who were less than 18 years in the study. Parental consent was also obtained verbally due to the level of education of parents. Participant consent was obtained verbally because a section of the respondents had no formal education and a good number had only completed primary education and were only ready for verbal consent when confronted. This was approved by the ethical review board after explanation.
The purpose of the research, expected duration and procedures were explained to the respondents. They were also informed of the rights to decline to participate and to withdraw from the research once it has started, as well as the anticipated consequences of doing so.
There was no external funding for this study. Every cost incurred as a result of this study was covered by the researchers themselves.
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Anokye, R., Acheampong, E., Mprah, W.K. et al. Perceived causes and risk factors of Buruli ulcer among patients at Agogo Presbyterian hospital in Ashanti Region of Ghana. BMC Res Notes 11, 64 (2018). https://doi.org/10.1186/s13104-018-3172-5