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Impact of mental resilience and perceived immune functioning on the severity of alcohol hangover



Recent research comparing hangover sensitive drinkers with hangover resistant drinkers has revealed that experiencing alcohol hangovers is associated with significantly poorer self-reported immune functioning (p < 0.0001). No significant difference between the groups was found on mental resilience. The objective of the current survey was to examine the association between hangover severity, perceived immune status, and mental resilience. N = 341 Dutch students, all hangover sensitive drinkers, completed an online survey. The Brief Resilience Scale was completed, and perceived immune functioning and overall hangover severity for their latest past month hangover were assessed.


Students consumed a mean (SD) of 12.3 (5.9) alcoholic drinks the evening before their latest hangover. A significant positive association was found between mental resilience and perceived immune functioning (r = 0.372, p = 0.000). No significant associations of hangover severity were found with mental resilience (r = − 0.010, p = 0.858), or perceived immune functioning (r = − 0.025, p = 0.645). Previous research revealed that hangover resistant and hangover sensitive drinkers report having significantly different levels of immune functioning, and that the immune system is involved in the development of alcohol hangover. These findings suggest that levels of mental resilience and perceived immune functioning are not related to the severity of hangovers in hangover sensitive drinkers.


The alcohol hangover is defined as the combination of mental and physical symptoms, experienced the day after a single episode of heavy drinking, starting when blood alcohol concentration approaches zero [1]. Whereas the majority of drinkers experiences hangovers following an evening of heavy alcohol consumption, a minority of drinkers claim to be hangover resistant [2, 3]. Several studies have compared the characteristics of these two groups of drinkers [4, 5], in order to further elucidate the pathology of the alcohol hangover. This is a potentially important avenue of research as individual differences in the typology of alcohol hangover may help to understand the pathology of alcohol hangover [6, 7], and identify factors that may aggravate or lessen hangover severity [8].

A recent study looked into biopsychological characteristics of hangover sensitive and hangover resistant drinkers, including mental resilience and perceived immune status [9, 10].

Mental resilience enables recovery from stress and the capacity to face the next stressor with optimism [11, 12]. Hence, this trait is considered to have a positive effect on mental and physical health [13, 14]. Also outside the context of alcohol hangover, van Schrojenstein Lantman et al. demonstrated the existence of interrelationships between mental resilience, self-reported immune functioning, and health [15]. In a first analysis [9] we compared mental resilience of hangover resistant drinkers and hangover sensitive drinkers. It was hypothesized that alcohol is an example of a stressor, and that hangover resistance of certain drinkers may be explained by having higher levels of mental resilience than hangover sensitive drinkers. This hypothesis was not supported. Specifically the data show that hangover sensitive drinkers did not significantly differ from hangover resistant drinkers on levels of mental resilience.

In a second analysis [10], we examined whether hangover resistant drinkers and hangover sensitive drinkers differ on levels of self-reported immune functioning. It was argued that if hangover sensitive drinkers report significantly poorer immune status this could explain why they experience relatively more/worse hangovers than hangover resistant drinkers. The data indeed revealed that hangover sensitive drinkers had significant poorer self-reported immune functioning scores compared to hangover resistant drinkers (p = 0.0001). Thus, hangover frequency and symptomatology appears to be associated with having a poorer baseline immune status.

It is important to stress that the study only differentiated between hangover resistant drinkers and hangover sensitive drinkers. No information was gathered about a possible relationship between mental resilience and perceived immune status with the severity of alcohol hangovers. However, it could be argued that, among hangover sensitive drinkers, hangovers are more severe in those drinkers who report a poorer perceived immune status, whereas lower levels of mental resilience would not affect hangover severity. This hypothesis was investigated in the current analysis.

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Data from an online survey [1] was used to examine our hypothesis. The online survey was designed using, advertised via, and conducted in December 2016. Subjects who completed the survey, and gave permission to be approached for follow-up research (N = 950), were invited by email to complete a follow up survey. Data from this follow-up survey was used for the current analysis. Subjects were included if they were Dutch university students, aged 18–30 years old, and reported to be sensitive to having hangovers. The and took about 10 min to complete.

Alcohol consumption and hangover severity

In addition to demographic data, weekly alcohol consumption was assessed, as well as the amount of alcohol consumption the day before the past month latest hangover. Information about weight and gender was used to calculate an estimated peak Blood Alcohol Concentration (e-pBAC) for this drinking occasion, using an adapted Widmark equation [16]. Overall hangover severity was rated on an 11-point scale ranging from 0 (absent) to 10 (extreme) [4].

Perceived immune functioning

Perceived immune functioning was assessed with a scale ranging from 0 (very poor) to 10 (excellent) [15]. Previous studies revealed significant correlations of 1-item perceived immune functioning scores with mental resilience [15], autism traits [17], and the Immune Function Questionnaire [15].

Mental resilience

Mental resilience was determined with the Brief Resilience Scale (BRS) [18]. The BRS consists of 6 items and measures the ability to recover from stress, i.e. to bounce back. BRS items are scored on a 5-point Likert scale ranging from 1 (‘strongly disagree’) to 5 (‘strongly agree’). Higher scores imply higher levels of mental resilience. Previous research showed that BRS scores correlated significantly with various personality characteristics, psychological coping strategies and health [15, 18].

Statistical analysis

Data were analyzed using SPSS, version 24. Means and standard deviations (SD) of each variable were computed. Individual scores on mental resilience, perceived immune functioning, hangover severity, e-pBAC, and number of alcoholic drinks consumed were correlated using nonparametric Spearman’s rho correlations. Correlations were considered significant if p < 0.05. Data from men and women was compared using independent t-tests or a nonparametric Independent Samples Man-Whitney U test.


N = 341 subjects completed the survey. Their mean (SD) age was 20.9 (2.4) years old, and N = 156 of them was men (45.7%). A summary of their demographics and other assessments is given in Table 1.

Table 1 Summary of assessments

Table 1 shows that men and women differ significantly on all demographic assessments. Also alcohol consumption levels, both regular and on the latest past month heavy drinking occasion resulting in a hangover, are significantly higher in men compared to women. Hangover severity scores, for the latest heavy drinking occasion, did not significantly differ between men and women.

A significant association was found between alcohol hangover severity and the number of alcoholic drinks that were consumed on the latest past month drinking session resulting in a hangover (r = 0.158, p = 0.003) and the duration of drinking (r = 0.189, p = 0.000). The association with e-pBAC was not significant (r = 0.097, p = 0.073). Hangover severity did not correlate significantly with usual weekly alcohol consumption (r = 0.046, p = 0.399), and also no significant associations of hangover severity were found with age (r = 0.046, p = 0.392), body weight (r = 0.021, p = 0.693), mental resilience (r = − 0.010, p = 0.858), or perceived immune functioning (r = − 0.025, p = 0.645).

The number of alcoholic drinks consumed on the latest drinking session resulting in a hangover correlated significantly positive with mental resilience (r = 0.171, p = 0.002) and perceived immune functioning (r = 0.115, p = 0.034). These associations were not significant for the duration of the drinking session. Usual weekly alcohol intake correlated significantly with mental resilience (r = 0.117, p = 0.032), but not with perceived immune functioning (r = 0.070, p = 0.903). eBAC did not correlated significantly with mental resilience (r = 0.094, p = 0.084) and perceived immune functioning (r = − 0.009, p = 0.868). Finally, a significant positive association was found between mental resilience and perceived immune functioning (r = 0.372, p = 0.000).


Although hangover resistant and hangover sensitive drinkers differ significantly in self-reported immune functioning (p = 0.000) [10], the current findings show that levels of perceived immune functioning do not affect the severity of hangovers within a hangover sensitive cohort. Thus, whereas hangover sensitive drinkers typically report having lower immune status compared to hangover resistant drinkers, having a better perceived immune functioning does not imply that one has less severe hangovers. Also, at least within this cohort, the level of mental resilience was not significantly associated with hangover severity.

Research into biopsychological factors that may influence the presence and severity of alcohol hangovers is scarce. To date, these studies suggest that immune status can have an influence on the presence of hangovers, but not on their severity. This warrants further investigation. For example, hangover susceptibility can be compared in drinkers who claim to be hangover sensitive and resistant by assessing biomarkers of immune status (e.g. cytokines in blood or saliva). Clearly, other factors impacting alcohol consumption may have an influence on hangover susceptibility and these merit further investigation, as do immune status-related individual differences. Studies that experimentally manipulate immune status, together with biomarker assessments, may help to further increase our knowledge on the pathology of the alcohol hangover.

Notwithstanding the common limitations of survey research per se (e.g., recall bias), the current literature suggest a role of the immune system in the development of the alcohol hangover, and further research is necessary to elucidate this interaction.


The current self-reported data may suffer from common limitations experienced in survey research such as recall bias or socially desirable answering. However, as the survey was anonymous, this reduced the possibility of obtaining socially desirable answering. Also, if recall bias would have played a role there is no reason to assume that this would have a differential impact for hangover resistant and hangover sensitive drinkers. Finally, the study was conducted among young adults, which makes it unclear to what extend the results are generalizable to other age groups.


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Authors' contributions

JV, AVDL, AS, MM, MVSL and JV made substantial contributions to conception and design, JV and AVDL analyzed the data and drafted the manuscript, and all authors revised it critically for important intellectual content. All authors read and approved the final manuscript.


Not applicable.

Competing interests

AS has received research funding and/or consultancy/speaker fees from Abbott Nutrition, Arla Foods, Australian Wine Research Institute, Barilla, Bayer Healthcare, Blackmores, Cognis, Cyvex, Dairy Health Innovation Consortium, Danone, Ginsana, GlaxoSmithKline Healthcare, Masterfoods, Martek, Naturex, Nestlé, Novartis, Red Bull, Sanofi, Unilever, Verdure Sciences, Wrigley. Joris Verster has received grants/research support from the Dutch Ministry of Infrastructure and the Environment, Janssen, Nutricia, Red Bull, Sequential, and Takeda, and via NeuroClinics has acted as a consultant for the Canadian Beverage Association, Centraal Bureau Drogisterijbedrijven, Clinilabs, Coleman Frost, Danone, Deenox, Eisai, Janssen, Jazz, Purdue, Red Bull, Sanofi-Aventis, Sen-Jam Pharmaceutical, Sepracor, Takeda, Transcept, Trimbos Institute, Vital Beverages, and ZBiotics. The other authors have no potential conflicts of interests to disclose.

Availability of data and materials

The dataset analyzed during the current study is available from the corresponding author on reasonable request.

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Not applicable.

Ethics approval and consent to participate

Online informed consent was obtained from all participants. No formal ethics approval was required for this type of survey research according to the Central Committee of Research Involving Human Subjects (CCMO), The Netherlands.


The survey was funded by Sen-Jam Pharmaceutical, and conducted by NeuroClinics. The companies were not involved in the current analysis and composing of the article. Unrestricted use of the data was granted to the authors.

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van de Loo, A.J.A.E., van Schrojenstein Lantman, M., Mackus, M. et al. Impact of mental resilience and perceived immune functioning on the severity of alcohol hangover. BMC Res Notes 11, 526 (2018).

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