Table 2 List of BCR::ABL1 KD mutations identified in the present study that associated with TKIs resistance
TKI | Sensitive mutants | Resistant mutants |
|---|---|---|
Imatinib | Â | M244V G250E Y253H E255K T315I F317L E355G F359V/C E459K |
Nilotinib | M244V F317L L387M | Y253H E255K T315I F359V/C |
Dasatinib | M244V Y253H F359V/C L387M E459K | E255K T315I F317L |
Bosutinib | M244V E255K Y253H F317L E355G | G250E T315I |
Ponatinib | M244V T315I F317L | E255K |