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  1. The transmissible spongiform encephalopathies (TSEs) comprise a group of fatal degenerative neurological diseases in humans and other mammals. After infection, the cellular prion protein isoform PrPC is converted...

    Authors: Michael J Taheny, Nerik Izkhakov, Alexander A Vostrov and Wolfgang W Quitschke
    Citation: BMC Research Notes 2009 2:178
  2. Fragile × syndrome is caused by loss of expression of the FMRP protein involved in the control of a large number of mRNA targets. The Drosophila ortholog dFXR interacts with a protein complex that includes Arg...

    Authors: Charlotte Madsen, Karen Grønskov, Karen Brøndum-Nielsen and Thomas G Jensen
    Citation: BMC Research Notes 2009 2:177
  3. Discrete RNA structures such as cis-acting replication elements (cre) in the coding region of RNA virus genomes create characteristic suppression of synonymous site variability (SSSV). Different phylogenetic meth...

    Authors: Matías Victoria, Rodney Colina, Marize Pereira Miagostovich, José P Leite and Juan Cristina
    Citation: BMC Research Notes 2009 2:176
  4. Zbtb7A is a proto-oncogenic transcriptional regulator that plays an important role in adipogenesis, osteogenesis and oncogenesis, but little is known about the regulation of Zbtb7A gene expression which is of ...

    Authors: Xuyu Zu, Lingling Yu, Qinsheng Sun, Feng Liu, Jue Wang, Zhenhua Xie, Ying Wang, Wei Xu and Yuyang Jiang
    Citation: BMC Research Notes 2009 2:175
  5. Neuro-imaging studies demonstrate plasticity of cortical gray matter before and after practice for some motor and cognitive tasks in adults. Other imaging studies show functional changes after practice, but th...

    Authors: Richard J Haier, Sherif Karama, Leonard Leyba and Rex E Jung
    Citation: BMC Research Notes 2009 2:174
  6. Although the Jamaica road traffic act mandates motorcycle riders to wear approved helmets, opponents suggest that the local road conditions obviate any benefits from helmet use that have been proven in Develop...

    Authors: Ivor W Crandon, Hyacinth E Harding, Shamir O Cawich, Morton AC Frankson, Georgiana Gordon-Strachan, Noel McLennon, Archibald H McDonald, Doreen Fearon-Boothe, Nicole Meeks-Aitken, Karen Watson-Jones and Kenneth C James
    Citation: BMC Research Notes 2009 2:172
  7. Guillain-Barré Syndrome (GBS), the leading cause of acute flaccid paralysis worldwide, is an autoimmune disorder involving the loss of the myelin sheaths encasing peripheral nerve axons, leading to a loss of n...

    Authors: Laura Nelson, Robert Gormley, Mark S Riddle, David R Tribble and Chad K Porter
    Citation: BMC Research Notes 2009 2:171
  8. Recent studies investigating off-line processes of consolidation in motor learning have demonstrated a sudden, short-lived improvement in performance after 5–30 minutes of post-training inactivity. Here, we in...

    Authors: Remy Schmitz, Manuel Schabus, Fabien Perrin, André Luxen, Pierre Maquet and Philippe Peigneux
    Citation: BMC Research Notes 2009 2:170
  9. Identifying the endogenous RNA induced silencing complex(RISC)-associated RNAs is essential for understanding the cellular regulatory networks by miRNAs. Recently, isolation of RISC-associated mRNAs using anti...

    Authors: Yukinobu Hayashida, Takahiro Nishibu, Kunio Inoue and Tsutomu Kurokawa
    Citation: BMC Research Notes 2009 2:169
  10. Viruses and small-genome bacteria (~2 megabases and smaller) comprise a considerable population in the biosphere and are of interest to many researchers. These genomes are now sequenced at an unprecedented rat...

    Authors: Padmanabhan Mahadevan, John F King and Donald Seto
    Citation: BMC Research Notes 2009 2:168
  11. The expression of vaccine antigens in lactic acid bacteria (LAB) is a safe and cost-effective alternative to traditional expression systems. In this study, we investigated i) the expression of Human papillomav...

    Authors: Naima G Cortes-Perez, Pascale Kharrat, Philippe Langella and Luis G Bermúdez-Humarán
    Citation: BMC Research Notes 2009 2:167
  12. Haemophilus influenzae requires a porphyrin source for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient. This porphyrin requirement may be satisfied by either heme alone, or prot...

    Authors: Daniel J Morton, Thomas W Seale, Timothy M VanWagoner, Paul W Whitby and Terrence L Stull
    Citation: BMC Research Notes 2009 2:166
  13. It was hypothesised that colorectal cancer (CRC) could be diagnosed in biopsies by measuring the combined expression of a small set of well known genes. Genes were chosen based on their role in either the brea...

    Authors: Caroline A Kerr, Robert Dunne, Barney M Hines, Michelle Zucker, Leah Cosgrove, Andrew Ruszkiewicz, Trevor Lockett and Richard Head
    Citation: BMC Research Notes 2009 2:164
  14. Venturia inaequalis is an economically-important disease of apple causing annual epidemics of scab worldwide. The pathogen is a heterothallic ascomycete with an annual cycle of sexual reproduction on infected app...

    Authors: Xiangming Xu, Tony Roberts, Dez Barbara, Nick G Harvey, Liqiang Gao and Daniel J Sargent
    Citation: BMC Research Notes 2009 2:163
  15. In view of the role of TLR2 activation in host defense against mycobacteria, the present study was conducted to examine whether TLR2 polymorphisms could account for the increased prevalence of tuberculosis in ...

    Authors: Debasis Biswas, Shailendra K Gupta, Girish Sindhwani and Abhishek Patras
    Citation: BMC Research Notes 2009 2:162
  16. We assessed the quality of life of ICU survivors using SF-36 at 4 months after ICU discharge and investigated any correlation of PCS and MCS with age, illness severity and hospital or ICU length of stay. We ex...

    Authors: Fiona J Baldwin, Denise Hinge, Joanna Dorsett and Owen F Boyd
    Citation: BMC Research Notes 2009 2:160
  17. In Japan, high incidences of interstitial lung disease (ILD) and ILD-related deaths have been reported among gefitinib-treated patients with non-small cell lung cancer (NSCLC). We investigated the efficacy of ...

    Authors: Masatsugu Nakagawa, Tsutomu Nishimura, Satoshi Teramukai, Harue Tada, Fumihiro Tanaka, Kazuhiro Yanagihara, Kiyoyuki Furuse, Hiromi Wada and Masanori Fukushima
    Citation: BMC Research Notes 2009 2:157
  18. Genome sequencing projects and comparative genomics studies typically aim to trace the evolutionary history of large gene sets, often requiring human inspection of hundreds of phylogenetic trees. If trees are ...

    Authors: Wei-Hua Chen and Martin J Lercher
    Citation: BMC Research Notes 2009 2:155
  19. Previous studies showed an association between Coagulation Factor XII 46C>T polymorphism and variation in FXII plasma levels, as 46C>T seems to affect the translation efficiency. Case-control studies in Spanis...

    Authors: Georgios Athanasiadis, Esther Esteban, Magdanela Gayà Vidal, Robert Carreras Torres, Raoudha Bahri and Pedro Moral
    Citation: BMC Research Notes 2009 2:154
  20. THP-1 is a human monocytic leukemia cell line derived from a patient with acute monocytic leukemia. The cell line differentiates into macrophage-like cells by stimulation with phorbol myristate acetate (PMA). ...

    Authors: Naoki Adati, Ming-Chih Huang, Takahiro Suzuki, Harukazu Suzuki and Toshio Kojima
    Citation: BMC Research Notes 2009 2:153
  21. The Croatian higher education system is in the process of reforming its medical curricula to comply with European Union standards. We conducted a survey of students enrolled at the University of Zagreb (Croati...

    Authors: Katarina Bojanić, Gregory J Schears, Darrell R Schroeder, Sarah M Jenkins, David O Warner and Juraj Sprung
    Citation: BMC Research Notes 2009 2:152
  22. An increase in the number of overweight and obese subjects in the general population has been observed.

    Authors: Antonio Hernández-Mijares, Eva Solá-Izquierdo, Francisco Ballester-Mechó, María Teresa Marí-Herrero, Juan Vicente Gilabert-Molés, Natalia Gimeno-Clemente and María Morales-Suárez-Varela
    Citation: BMC Research Notes 2009 2:151
  23. There are two main technologies for transcriptome profiling, namely, tiling microarrays and high-throughput sequencing. Recently there has been a tremendous amount of excitement about the latter because of the...

    Authors: Rajkumar Sasidharan, Ashish Agarwal, Joel Rozowsky and Mark Gerstein
    Citation: BMC Research Notes 2009 2:150
  24. Human geneticists are now capable of measuring more than one million DNA sequence variations from across the human genome. The new challenge is to develop computationally feasible methods capable of analyzing ...

    Authors: Nicholas A Sinnott-Armstrong, Casey S Greene, Fabio Cancare and Jason H Moore
    Citation: BMC Research Notes 2009 2:149
  25. The recent availability of genomic sequences and BAC libraries for a large number of mammals provides an excellent opportunity for identifying comparatively-anchored markers that are useful for creating high-r...

    Authors: Ravikiran Donthu, Harris A Lewin and Denis M Larkin
    Citation: BMC Research Notes 2009 2:148
  26. The purpose of this study was to test the null hypothesis that there is no difference between the effect of (1) a 5000 ppm fluoride toothpaste, and (2) a 250 ppm fluoride mouth rinse on demineralized human den...

    Authors: Mozhgan Bizhang, Yong-Hee P Chun, Mai-Trinh Winterfeld, Markus J Altenburger, Wolfgang HM Raab and Stefan Zimmer
    Citation: BMC Research Notes 2009 2:147
  27. Bloodstream infections are frequent causes of human illness and cause major morbidity and death. In order to best define the epidemiology of these infections and to track changes in occurrence, adverse outcome...

    Authors: Kevin B Laupland, Henrik C Schønheyder, Karina J Kennedy, Outi Lyytikäinen, Louis Valiquette, John Galbraith, Peter Collignon, Deirdre L Church, Daniel B Gregson and Pamela Kibsey
    Citation: BMC Research Notes 2009 2:146
  28. The high diversity of ornamentation type in pollen grains of angiosperms has often been suggested to be linked to diversity in pollination systems. It is commonly stated that smooth pollen grains are associate...

    Authors: Julie Sannier, William J Baker, Marie-Charlotte Anstett and Sophie Nadot
    Citation: BMC Research Notes 2009 2:145
  29. Adult minimal changes disease (MCD) is usually treated by high corticosteroids dose in order to achieve remission of nephrotic syndrome. In this study, the administration of high steroid dose (prednisolone 1 m...

    Authors: Dimitrios S Goumenos, Pantelitsa Kalliakmani, Eirini Savvidaki and John G Vlachojannis
    Citation: BMC Research Notes 2009 2:144
  30. Fruit normally develops from the ovary after pollination and fertilization. However, the ovary can also generate seedless fruit without fertilization by parthenocarpy. Parthenocarpic fruit development has been...

    Authors: Barbara Molesini, Giuseppe L Rotino, Angelo Spena and Tiziana Pandolfini
    Citation: BMC Research Notes 2009 2:143
  31. The cell cycle is promoted by activation of cyclin dependent kinases (Cdks), which are regulated positively by cyclins and negatively by Cdk inhibitors. Proliferation of carcinoma is associated with altered re...

    Authors: Pia Boström, Mirva Söderström, Tuire Palokangas, Tero Vahlberg, Yrjö Collan, Olli Carpen and Pirkko Hirsimäki
    Citation: BMC Research Notes 2009 2:140
  32. Epithelial cells in first catch urine (FCU) specimens from 87 men with and without urethritis were quantified. Epithelial cells were broadly categorised into transitional and squamous populations using morphol...

    Authors: Rebecca Wiggins, Patrick J Horner, Kate Whittington and Christopher H Holmes
    Citation: BMC Research Notes 2009 2:139
  33. R is the statistical language commonly used by many life scientists in (omics) data analysis. At the same time, these complex analyses benefit from a workflow approach, such as used by the open source workflow...

    Authors: Ingo Wassink, Han Rauwerda, Pieter BT Neerincx, Paul E van der Vet, Timo M Breit, Jack AM Leunissen and Anton Nijholt
    Citation: BMC Research Notes 2009 2:138
  34. Hydrocephalus can be classified as purely obstructive, purely communicating or due to combinations of pathologies (obstruction in addition to defective absorption). Endoscopic third ventriculostomy (ETV) as an...

    Authors: Yad Ram Yadav, Gaurav Mukerji, Vijay Parihar, Mallika Sinha and Sanjay Pandey
    Citation: BMC Research Notes 2009 2:137
  35. Antimicrobial peptides (AMP) are important effectors of the innate immune system. Although there is increasing evidence that AMPs influence bacteria in a multitude of ways, bacterial wall rupture plays the piv...

    Authors: Mukesh Pasupuleti, Mina Davoudi, Martin Malmsten and Artur Schmidtchen
    Citation: BMC Research Notes 2009 2:136
  36. We previously developed a set of rationally designed mutant MICA protein ligands for the NKG2D immunoreceptor in which MICA was mutated at residues that do not contact NKG2D. Some of these MICA mutants, predic...

    Authors: Chad L Mayer, W Kalani Snyder, Monika A Swietlicka, Andrew D VanSchoiack, Chad R Austin and Benjamin J McFarland
    Citation: BMC Research Notes 2009 2:135
  37. Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic va...

    Authors: Mangesh R Bhide, Raquel Escudero, Emilio Camafeita, Horacio Gil, Isabel Jado and Pedro Anda
    Citation: BMC Research Notes 2009 2:134
  38. Adherence to osteoporosis pharmacotherapy is poor, and linked with patient perceptions of the benefits of, and barriers to taking these treatments. To better understand the association between patient percepti...

    Authors: Suzanne M Cadarette, Monique AM Gignac, Susan B Jaglal, Dorcas E Beaton and Gillian A Hawker
    Citation: BMC Research Notes 2009 2:133
  39. Ethyl-2-cyanoacrylate (ECA) is a tissue adhesive material applied to close superficial wounds. The aim of this study was to explore the benefits of cyanoacrylates in the emergency department in children with c...

    Authors: Betul Gulalp, Tamer Seyhan, Sonnur Gursoy and M Nur Altinors
    Citation: BMC Research Notes 2009 2:132
  40. Marbling defined by the amount and distribution of intramuscular fat, so-called Shimofuri, is an economically important trait of beef cattle in Japan. The c17-25 expressed sequence tag (EST) has been previously s...

    Authors: Seiki Sasaki, Takahisa Yamada, Shin Sukegawa, Takeshi Miyake, Tatsuo Fujita, Mitsuo Morita, Takeshi Ohta, Youichi Takahagi, Hiroshi Murakami, Fumiki Morimatsu and Yoshiyuki Sasaki
    Citation: BMC Research Notes 2009 2:131

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