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  1. Human Papillomavirus (HPV) is considered as a necessary, but not sufficient, cause of cervical cancer. In this study, we aimed to assess the prevalence of HPV in a series of pre-malignant and malignant cervica...

    Authors: José V Fernandes, Rosely V Meissner, Maria GF Carvalho, Thales AAM Fernandes, Paulo RM Azevedo, João S Sobrinho, José CM Prado and Luisa L Villa
    Citation: BMC Research Notes 2010 3:96
  2. Due to its high sensitivity, the Smith-Waterman algorithm is widely used for biological database searches. Unfortunately, the quadratic time complexity of this algorithm makes it highly time-consuming. The exp...

    Authors: Yongchao Liu, Bertil Schmidt and Douglas L Maskell
    Citation: BMC Research Notes 2010 3:93
  3. Recently, the promise of a new universal long-term flu vaccine has become more tangible than ever before. Such a vaccine would protect against very many seasonal and pandemic flu strains for many years, making...

    Authors: Raffaele Vardavas, Romulus Breban and Sally Blower
    Citation: BMC Research Notes 2010 3:92
  4. Cryptosporidiosis and strongyloidiasis have been reported to be associated with HIV/AIDS. The present study was designed to determine the prevalence of Cryptosporidium and Strongyloides stercoralis infections amo...

    Authors: Amde Getaneh, Girmay Medhin and Techalew Shimelis
    Citation: BMC Research Notes 2010 3:90
  5. Microarray data interpretation can be affected by sample RNA integrity. The ScreenTape Degradation Value (SDV) is a novel RNA integrity metric specific to the ScreenTape® platform (Lab901). To characterise the pe...

    Authors: Timothy M Wilkes, Alison S Devonshire, Stephen LR Ellison and Carole A Foy
    Citation: BMC Research Notes 2010 3:89
  6. The Relative Codon Deoptimization Index (RCDI) was developed by Mueller et al. (2006) as measure of codon deoptimization by comparing how similar is the codon usage of a gene and the codon usage of a reference...

    Authors: Pere Puigbò, Lluís Aragonès and Santiago Garcia-Vallvé
    Citation: BMC Research Notes 2010 3:87
  7. The ubiquitin-based molecular switch dictating error free versus error prone repair has been conserved throughout eukaryotic evolution. A central component of this switch is the homotrimeric clamp PCNA, which ...

    Authors: Jan Brun, Roland K Chiu, Bradly G Wouters and Douglas A Gray
    Citation: BMC Research Notes 2010 3:85
  8. Typically, electrodes for Deep Brain Stimulation (DBS) are used for chronic stimulation. However, there are conditions where this therapy has to be discontinued. In such cases using the DBS electrodes as a too...

    Authors: Thomas L Hauska, Hermann Lanmüller, Wolfgang Kainz and François Alesch
    Citation: BMC Research Notes 2010 3:84
  9. Chronic diseases cause an ever-increasing percentage of morbidity and mortality, but many have modifiable risk factors. Many behaviors that predispose or protect an individual to chronic disease are interrelat...

    Authors: Federico Alonso, Carolyn O Walsh and Luis Salvador-Carulla
    Citation: BMC Research Notes 2010 3:83
  10. Many breastfeeding women seek medical care from general practitioners (GPs) for various health problems and GPs may consider prescribing medicines in these consultations. Prescribing medicines to a breastfeedi...

    Authors: Hiranya S Jayawickrama, Lisa H Amir and Marie V Pirotta
    Citation: BMC Research Notes 2010 3:82
  11. Large scale microarray experiments are becoming increasingly routine, particularly those which track a number of different cell lines through time. This time-course information provides valuable insight into t...

    Authors: Colin S Gillespie, Guiyuan Lei, Richard J Boys, Amanda Greenall and Darren J Wilkinson
    Citation: BMC Research Notes 2010 3:81
  12. microRNAs (miRNA) are short, endogenous transcripts that negatively regulate the expression of specific mRNA targets. The relative abundance of miRNAs is linked to function in vivo and miRNA expression patterns a...

    Authors: Sachin Sah, Matthew N McCall, Deepa Eveleigh, Michael Wilson and Rafael A Irizarry
    Citation: BMC Research Notes 2010 3:80
  13. Argininosuccinic aciduria (ASAuria) is an autosomal recessive disorder of the urea cycle relatively common in Saudi Arabia as a consequence of extensive consanguinity. It is the most common urea cycle disorder...

    Authors: Faiqa Imtiaz, Moeen Al-Sayed, Danyah Trabzuni, Bashair R Al-Mubarak, Osama Alsmadi, Mohamed S Rashed and Brian F Meyer
    Citation: BMC Research Notes 2010 3:79
  14. Accurate nationally representative statistics on total and cause-specific mortality in Vietnam are lacking due to incomplete capture in government reporting systems. This paper presents total and cause-specifi...

    Authors: Anh D Ngo, Chalapati Rao, Nguyen Phuong Hoa, Timothy Adair and Nguyen Thi Kim Chuc
    Citation: BMC Research Notes 2010 3:78
  15. The prevalence of cigarette smoking in Ukraine is different between genders and is among the highest in the world. There is need to identify gender-specific factors that are associated with having stopped smok...

    Authors: Alice Hazemba, Seter Siziya, Adamson S Muula and Emmanuel Rudatsikira
    Citation: BMC Research Notes 2010 3:76
  16. Transcriptome analysis during embryogenesis usually requires pooling of embryos to obtain sufficient RNA. Hence, the measured levels of gene-expression represent the average mRNA levels of pooled samples and t...

    Authors: Mark de Jong, Han Rauwerda, Oskar Bruning, Jurgo Verkooijen, Herman P Spaink and Timo M Breit
    Citation: BMC Research Notes 2010 3:73
  17. Detection of Tuberculosis agent like nontuberculous mycobacteria (NTM) species by culture and microscopic methods remains difficult and time consuming. A fast and reliable diagnosis of tuberculosis would great...

    Authors: Mochammad Hatta, Andi Rofian Sultan, Nataniel Tandirogang, Masjudi and Yadi
    Citation: BMC Research Notes 2010 3:72
  18. To evaluate whether the volume of blood suctioned during vacuum-assisted breast biopsy (VABB) is associated with hematoma formation and progression, patient's age and histology of the lesion.

    Authors: Flora Zagouri, Theodoros N Sergentanis, Philip Domeyer, Dimosthenis Chrysikos, Georgia Giannakopoulou, Nikolaos V Michalopoulos, Panagiotis Safioleas, Ioannis Flessas, Effrosyni Panopoulou, Garifallia Bletsa and George C Zografos
    Citation: BMC Research Notes 2010 3:70
  19. In the last decade, the availability of gene sequences of many plant species, including tomato, has encouraged the development of strategies that do not rely on genetic transformation techniques (GMOs) for imp...

    Authors: Silvia Minoia, Angelo Petrozza, Olimpia D'Onofrio, Florence Piron, Giuseppina Mosca, Giovanni Sozio, Francesco Cellini, Abdelhafid Bendahmane and Filomena Carriero
    Citation: BMC Research Notes 2010 3:69
  20. The permeabilization of mitochondrial membranes is a decisive event in apoptosis or necrosis culminating in cell death. One fundamental mechanism by which such permeabilization events occur is the calcium-induced...

    Authors: Sabine Eisenhofer, Ferenc Toókos, Burkhard A Hense, Sabine Schulz, Frank Filbir and Hans Zischka
    Citation: BMC Research Notes 2010 3:67
  21. Marbling, defined by the amount and the distribution of intramuscular fat and measured as beef marbling score (BMS), is an economically important trait of beef cattle in Japan. We recently reported that a sing...

    Authors: Shin Sukegawa, Takeshi Miyake, Yoichi Takahagi, Hiroshi Murakami, Fumiki Morimatsu, Takahisa Yamada and Yoshiyuki Sasaki
    Citation: BMC Research Notes 2010 3:66
  22. Less is known about the influence of hematocrit detection methodology on transfusion triggers. Therefore, the aim of the present study was to compare two different hematocrit-assessing methods. In a total of 5...

    Authors: Marco Bosshart, John F Stover, Reto Stocker, Lars M Asmis, Jörg Feige, Thomas A Neff, Reto A Schuepbach, Silvia R Cottini and Markus Béchir
    Citation: BMC Research Notes 2010 3:65
  23. In Trypanosoma brucei, the African trypanosome, endocytosis is developmentally regulated and substantially more active in all known mammalian infective stages. In both mammalian and insect stages endocytic activi...

    Authors: Senthil KA Natesan, Lori Peacock, Ka Fai Leung, Wendy Gibson and Mark C Field
    Citation: BMC Research Notes 2010 3:63
  24. microRNAs (miRNAs) are endogenous small non-coding RNAs that post-transcriptionally regulate gene expression. In plants, they typically show high complementarity to a single sequence motif within their target ...

    Authors: Sandra Niemeier, Leonardo Alves Junior and Thomas Merkle
    Citation: BMC Research Notes 2010 3:59
  25. The chick chorio-allantoic membrane (CAM) assay is a commonly used method for studying angiogenic or anti-angiogenic activities in vivo. The ease of access allows direct monitoring of tumour growth by biomicrosco...

    Authors: Maurice Balke, Anna Neumann, Christian Kersting, Konstantin Agelopoulos, Carsten Gebert, Georg Gosheger, Horst Buerger and Martin Hagedorn
    Citation: BMC Research Notes 2010 3:58
  26. Decomposition of concentration indices yields useful information regarding the relative importance of various determinants of inequitable health outcomes. But the two estimation approaches to decomposition in ...

    Authors: Vasoontara Yiengprugsawan, Lynette LY Lim, Gordon A Carmichael, Keith BG Dear and Adrian C Sleigh
    Citation: BMC Research Notes 2010 3:57
  27. Heavy chain phosphorylation plays a central role in regulating myosin II bipolar filament assembly in Dictyostelium, as well as in higher eukaryotic nonmuscle cells. Our previous work has demonstrated that the WD...

    Authors: Julie Underwood, Jonathan Greene and Paul A Steimle
    Citation: BMC Research Notes 2010 3:56
  28. Previous studies have suggested a probable association between the polymorphism of a microsatellite locus located in the promoter of IGF1 (Insulin-like growth factor 1) gene and the serum level of IGF1, as wel...

    Authors: Liang Xie, Yuan-ying Gong, Shi-gang Lian, Juan Yang, Shou-jun Gao, Liang-you Xu and Ya-ping Zhang
    Citation: BMC Research Notes 2010 3:55
  29. The origin of adenocarcinomas presenting on the cervix uteri may be doubtful, i.e. whether it is of cervical or endometrial origin, due to the overlapping morphological features. In HPV negative samples, furth...

    Authors: Michael Odida, Belen Lloveras, Nuria Guimera and Elisabete Weiderpass
    Citation: BMC Research Notes 2010 3:54
  30. RNA interference (RNAi) has been one of the most rapidly expanding areas of biological research in the past decade, revolutionizing the ability to analyze gene function. Thorough validation of siRNA duplexes i...

    Authors: Katherine Holmes, Catrin M Williams, Elinor A Chapman and Michael J Cross
    Citation: BMC Research Notes 2010 3:53
  31. Presence of phosphorylated Serine biosynthesis pathway upstream to the de novo cysteine biosynthesis pathway makes PSAT a crucial enzyme. Besides this, phoshoserine produced by the enzyme can also be taken up ...

    Authors: Vibhor Mishra, Vahab Ali, Tomoyoshi Nozaki and Vinod Bhakuni
    Citation: BMC Research Notes 2010 3:52
  32. In order to identify single nucleotide polymorphisms (SNPs) efficiently from a species with a large genome, SNPs were identified from an expressed sequence tag (EST) database combined with High Resolution Melt...

    Authors: Tokuko Ujino-Ihara, Yuriko Taguchi, Yoshinari Moriguchi and Yoshihiko Tsumura
    Citation: BMC Research Notes 2010 3:51
  33. Optic nerve regeneration (ONR) following injury is a model for central nervous system regeneration. In zebrafish, ONR is rapid - neurites cross the lesion and enter the optic tectum within 7 days; in mammals r...

    Authors: Joseph R Koke, Amanda L Mosier and Dana M García
    Citation: BMC Research Notes 2010 3:50
  34. The emergence of drug resistant strains of Mycobacterium tuberculosis complex has made the management of tuberculosis difficult. Also, Mycobacterium species has a peculiar cell wall, made of an impermeable comple...

    Authors: Adolf K Awua, Edna D Doe and Oti K Gyamfi
    Citation: BMC Research Notes 2010 3:48
  35. Oral administration of probiotics is known to modulate cytokines profile not only locally, but also systemically. Four strains of Lactobacillus salivarius, LDR0723, BNL1059, RGS1746 and CRL1528, were evaluated fo...

    Authors: Lorenzo Drago, Lucia Nicola, Enrico Iemoli, Giuseppe Banfi and Elena De Vecchi
    Citation: BMC Research Notes 2010 3:44

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