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  1. Large-scale genome-wide association studies are promising for unraveling the genetic basis of complex diseases. Population structure is a potential problem, the effects of which on genetic association studies ...

    Authors: Hongyan Xu, Bayazid Sarkar and Varghese George
    Citation: BMC Research Notes 2009 2:21
  2. IFN-γ responses to M. tuberculosis antigens are used as in-vitro diagnostic tests for tuberculosis infection. The tests are highly specific but sensitivity may be impaired due to immuno-suppression. The objective...

    Authors: Morten Ruhwald, Morten Bjerregaard-Andersen, Paulo Rabna, Jesper Eugen-Olsen and Pernille Ravn
    Citation: BMC Research Notes 2009 2:19
  3. Analyses based on phylogenetic and ultrastructural data have suggested that euglenids (such as Euglena gracilis), trypanosomatids and diplonemids are members of a monophyletic lineage termed Euglenozoa. However, ...

    Authors: Ryan MR Gawryluk and Michael W Gray
    Citation: BMC Research Notes 2009 2:16
  4. Neuronal plasticity is initiated by transient elevations of neuronal networks activity leading to changes of synaptic properties and providing the basis for memory and learning [1]. An increase of electrical acti...

    Authors: Frédéric D Broccard, Silvia Pegoraro, Maria Elisabetta Ruaro, Claudio Altafini and Vincent Torre
    Citation: BMC Research Notes 2009 2:13
  5. Unlike mouse immature bone marrow (BM)-derived dendritic cells (DC), rat immature BMDC have not been thoroughly characterised in vitro for the mechanisms underlying their suppressive effect. To better characteris...

    Authors: George Tiurbe, Anja Matuschek, Ulrike Kämmerer, Manuela Schneider, Arnulf Thiede, Karin Ulrichs and Christoph Otto
    Citation: BMC Research Notes 2009 2:12
  6. Fine-mapping projects require a high density of SNP markers and positional candidate gene sequences. In species with incomplete genomic sequence, the DNA sequences needed to generate markers for fine-mapping w...

    Authors: James E Koltes, Zhi-Liang Hu, Eric Fritz and James M Reecy
    Citation: BMC Research Notes 2009 2:11
  7. We report the expression pattern of 5S rDNA in the eggs of water frogs Rana lessonae, Rana ridibunda and Rana esculenta using the quantitative real-time PCR. This kind of research had never been performed before.

    Authors: Elżbieta Czarniewska and Robert Plewa
    Citation: BMC Research Notes 2009 2:10
  8. Two commercial interferon gamma release assays (IGRAs) (QuantiFERON®-TB Gold in Tube and T SPOT®-TB) to detect a contact with M. tuberculosis have recently become available. The majority of studies agree that the...

    Authors: Esko Tavast, Eeva Salo, Ilkka Seppälä and Tamara Tuuminen
    Citation: BMC Research Notes 2009 2:9
  9. Gene expression studies related to cancer diagnosis and treatment are important. In order to conduct such experiment accurately, absolutely reliable housekeeping genes are essential to normalize cancer related...

    Authors: Harun M Said, Buelent Polat, Carsten Hagemann, Jelena Anacker, Michael Flentje and Dirk Vordermark
    Citation: BMC Research Notes 2009 2:8
  10. Dictyostelium amoebae are frequently used to study the organization and function of the endocytic pathway, and specific protocols are essential to measure the dynamics of endocytic compartments and their internal...

    Authors: Anna Marchetti, Emmanuelle Lelong and Pierre Cosson
    Citation: BMC Research Notes 2009 2:7
  11. Adherence to antipsychotics for schizophrenia is associated with favorable clinical outcomes. This study compared annual mental-health service utilization by recent medication adherence levels for patients tre...

    Authors: Haya Ascher-Svanum, Baojin Zhu, Douglas E Faries, Nicolas M Furiak and William Montgomery
    Citation: BMC Research Notes 2009 2:6
  12. A recent and provocative meta-analysis, based on few outcome events, suggested that rosiglitazone increased cardiovascular mortality and myocardial infarction. However, results of meta-analyses of trials with ...

    Authors: Jan O Friedrich, Joseph Beyene and Neill KJ Adhikari
    Citation: BMC Research Notes 2009 2:5
  13. Panic disorder (PD) is a serious DSM-IV axis I disorder affecting up to 3% of the adult population each year. It is associated with a large burden of disease and extensive economic costs. This study aims to ex...

    Authors: Peter Meulenbeek, Godelief Willemse, Filip Smit, Niels Smits, Anton van Balkom, Philip Spinhoven and Pim Cuijpers
    Citation: BMC Research Notes 2009 2:4
  14. Pancreatic duodenal homeobox-1 (Pdx-1) or Pdx-1-VP16 gene transfer has been shown to induce in vitro rat liver-stem WB cell conversion into pancreatic endocrine precursor cells. High glucose conditions were neces...

    Authors: Juliette Cuvelier Delisle, Lionel Martignat, Laurence Dubreil, Pierre Saï, Jean-Marie Bach, Vanessa Louzier and Steffi Bösch
    Citation: BMC Research Notes 2009 2:3
  15. As the hepatitis B genotyping is important for assessing its clinical implications and geographical distribution, the sub-genotypes have been found useful for determination of specific genomic markers related ...

    Authors: Saeeda Baig, Anwar Siddiqui, Runu Chakravarty and Tariq Moatter
    Citation: BMC Research Notes 2009 2:1
  16. Peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A) is a coactivator with a vital and central role in fat and energy metabolism. It is considered to be a candidate gene for meat quality in pigs...

    Authors: Tim Erkens, Karel Bilek, Alex Van Zeveren and Luc J Peelman
    Citation: BMC Research Notes 2008 1:138
  17. The human GLB1 gene is known to give rise to two alternatively spliced mRNAs, which encode two different proteins: lysosomal β-galactosidase (β-gal) and elastin-binding protein (EBP). The β-gal transcript include...

    Authors: Raül Santamaria, Lluïsa Vilageliu and Daniel Grinberg
    Citation: BMC Research Notes 2008 1:137
  18. Liver-to-pancreas conversion offers new possibilities for β-cell engineering for type 1 diabetes therapy. Among conceivable sources of liver cells, we focused on BMEL cells. These untransformed mouse embryonic...

    Authors: Juliette Cuvelier Delisle, Lionel Martignat, Jean-Marie Bach, Steffi Bösch and Vanessa Louzier
    Citation: BMC Research Notes 2008 1:136
  19. Adynamia in fibromyalgia (FM) may be an expression of a functional deficit of the hypothalamic-pituitary-adrenal axis and be associated with below-normal levels of urinary cortisol. Our aim was to demonstrate ...

    Authors: Silvia Izquierdo–Álvarez, Julia Pilar Bocos–Terraz, Jose Luis Bancalero–Flores, Lenin Pavón–Romero, Enrique Serrano–Ostariz and Cayetano Alegre de Miquel
    Citation: BMC Research Notes 2008 1:134
  20. We sought to describe the integrity of human genomic DNA extracted from saliva saturated cotton spit wads stored at -20°C for approximately 11 years. 783 spit wad samples were collected from an ADHD sample pop...

    Authors: Erik A Ehli, Timea Lengyel-Nelson, James J Hudziak and Gareth E Davies
    Citation: BMC Research Notes 2008 1:133
  21. Plant cell cultures have been shown as feasible systems for the production of secondary metabolites, being the elicitation with biotic or abiotic stimuli the most efficient strategy to increase the production ...

    Authors: Diego Lijavetzky, Lorena Almagro, Sarai Belchi-Navarro, José M Martínez-Zapater, Roque Bru and Maria A Pedreño
    Citation: BMC Research Notes 2008 1:132
  22. Mass spectrometric analysis of peptides is an essential part of protein identification and characterization, the latter meaning the identification of modifications and amino acid substitutions. There are two m...

    Authors: Harald Barsnes, Svein-Ole Mikalsen and Ingvar Eidhammer
    Citation: BMC Research Notes 2008 1:130
  23. Medicago truncatula is a model species for legumes. Its functional genomics have been considerably boosted in recent years due to initiatives based both in Europe and US. Collections of mutants are becoming incre...

    Authors: Andrea Porceddu, Francesco Panara, Ornella Calderini, Lorna Molinari, Paola Taviani, Luisa Lanfaloni, Carla Scotti, Maria Carelli, Laura Scaramelli, Gianluca Bruschi, Viviane Cosson, Pascal Ratet, Henri de Larembergue, Gerard Duc, Efisio Piano and Sergio Arcioni
    Citation: BMC Research Notes 2008 1:129
  24. Individuals who are aware of the risk of infection and perceive themselves to be at risk of infection are more likely to take action to prevent HIV infection. The aim of this study was to assess the knowledge ...

    Authors: Seter Siziya, Adamson S Muula and Emmanuel Rudatsikira
    Citation: BMC Research Notes 2008 1:123
  25. Actinobacillus pleuropneumoniae, the causative bacterial agent of porcine pleuropneumonia, produces Apx toxins which belong to RTX toxin family and are recognized as the major virulence factors. So far, their tar...

    Authors: Philippe GAC Vanden Bergh, Laurent LM Zecchinon, Thomas Fett and Daniel Desmecht
    Citation: BMC Research Notes 2008 1:121
  26. The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized wi...

    Authors: Eric M Mortensen, Marcos I Restrepo, Jacqueline A Pugh and Antonio Anzueto
    Citation: BMC Research Notes 2008 1:120
  27. The mocha mouse carries a spontaneous deletion in the Ap3d1 gene, encoding the delta 1 subunit of the adaptor related protein complex 3, (Ap3d1), and subsequently lack the expression of functional AP-3. This lead...

    Authors: Kim Ryun Drasbek, Mai Marie Holm, Marion Delenclos and Kimmo Jensen
    Citation: BMC Research Notes 2008 1:119
  28. Symbiotic relationships between intracellular bacteria and eukaryotes are widespread in nature. Genome sequencing of the bacterial partner has provided a number of key insights into the basis of these symbiose...

    Authors: Gaku Tokuda, Nathan Lo, Aya Takase, Akinori Yamada, Yoshinobu Hayashi and Hirofumi Watanabe
    Citation: BMC Research Notes 2008 1:118
  29. Access to health professionals is a key UK NHS priority, and meeting access targets is rewarded through the new General Medical Services (GMS) contract in the UK. We sought to determine the current state of ap...

    Authors: Andrea Edwards and Richard D Neal
    Citation: BMC Research Notes 2008 1:117
  30. Pneumococcal hand contamination in Indigenous children in remote communities is common (37%). It is not clear whether this requires frequent inoculation, or if pneumococci will survive on hands for long period...

    Authors: Heidi Smith-Vaughan, Faith Crichton, Jemima Beissbarth, Peter S Morris and Amanda J Leach
    Citation: BMC Research Notes 2008 1:112

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