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  1. Thyroid function changes during pregnancy and maternal thyroid dysfunction have been associated with adverse outcomes. Our aim was to evaluate thyroid hormones levels in pregnant women resident in Aragon, Spain.

    Authors: Julia Pilar Bocos-Terraz, Silvia Izquierdo-Álvarez, Jose Luís Bancalero-Flores, Rosa Álvarez-Lahuerta, Ana Aznar-Sauca, Elisabet Real-López, Raquel Ibáñez-Marco, Virgilio Bocanegra-García and Gildardo Rivera-Sánchez
    Citation: BMC Research Notes 2009 2:237
  2. The quantitative polymerase chain reaction (qPCR) is a widely utilized method for gene-expression analysis. However, insufficient material often compromises large-scale gene-expression studies. The aim of this...

    Authors: Joëlle Vermeulen, Stefaan Derveaux, Steve Lefever, Els De Smet, Katleen De Preter, Nurten Yigit, Anne De Paepe, Filip Pattyn, Frank Speleman and Jo Vandesompele
    Citation: BMC Research Notes 2009 2:235
  3. Recent evidence suggests erythropoietin (EPO) and the erythropoietin receptor (EPOR) may play a direct role in the pathogenesis of diabetic retinopathy. Better characterization of the EPO-EPOR signaling system in...

    Authors: Shaival S Shah, Stephen H Tsang and Vinit B Mahajan
    Citation: BMC Research Notes 2009 2:234
  4. Paratuberculosis vaccination has been in use in some regions for many decades, but results have not been widely spread. A new Mycobacterium avium subsp. paratuberculosis (MAP) killed vaccine was studied in relati...

    Authors: Ramon A Juste, Marta Alonso-Hearn, Elena Molina, Marivi Geijo, Patricia Vazquez, Iker A Sevilla and Joseba M Garrido
    Citation: BMC Research Notes 2009 2:233
  5. Traumatic perforation of the tympanic membrane may be due to direct or indirect source. The aim of the study is to profile the various aetiologies of traumatic tympanic membrane perforation in Ilorin, north ce...

    Authors: Olushola A Afolabi, Shuaib K Aremu, Biodun S Alabi and S Segun-Busari
    Citation: BMC Research Notes 2009 2:232
  6. The zebrafish, Danio rerio, possesses the paralogous genes aplnra and aplnrb that are duplicates of an ancestral orthologue of the human APLNR gene encoding a G-protein coupled receptor that binds the peptide lig...

    Authors: Svanhild Nornes, Ben Tucker and Michael Lardelli
    Citation: BMC Research Notes 2009 2:231
  7. We used Global Positioning System (GPS) data from radiocollared pumas (Puma concolor) to identify kill sites of pumas preying upon an endangered population of bighorn sheep (Ovis canadensis) in southern Californi...

    Authors: Sean M Clemenza, Esther S Rubin, Christine K Johnson, Randall A Botta and Walter M Boyce
    Citation: BMC Research Notes 2009 2:230
  8. The fibroblast-populated 3D collagen matrix is a model of tissue and healing which has been used since the 1980's. It was hypothesized that anchorage disruption of the collagen matrix would produce p53-depende...

    Authors: Mark A Carlson, Amy K Prall, Jeremiah J Gums, Alex Lesiak and Valerie K Shostrom
    Citation: BMC Research Notes 2009 2:229
  9. Several pathogens that cause important zoonotic diseases have been frequently associated with armadillos and other xenarthrans. This mammal group typically has evolved on the South American continent and many ...

    Authors: Virgínia B Richini-Pereira, Sandra MG Bosco, Raquel C Theodoro, Lígia Barrozo, Silvia CB Pedrini, Patrícia S Rosa and Eduardo Bagagli
    Citation: BMC Research Notes 2009 2:228
  10. The shikimate pathway is an attractive target for the development of antitubercular agents because it is essential in Mycobacterium tuberculosis, the causative agent of tuberculosis, but absent in humans. M. tube...

    Authors: Valnês S Rodrigues Junior, Ardala Breda, Diógenes S Santos and Luiz A Basso
    Citation: BMC Research Notes 2009 2:227
  11. The plasticizer di-(2-ethylhexyl) phthalate (DEHP) has been shown to stimulate a non-allergy related immune response with increased levels of IgG1 and IgG2a, but not IgE, after co-administration with the model...

    Authors: Søren T Larsen and Gunnar D Nielsen
    Citation: BMC Research Notes 2009 2:225
  12. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in vi...

    Authors: Dawn N Birdsell, Tasha Stewart, Amy J Vogler, Elisabeth Lawaczeck, Alisa Diggs, Tammy L Sylvester, Jordan L Buchhagen, Raymond K Auerbach, Paul Keim and David M Wagner
    Citation: BMC Research Notes 2009 2:223
  13. Attributes of teams could affect the quality of care delivered in primary care. The aim of this study was to systematically review studies conducted within the UK NHS primary care that have measured team clima...

    Authors: Teik T Goh and Martin P Eccles
    Citation: BMC Research Notes 2009 2:222
  14. Research has shown that fecal biomarkers are useful to assess the activity of inflammatory bowel disease (IBD). The aim of the study is: to evaluate the efficacy of the fecal lactoferrin and calprotectin as in...

    Authors: Andrea Vieira, Chia Bin Fang, Ernani Geraldo Rolim, Wilmar Artur Klug, Flávio Steinwurz, Lucio Giovanni Battista Rossini and Paulo Azevedo Candelária
    Citation: BMC Research Notes 2009 2:221
  15. High-throughput screening of protein-protein interactions opens new systems biology perspectives for the comprehensive understanding of cell physiology in normal and pathological conditions. In this context, y...

    Authors: Johann Pellet, Laurène Meyniel, Pierre-Olivier Vidalain, Benoît de Chassey, Lionel Tafforeau, Vincent Lotteau, Chantal Rabourdin-Combe and Vincent Navratil
    Citation: BMC Research Notes 2009 2:220
  16. C21, the C-terminal peptide of thrombospondin-4, has growth promoting activity and was discovered as one of several erythropoietin-dependent endothelial proteins. C21 stimulates red cell formation in anemic mi...

    Authors: Gulzhakhan Sadvakassova, Monica C Dobocan and Luis F Congote
    Citation: BMC Research Notes 2009 2:215
  17. Single nucleotide polymorphism (SNP) genotyping is a major activity in biomedical research. Scientists prefer to have a facile access to the results which may require conversions between data formats. First ha...

    Authors: Bowang Chen, Stefan Wilkening, Marion Drechsel and Kari Hemminki
    Citation: BMC Research Notes 2009 2:214
  18. Toxoplasmosis in immuno-compromised hosts manifests primarily as a life threatening condition, toxoplasmic encephalitis. However, there is scarce information about the magnitude of Toxoplasma gondii infection amo...

    Authors: Techalew Shimelis, Mekashaw Tebeje, Endale Tadesse, Belete Tegbaru and Ashenafi Terefe
    Citation: BMC Research Notes 2009 2:213
  19. We are correcting the abstract of our published article ([1]). The sentence that starts "We observe that 4.5% of MPSS tags...." was not scientifically complete in the original abstract, having only two of the fou...

    Authors: Rajkumar Sasidharan, Ashish Agarwal, Joel Rozowsky and Mark Gerstein
    Citation: BMC Research Notes 2009 2:211

    The original article was published in BMC Research Notes 2009 2:150

  20. To analyze gene function in mammalian cells tetracycline inducible expression of a gene-of-interest at a specific genomic location (Flp-In T-REx™) is most attractive. However, leakiness of basal transgene expr...

    Authors: Sabine Senkel, Christoph Waldner, Gerhart U Ryffel and Heike Thomas
    Citation: BMC Research Notes 2009 2:210
  21. Bovine herpesviruses type 1 (BoHV1) and type 5 (BoHV5) are two closely related pathogens of cattle. The identity of the two viruses on the amino acid level averages 82%. Despite their high antigenetic similari...

    Authors: Evgeni Gabev, Cornel Fraefel, Mathias Ackermann and Kurt Tobler
    Citation: BMC Research Notes 2009 2:209
  22. There is little confidence in the consistency of estimation of DNA concentrations when samples move between laboratories. Evidence on this consistency is largely anecdotal. Therefore there is a need first to m...

    Authors: Jay Brown, Alexander N Donev, Charalampos Aslanidis, Pippa Bracegirdle, Katherine P Dixon, Manuela Foedinger, Rhian Gwilliam, Matthew Hardy, Thomas Illig, Xiayi Ke, Dagni Krinka, Camilla Lagerberg, Päivi Laiho, David H Lewis, Wendy McArdle, Simon Patton…
    Citation: BMC Research Notes 2009 2:208
  23. Deschampsia antarctica shows tolerance to extreme environmental factors such as low temperature, high light intensity and an increasing UV radiation as result of the Antarctic ozone layer thinning. It is very lik...

    Authors: Jaime R Sánchez-Venegas, Alejandro Navarrete, Jorge Dinamarca, León A Bravo Ramírez, Ana Gutiérrez Moraga and Manuel Gidekel
    Citation: BMC Research Notes 2009 2:207
  24. Our SigWin-detector discovers significantly enriched windows of (genomic) elements in any sequence of values (genes or other genomic elements in a DNA sequence) in a fast and reproducible way. However, since i...

    Authors: Wim C de Leeuw, Han Rauwerda, Márcia A Inda, Oskar Bruning and Timo M Breit
    Citation: BMC Research Notes 2009 2:205
  25. The reindeer lichen is the product of a mutualistic relationship between a fungus and an algae. Lichen demonstrate a remarkable capacity to tolerate dehydration. This tolerance is driven by a variety of bioche...

    Authors: Sini Junttila, Kean-Jin Lim and Stephen Rudd
    Citation: BMC Research Notes 2009 2:204
  26. BMI was increased (>25) in 22% of young healthy subjects. Increased cholesterol values (>5.0 mmol/L) were found in 23% of subjects, LDL-C (>3.0 mmol/L) in 23%, triglycerides (>1.7 mmol/L) in 11% of subjects. W...

    Authors: Jadranka Sertic, Ljiljana Juricic, Hana Ljubic, Tamara Bozina, Jasna Lovric, Jasenka Markeljevic, Bojan Jelakovic, Marijan Merkler and Zeljko Reiner
    Citation: BMC Research Notes 2009 2:203
  27. The availability of research platforms like the web tools of the National Center for Biotechnology Information (NCBI) has transformed the time-consuming task of identifying candidate genes from genetic studies...

    Authors: Rajani S Sadasivam, Gayathri Sundar, Laura K Vaughan, Murat M Tanik and Donna K Arnett
    Citation: BMC Research Notes 2009 2:201
  28. In cancer care, a GP's work is rarely defined clearly. Our aim was to assess GPs' work with cancer patients in France and in Norway, where the roles of the GP and the organization of the system are rather diff...

    Authors: Lise Demagny, Knut Holtedahl, Janine Bachimont, Tommy Thorsen, Alain Letourmy and Martine Bungener
    Citation: BMC Research Notes 2009 2:200
  29. Consolidating transcriptome data of non-human primates is essential to annotate primate genome sequences, and will facilitate research using non-human primates in the genomic era. Macaca fascicularis is a macaque...

    Authors: Naoki Osada, Makoto Hirata, Reiko Tanuma, Yutaka Suzuki, Sumio Sugano, Keiji Terao, Jun Kusuda, Yosuke Kameoka, Katsuyuki Hashimoto and Ichiro Takahashi
    Citation: BMC Research Notes 2009 2:199
  30. The Copper/Zinc superoxide dismutase (Cu/ZnSOD) gene, SOD gene, was isolated from a Deschampsia antarctica Desv. by cDNA library screening. The expression of SOD gene in the leaves of D. antarctica was determined...

    Authors: Jaime R Sánchez-Venegas, Jorge Dinamarca, Ana Gutiérrez Moraga and Manuel Gidekel
    Citation: BMC Research Notes 2009 2:198
  31. Our aim was to develop an objective computerised system for measuring different types of retinal haemorrhages in differing digital images, for use as a research tool. Despite developing various fully automated...

    Authors: Tariq Aslam, Paul Chua, Matthew Richardson, Praveen Patel and Mohammed Musadiq
    Citation: BMC Research Notes 2009 2:196
  32. The functional integration of the neuro-, endocrine- and immune-systems suggests that the transcriptome of white blood cells may reflect neuropsychiatric states, and be used as a non-invasive diagnostic indica...

    Authors: Johan H van Heerden, Ana Conesa, Dan J Stein, David Montaner, Vivienne Russell and Nicola Illing
    Citation: BMC Research Notes 2009 2:195
  33. Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Increased succinate or fumarate levels as a consequen...

    Authors: Katie T Huang, Alexander Dobrovic and Stephen B Fox
    Citation: BMC Research Notes 2009 2:194
  34. Mitochondria (mt) contain their own autonomously replicating DNA, constituted as a small circular genome encoding essential subunits of the respiratory chain. Mt DNA is characterized by a genetic code which di...

    Authors: Joachim EM Jacob, Bartel Vanholme, Thomas Van Leeuwen and Godelieve Gheysen
    Citation: BMC Research Notes 2009 2:192
  35. Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB...

    Authors: Valerie Tilston, Stephen S Taylor and David Perera
    Citation: BMC Research Notes 2009 2:190
  36. Saffron (Crocus sativus) is considered the world's most expensive spice. Used mainly as a colorant for foodstuffs, it is highly appreciated for its aromatic and flavouring properties. Since no molecular markers f...

    Authors: Angela Rubio-Moraga, Raquel Castillo-López, Lourdes Gómez-Gómez and Oussama Ahrazem
    Citation: BMC Research Notes 2009 2:189
  37. The cultivated strawberry Fragaria ×ananassa is one of the most economically-important soft-fruit species. Few structural genomic resources have been reported for Fragaria and there exists an urgent need for the ...

    Authors: Julio Bonet, Elena Lopez Girona, Daniel J Sargent, Monica C Muñoz-Torres, Amparo Monfort, Albert G Abbott, Pere Arús, David W Simpson and Jahn Davik
    Citation: BMC Research Notes 2009 2:188

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