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  1. The fabric of science is changing, driven by a revolution in digital technologies that facilitate the acquisition and communication of massive amounts of data. This is changing the nature of collaboration and ...

    Authors: Vincent S Smith
    Citation: BMC Research Notes 2009 2:113
  2. The development of reverse transcription – quantitative real-time PCR (RT-qPCR) platforms that can simultaneously measure the expression of multiple genes is dependent on robust assays that function under iden...

    Authors: Thomas Mikeska and Alexander Dobrovic
    Citation: BMC Research Notes 2009 2:112
  3. Protein Post-Translational Modification (PTM) plays an essential role in cellular control mechanisms that adjust protein physical and chemical properties, folding, conformation, stability and activity, thus al...

    Authors: Tzong-Yi Lee, Justin Bo-Kai Hsu, Wen-Chi Chang, Ting-Yuan Wang, Po-Chiang Hsu and Hsien-Da Huang
    Citation: BMC Research Notes 2009 2:111
  4. Diarrhoea is the second leading cause of illness and death in developing countries and the second commonest cause of death due to infectious diseases among children under five in such countries. Parasites, as ...

    Authors: Avik Kumar Mukherjee, Punam Chowdhury, Mihir Kumar Bhattacharya, Mrinmoy Ghosh, Krishnan Rajendran and Sandipan Ganguly
    Citation: BMC Research Notes 2009 2:110
  5. Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several...

    Authors: Jinsheng Yu, Xiqiang Liu, Hui Ye and Xiaofeng Zhou
    Citation: BMC Research Notes 2009 2:109
  6. Staphylococcus aureus is a major cause of food poisoning due to their ability to produce enterotoxins which if ingested in sufficient amounts results in sickness. Food handlers carrying enterotoxin-producing S. a...

    Authors: Edet E Udo, Siham Al-Mufti and M John Albert
    Citation: BMC Research Notes 2009 2:108
  7. As FTA® cards provide an ideal medium for the field collection of DNA we sought to assess the quality of genomic DNA extracted from this source for use on the Illumina BovineSNP50 iSelect BeadChip which requires ...

    Authors: Matthew C McClure, Stephanie D McKay, Robert D Schnabel and Jeremy F Taylor
    Citation: BMC Research Notes 2009 2:107
  8. Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more var...

    Authors: Nick T Peters, Anne Catherine Miller and Darryl L Kropf
    Citation: BMC Research Notes 2009 2:106
  9. Differential expression of perforin (PRF1), a gene with a pivotal role in immune surveillance, can be attributed to differential methylation of CpG sites in its promoter region. A reproducible method for quantita...

    Authors: Supraja Narasimhan, Virginia R Falkenberg, Maung M Khin and Mangalathu S Rajeevan
    Citation: BMC Research Notes 2009 2:104
  10. The Clubfoot Assessment Protocol (CAP) was developed for follow-up of children treated for clubfoot. The objective of this study was to analyze reliability and validity of the six items used in the domain CAPM...

    Authors: Hanneke Andriesse, Gunnar Hägglund and Per-Erik Isberg
    Citation: BMC Research Notes 2009 2:103
  11. The human cancer-related nucleoside triphosphatase (HCR-NTPase) is overexpressed in several tumour tissues including neuroblastoma. HCR-NTPase is an enzyme exhibiting a slow in vitro activity in hydrolysing nucle...

    Authors: Markus Pasdziernik, Barbara Kaltschmidt, Christian Kaltschmidt, Claudia Klinger and Michael Kaufmann
    Citation: BMC Research Notes 2009 2:102
  12. GenBank(R) is a public repository of all publicly available molecular sequence data from a range of sources. In addition to relevant metadata (e.g., sequence description, source organism and taxonomy), publica...

    Authors: Holly Miller, Catherine N Norton and Indra Neil Sarkar
    Citation: BMC Research Notes 2009 2:101
  13. A phenotype of increased muscle mass (IMM) and reduced fat, comparable to reported effects of deleterious mutations in the myostatin gene (MSTN), has been observed in the Norwegian Spælsau breed. However, the gen...

    Authors: Inger A Boman and Dag I Våge
    Citation: BMC Research Notes 2009 2:98
  14. Lower respiratory tract infections are a major cause of illness and death. Such infections are common in intensive care units (ICU) and their lethality persists despite advances in diagnosis, treatment and pre...

    Authors: Virgilio Bocanegra-García, María del Rayo Camacho-Corona, Mónica Ramírez-Cabrera, Gildardo Rivera and Elvira Garza-González
    Citation: BMC Research Notes 2009 2:95
  15. Germline mutations in the BRCA2 gene have been suggested to account for about 5% of familial prostate cancer; mutations have been reported in 2% of early onset (i.e., ≤ 55 years) prostate cancer cases and a segre...

    Authors: Kristina Allen-Brady, James M Farnham, Nicola J Camp, Eric Karlins, Elaine A Ostrander and Lisa A Cannon-Albright
    Citation: BMC Research Notes 2009 2:94
  16. In the past, rice genome served as a good model for studies involving comparative genomics of grass species. More recently, however, Brachypodium distachyon genome has emerged as a better model system for genomes...

    Authors: Sachin Kumar, Amita Mohan, Harindra S Balyan and Pushpendra K Gupta
    Citation: BMC Research Notes 2009 2:93
  17. There is a need for software scripts and modules for format parsing, data manipulation, statistical analysis and annotation especially for tasks related to marker identification from sequence data and sequence...

    Authors: B Jayashree, A BhanuPrakash, Anusha Jami, P Srinivasa Reddy, Spurthi Nayak and Rajeev K Varshney
    Citation: BMC Research Notes 2009 2:92
  18. It has been demonstrated that extracellular mRNA can be detected in the circulation. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of breast cancer patie...

    Authors: Weizhu Zhu, Wenyi Qin, Ulus Atasoy and Edward R Sauter
    Citation: BMC Research Notes 2009 2:89
  19. Within-species genome diversity has been best studied in humans. The international HapMap project has revealed a tremendous amount of single-nucleotide polymorphisms (SNPs) among humans, many of which show sig...

    Authors: Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura and Hiroshi Mitani
    Citation: BMC Research Notes 2009 2:88
  20. Myosin II-dependent contraction of the cytokinetic ring and primary septum formation by chitin synthase II are interdependent processes during cytokinesis in Saccharomyces cerevisiae. Hence, null mutants of myosi...

    Authors: José F Rodríguez-Quiñones and José R Rodríguez-Medina
    Citation: BMC Research Notes 2009 2:87
  21. From October 2006 to February 2007, clinical specimens from 452 patients with symptoms related to respiratory tract infection in the northern region of Taiwan were collected. Real-time PCR and direct immunoflu...

    Authors: Yuan-Ming Lee, Sheng-Fan Wang, Cheng-Ming Lee, Kuan-Hsuan Chen, Yu-Jiun Chan, Wu-Tse Liu and Yi-Ming Arthur Chen
    Citation: BMC Research Notes 2009 2:86
  22. The murine ghrelin gene (Ghrl), originally sequenced from stomach tissue, contains five exons and a single transcription start site in a short, 19 bp first exon (exon 0). We recently isolated several novel first ...

    Authors: Inge Seim, Shea L Carter, Adrian C Herington and Lisa K Chopin
    Citation: BMC Research Notes 2009 2:85
  23. The treatment of acute acromioclavicular (AC) joint injuries depends mainly on the type of the dislocation and patient demands. This study compares the mid term outcome of two frequently performed surgical con...

    Authors: Bernd A Leidel, Volker Braunstein, Susann Pilotto, Wolf Mutschler and Chlodwig Kirchhoff
    Citation: BMC Research Notes 2009 2:84
  24. Women with rheumatoid arthritis (RA) have increased morbidity and mortality due to coronary heart disease. Chronic systemic inflammation is known to accelerate atherosclerosis and increase arterial stiffness i...

    Authors: Philip W Pemberton, Yasmeen Ahmad, Helena Bodill, Daniel Lokko, Samantha L Hider, Allen P Yates, Michael G Walker, Ian Laing and Ian N Bruce
    Citation: BMC Research Notes 2009 2:83
  25. We assessed NanoString's nCounter™ Analysis System for its ability to quantify gene expression of forty-eight genes in a single reaction with 100 ng of total RNA or an equivalent amount of tissue lysate. In th...

    Authors: Vladislav A Malkov, Kyle A Serikawa, Noel Balantac, James Watters, Gary Geiss, Afshin Mashadi-Hossein and Thomas Fare
    Citation: BMC Research Notes 2009 2:80
  26. Marbling defined by the amount and distribution of intramuscular fat is an economically important trait of beef cattle in Japan. We have recently reported that single nucleotide polymorphisms (SNPs) in the endoth...

    Authors: Takahisa Yamada, Seiki Sasaki, Shin Sukegawa, Sachiyo Yoshioka, Youichi Takahagi, Mitsuo Morita, Hiroshi Murakami, Fumiki Morimatsu, Tatsuo Fujita, Takeshi Miyake and Yoshiyuki Sasaki
    Citation: BMC Research Notes 2009 2:78
  27. The aim of this study was to develop a simple organ score derived from the Critical Care Minimum Data Set (CCMDS) to compare with the Sequential Organ Failure Assessment (SOFA) score, a previously validated sc...

    Authors: Tim W Felton, Rebecca Sander, Mo Al-Aloul, Paul Dark and Andrew M Bentley
    Citation: BMC Research Notes 2009 2:77
  28. This study investigated the nosocomial blood stream infection (BSI) in the adult ICUs in Assiut university hospitals to evaluate the rate of infection in different ICUs, causative microorganisms, antimicrobial...

    Authors: Shaaban H Ahmed, Enas A Daef, Mohammed S Badary, Mohammed A Mahmoud and Alaa A Abd-Elsayed
    Citation: BMC Research Notes 2009 2:76
  29. Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder that is more frequent in males than females. Several genes on the X chromosome have been studied as cand...

    Authors: Xiaohui Xu, Keeley Brookes, Bo Sun, Nicholas Ilott and Philip Asherson
    Citation: BMC Research Notes 2009 2:71
  30. Apart from simple steatosis, the non-alcoholic steatohepatitis (NASH) can progress into liver fibrosis and cirrhosis. To date, however, no widely accepted therapeutic modalities have been established against N...

    Authors: Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Masaharu Yamazaki, Tatsuhiro Tsujimoto, Hideto Kawaratani, Takemi Akahane, Yosuke Aihara and Hiroshi Fukui
    Citation: BMC Research Notes 2009 2:70
  31. It can be seen from the available mollusk mitogenomes that the family Pectinidae exhibits the most variation in genome organization. In this study, comparative mitogenomic analyses were performed for three sca...

    Authors: Xiangyun Wu, Xiaodong Xu, Ziniu Yu and Xiaoyu Kong
    Citation: BMC Research Notes 2009 2:69
  32. Oxygenases belong to the oxidoreductive group of enzymes (E.C. Class 1), which oxidize the substrates by transferring oxygen from molecular oxygen (O2) and utilize FAD/NADH/NADPH as the co-substrate. Oxygenases c...

    Authors: Pankaj K Arora, Manish Kumar, Archana Chauhan, Gajendra PS Raghava and Rakesh K Jain
    Citation: BMC Research Notes 2009 2:67
  33. Activating mutations in the PIK3CA gene have been identified in a variety of human malignancies and are commonly detected in hotspot codons located in the helical and kinase domains in exons 9 and 20. Existing me...

    Authors: Carolyn D Hurst, Tahlita CM Zuiverloon, Christian Hafner, Ellen C Zwarthoff and Margaret A Knowles
    Citation: BMC Research Notes 2009 2:66
  34. Cell-specific expression of a subset of Enhancer of split (E(spl)-C) genes in proneural clusters is mediated by synergistic interactions between bHLH A (b asic H elix-L oop-H elix A ctivator) and Notch-signalling...

    Authors: John W Cave, Li Xia and Michael A Caudy
    Citation: BMC Research Notes 2009 2:65

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