Modi S, Stopeck AT, Gordon MS, Mendelson D, Solit DB, Bagatell R, Ma W, Wheler J, Rosen N, Norton L, Cropp GF, Johnson RG, Hannah AL, Hudis CA: Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2-overexpressing breast cancer: A Phase I dose-escalation study. J Clin Oncol. 2007, 25: 5410-5417. 10.1200/JCO.2007.11.7960.
Article
PubMed
CAS
Google Scholar
Modi S, Stopeck AT, Linden HM, Solit DB, Chandarlapaty S, Rosen N, D’Andrea G, Dickler MN, Moynahan ME, Sugarman S, Ma W, Patil S, Norton L, Hannah AL, Hudis C: HSP90 Inhibition is Effective in Breast Cancer: A Phase 2 Trial of Tanespimycin (17AAG) plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab. Clin Cancer Res. 2011, 17: 5132-5139. 10.1158/1078-0432.CCR-11-0072.
Article
PubMed
CAS
Google Scholar
Arteaga CL: Why Is This Effective HSP90 Inhibitor Not Being Developed in HER2+ Breast Cancer?. Clin Cancer Res. 2011, 17: 4919-4921. 10.1158/1078-0432.CCR-11-1218.
Article
PubMed
CAS
PubMed Central
Google Scholar
Slamon DJ, Clarke GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER2/neu oncogene. Science. 1987, 235: 177-182. 10.1126/science.3798106.
Article
PubMed
CAS
Google Scholar
Montemurro F, Donadio M, Clavarezza M, Redana S, Jacomuzzi ME, Valabrega G, Danese S, Vietti-Ramus G, Durando A, Venturini M, Aglietta M: Outcome of patients with HER2-positive advanced breast cancer progressing during trastuzumab-based therapy. Oncologist. 2006, 11: 318-324. 10.1634/theoncologist.11-4-318.
Article
PubMed
CAS
Google Scholar
Sharp SY, Boxall K, Rowlands M, Prodromou C, Roe SM, Maloney A, Powers M, Clarke PA, Box G, Sanderson S, Patterson L, Matthews TP, Cheung KM, Ball K, Hayes A, Raynaud F, Marais R, Pearl L, Eccles S, Aheme W, McDonald E, Workman P: In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 2007, 67: 2206-2216. 10.1158/0008-5472.CAN-06-3473.
Article
PubMed
CAS
Google Scholar
Neckers L, Workman P: HSP90 molecular chaperone inhibitors: are we there yet?. Clin Cancer Res. 2012, 18 (1): 64-76. 10.1158/1078-0432.CCR-11-1000.
Article
PubMed
CAS
PubMed Central
Google Scholar
Basso A, Solit D, Munster P, Rosen N: Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that over express HER2. Oncogene. 2002, 21: 1159-1166. 10.1038/sj.onc.1205184.
Article
PubMed
CAS
PubMed Central
Google Scholar
Pearl LH, Prodromou C, Workman P: The HSP90 molecular chaperone: an open and shut case for treatment. Biochem J. 2008, 410: 439-453. 10.1042/BJ20071640.
Article
PubMed
CAS
Google Scholar
Workman P, Maloney A: Hsp90 as a new therapeutic target for cancer therapy: the story unfolds. Expert Opin Biol Ther. 2002, 2: 3-24. 10.1517/14712598.2.1.3.
Article
PubMed
Google Scholar
Travers J, Sharp S, Workman P: HSP90 inhibition: two-pronged exploitation of cancer dependencies. Drug Discov Today. 2012, 17 (5-6): 242-252. 10.1016/j.drudis.2011.12.021. Epub 2011 Dec 30
Article
PubMed
CAS
Google Scholar
Workman P, Burrows F, Neckers L, Rosen N: Drugging the cancer chaperone HSP90. Ann N Y Acad Sci. 2007, 1113: 202-216. 10.1196/annals.1391.012.
Article
PubMed
CAS
Google Scholar
Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC, Burrows FJ: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature. 2003, 425: 357-359. 10.1038/425357a.
Article
Google Scholar
Whitesell L, Lindquist S: HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005, 5: 761-772. 10.1038/nrc1716.
Article
PubMed
CAS
Google Scholar
Ursini-Siegel J, Schade B, Cardiff RD, Muller WJ: Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer. 2007, 7: 389-397. 10.1038/nrc2127.
Article
PubMed
CAS
Google Scholar
Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P: Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988, 54: 105-115.
Article
PubMed
CAS
Google Scholar
Workman P, Aboagye EO, Chung Y-L, Griffiths JR, Hart R, Leach MO, Maxwell RJ, McSheehy PMJ, Price PM, Zweit J: Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. J Natl Cancer Inst. 2006, 98: 580-598. 10.1093/jnci/djj162.
Article
PubMed
CAS
Google Scholar
Smith-Jones PM, Solit D, Afroze F, Rosen N, Larson M: Early tumour response to Hsp90 therapy using HER2 PET: comparison with 18F- FDG PET. J Nucl Med. 2006, 47: 793-796.
PubMed
CAS
PubMed Central
Google Scholar
Wilmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS: Molecular imaging in drug development. Nat Rev Drug Discov. 2008, 7: 591-607. 10.1038/nrd2290.
Article
Google Scholar
Gillies RJ, Bhujwalla ZM, Evelhoch J, Garwood M, Neeman M, Robinson SP, Sotak CH, Van Der Sanden B: Applications of magnetic resonance in model systems. Tumour Biology and Physiology. Neoplasia. 2000, 2: 139-151. 10.1038/sj.neo.7900076.
Article
PubMed
CAS
PubMed Central
Google Scholar
Evelhoch JL, Gillies RJ, Karczmar GS, Koutcher JA, Maxwell RJ, Nalcioglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM: Applications of magnetic resonance in model systems: Cancer Therapeutics. Neoplasia. 2000, 2: 152-165. 10.1038/sj.neo.7900078.
Article
PubMed
CAS
PubMed Central
Google Scholar
Rodrigues LM, Stubbs M, Robinson SP, Newell B, Mansi J, Griffiths JR: The C-neu mammary carcinoma in oncomice; characterization and monitoring response to treatment with herceptin by magnetic resonance methods. MAGMA. 2004, 17: 260-270. 10.1007/s10334-004-0070-8.
Article
PubMed
CAS
Google Scholar
Leach MO, Verrill M, Glaholm J, Smith TA, Colins DJ, Payne GS, Sharp JC, Ronen SM, McCready VR, Powles TJ, Smith IE: Measurements of human breast cancer using magnetic resonance spectroscopy: a review of clinical measurements and a report of localized 31P measurements of response to treatment. NMR Biomed. 1998, 11: 314-340. 10.1002/(SICI)1099-1492(1998110)11:7<314::AID-NBM522>3.0.CO;2-Z.
Article
PubMed
CAS
Google Scholar
Griffiths JR, Tate AR, Howe FA, Stubbs M: Magnetic resonance spectroscopy of cancer-practicalities of multi-cancer trials and early results in non-Hodgkins lymphoma. Eur J Cancer. 2002, 38: 2085-2093. 10.1016/S0959-8049(02)00389-1.
Article
PubMed
CAS
Google Scholar
Chung YL, Griffiths JR: Using metabolomics to monitor anticancer drugs. Ernst Schering Found Symp Proc. 2007, 4: 55-78.
PubMed
Google Scholar
Chung Y-L, Troy H, Banerji U, Jackson LE, Walton MI, Stubbs M, Griffiths JR, Judson IR, Leach MO, Workman P, Ronen SM: Magnetic Resonance Spectroscopic Pharmacodynamic markers of Hsp90 inhibitor, 17-allylamino-17-demethoxygeldanamycin (17-AAG) in human colon cancer models. J Natl Cancer Inst. 2003, 95: 1624-1633. 10.1093/jnci/djg084.
Article
PubMed
CAS
Google Scholar
Brandes AH, Ward CS, Ronen SM: 17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2. Breast Cancer Res. 2010, 12: R84-10.1186/bcr2729.
Article
PubMed
PubMed Central
Google Scholar
Le Carl H, Lupu M, Kotedia K, Rosen N, Solit D, Koutcher JA: Proton MRS detects Metabolic Changes in Hormone Sensitive and Resistant Human Prostate Cancer Model CWR22 and CWR22r. Magn Reson Med. 2009, 62 (5): 1112-1119. 10.1002/mrm.22137.
Article
PubMed
CAS
PubMed Central
Google Scholar
Workman P, et al: UKCCCR Guidelines for the welfare of animals in experimental neoplasia. Br J Cancer. 1998, 77 (1): 1-10.
Article
Google Scholar
Ordidge RJ, Connelly A, Lohman JAB: Image selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J Magn Reson. 1986, 66: 283-294. 10.1016/0022-2364(86)90031-4.
CAS
Google Scholar
Van der Veen JWC, de Beer R, Luyten PR, van Ormondt D: Accurate quantification of in vivo 31P NMR signals using the variable projection method and prior knowledge. Magn Reson Med. 1988, 6: 92-98. 10.1002/mrm.1910060111.
Article
PubMed
CAS
Google Scholar
Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P: Establishment of an isogenic human colon tumour model for NQO1 gene expression: Application to investigate the role of DT- diaphorase in bioreductive drug activation in vitro and in vivo. Mol Pharmacol. 2000, 58: 1146-1155.
PubMed
CAS
Google Scholar
Hotz MA, Gong J, Traganos F, Darzynkiewicz Z: Flow Cytometric Detection of Apoptosis: Comparison of the Assays of In Situ DNA Degradation and Chromatin Changes. Cytometry. 1994, 15: 237-244. 10.1002/cyto.990150309.
Article
PubMed
CAS
Google Scholar
Al-Saffar NMS, Troy H, RamirezdeMolina A, Jackson LE, Madhu B, Griffiths JR, Leach MO, Workman P, Lacal JC, Judson IR, Chung YL: Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models. Cancer Res. 2006, 66 (1): 427-434. 10.1158/0008-5472.CAN-05-1338.
Article
PubMed
CAS
Google Scholar
Tyagi RK, Azrad A, Degani H, Salomon Y: Simultaneous extraction of cellular lipids and water-soluble metabolites: Evaluation by NMR spectroscopy. Magn Reson Med. 1996, 35: 194-200. 10.1002/mrm.1910350210.
Article
PubMed
CAS
Google Scholar
Sharp SY, Prodromou C, Boxall K, Powers MV, Holmes JL, Box G, Matthews TP, Cheung KM, Kalusa A, James K, Hayes A, Hardcastle A, Dymock B, Brough PA, Barril X, Cansfield JE, Wright L, Surgenor A, Foloppe N, Hubbard RE, Aherne W, Pearl L, Jones K, McDonald E, Raynaud F, Eccles S, Drysdale M, Workman P: Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007, 6 (4): 1198-1211. 10.1158/1535-7163.MCT-07-0149.
Article
PubMed
CAS
Google Scholar
Banerji U, O’Donnell A, Scurr M, Pacey S, Stapleton S, Asad Y, Simmons L, Maloney A, Raynaud F, Campbell M, Walton M, Lakhani S, Kaye S, Workman P, Judson I: Phase I pharmacokinetic and pharmacodynamic study of 17-Allylamino, 17-Demethoxygeldanamycin in patients with advanced malignancies. J Clin Oncol. 2005, 23: 4152-4161. 10.1200/JCO.2005.00.612.
Article
PubMed
CAS
Google Scholar
Banerji U, Walton M, Raynaud F, Grimshaw R, Kelland L, Valenti M, Judson I, Workman P: Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino,17-demethoxygeldanamycin in human ovarian cancer xenograft models. Clin Cancer Res. 2005, 11: 7023-7032. 10.1158/1078-0432.CCR-05-0518.
Article
PubMed
CAS
Google Scholar
Eaton JD, Perry MJA, Todryk SM, Mazucco RA, Kirby RS, Griffiths JR, Dalgleish AG: Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques. Gene Ther. 2001, 8: 557-567. 10.1038/sj.gt.3301432.
Article
PubMed
CAS
Google Scholar
Clarke PA, Hostein I, Banerji U, Di Stefano F, Maloney A, Walton M, Judson I, Workman P: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demthoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene. 2000, 19: 4125-4133. 10.1038/sj.onc.1203753.
Article
PubMed
CAS
Google Scholar
Negendank W: Studies of human tumours by MRS: a review. NMR Biomed. 1992, 5: 303-324. 10.1002/nbm.1940050518.
Article
PubMed
CAS
Google Scholar
Beloueche-Babari M, Arunan V, Jackson LE, Perusinghe N, Sharp SY, Workman P, Leach MO: Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition. Oncotarget. 2010, 1 (3): 185-197.
Article
PubMed
PubMed Central
Google Scholar
Sharpless NE, DePinho RA: The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov. 2006, 5: 741-754. 10.1038/nrd2110.
Article
PubMed
CAS
Google Scholar
Olive K, Tuveson D: The use of targeted mouse models for preclinical testing of novel cancer therapeutics. Clin Cancer Res. 2006, 12: 5277-5287. 10.1158/1078-0432.CCR-06-0436.
Article
PubMed
CAS
Google Scholar
Field SB, Needham S, Burney IA, Maxwell RJ, Coggle JE, Griffiths JR: Differences in vascular response between primary and transplanted tumours. Br J Cancer. 1991, 63: 723-726. 10.1038/bjc.1991.163.
Article
PubMed
CAS
PubMed Central
Google Scholar