Open Access

Alcohol use disorders and associated factors among people living with HIV who are attending services in south west Ethiopia

  • Matiwos Soboka1Email author,
  • Markos Tesfaye1,
  • Garumma Tolu Feyissa2 and
  • Charlotte Hanlon3, 4
BMC Research Notes20147:828

https://doi.org/10.1186/1756-0500-7-828

Received: 23 November 2013

Accepted: 11 November 2014

Published: 24 November 2014

Abstract

Background

Alcohol use disorders (AUDs) in persons living with human immunodeficiency virus (PLHIV) in high-income countries have been associated with poor adherence to antiretroviral medications and worse HIV-related outcomes. Little is known about AUDs among people attending HIV services in sub-Saharan Africa.

Methods

Across-sectional study was carried out among PLHIV who attended HIV services at Jimma University Specialized Hospital in September 2012. The World Health Organization’s Alcohol Use Disorders Identification Tool (AUDIT) was used to measure probable hazardous, harmful and dependent use of alcohol (‘alcohol use disorders’). Associations between AUDs and other variables were explored using logistic regression analysis. All variables associated with AUDs with a p value <0.25 were included in the final multivariable model.

Results

The overall prevalence of AUDs was 32.6%, with hazardous use, harmful use and alcohol dependence accounting for 24.7%, 2.8% and 5.1% of the total, respectively. There was no significant difference in the prevalence of AUDs in persons receiving antiretroviral treatment compared to those who were antiretroviral therapy naïve (32.6% vs. 38.6%). AUDs were identified in 26.0% and 44.1% of females and males, respectively. Male gender, smoking cigarettes and psychological distress were positively associated independently with AUDs.

Conclusion

The high prevalence of AUDs detected in our facility-based survey of PLHIV in Ethiopia highlights the need to integrate delivery of effective and feasible interventions for AUDs into HIV care.

Keywords

Alcohol use disorders Hazardous alcohol use Harmful alcohol use Alcohol dependence HIV Sub-Saharan Africa Mental health Depression

Background

Alcohol use disorders (AUDs) contribute to 3.8% of the overall global burden of disease [1, 2]. The number of deaths attributed to alcohol worldwide is greater than the combined number of deaths from human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), violence and tuberculosis [3]. AUDs can be categorized as harmful use, hazardous use or dependence [4, 5]. Harmful alcohol use is characterized by an alcohol consumption pattern that is within the individual’s control but which is causing physical or mental problems and may also have social consequences [4, 5]. Hazardous use of alcohol considers both the increased risk of harmful physical, mental or social consequences for the user and harm to others. Dependent alcohol drinking is characterized by alcohol use that takes over a person’s life to the extent that they have a physiological or psychological need to continue drinking. Dependence is the most severe end of the AUD spectrum and is invariably associated with many social, psychological and physical health problems [1, 4, 5].

The prevalence of alcohol use disorders appears to be high among people living with HIV (PLHIV) compared to the general population [6]. AUDs are associated with premature mortality in PLHIV [79], thought to occur due to alcohol enhancing the toxicity of antiretroviral treatment (ART), increasing liver damage from concurrent infection with hepatitis C virus, and increasing the risk of opportunistic infection due to decreased effectiveness of ART and exacerbation of immune suppression [1015]. Hazardous levels of alcohol use have also been associated with non-adherence to ART medication [3, 1619], late presentation to HIV/AIDS care [20], higher viral load during the course of HIV treatment [15, 18], accelerated decline of CD4 cells in HIV infected persons, faster disease progression and development of resistant strains of HIV [3, 1518]. Furthermore, alcohol use has been associated with increased HIV risk behaviors, including unprotected sex, multiple sexual partners and high-risk injection behaviors [9, 2123]. In the USA (Veterans Aging Cohort Study), any alcohol consumption was shown to decrease overall survival in PLHIV by more than two years if the frequency of consumption was once per week or greater, and by 6.4 years with daily consumption [24]. Other studies have shown that most PLHIV fear the interaction between their medication and alcohol and, therefore, skip medication while drinking alcohol [16, 25]. Research suggests that alcohol consumption accelerates HIV/AIDS disease progression even if medications are taken correctly, by adversely impacting drug absorption and metabolism [25].

In HIV services in African hospital settings, the prevalence of AUDs has been found to vary from 12% in a teaching hospital in Nigeria [26], 15% in a Ugandan university teaching hospital [27], and 39.4% in a specialist hospital in Nigeria [28]. Factors found to be associated with AUDs in these settings include male gender, psychological morbidity, smoking cigarettes, Christian religion, lower education, peer pressure, parental modeling and drinking in order to assist social interactions [26, 2832].

In Ethiopia, people who self-report drinking alcohol most of the time are more likely to default from ART and present late to HIV/AIDS care [20, 33]. An association between alcohol consumption and unprotected sexual behavior in Ethiopian commercial sex workers and school-age youth has also been reported [34, 35]. However, there is no information about the magnitude of specific AUDs and the associated factors in PLHIV who are in contact with HIV services in Ethiopia [36]. Such information is important in order to identify PLHIV who are at greatest risk of AUDs and to inform the development of interventions and services to meet the specific needs of people in each category of AUDs. The objective of this study was, therefore, to assess the prevalence of hazardous, harmful and dependent AUDs, and the associated factors, in PLHIV attending HIV services in Ethiopia.

Methods

Setting

This study was conducted in Jimma University Specialized Hospital (‘Jimma hospital’) which is located in the south western part of Ethiopia. Jimma hospital is one of the oldest hospitals in the country and provides services for approximately 9,000 inpatient and 80,000 outpatient attendances per year, serving a catchment population of about 15 million people [37, 38]. Out-patient treatment services for HIV were established in 2005 and now provide care for a total of 6,561patients: 3,524 receiving ART and 3,037 under pre-ART follow-up. In this study, data were collected from adult people living with HIV attending the Jimma hospital clinic for follow up care during September 2012.

Study design

A facility-based, cross-sectional survey.

Sample size assumptions and sampling procedure

The sample size was determined by assuming a prevalence of alcohol use disorders of 50%, with any particular outcome to be with 5% margin of error and 95% confidence interval of certainty (alpha =0.05). Based on this assumption, the actual sample size for the study was computed using a one-sample population proportion formula. The total sample size was 401.

Sampling procedure

All eligible adult attendees of the ART clinic at JUSH during the study period were invited consecutively to participate in the study.
  1. 1.

    Outcome: Alcohol Use Disorders

    A structured questionnaire, the WHO’s Alcohol Use Disorder Identification Test (AUDIT) was used to measure AUDs [4]. The AUDIT has been evaluated over a period of two decades, and provides an accurate measure of risk of AUDs across gender, age and cultures. A multi-country validation of AUDIT in people attending primary health care in Norway, Australia, Kenya, Bulgaria, Mexico and the United States of America found that, at a cut-off score of eight or more, the sensitivity and specificity of AUDIT for AUDs were 0.90 and 0.80, respectively [4]. For this study, the AUDIT was translated into both Amharic and Afan Oromo languages, the main languages spoken in the study site. Back-translation into English was undertaken for both languages and the final versions obtained through expert consensus. The cultural appropriateness of the AUDIT was improved by modifying the ‘standard drink’, referred to in questions two and three, so as to be more understandable to participants. Local alcohol drinks, for example ‘arake’ (distilled from fermented barley or maize combined with ‘gesho’[Rhamnusprinioides]), ‘tela’ (a beer-like drink fermented from barley and Rhamnusprinioides) and ‘teji’ (honey wine) were first converted from local measurements to milliliters based on previous studies in Ethiopia that investigated the ethanol content of local beverages [39]. Then the measured alcohol was converted into a standard drink by calculating the mass and volume of the alcohol. Similarly, local beer (bottles and glasses) and wine were converted to standard drinks based on their alcohol content. Since Ethiopia has no alcohol policy defining standard alcohol drinks, the South African standard drink (containing 12 g of alcohol) was used [40]. Locally, different receptacles, including ‘malekia’, ‘tassa’ and ‘birille’ are used when drinking Arake, Tella and Teji respectively. Therefore, we measured the volume of each of these receptacles and converted the drinks to milliliters in order to obtain a standard drink that is comparable internationally.

    In accordance with the recommended scoring, a total AUDIT score of eight or more was used to define probable ‘alcohol use disorder’ (AUD). A total AUDIT score of 1–7 indicated social drinking, a score of 8–15 indicated “hazardous drinking” a score of 16-19indicated “harmful drinking” and a score of 20 or above indicated probable alcohol dependence. Harmful drinking and alcohol dependence are both indicative of severe AUD. The total AUDIT score, alcohol consumption level, signs of dependence, and markers of present harm should all play a role in determining how to manage a patient with AUD [4].

     
  2. 2.

    Potential explanatory variables for AUDs

    The following variables were assessed:

    Socio-demographic variables: age, gender, educational level, marital status, living conditions, ethnicity, religion and frequency of attending a place of worship

    Socioeconomic status: employment status, yearly income, and social support

    Illness-specific characteristics: WHO stage of HIV status classification and CD4 count. Self-report questions were used to assess whether the patient took ART regularly or not.

    Mental distress: The Kessler 6-item scale (Kessler 6) was used to measure mental distress (depressive, anxiety and somatic symptoms) [41]. The Kessler 6 has been adapted and validated in Ethiopia previously, demonstrated to have a sensitivity and specificity of 84.2% and 82.7%, respectively, at a cut-off point of 4/5 to screen for symptoms of common mental disorders [42].

    Impaired functioning: The 12-item WHO Disability Assessment Schedule (WHODAS) was used to assess functional impairment [43].

    Other factors: family history of alcohol use disorders (AUDs), cigarette smoking and use of khat (amphetamine-like psychostimulant).

     
  3. 3.

    Reasons for initiation of drinking alcohol: people who reported drinking alcohol were asked about the main reasons for starting drinking. The following response categories were recorded: easy availability of alcohol, parental modeling, peer pressure to drink, lack of somebody to provide support, drinking to increase self-confidence, drinking to alleviate fear of socializing, drinking to forget financial difficulties, longstanding life stressors, longstanding marital disharmony and family history of alcohol use disorders.

     

Data collection procedures

Data were collected by seven health professionals with nursing qualifications (four of degree level and three with diploma) after three days of training to familiarize them with the instruments. Data collection was carried out after the questionnaires were pretested on a sample of (5% of the total sample) people living with HIV attending the ART clinic at Agaro health center which is 45 km away from Jimma town. The data collection was supervised by a degree level health officer. The supervisor monitored data quality and checked all questionnaires for completeness. Incomplete and unclear questionnaires were returned to the data collectors for correction.

Data analysis

After double data entry, data were exported from EpiData and analyzed using the Statistical Package for Social Science (SPSS, version 16). Data were then cleaned. The outcome and explanatory variables were entered into a bivariate logistic regression analysis, one at a time, in order to estimate the strength of association using Odds Ratios (OR). All variables associated with AUDs in the bivariate logistic regression with a p-value less than 0.25 were entered together into a multivariate logistic regression in order to control for potential confounders.

Ethical considerations

Ethical clearance was obtained from the Ethical Review Board of Jimma University. Written informed consent was obtained from each of the participants prior to participation. Information obtained was kept confidential and anonymous during all stages of the study.

Results

Participant characteristics

A total of 401 PLHIV were approached for enrolment in the study. Of these, 389 (97.0%) agreed to participate and 12 (3.0%) refused (seven females and five males).

The majority (63.2%; n = 246) of participants were female. The mean age of participants was 35.5 (SD 9.78) years, ranging from 18 to 70 years. The largest proportion of participants was aged between 25 and 34 years, accounting for 44.7% (n = 174) of the sample, followed by the 35 to 44 years age group which accounted for 30.0% (n = 117) of participants. Only 5.9% (n = 23) of participants were aged 18–24 or older than 54 years. Out of the total participants involved in this study, 85.3% (n = 332 participants) had been on ART (See Table 1).
Table 1

Socio-demographic characteristics of people living with HIV attending services at Jimma University Specialized Hospital in September 2012 (n = 389)

Characteristics

Frequency (%)

Sex

Male

143 (36.8)

Female

246 (63.2)

Age (years)

18-24

23 (5.9)

25-34

174 (44.7)

35-44

117 (30.1)

45-54

52 (13.4)

55 and above

23 (5.9)

Ethnicity

Oromo

182 (46.8)

Amhara

105 (27.0)

Gurage

10 (2.6)

Kefa

30 (7.7)

Yem

17 (4.4)

Others

45 (11.6)

Religious affiliation

Orthodox Christian

200 (51.4)

Muslim

125 (32.1)

Protestant Christian

58 (14.9)

Catholic

6 (1.5)

Educational level

Illiterate

71 (18.3)

Read and write only

11 (2.8)

Primary (grades 1–8)

172 (44.2)

Secondary (grades 9–12)

102 (26.2)

Tertiary (grades 12 or more)

33 (8.5)

Marital status

Single

48 (12.3)

Married

193 (49.6)

Divorced

92 (23.7)

Separated

15 (3.9)

Widowed

41 (10.5)

Occupation

Unemployed

97 (24.9)

Daily laborer

99 (25.4)

Employed

55 (14.1)

Farmer

9 (2.3)

Merchant

63 (16.2)

Student

3 (0.8)

Retired

11 (2.8)

Other

52 (13.4)

Living circumstances

Living alone

84 (21.6)

Living with close family(father, mother, brother, sister, husband/wife, children)

279 (71.7)

Living with other relatives (aunt, uncle, cousins, nieces or nephew)

22 (5.7)

Living with non-relatives

4 (1.0)4

4Other ethnicity = Dawuro, Wolayita and Tigray, Other occupation = House wife, house servant and driver.

Prevalence of alcohol use disorders

Nearly two thirds of participants (64%; n = 249) reported that they had drunk alcohol at some point in their life. Out of the total participants, 31.4% (n = 122) were identified as social drinkers (AUDIT score 1–7). The overall prevalence of alcohol use disorder (defined as an AUDIT score ≥8) was 32.6% (n = 127). Hazardous drinking, harmful drinking and alcohol dependence were found in 24.7% (n = 96), 2.8% (n = 11) and 5.1% (n = 20) of the participants, respectively. The internal consistency of AUDIT was within the accepted range (Cronbach’s α = 0.79).

Amongst patients who were taking ART, 31.6% (n = 105) were identified as having an alcohol use disorder. Of these, 24.7% (n = 82) were hazardous drinkers, 2.7% (n = 9) were harmful drinkers and 4.2% (n = 14) had probable alcohol dependence. The prevalence of AUDs in persons not on ART was 38.6% (n = 22).

Mental distress, as defined by a score of five or greater on Kessler 6, was found in 45.2% (n = 176) of the total sample. In patients with mental distress, 40.3% (n = 71) had an AUD, with 26.7% (n = 47), 4.0% (n = 7) and 9.7% (n = 17) having hazardous drinking, harmful drinking and alcohol dependence, respectively.

Amongst patients who missed doses of ART medication, 44.0% (n = 11) were identified as having an alcohol use disorder: 28.0% (n = 7) with hazardous use, 8.0% with harmful use (n = 2) and 8.0% (n = 2) with probable alcohol dependence. Amongst patients categorized as being in WHO’s stage two of HIV/AIDS classification, 40.6% (n = 52) had alcohol use disorders, with 30.8% (n = 53) in people with stage one and 26.6% (n = 17) WHO’s stage three. Only 21.1% (n = 4) of patients classified as stage four HIV/AIDS classification were found to have alcohol use disorders. AUD was more prevalent among patients with CD4 ≥ 200 cells/mm3compared to patients with CD4 < 200 cells/mm3 (36.7% vs. 10.3%). In patients with AUDs, 30.8% (n = 12) were functionally impaired for more than 15 days in the preceding month.

Reasons given for initiation of alcohol use

In participants who were categorized as having AUDs, 41.7% (n = 53) said that they started drinking alcohol due to peer pressure, 33.9% (n = 43) initiating drinking because of easy availability of alcohol and 29.1% (n = 37) started to drink alcohol due to parental modeling. Among participants with AUDs, 29.1% (n = 37) reported a family history of AUDs (See Table 2).
Table 2

Environmental and psychological factors associated with initiation of alcohol use disorders among people living with HIV attending services at Jimma University Specialized hospital

Variables

N (%)

Easily availability of alcohol

43(33.9)

Parental modeling

37(29.1)

Peer pressure to drink

53(41.7)

Lack of somebody who provide support

14(11)

To increase self confidence

11(8.7)

To alleviate fear of socializing

8(6.3)

To forget financial difficulties

11(8.7)

Due to long-standing life stressors

8(6.3)

Due to long-standing marital disharmony

6(4.7)

Like the way alcohol makes me feel happy

29(22.8)

Family history of AUDs

37(29.1)

Generally, 34.8% (n = 39) of participants with AUDs preferred bottled beer, followed by the home brewed beer ‘tella’ (30.4%, n = 34), teji (honey wine) 15.2% (n = 17) and arake 4.5% (n = 5).

Factors associated with AUDs

AUDs were present in 26% (n = 64) of females and 44.1% (n = 63) of males (crude odds ratio (COR) 2.24, 95% CI = 1.45 to 3.46). Males were more often identified as hazardous drinkers compared to females (30.1% (n = 43) vs. 21.5% (n = 53), p = 0.001). Males were also more likely to be dependent on alcohol than females (9.1% (n = 13) vs. 2.8% (n = 7), p = 0.001).

Orthodox Christians had two times increased odds of having AUDs compared to Muslims (COR = 1.99, 95% CI = 1.20-3.29) (see Table 3). Patients who chewed khat daily had more than four times increased odds of AUD compared to those patients who chewed khat weekly (cOR 4.25, 95% CI = 1.56, 11.58)(see Table 4). Patients with CD4 count of lower than 200 cells/mm3 had 80% lower odds of AUDs (cOR 0.20, 95% CI = 0.08-0.48).
Table 3

Socio-demographic factors associated with alcohol use disorders (AUDs) among people living with HIV attending services at Jimma University specialized hospital (n = 389)

Variables

AUDs

No AUD

P-value

Crude odds ratio

95% CI

N (%)

N (%)

Gender

Male

63 (44.1)

80 (55.9)

<0.001

2.24

1.45-3.46

Female

64 (26.0)

182 (74.0)

 

Reference

 

Age (years)

18-24

9 (39.1)

14 (60.9)

 

Reference

 

25-34

54 (31.0)

120 (69.0)

0.436

0.70

0.29-1.72

35-44

43 (36.8)

74 (63.2)

0.829

0.90

0.36-2.26

45-54

13 (25)

39 (75.0)

0.219

0.52

0.18-1.47

55 and above

8 (34.8)

15 (65.2)

0.760

0.83

0.25-2.75

Ethnicity

Oromo

46 (25.3)

136 (74.7)

 

Reference

 

Amhara

37 (35.2)

68 (64.8)

0.074

1.61

0.96-2.71

Gurage/Keffa/Yem/Others

44 (43.1)

58 (56.9)

0.002

2.24

1.34-3.75

Religion

Orthodox/Catholic

78 (37.9)

128 (62.1)

0.006

2.02.

1.22-3.33

Muslim

29 (23.2)

96 (76.8)

 

Reference

 

Protestant

20 (34.5)

38 (65.5)

0.111

1.74

0.88-3.45

Frequency of attending worship

Daily/2–3 weekly

48 (28.6)

120 (71.4)

 

Reference

 

Weekly

67 (35.3)

123 (64.7)

0.177

1.36

0.87-2.13

Less than a week

8 (38.1)

13 (61.9)

0.370

1.54

0.60-3.95

Never

4 (40.0)

6 (60.0)

0.444

1.67

0.45-6.17

Education

No formal education

28 (34.15)

54 (65.85)

 

Reference

 

Primary

63 (36.6)

109 (63.4)

0.700

1.12

0.64-1.94

Secondary/Tertiary

36 (26.7)

99 (73.3)

0.24

0.70

0.39-1.27

Occupation

Unemployed

30 (30.9)

67 (69.1)

0.

Reference

 

Daily laborer

29 (29.3)

70 (70.7)

0.80

0.93

0.50-1.70

Employed/Farmer

21 (32.8)

43 (67.2)

0.80

1.09

0.56-2.15

Merchant

20 (31.7)

43 (68.3)

0.91

1.04

0.53-2.17

Others

27 (40.9)

39 (59.1)

0.19

1.55

0.81-2.97

Marital status

Single

17 (35.4)

31 (64.6)

0.715

1.13

0.58-2.20

Married

63 (32.6)

130 (67.4)

 

Reference

 

Separated/Divorced /Widowed

47 (31.8)

101 (68.2)

0.862

0.96

0.61-1.52

Living condition

Alone

26 (31.0)

58 (69.0)

0.729

0.91

0.54-1.54

With family

92 (33.0)

187 (67.0)

 

Reference

 

Other

9 (34.6)

17 (65.4)

0.865

1.07

0.46-2.505

5Other occupation = House wife, house servant, students, retired and driver.

Other living condition = living with relative, Living with non-relative person.

Table 4

Association of mental distress and use of other substances with AUDs among people living with HIV attending services at Jimma University specialized hospital ART clinic 2012 (n = 389)

Variables

AUDs

No AUD

P value

Crude odds ratio

95% CI

N (%)

N (%)

Smoking cigarettes

Yes

23 (63.9)

13 (36.1)

<0.001

4.24

2.07-8.68

No

104 (29.5)

249 (70.5)

 

Reference

 

Chewing khat

Yes

42 (45.2)

51 (54.8)

0.003

2.04

1.27-3.30

No

85 (28.7)

211 (71.3)

 

Reference

 

Mental distress

Yes

71 (40.3)

105 (59.7)

0.003

1.90

1.24-2.91

No

56 (26.3)

157 (73.7)

 

Reference

 

There was no association between AUDs and cannabis use, living conditions, frequency of attending a place of worship, educational status, occupation, functional impairment, marital status, missing ART medication and WHO HIV/AIDS clinical stages (See Tables 3 and 4).

After adjusting for potential confounders using multiple logistic regression, it was found that the odds of having AUDs among male participants was more than two times higher when compared to that of female participants (adjusted OR (AOR) 2.23, 95% CI = 1.30, 3.83). Being in the 45 to 54 years age group was negatively associated with AUDs compared to 18–24 years age group (AOR 0.30, 95% CI = 0.09, 0.99). Being Orthodox Christian was positively associated with AUDs when compared to Islam followers (AOR 2.29, 95% CI = 1.22, 4.31). Chewing khat was not associated with AUDs in the final model. The odds of having an AUD among smokers was more than three times higher when compared to non-smokers (AOR 3.40, 95% CI = 1.38, 8.40) in the final model. The odds of having an AUD among mentally distressed patients was more than two times higher compared to those patients free of mental distress (AOR 2.24, 95% CI = 1.40, 3.64) (See Table 5).
Table 5

Multivariate logistic regression of factors associated independently with AUDs among people living with HIV attending services at Jimma University specialized hospital (n = 389)

Variables

P-value

Adjusted OR

95% CI

Ethnicity

Oromo

 

Reference

 

Amhara

0.54

1.21

0.66-2.24

Gurage/Keffa/Yem/Others

0.01

2.18

1.19-4.00

Sex

Male

0.004

2.23

1.30-3.83

Female

 

Reference

 

Age

18-24

 

Reference

 

25-34

0.34

0.61

0.22-1.69

35-44

0.38

0.62

0.22-1.77

45-54

0.05

0.30

0.09-0.99

55 and above

0.39

0.56

0.15-2.13

Religion

Orthodox/catholic

0.01

2.29

1.22-4.31

Muslim

 

Reference

 

Protestant

0.06

2.31

1.23-4.34

Frequency of attending worship place

Daily/2-3 weekly

 

Reference

 

Weekly

0.06

1.62

0.99-2.67

Less than weekly

0.74

1.20

0.42-3.41

Never

0.31

2.14

0.49-9.38

Mental distress

Yes

0.001

2.24

1.40-3.64

No

 

Reference

 

Smoking cigarettes

Yes

0.008

3.40

1.38-8.40

No

 

Reference

 

Khat chewing

Yes

0.12

1.63

0.88-3.01

No

 

Reference

 

Discussion

In this cross-sectional survey of alcohol use disorders in persons with HIV, nearly one third had a probable AUD. The overall prevalence of AUDs (32.6%), defined by an AUDIT score ≥8,was substantially higher than that found in community-based studies carried out in Addis Ababa and Butajira, Ethiopia (3.7% and 2.7%, respectively) [29, 30]. This may be due to the difference between tools used in this study (AUDIT vs. CAGE), as the CAGE is designed to detect more severe AUDs (alcohol dependence rather than harmful or hazardous drinking). Also, the prevalence of AUDs would be expected to be lower in community based studies. However, the prevalence of AUDs found in this study was similar to estimates from a case control study of factors associated with late presentation to HIV/AIDS care among PLHIV in South Wollo Hospital, Ethiopia, (33.8%) and a previous study from Jimma Hospital, Ethiopia, on defaulters from antiretroviral treatment among PLHIV (36.5%) [20, 33], although neither of these studies used a standardized questionnaire to define AUDs. Other studies from Africa also show a similar prevalence of AUDs in PLHIV. In Nigeria the prevalence of AUDs in PLHIV was 39.4% [28].

Prevalence of AUDs

The prevalence of alcohol dependence found in our study was higher than the result from a review of substance use in Ethiopia (1.5%) [36]. This is in keeping with other studies indicating higher levels of AUDs in PLHIV compared to the general population [6]. The prevalence was less than the report from a study done on sexual workers living with HIV in India (46%) [44]. The reason for this difference may be due to the difference in the tools used to screen AUDs.

In this study, harmful alcohol use was found in 2.8% of the total participants, which differs substantially from a similar study carried out in Nigeria in which the prevalence was 28.8% [28]. In the Nigeria study, a lower AUDIT cut-off point than the recommended cut-off was employed [4].

In this study, hazardous alcohol drinking was found in 24.7% of participants. This is higher than the prevalence of hazardous drinking found in similar studies from Uganda (15.4%) [27] and Nigeria (10.6%) [28], as well as from the review of substance use in Ethiopia (3.0%) [36].

Socio-demographic factors associated with AUDs

Alcohol use disorders among patients 25–34 age group (31.0%) were less prevalent than in the same age group in the Nigeria study (46%) [28]. Additionally, this study found AUDs to be higher among single participants than among married participants which was in agreement with the report from Nigerian study done on similar group. However, the AUD prevalence we found among single participants was lower than that in the Nigeria study (35.4% vs. 66.7%, respectively).

In this study, male gender was associated with increased odds of all categories of alcohol use disorder, which is in agreement with previous study done in different countries [26, 28].

Socio-economic factors associated with AUDs

In this study, earning annual income of 2,400-5,399 Ethiopian birr and annual income of 5,400-10,800 Ethiopian birr were significantly associated with alcohol use disorder (OR 0.22, 95% CI = 0.12,0.41 and OR 0.05, 95% CI = 0.02,0.10) compared to annual income of less than 2400 Ethiopian birr. This indicated that, as income of the individual increased the probability to have alcohol use disorder decreases.

HIV-related factors and AUDs

In this study, the prevalence of AUDs in the ART-naïve group was 38.6% which was higher than the prevalence of AUDs among those who had taken ART (31.6%). The potential effect of pre-ART counseling offered by the ART clinic health professionals might explain the observed difference. The prevalence of AUDs among ART naïve patients (38.6%) was lower than the result from similar study done in Nigeria (57%) [26]. The prevalence of hazardous drinking among PLHIV who has taken ART was 24% which was higher than a similar study carried out in south west Uganda (15.4%) [27]. However, it was less than that found in a similar study from Nigeria (42%) [26].

AUD was higher among patients who did not take their ART medication as prescribed compared to patients who were taking their ART drugs appropriately (44% (n = 11) vs. 30.6% (n = 94)). It is possible that patients who missed taking doses of ART drugs so that they could continue to drink alcohol. It also indicates that when working to improve adherence to ART, it is important to consider AUD as one factor.

Participants categorized as being in WHO’s stage two of HIV/AIDS classification were more often identified to have higher AUDs than those who were categorized as being in stage four (40.6% vs. 21.1%). Since stage four of HIV/AIDS classification is a worse HIV stage, people who are in this stage may drink less as they are too ill. Similarly patients with CD4 ≥ 200 cells/mm3 were identified to have higher AUDs than patients with CD4 < 200 cells/mm3 (36.7% vs. 10.3%).

Substance use, mental distress and AUDs

AUD prevalence among mentally distressed participants was higher than those who had low levels of mental distress (40.3% vs. 26.3%). It is possible that patients with mental distress use alcohol as a self-treatment, but AUDs are also associated with increased risk of developing mental distress. A cause-effect relationship could not be established because our study employed a cross-sectional study design.

Limitations

This study used AUDIT to determine the presence of probable AUD. AUDIT is a screening tool and may not give an accurate estimate of alcohol use disorders. Furthermore, AUDIT was not validated in our population even though it has been shown to be useful in screening for AUDs cross-culturally. The absence of a validated cut-off point for persons living with HIV is a further limitation. Social desirability bias could be an important limitation as persons who use alcohol and other substances tend to under-report or deny their use when questionnaires are administered by interview. Although we went to extensive efforts to adapt the concept of a ‘standard drink’ to the Ethiopian setting, the absence of a policy defining the standard alcohol drink in Ethiopia was a limitation. Lastly, we relied upon self-report of adherence to ART which is likely to underestimate non-adherence.

Conclusions

The high prevalence of hazardous and dependent alcohol use disorders found in this study of PLHIV in Ethiopia highlights a need to improve detection and treatment of alcohol use disorders as an integrated part of HIV services. Our study shows that AUDs go hand-in-hand with mental distress and use of other substances, which are likely to have cumulative effects on prognosis and quality of life in PLHIV.

Declarations

Acknowledgements

We are grateful to all the participants of the study for kindly giving their time to participate in this study. Additionally, we are thankful to Jimma University for providing financial support. We also like to acknowledge Center for International Health Ludwig-Maximilians-University, Munich Germany for their technical support throughout the process of the research activities.

Authors’ Affiliations

(1)
Department of Psychiatry, College of Public Health and Medical Sciences, Jimma University
(2)
Department of Health Education and Behavioral Science, College of Public Health and Medical Sciences, Jimma University
(3)
Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University
(4)
Centre for Global Mental Health, Health Services and Population Research Department, King’s College London

References

  1. Mathers C, Ayuso-Mateos JL: Global Burden of Alcohol Use Disorders in the Year 2000: Summary of Methods and Data Sources. 2000, Geneva Switzerland: Global Burden of DiseaseGoogle Scholar
  2. Global Burden of Disease 2010: Understanding Disease, Injury, and Risk. 2012, Available at www.thelancet.com Vol 380 December 15, 2012
  3. WHO: The World Health Report; Global Status Report on Alcohol and Health. 2011, Geneva SwitzerlandGoogle Scholar
  4. Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG: AUDIT: The Alcohol Use Disorders Identification Test. Guidelines for Use in Primary Care. 2001, Geneva, Switzerland: World Health Organization, Department of Mental Health and Substance DependenceGoogle Scholar
  5. Lexicon of Alcohol and Drug Terms Published by the World Health Organization. Available at http://www.who.int/substance_abuse/terminology/who_lexicon/en/Accessed on 10/06/2012
  6. Selnes OA: Impact of HIV infection and alcohol on cognition: a review. Neurobehav Hiv Med. 2010, 2: 85-94. Dove pressView ArticleGoogle Scholar
  7. Bryant KJ, Nelson S, Braithwaite S, Roach D: Integrating HIV/AIDS and alcohol research. Alcohol Res Health. 2010, 33 (3): 165-255.Google Scholar
  8. Alcohol and HIV/AIDS. Available at http://alcoholism.about.com/library/blnaa57.htm Accessed on 10/06/2012
  9. Achola J, Ghee AE, Kihara AN: High HIV prevalence, low condom use and gender differences in sexual behavior among patients with STD-related complaints at a Nairobi primary health care clinic. Int J STD AIDS. 1997, 8: 506-514. 10.1258/0956462971920668.View ArticleGoogle Scholar
  10. Meyerhoff DJ: Effects of alcohol and HIV infection on the Central Nervous System. Alcohol Res Health. 2001, 25 (4): 288-296.PubMedGoogle Scholar
  11. Petry NM: Alcohol use in HIV patients: what we don’t know may hurt us: reviewed article. Int J STD AIDS. 1999, 10: 561-570. 10.1258/0956462991914654.PubMedView ArticleGoogle Scholar
  12. Alcohol and HIV: mix you can avoid. Available at http://www.health.ny.gov/publications/9609.pdf Accessed on 03//07/2012
  13. Braithwaite RS, Bryant KJ: Influence of alcohol consumption on adherence to and toxicity of antiretroviral therapy and survival. Alcohol Res Health. 2010, 33 (3): 280-286.PubMedPubMed CentralGoogle Scholar
  14. Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA: Alcohol consumption and HIV disease progression: are they related?. Alcohol Clin Exp Res. 2003, 27 (5): 862-867. 10.1097/01.ALC.0000065438.80967.56.PubMedView ArticleGoogle Scholar
  15. Kumar R, Perez-Casanova AE, Tirado G, Noel RJ, Torres C, Rodriguez I, Martinez M, Staprans S, Kraiselburd E, Yamamura Y, Higley D, Kumar A: Increased viral replication in simian immunodeficiency virus/simian-HIV–infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr. 2005, 39 (4): 386-390. 10.1097/01.qai.0000164517.01293.84.PubMedView ArticleGoogle Scholar
  16. Neuman MG, Schneider M, Nanau RM, Parry C: Alcohol consumption, progression of disease and other co morbidities, and responses to antiretroviral medication in people living with HIV: reviewed article. AIDS Res Treat. 2012, 2012: 2-11.Google Scholar
  17. Wilcox RD: Alcohol and HIV: a serious cocktail for transmission and medication adherence: a peer reviewed article. Delta Region AIDS Education & Training Center. 2009, 21 (1): 1-4.Google Scholar
  18. Baum MK, Rafie C, Lai S, Sales S, Page JB, Campa A: Alcohol use accelerates HIV disease progression. AIDS Res Hum Retrovir. 2010, 26 (5): 511-516. 10.1089/aid.2009.0211.PubMedPubMed CentralView ArticleGoogle Scholar
  19. Chander G, Lau B, Moore RD: Hazardous alcohol use: a risk factor for non-adherence and lack of suppression in HIV infection. J Acquir Immune Defic Syndr. 2006, 43 (4): 411-417. 10.1097/01.qai.0000243121.44659.a4.PubMedPubMed CentralView ArticleGoogle Scholar
  20. Abaynew Y, Deribew A, Deribe K: Factors associated with late presentation to HIV/AIDS care in South Wollo Zone Ethiopia: a case–control study. AIDS Res Ther. 2011, 8 (8): 1-6.Google Scholar
  21. Pandrea I, Happel KI, Amedee AM, Bagby GJ, Nelson S: Alcohol’s role in HIV transmission and disease progression. Alcohol Res Health. 2010, 33 (3): 203-218.PubMedPubMed CentralGoogle Scholar
  22. Krupitsky EM, Horton NJ, Williams EC, Lioznov D, Kuznetsova M, Zvartau E, Samet JH: Alcohol use and HIV risk behaviors among HIV-infected hospitalized patients in St. Petersburg, Russia. Drug Alcohol Depend. 2005, 79 (2): 251-256. 10.1016/j.drugalcdep.2005.01.015.PubMedPubMed CentralView ArticleGoogle Scholar
  23. Kalichman SC, Simbayi LC, Kaufman M, Cain D, Jooste S: Alcohol use and sexual risks for HIV/AIDS in Sub-Saharan Africa: systematic review of empirical findings. Prev Sci. 2007, 8: 141-151. 10.1007/s11121-006-0061-2.PubMedView ArticleGoogle Scholar
  24. Braithwailte RS, Conigliaro J, Roberts MS, Shechter S, Schaefer A, Mcginnis K, Rodriguez MC, Rabeneck L, Bryant K, Justice AC: Estimating the impact of alcohol consumption on survival for HIV individuals. AIDS Care. 2007, 19 (4): 459-466. 10.1080/09540120601095734.View ArticleGoogle Scholar
  25. Hormes JM, Gerhardstein KR, Griffin PT: Brief screening for alcohol use disorders in HIV primary care: a peer reviewed article, HIV Clinician. Delta Region AIDS Education & Training Center. 2011, 23 (4): 8-13.Google Scholar
  26. Farly J, Miller E, Zamani A, Tepper V, Morris C, Oyegunle M, Lin Eng M, Charurat M, Blattner W: Screening for hazardous alcohol use and depressive symptomatology among HIV-infected Patients in Nigeria: prevalence, predictors, and association with adherence. J Int Assoc Physicians AIDS Care (Chic). 2010, 9 (4): 218-226. 10.1177/1545109710371133.View ArticleGoogle Scholar
  27. Martinez P, Andia I, Emenyonu N, Hahn JA, Hauff E, Pepper L, Bangsberg DR: Alcohol use, depressive symptoms and the receipt of antiretroviral therapy in Southwest Uganda. AIDS Behav. 2008, 12: 605-612. 10.1007/s10461-007-9312-x.PubMedPubMed CentralView ArticleGoogle Scholar
  28. Goar SG, Audu MD, Agbir MT, Dochalson E: Prevalence and socio-demographic correlates of alcohol use disorder among HIV patients. Afr J Drug Alcohol Stud. 2011, 10 (1): 42-47.Google Scholar
  29. Alem A, Kebede D, Kullgren G: The epidemiology of problem drinking in Butajira, Ethiopia. Acta Psychiatrica Scandinavica. 1999, 100: 77-83.View ArticleGoogle Scholar
  30. Kebede D, Alem A: The epidemiology of alcohol dependence and problem drinking in Addis Ababa, Ethiopia. Acta Psychiatrica Scandinavica. 1999, 100: 30-34.View ArticleGoogle Scholar
  31. Pengpid S, Pelzer K, Van der Heever H: Prevalence of alcohol use and associated factors in urban Hospital outpatients in South Africa. Int J Environ Res. 2011, 8: 2629-2639.Google Scholar
  32. Sher KJ, Grekin ER, Williams NA: The development of alcohol use disorders. Annu Rev Clin Psychol. 2005, 1: 493-523. 10.1146/annurev.clinpsy.1.102803.144107.PubMedView ArticleGoogle Scholar
  33. Deribe K, Hailekiros F, Biadgilign S, Amberbir A, Beyene BK: Defaulters from antiretroviral treatment in Jimma University Specialized Hospital, Southwest Ethiopia. Trop Med Int Health. 2008, 13 (3): 328-333. 10.1111/j.1365-3156.2008.02006.x.PubMedView ArticleGoogle Scholar
  34. Alem A, Kebede D, Mitike G, Enquselassie F, Lemma W: Unprotected sex, sexually transmitted infections and problem drinking among female sex workers in Ethiopia. Ethiop J Health Dev. 2006, 20 (2): 93-98.Google Scholar
  35. Kebede D, Alem A, Mitike G, Enquselassie F, Berhane F, Abebe Y, Ayele R, Lemma W, Assefa T, Gebremichael T: Khat and alcohol use and risky sex behaviour among in-school and out-of-school youth in Ethiopia. BMC Public Health. 2005, 5: 109-10.1186/1471-2458-5-109.PubMedPubMed CentralView ArticleGoogle Scholar
  36. Fekadu A, Alem A, Hanlon C: Alcohol and drug abuse in Ethiopia: past, present and future. Afr J Drug Alcohol Stud. 2007, 6 (1): 40-53.Google Scholar
  37. Jimma University specialized services on Jimma University official website: http://www.ju.edu.et/node/94 Accessed on 06/05/2012
  38. Jimma University specialized services on Jimma University specialized hospital website: http://www.ju.edu.et/existing-medical-services-ju-specialized-hospital Accessed on 06/05/2012
  39. Debebe G: Determination of Ethanol Level in Beverages. 2006, Addis Ababa University, http://hdl.handle.net/123456789/303 accessed on 06/05/2012Google Scholar
  40. Standard drinks: Available at http://www.icap.org/PolicyTools/ICAPBlueBook/BlueBookModules/20StandardDrinks/tabid/161/Default.aspx accessed on 25/12/2012
  41. Kessler 6 questionnaire: Available at https://www.gem-measures.org/public/DownloadMeasure.aspx?mid=35 Accessed on 06/05/2012
  42. Tesfaye M, Hanlon C, Wondimagegn D, Alem A: Detecting postnatal common mental disorders in Addis Ababa, Ethiopia: validation of the Edinburgh postnatal depression scale and Kessler scales. J Affect Disord. 2010, 122: 102-108. 10.1016/j.jad.2009.06.020.PubMedView ArticleGoogle Scholar
  43. World Health Organization Disability Assessment Schedule II: Available at http://www.unescap.org/stat/disability/census-ws/WHODAS-English.pdf Accessed on 21/12/2012
  44. Samet JH, Pace CA, Cheng DM, Coleman S, Bridden C, Pardesi M, Saggurti N, Raj A: Alcohol use and sex risk behaviors among HIV-infected female sex workers and HIV-infected male. AIDS Behav. 2010, 14: S74-S83. 10.1007/s10461-010-9723-y.PubMedPubMed CentralView ArticleGoogle Scholar

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© Soboka et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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