Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis. 1974;129(3):304–9.
Article
CAS
PubMed
Google Scholar
Brown BA, Pallansch MA. Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus. Virus Res. 1995;39(2–3):195–205.
Article
CAS
PubMed
Google Scholar
Chung YC, Ho MS, Wu JC, Chen WJ, Huang JH, Chou ST, Hu YC. Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge. Vaccine. 2008;26(15):1855–62.
Article
CAS
PubMed
Google Scholar
Tuthill T, Groppelli E, Hogle J, Rowlands D: Picornaviruses. In: Johnson JE, editor. Cell Entry by Non-Enveloped Viruses, vol. 343. Berlin Heidelberg: Springer; 2010. p. 43–89.
Chow M, Newman JFE, Filman D, Hogle JM, Rowlands DJ, Brown F. Myristylation of picornavirus capsid protein VP4 and its structural significance. Nature. 1987;327(6122):482–6.
Article
CAS
PubMed
Google Scholar
Lewis JK, Bothner B, Smith TJ, Siuzdak G. Antiviral agent blocks breathing of the common cold virus. Proc Natl Acad Sci USA. 1998;95(12):6774–8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang X, Peng W, Ren J, Hu Z, Xu J, Lou Z, Li X, Yin W, Shen X, Porta C, et al. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol. 2012;19(4):424–9.
Article
PubMed Central
CAS
PubMed
Google Scholar
McMinn PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev. 2002;26(1):91–107.
Article
CAS
PubMed
Google Scholar
Suzuki Y, Taya K, Nakashima K, Ohyama T, Kobayashi JM, Ohkusa Y, Okabe N. Risk factors for severe hand foot and mouth disease. Pediatr Int. 2010;52(2):203–7.
Article
PubMed
Google Scholar
Zeng M, El Khatib NF, Tu S, Ren P, Xu S, et al. Seroepidemiology of Enterovirus 71 infection prior to the 2011 season in children in Shanghai. J Clin Virol. 2012;53(4):285–9.
Article
PubMed
Google Scholar
Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VTK. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis. 2010;14(12):e1076–81.
Article
PubMed
Google Scholar
Chen KT, Chang HL, Wang ST, Cheng YT, Yang JY. Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998–2005. Pediatrics. 2007;120(2):e244–52.
Article
PubMed
Google Scholar
Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis. 2010;10(11):778–90.
Article
PubMed
Google Scholar
Chen SC, Chang HL, Yan TR, Cheng YT, Chen KT. An eight-year study of epidemiologic features of enterovirus 71 infection in taiwan. Am J Trop Med Hyg. 2007;77(1):188–91.
PubMed
Google Scholar
Wu CN, Lin YC, Fann C, Liao NS, Shih SR, Ho MS. Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus. Vaccine. 2001;20(5–6):895–904.
Article
CAS
PubMed
Google Scholar
Liu CC, Chou AH, Lien SP, Lin HY, Liu SJ, Chang JY, Guo MS, Chow YH, Yang WS, Chang KHW, et al. Identification and characterization of a cross-neutralization epitope of Enterovirus 71. Vaccine. 2011;29(26):4362–72.
Article
CAS
PubMed
Google Scholar
Chang GH, Luo YJ, Wu XY, Si BY, Lin L, Zhu QY. Monoclonal antibody induced with inactived EV71-Hn2 virus protects mice against lethal EV71-Hn2 virus infection. Virol J. 2010;7:106.
Article
PubMed Central
PubMed
Google Scholar
Foo DG, Alonso S, Phoon MC, Ramachandran NP, Chow VT, Poh CL. Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides. Virus Res. 2007;125(1):61–8.
Article
CAS
PubMed
Google Scholar
Foo DG, Alonso S, Chow VT, Poh CL. Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide. Microbes Infect. 2007;9(11):1299–306.
Article
CAS
PubMed
Google Scholar
Liu JN, Wang W, Duo JY, Hao Y, Ma CM, Li WB, Lin SZ, Gao XZ, Liu XL, Xu YF, et al. Combined peptides of human enterovirus 71 protect against virus infection in mice. Vaccine. 2010;28(46):7444–51.
Article
CAS
PubMed
Google Scholar
Kwag HL, Kim HJ, Chang DY. The production and immunogenicity of humanpapillomavirus type 58 virus-like particles produced in Saccharomyces cerevisiae. J Microbiol. 2012;50(5):813–20.
Article
CAS
PubMed
Google Scholar
Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, et al. Pro-phylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blindplacebo-controlled multicentre phase II efficacy trial. Lancet Oncol. 2005;6(5):271–8.
Article
PubMed
Google Scholar
Ludwig C, Wagner R. Virus-like particles-universal molecular toolboxes. Curr Opin Biotech. 2007;18(6):537–45.
Article
CAS
PubMed
Google Scholar
Wang M, Jiang S, Wang Y. Recombinant VP1 protein expressed in Pichia pastoris induces protective immune responses against EV71 in mice. Biocheml Biophys Res Commun. 2013;430(1):387–93.
Article
CAS
Google Scholar
Chiu CH, Chu C, He CC, Lin TY. Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71. Microbes Infect. 2006;8(7):1671–8.
Article
CAS
PubMed
Google Scholar
Arita M, Nagata N, Iwata N, Ami Y, Suzaki Y, Mizuta K, Iwasaki T, Sata T, Wakita T, Shimizu H. An attenuated strain of enterovirus 71 belonging to genotype A showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys. J Virol. 2007;81(17):9386–95.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chung CY, Chen CY, Lin SY, Chung YC, Chiu HY, Chi WK, Lin YL, Chiang BL, Chen WJ, Hu YC. Enterovirus 71 virus-like particle vaccine: improved production conditions for enhanced yield. Vaccine. 2010;28(43):6951–7.
Article
CAS
PubMed
Google Scholar
Li HY, Han JF, Qin CF, Chen R. Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice. Vaccine. 2013;31(32):3281–7.
Article
CAS
PubMed
Google Scholar
Tung WS, Bakar SA, Sekawi Z, Rosli R. DNA vaccine constructs against enterovirus 71 elicit immune response in mice. Genet Vaccines Ther. 2007;5:6.
Article
PubMed Central
PubMed
Google Scholar
Dong C, Wang J, Liu L, Zhao H, Shi H, Zhang Y, Jiang L, Li Q. Optimized development of a candidate strain of inactivated EV71 vaccine and analysis of its immunogenicity in rhesus monkeys. Hum Vaccines. 2010;6(12):1028–37.
Article
CAS
Google Scholar
Liu L, Zhang Y, Wang J, Zhao H, Jiang L, Che Y, Shi H, Li R, Mo Z, Huang T, et al. Study of the integrated immune response induced by an inactivated EV71 vaccine. PLoS One. 2013;8(1):e54451.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dong C, Liu L, Zhao H, Wang J, Liao Y, Zhang X, Na R, Liang Y, Wang L, Li Q. Immunoprotection elicited by an enterovirus type 71 experimental inactivated vaccine in mice and rhesus monkeys. Vaccine. 2011;29(37):6269–75.
Article
CAS
PubMed
Google Scholar
Bek EJ, Hussain KM, Phuektes P, Kok CC, Gao Q, Cai F, Gao Z, McMinn PC. Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection. Vaccine. 2011;29(29–30):4829–38.
Article
CAS
PubMed
Google Scholar
Chou AH, Liu CC, Chang JY, Lien SP, Guo MS, Tasi HP, Hsiao KN, et al. Immunological evaluation and comparison of different EV71 vaccine candidates. Clin Dev Immunol. 2012;2012:831282.
Article
PubMed Central
PubMed
Google Scholar
Ye X, Ku Z, Liu Q, Wang X, Shi J, Zhang Y, Kong L, Cong Y, Huang Z. Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms. J Virol. 2014;88(1):72–81.
Article
PubMed Central
PubMed
Google Scholar
Zhao M, Bai Y, Liu W, Xiao X, Huang Y, Cen S, Chan PK, Sun X, et al. Immunization of N terminus of enterovirus 71 VP4 elicits cross-protective antibody responses. BMC Microbiol. 2013;10(13):196–287.
Google Scholar
Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, et al. Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014;4(5):498–513.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pushko P, Pumpens P, Grens E. Development of virus-like particle technology from small highly symmetric to large complex virus-like particle structures. Intervirology. 2013;56(3):141–65.
Article
CAS
PubMed
Google Scholar
Chung YC, Huang JH, Lai CW, Sheng HC, Shih SR, Ho MS, Hu YC. Expression, purification and characterization of enterovirus-71 virus-like particles. World J Gastroenterol. 2006;12(6):921–7.
PubMed Central
CAS
PubMed
Google Scholar
Liu CC, Guo MS, Lin FH, Hsiao KN, Chang KH, Chou AH, Wang YC, et al. Purification and characterization of enterovirus 71 viral particles produced from Vero cells grown in a serum-free microcarrier bioreactor system. PLoS One. 2011;6(5):e20005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zaragoza C, Saura M, Padalko EY, Lopez-Rivera E, Lizarbe TR, Lamas S, Lowenstein CJ. Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. Proc Natl Acad Sci USA. 2006;103(50):19051–6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Blanco R, Carrasco L, Ventoso I. Cell killing by HIV-1 protease. J Biol Chem. 2003;278(2):1086–93.
Article
CAS
PubMed
Google Scholar
Yoke-Fun C, AbuBakar S. Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes. BMC Microbiol. 2006;6:74.
Article
PubMed Central
PubMed
Google Scholar
Zhang Y, Tan X, Cui A, Mao N, Xu S, Zhu Z, Zhou J, Shi J, Zhao Y, Wang X, et al. Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years. PLoS One. 2013;8(2):e56341.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rao CD, Yergolkar P, Shankarappa KS. Antigenic diversity of enteroviruses associated with nonpolio acute flaccid paralysis, India, 2007–2009. Emerg Infect Dis. 2012;18:1833–40.
Article
PubMed Central
PubMed
Google Scholar
Bessaud M, Razafindratsimandresy R, Nougairède A, Joffret ML, Deshpande JM, Dubot-Pérès A, et al. Molecular comparison and evolutionary analyses of VP1 nucleotide sequences of new African human enterovirus 71 isolates reveal a wide genetic diversity. PLoS One. 2014;9(3):e90624.
Article
PubMed Central
PubMed
Google Scholar
Huang SW, Hsu YW, Smith DJ, Kiang D, Tsai HP, et al. Reemergence of enterovirus 71 in 2008 in Taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008. J Clin Microbiol. 2009;47(11):3653–62.
Article
PubMed Central
PubMed
Google Scholar
Mao Q, Cheng T, Zhu F, Li J, Wang Y, Li Y, Gao F, Yang L, Yao X, Shao J, Xia N, Liang Z, Wang J. The cross-neutralizing activity of enterovirus 71 subgenotype C4 vaccines in healthy chinese infants and children. PLoS One. 2013;8(11):e79599.
Article
PubMed Central
PubMed
Google Scholar
Chou AH, Liu CC, Chang JY, Jiang R, Hsieh YC, Tsao A, Wu CL, Huang JL. Formalin-inactivated EV71 vaccine candidate induced cross-neutralizing antibody against subgenotypes B1, B4, B5 and C4A in adult volunteers. PLoS One. 2013;8(11):e79783.
Article
PubMed Central
PubMed
Google Scholar