- Research note
- Open Access
Can a 3 months treatment with oral Desogestrel prior to insertion of the etonogestrel-releasing contraceptive implant improve continuation rate at 1 year? A randomized trial
BMC Research Notes volume 16, Article number: 35 (2023)
To evaluate if daily oral 75 µg of Desogestrel (DSG) for 3 months prior to the insertion of etonogestrel-releasing contraceptive implant (ENG-IMPLANT) might help reduce its premature discontinuation.
A total of 66 women were randomized in the ENG-IMPLANT group (26) and in the DSG + ENG-IMPLANT group (40), respectively, in the Geneva University Hospitals and Basel University Hospital, from August 15th, 2016 through September 30th, 2019. In the DSG + ENG-IMPLANT group, patients were given a 3 months’ supply of 75 µg of DSG before the insertion of the ENG-IMPLANT. All women were seen after 3 months for bleeding and satisfaction evaluation, and at 12 months post ENG-IMPLANT insertion. Higher levels of satisfaction at 12-months were found in the ENG-IMPLANT group compared to the DSG + ENG-IMPLANT group (8.5 ± 1.7 vs. 6.6 ± 2.9, p = 0.012). There were no statistically significant differences regarding tolerance (7.8 ± 2.5 vs 6.8 ± 2.6, p = 0.191) and contraceptive continuation (80% vs 72.4%, p = 0.544) between groups.
DSG prior to insertion of the ENG-IMPLANT did not improve its continuation rate neither its satisfaction at 1 year.
Trial registration NCT05174195. Retrospectively registered, the 30th December 2021
Etonogestrel-releasing contraceptive implant (ENG-IMPLANT) is a single rod implant containing 68 mg of etonogestrel which is user independent and can be used for three years. Main side effects of ENG-IMPLANT are related to irregular vaginal bleeding. Other side effects such as weight gain, headache, acne, mastodynia, abdominal pain, emotional liability and vaginal infection are less frequent . These side effects reduce tolerance of implants, which can lead to its premature removal . The results of 11 international studies showed a continuation rate of 65% at 12 months , which is similar to data described in other European  and worldwide studies [5, 6].
An approach that would triage women who may have side effects and consequently difficulties adhering to ENG-IMPLANT could decrease premature removal. Such approach could be the use of daily oral 75 µg of Desogestrel (DSG) prior to the insertion of ENG-IMPLANT. In fact, DSG is transformed into its active form, etonogestrel, after hepatic metabolism and a very similar side effect profile has been described between ENG-IMPLANT and DSG users . An initial treatment with DSG prior to ENG-IMPLANT insertion may indicate the presence of individual intolerance. In other words, women who will not tolerate the side effects induced by DSG will be probably less inclined to have an ENG-IMPLANT insertion and opt for another contraceptive. With this approach a more tolerant population is believed to be attained, leading to less premature removal of the more expensive ENG-IMPLANT, supporting a better cost-effective choice.
This prospective randomized study aims to evaluate if the pre-treatment with DSG prior to ENG-IMPLANT insertion (I) increases the continuation rate at one year, if it (II) increases the tolerance of the implant and (III) to compare side effects profile of DSG and ENG-IMPLANT at 3 months.
Materials and methods
Setting and study population
Between August 15th, 2016 and September 30th, 2019, we conducted a randomized prospective open-label study of women aged 18 to 42 years who were interested in using ENG-IMPLANT and were willing to have 90 days of pre-treatment with DSG. The study was conducted in the family planning clinic of the Geneva University Hospitals and women’s policlinic of the University Hospital Basel. The exclusion criteria were pregnancy, lactation, vaginal bleeding of unknown origin, wish to become pregnant, weight > 80 kg, history of venous thromboembolism, hypertension, diabetes or other metabolic diseases, coagulation disorders, severe hepatic disorder, history of gynaecological cancer, known hypersensitivity to study drugs and current treatment with enzyme inducing drugs. The study was approved by the ethics committees of both hospitals (CCER 16-972). All patients signed an informed consent prior to recruitment.
Once consent was obtained, women were randomized either to the ENG-IMPLANT group or the DSG + ENG-IMPLANT group. In the ENG-IMPLANT group, the implant was inserted immediately. In the DSG + ENG-IMPLANT group, patients were given a 3 months’ supply of DSG to be started immediately after which insertion of ENG-IMPLANT was proposed. In both groups, patients were instructed to complete a bleeding calendar and a satisfaction questionnaire. A 3-month visit was pre-programmed for all participants, during which the bleeding calendar and the questionnaire were collected. Participants in the DSG + ENG-IMPLANT group who completed the 3 months on DSG pill had their ENG-IMPLANT inserted during this visit. All patients were seen or called over the phone after 12 months post ENG-IMPLANT insertion in both groups. Women who had their implant removed between 3 to 12 months after the insertion completed the satisfaction questionnaire at the time of removal.
Measurement of outcomes and other variables of interest
Socio-demographic characteristics were collected. Data collectors recorded the date of implant insertion or the date of DSG initiation. The main outcome variable for this study was method discontinuation. Secondary outcomes were the side effects, tolerance and satisfaction 3 months after inclusion and 12 months after ENG-IMPLANT insertion.
A satisfaction questionnaire and a bleeding calendar was used to assess bleeding patterns throughout the first 3 months of use in both groups. Overall, irregular vaginal bleeding was defined as any deviation from their habitual menstrual patterns of bleeding.
The satisfaction questionnaire evaluated side effects on skin, mood, sex-drive, abdomino-pelvic or breast pain, headaches, changes to vaginal discharge, and irregular vaginal bleeding according to a graded 5 points Likert score, from never experiencing (1 point) to all the time experiencing (5 points). Two separate questions evaluated tolerance and satisfaction and were graded on a scale from 0 to 10 (0 not tolerating or unsatisfied with the method and 10 being totally satisfied and perfectly tolerating). Weight gain as cause for removal was noted when relevant.
Randomization and statistical analysis
Statistical analysis was performed using the Stata program version 13 (StataCorp LP: College Station, TX, USA); the significance level for all tests was p < 0.05. To detect a mean difference of 0.5 standard deviation on the numerical tolerance scale, with a power of 0.85 and type 1 error rate of 0.05, we needed 2 groups of 74 participants. The randomization plan was so as to have 33% more participants in the DSG + ENG-IMPLANT group, with a 1:3 ratio, because of 35% drop out in the ENG-IMPLANT group. This would have provided a power of 0.8 to detect a difference in proportions with implant removal of 0.35 versus 0.15 to compensate for possible loss to follow-up. Sample size was set to 80 participants in the ENG-IMPLANT only group, and 120 in the DSG + ENG-IMPLANT group. Randomization was conducted on www.randomization.com using randomly permuted blocs of 14, 21 and 28 patients. The participants' study allocation was included in opaque, sealed envelopes, prepared by the Clinical Research Platform (PGO) in the University Hospital of Geneva.
For continuous variables, means and standard deviation (SD) were calculated; for categorical data, proportions were calculated. The chi-square test and Fisher´s exact test were used when appropriate, as well as the student’s t-test and Mann–Whitney test. Descriptive statistics were used to analyse the baseline characteristics of the study population.
Among the 67 women assessed for eligibility, 66 (98.5%) were included in the study and were allocated either to the ENG-IMPLANT group (26, 39.4%) or the DSG + ENG-IMPLANT group (40, 60.6%) (Fig. 1). After 3 years of recruitment, 33.5% of the expected patients were recruited (67 patients instead of 200 patients as calculated in the sample size), Patient recruitment was more difficult than expected and after 3 years decision was made to terminate the study. Loss to follow-up at 3 months was similar in the two groups: 2 missed patients in the ENG-IMPLANT group and 3 in the DSG + ENG-IMPLANT group. Loss to follow-up at 12 months was also similar between groups: 3 additional missed patients in the ENG-IMPLANT group and 6 in the DSG + ENG-IMPLANT group. Overall, 1 patient was excluded before the 3-months assessment in the ENG-IMPLANT group because removal of the implant in less than a month after insertion (wish to conceive) and 2 patients did not complete the second questionnaire after demanding premature implant removal.
Additional file 1: Table S1 summarizes participants’ characteristics in each group (total N = 60). The median age was 25 years (IQR: 20–31). Most of the women were nulliparous (73.3%). There were no statistical differences in the distribution of sociodemographic characteristics between the two groups.
Patients’ satisfaction and contraceptive side effects at 3 and 12- months’ assessment
Questionnaires about satisfaction were filled by 60 patients at 3-months and by 47 patients at 12-months (Table 1). There was no statistically significant difference between the two groups with respect to side effects. Women in the ENG-IMPLANT group reported a higher level of satisfaction at 12-months than the DSG + ENG-IMPLANT group (8.5 ± 1.7 vs. 6.6 ± 2.9, p = 0.012). There was no statistically significant difference regarding average tolerance between groups. Overall, the desire to continue the contraceptive method at 12 months was reported by 80.0% of women in the ENG-IMPLANT and 72.4% of women in the DSG + ENG-IMPLANT group (p = 0.544). At 12 months, 9 women in total (23.0%) did not want to continue with the ENG-IMPLANT. The reasons evoked for discontinuation were irregular vaginal bleeding (27.3%), weight gain (9.1%), multiple side effects (54.6%) and desire for pregnancy (9.1%). There were no differences in motives for discontinuation between the two groups.
Factors associated with contraceptive discontinuation at 3 and 12- months are represented in Table 2. Statistically significant side effects associated with ENG-IMPLANT discontinuation at 3 months were mood swings, reduced sex drive and irregular vaginal bleeding. Reduced sex drive was also found to be a reason for DSG discontinuation at 3 months. Women who experienced mastodynia and irregular bleeding were also more likely to discontinue the Implant at 12 months in the DSG + ENG-IMPLANT group. There was a statistically significant improvement over time for both groups concerning the reporting of headache, acne and abdominal pain.
Additional file 2: Table S2 reports patients’ satisfaction, at 3 and 12- months assessment, for the DSG + ENG-IMPLANT group in terms of overall tolerance and satisfaction according to various categories with scores ranging from poor and medium (score ≤ 5) to good and excellent (score > 5). According to this calculation, women who tolerated well the DSG pill at 3 months (score > 5) did not seem to better tolerate the implant at 12 months, as the proportion of women reporting good to excellent tolerance at 12 months was lower compared to the ENG-IMPLANT group (58.6% vs. 88.9% in DSG + ENG-IMPLANT and ENG-IMPLANT group, respectively, p = 0.027) and the continuation rate at 12 months seemed even lower, though not statistically significant (72.4% vs. 80.0%, p = 0.544).
Findings, their interpretation and comparison to other studies
There have been numerous studies evaluating ENG-IMPLANT side effects but no trial, to our knowledge, who evaluate whether the practice of 3 months oral intake of DSG prior to ENG-IMPLANT insertion improves its continuation rate at-1-year.
There was no statistically significant difference regarding overall satisfaction or method continuation when using DSG for 3 months prior to ENG-IMPLANT insertion. Women who tolerated well the DSG pill at 3 months (score > 5) did not seem to better tolerate the implant at 12 months, since the proportion of women reporting good to excellent tolerance at 12 months was lower compared to the ENG-IMPLANT group alone. This might suggest that using DSG in order to predict or improve the continuation rate at one year of ENG-IMPLANT is not a promising strategy.
Analysis of side effects reported in both groups did not show a difference in average tolerance between the two groups at 3 and 12 months. However, women reported a higher level of satisfaction in the ENG-IMPLANT group than the DSG + ENG-IMPLANT group at 12 months (8.5 vs. 6.6, p = 0.012). The incidence of side effects with ENG-IMPLANT at 3 and 12 months are congruent with previous publications [1, 8, 9]. Of notice, in both groups, with time, headache, acne and abdominal pain improved, similar to other reporting . These results had no effect on the desire to continue with the implant after 12 months, which was similar between groups (80.0% vs 72.4%, ENG-IMPLANT and DSG + ENG-IMPLANT groups, respectively). The continuation rates with ENG-IMPLANT in our cohort are similar to those reported in the literature (70–75%) [5, 8], comparable to intrauterine methods adherence (73–91%) [9, 10], however, higher than with oral contraceptive use (32–68%) [4, 8].
The higher level of satisfaction at 12 months in the ENG-IMPLANT group compared with the DSG + ENG-IMPLANT group is probably related to the fact that the study was offered only to patients interested in a long-acting reversible contraception willing to accept the possibility of a randomisation to an initial 3 months period of pill intake. Patients’ self-determination when choosing a contraceptive method has shown to ultimately result in greater satisfaction and higher continuation rates , which could explain why women who wanted the implant from the outset and received it, were more satisfied.
In conclusion, although our small sample size, it seems that the use of DSG prior to ENG-IMPLANT insertion does not help in predicting the continuation rate of the implant at one year.
The main limitation of our study is the small number of patients included and the high rate of loss at follow-up. Therefore, no definitive conclusions can be drawn to enforce change in attitude.
Availability of data and materials
According to Institutional Policies the database will be available upon request.
Daily oral 75 µg of Desogestrel
Etonogestrel-releasing contraceptive implant
Blumenthal PD, Gemzell-Danielsson K, Marintcheva-Petrova M. Tolerability and clinical safety of Implanon®. Eur J Contracept Reprod Health Care. 2008;13(sup1):29–36.
Urbancsek J. An integrated analysis of nonmenstrual adverse events with Implanon. Contraception. 1998;58(6 Suppl):109S-115S.
Darney P, Patel A, Rosen K, Shapiro LS, Kaunitz AM. Safety and efficacy of a single-rod etonogestrel implant (Implanon): results from 11 international clinical trials. Fertil Steril. 2009;91(5):1646–53.
National Institute for Health and Clinical Excellence (Great Britain), Royal College of Obstetricians and Gynaecologists (Great Britain), National Collaborating Centre for Women’s and Children’s Health (Great Britain). Long-acting reversible contraception: the effective and appropriate use of long-acting reversible contraception. 2005.
Croxatto HB, Urbancsek J, Massai R, Coelingh Bennink H, van Beek A. A multicentre efficacy and safety study of the single contraceptive implant Implanon. Implanon Study Group. Hum Reprod Oxf Engl. 1999;14(4):976–81.
Che Y, Taylor D, Luo D, Maldonado LY, Wang M, Wevill S, et al. Cohort study to evaluate efficacy, safety and acceptability of a two-rod contraceptive implant during third, fourth and fifth year of product use in China. Contracept X. 2019;1: 100008.
Guillebaud J. CEU New Product Review of the desogestrel-only pill. J Fam Plann Reprod Health Care. 2004;30(1):64–5.
Harvey C, Seib C, Lucke J. Continuation rates and reasons for removal among Implanon® users accessing two family planning clinics in Queensland, Australia. Contraception. 2009;80(6):527–32.
Wong RC, Bell RJ, Thunuguntla K, McNamee K, Vollenhoven B. Implanon users are less likely to be satisfied with their contraception after 6 months than IUD users. Contraception. 2009;80(5):452–6.
Glasier A. Implantable contraceptives for women: effectiveness, discontinuation rates, return of fertility, and outcome of pregnancies. Contraception. 2002;65(1):29–37.
Akers AY, Harding J, Perriera LK, Schreiber C, Garcia-Espana JF, Sonalkar S. Satisfaction with the intrauterine device insertion procedure among adolescent and young adult women. Obstet Gynecol. 2018;131(6):1130–6.
Funding for DSG and ENG-IMPLANT were provided for the study by MSD Switzerland.
Ethics approval and consent to partcipate
Approved by the Ethics Committee of Geneva on 12.04.2017 (CCER 2016-00972).
The trial was retrospectively registered on www.clinicaltrials.gov with the ID NCT05174195, the 30th December 2021. The manuscript adheres to CONSORT guidelines. All patients signed an informed consent prior to recruitment.
Consent for publication
All the authors have approved the manuscript for publication.
There are no disclosures of interest regarding financial, personal, intellectual, or religious interests. Completed disclosure of interests are available to view online as supporting information.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Additional file 1: Table S1.
Baseline sociodemographic and reproductive health characteristics of study participants
Additional file 2: Table S2.
Satisfaction results at 3 and 12- month assessment on the DSG + ENG-Implant group
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Lombardi Fäh, V., Catarino, R., Castillo, S. et al. Can a 3 months treatment with oral Desogestrel prior to insertion of the etonogestrel-releasing contraceptive implant improve continuation rate at 1 year? A randomized trial. BMC Res Notes 16, 35 (2023). https://doi.org/10.1186/s13104-023-06304-3
- Desogestrel pill
- Long-acting reversible contraceptives (LARC)
- Etonogestrel-releasing contraceptive implant