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  1. Many different genetic variants of proprotein convertase subtilisin kexin 9 (PCSK9) are related to the serum levels of cholesterol and LDL cholesterol (LDL-C). The rs615563 variant of PCSK9 (a gain-of-function...

    Authors: Samira Taghizadeh Jazdani, Hajieh Bibi Shahbazian, Bahman Cheraghian, Mohammad Taha Jalali and Narges Mohammadtaghvaei
    Citation: BMC Research Notes 2021 14:309
  2. Complex algae are photosynthetic organisms resulting from eukaryote-to-eukaryote endosymbiotic-like interactions. Yet the specific lineages and mechanisms are still under debate. That is why large scale phylog...

    Authors: Mick Van Vlierberghe, Arnaud Di Franco, Hervé Philippe and Denis Baurain
    Citation: BMC Research Notes 2021 14:306
  3. Navigation is the most important feature of homing pigeons, however no integrated response to genetic mechanism of navigation has been reported. The generated data herein represent whole-genome resequencing da...

    Authors: Ali Esmailizadeh, Hamed Kharrati-Koopaee and Hojjat Assadoullahpour Nanaei
    Citation: BMC Research Notes 2021 14:305
  4. There have been few descriptions of how outpatient cancer care is provided to patients from culturally and linguistically diverse (CALD) communities. As populations who experience disparities in cancer care ac...

    Authors: Bróna Nic Giolla Easpaig, Yvonne Tran, Teresa Winata, Klay Lamprell, Diana Fajardo Pulido, Gaston Arnolda, Geoff P. Delaney, Winston Liauw, Kylie Smith, Sandra Avery, Kim Rigg, Johanna Westbrook, Ian Olver, David Currow, Afaf Girgis, Jonathan Karnon…
    Citation: BMC Research Notes 2021 14:304
  5. Type 2 diabetes mellitus (T2DM) is still a challenge for physicians to manage patient’s circumstances. It is assumed that alterations in the normal flora may be involved in the pathogenesis of T2DM through ind...

    Authors: Fatemeh Bootorabi, Farshid Saadat, Reza Falak, Hamed Manouchehri, Reza Changizi, Hasan Mohammadi, Farnaz Safavifar and Mohammad Reza Khorramizadeh
    Citation: BMC Research Notes 2021 14:302
  6. MPDB 2.0 is built to be the continuation of MPDB 1.0, to serve as a more comprehensive data repertoire for Bangladeshi medicinal plants, and to provide a user-friendly interface for researchers, health practit...

    Authors: Nazmul Hussain, Rony Chanda, Ruhshan Ahmed Abir, Mohsina Akter Mou, Md. Kamrul Hasan and M. Arif Ashraf
    Citation: BMC Research Notes 2021 14:301
  7. The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial...

    Authors: Crystal L. Sigulinsky, Xiaodong Li and Edward M. Levine
    Citation: BMC Research Notes 2021 14:300
  8. The purpose of this study is to examine the prevalence of social needs by English proficiency using data from Northwell Health’s social determinants of health screening program. The screening program evaluates...

    Authors: Austin Fischer, Joseph Conigliaro, Shaun Allicock and Eun Ji Kim
    Citation: BMC Research Notes 2021 14:299
  9. In present study, the effects of the leaf extract of Pyrus biossieriana Buhse on tert-Butyl hydroperoxide (t-BHP) induced toxicity in the HepG2 cell line were investigated.

    Authors: Hamed Mir, Daniel Elieh Ali Komi, Mahdi Pouramir, Hadi Parsian, Ali Akbar Moghadamnia, Nayer Seyfizadeh and Mostafa Lakzaei
    Citation: BMC Research Notes 2021 14:298
  10. Shame contains external and internal aspects. However, a Japanese language scale for simultaneously assessing both aspects of shame has not been developed to date. This study aimed to standardize the Japanese ...

    Authors: Yoichi Hiramatsu, Kenichi Asano, Yasuhiro Kotera, Ayumu Endo, Eiji Shimizu and Marcela Matos
    Citation: BMC Research Notes 2021 14:297
  11. The risk of contracting tuberculosis (TB) and the efficacy of TB therapy are affected by several factors, including genetic variation among populations. In the Indonesian population, data on the genes involved...

    Authors: Melisa Intan Barliana, Arif Satria Wira Kusuma, Widya Norma Insani, Sofa Dewi Alfian, Ajeng Diantini, Mutakin Mutakin, Tina Rostinawati, Herlambang Herlambang, Irma Melyani Puspitasari, Auliya Abdurrohim Suwantika and Rizky Abdulah
    Citation: BMC Research Notes 2021 14:295
  12. MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders...

    Authors: Uzair Abbas, Bushra Imdad, Sikander Adil Mughal, Israr Ahmed Baloch, Afshan Mehboob Khan and Durr-e-Sameen Kamran
    Citation: BMC Research Notes 2021 14:294
  13. The introduction of a new technology has the potential to modify clinical practices, especially if easy to use, reliable and non-invasive. This observational before/after multicenter service evaluation compare...

    Authors: Patrice Forget, Simon Lacroix, Eric P. Deflandre, Anne Pirson, Nicolas Hustinx, Olivier Simonet, Fabrice Wandji, Serge von Montigny and Jibba Amraoui
    Citation: BMC Research Notes 2021 14:293
  14. In March 2020, Iran tackled the first national wave of COVID-19 that was particularly felt in Mashhad, Iran’s second-most populous city. Accordingly, we performed a spatio-temporal study in this city to invest...

    Authors: Shahab MohammadEbrahimi, Alireza Mohammadi, Robert Bergquist, Mahsan Akbarian, Mahnaz Arian, Elahe Pishgar and Behzad Kiani
    Citation: BMC Research Notes 2021 14:292
  15. The proposed candidate gene underlying the Malus fusca fire blight resistance locus on chromosome 10 was previously predicted to possess 880 amino acids and 8 exons. Eight base pair (8 bp) insertion/deletion in t...

    Authors: Ofere Francis Emeriewen, Henryk Flachowsky and Andreas Peil
    Citation: BMC Research Notes 2021 14:291
  16. Pistacia genus belongs to the flowering plants in the cashew family and contains at least 11 species. The whole-genome resequencing data of different species from Pistacia genus are described herein. The data rep...

    Authors: Ali Tajabadipour and Ali Esmailizadeh
    Citation: BMC Research Notes 2021 14:290

    The Correction to this article has been published in BMC Research Notes 2021 14:392

  17. Four-dimensional flow CMR allows for a comprehensive assessment of the blood flow kinetic energy of the ventricles of the heart. In comparison to standard two-dimensional image acquisition, 4D flow CMR is felt...

    Authors: Ciaran Grafton-Clarke, Saul Crandon, Jos J. M. Westenberg, Peter P. Swoboda, John P. Greenwood, Rob J. van der Geest, Andrew J. Swift, Vassilios S. Vassiliou, Sven Plein and Pankaj Garg
    Citation: BMC Research Notes 2021 14:289
  18. In a previous study we demonstrated that the occurrence of sexual jokes in the class was associated with higher levels of psychological health complaints. Building on and extending these findings, the aim of t...

    Authors: Sara Brolin Låftman, Ylva Bjereld, Bitte Modin and Petra Löfstedt
    Citation: BMC Research Notes 2021 14:288
  19. The aim of this study is to qualitatively investigate the lived experiences of mental health among frontline health workers providing COVID-19-realted care in Uganda. This study provides insights into the cont...

    Authors: Choolwe Muzyamba, Ogylive Makova and Geofrey Samukulu Mushibi
    Citation: BMC Research Notes 2021 14:286
  20. Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted...

    Authors: Robert Ruemmler, Alexander Ziebart, Elisabeth Britten, Moritz Gosling, Rene Rissel and Erik K. Hartmann
    Citation: BMC Research Notes 2021 14:285
  21. Restless Legs Syndrome (RLS) is commonly known to cause morbidity in patients on hemodialysis, making them prone to chronic mental health illnesses such as depression and anxiety, and also adversely impact qua...

    Authors: Mahjabeen Yaseen, Furqan Ahmad Jarullah, Sadia Yaqoob, Hassan Abdullah Shakeel, Hamza Maqsood and Sadiq Naveed
    Citation: BMC Research Notes 2021 14:284
  22. The purpose of this clinical trial was to examine the effect of omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels and gene expression of VCAM in patients with episodic migraine.

    Authors: Mina Abdolahi, Elmira Karimi, Payam Sarraf, Abbas Tafakhori, Goli Siri, Farahnaz Salehinia, Mohsen Sedighiyan, Behzad Asanjarani, Mostafa Badeli, Hamed Abdollahi, Niyoosha Yoosefi, Abolghasem yousefi, Amir Shayegan rad and Mahmoud Djalali
    Citation: BMC Research Notes 2021 14:283
  23. In order to assess the applicability of a direct-to-consumer (DTC) genetic testing to translational research for obtaining new knowledge on relationships between drug target genes and diseases, we examined pos...

    Authors: Masahiro Inoue, Shota Arichi, Tsuyoshi Hachiya, Anna Ohtera, Seok-Won Kim, Eric Yu, Masatoshi Nishimura, Kazuhito Shiosakai and Takeshi Ohira
    Citation: BMC Research Notes 2021 14:282
  24. Eritrea is the most frequent country of origin among asylum seekers in Switzerland. On their journey through the desert and across the Mediterranean Sea, Eritrea refugees are often exposed to traumatizing expe...

    Authors: Afona Chernet, Nicole Probst-Hensch, Véronique Sydow, Daniel H. Paris and Niklaus D. Labhardt
    Citation: BMC Research Notes 2021 14:281
  25. The present population-based study aimed to examine the association of chronic stress and sleeping difficulties with self-reported irritable bowel syndrome (IBS), gastrointestinal (GI) symptoms past 2 weeks, a...

    Authors: Jasmin Zejnelagic and Bodil Ohlsson
    Citation: BMC Research Notes 2021 14:280
  26. The associations between dietary carbohydrate, fat intake, and inflammation are controversial. Most existing data are from industrialized societies which low-carbohydrate and high-fat diet is common and so the...

    Authors: Elmira Karimi, Habib Yarizadeh, Leila Setayesh, Seyyedeh Forough Sajjadi, Nasim Ghodoosi, Leil Khorraminezhad and Khadijeh Mirzaei
    Citation: BMC Research Notes 2021 14:279
  27. Mediastinal schwannomas are sometimes confused with other neoplasms during initial radiological studies, especially when there is a history of cancer in another area. In these cases, a more accurate analysis u...

    Authors: Ramiro Sandoval-Macias, Irving Daniel Ortiz-Sanchez, Ana Lilia Remirez-Castellanos, Luis Mora-Hernandez, Candelaria Cordova-Uscanga, Alejandra Mantilla-Morales, Tania Alejandra Galindo-Garcia, Armando Gamboa-Dominguez and Fernando Candanedo-Gonzalez
    Citation: BMC Research Notes 2021 14:278
  28. Strengthening the organizational agility of the hospital can lead to decreased production costs and increased market share, better serving to patients' needs, introduction of new services and increased competi...

    Authors: Zahra Kavosi, Sajad Delavari, Mohammad Mehdi Kiani, Peivand Bastani, Mohebat Vali and Marzieh Salehi
    Citation: BMC Research Notes 2021 14:277
  29. Marginalised populations are less likely to take part in health research, and are sometimes considered ‘easy to ignore’. We aimed to describe our approach and results of recruiting parents who experience disad...

    Authors: Louise Tully, Eleni Spyreli, Virginia Allen-Walker, Karen Matvienko-Sikar, Sheena McHugh, Jayne Woodside, Michelle C. McKinley, Patricia M. Kearney, Moira Dean, Catherine Hayes, Caroline Heary and Colette Kelly
    Citation: BMC Research Notes 2021 14:276
  30. Food frequency questionnaires are widely used as a dietary assessment tool in nutritional epidemiology to determine the relationship between diet and diseases. In Tanzania, there are several cultural variation...

    Authors: Ahmed Gharib Khamis, Akwilina Wendelin Mwanri, Julius Edward Ntwenya, Mbazi Senkoro, Katharina Kreppel, Bassirou Bonfoh, Sayoki Godfrey Mfinanga and Gideon Kwesigabo
    Citation: BMC Research Notes 2021 14:274
  31. Visualisation methods, primarily color-coded representation of sequence data, have been a predominant means of representation of DNA data. Algorithmic conversion of DNA sequence data to sound—sonification—repr...

    Authors: Heleen Plaisier, Thomas R. Meagher and Daniel Barker
    Citation: BMC Research Notes 2021 14:273
  32. The COVID-19 pandemic has brought about a major upheaval in the lives of older adults and their family/friend caregivers, including those utilizing home care services. In this article, we focus on results from...

    Authors: Lori E. Weeks, Sue Nesto, Bradley Hiebert, Grace Warner, Wendy Luciano, Kathleen Ledoux and Lorie Donelle
    Citation: BMC Research Notes 2021 14:271
  33. Canine visceral leishmaniasis (CVL) is the main source of human visceral leishmaniosis (HVL) in Mediterranean region, including Iran and is spread from domestic dogs to Phlebotomine sand flies vectors to humans. ...

    Authors: Yonas Yimam Ayene, Mehdi Mohebali, Homa Hajjaran, Behnaz Akhoundi, Saeedeh Shojaee, Abbas Rahimi-Foroushani, Mohammad Javad Abbaszadeh Afshar and Z. Zarei
    Citation: BMC Research Notes 2021 14:270
  34. Sulfation is an essential physiological process that regulates the function of a wide array of molecules involved in brain development. We have previously shown expression levels for the sulfate transporter Slc13...

    Authors: Tracey J. Harvey, Raul Ayala Davila, Diana Vidovic, Sazia Sharmin, Michael Piper and David G. Simmons
    Citation: BMC Research Notes 2021 14:269
  35. The “Integrating a neonatal healthcare package for Malawi” (IMCHA#108030) project conducted mixed-methods to understand facility-based implementation factors for newborn health innovations in low-resourced hea...

    Authors: Mai-Lei Woo Kinshella, Alinane Linda Nyondo-Mipando, Queen Dube, David M. Goldfarb and Kondwani Kawaza
    Citation: BMC Research Notes 2021 14:267
  36. To find mutations that may have recently occurred in Plum pox virus (PPV), we collected six PPV-infected plum/peach trees from the western part of Japan and one from the eastern part. After sequencing the full-le...

    Authors: Tomoaki Mori, Chiaki Warner, Serika Ohno, Koichi Mori, Takamasa Tobimatsu and Takashi Sera
    Citation: BMC Research Notes 2021 14:266
  37. This study aimed to investigate the short-term effect of ovariohysterectomy on urine levels of serotonin and its relation to levels of cortisol, testosterone and progesterone in female dogs. Seven bitches were...

    Authors: Eva Hydbring-Sandberg, Elin Larsson, Andrzej Madej and Odd Viking Höglund
    Citation: BMC Research Notes 2021 14:265
  38. Malaria is a major global health concern with the urgent need for new treatment alternatives due to the alarming increase of drug-resistant Plasmodium strains. Chalcones and its derivatives are important pharmaco...

    Authors: Shweta Sinha, Ajay Prakash, Bikash Medhi, Alka Sehgal, Daniela I. Batovska and Rakesh Sehgal
    Citation: BMC Research Notes 2021 14:264
  39. There has been much discussion and debate around the underreporting of COVID-19 infections and deaths in India. In this short report we first estimate the underreporting factor for infections from publicly ava...

    Authors: Soumik Purkayastha, Ritoban Kundu, Ritwik Bhaduri, Daniel Barker, Michael Kleinsasser, Debashree Ray and Bhramar Mukherjee
    Citation: BMC Research Notes 2021 14:262
  40. Sengon (Falcataria moluccana) is a popular tree species in community plantation forests in Java, Indonesia due to its fast-growing and multipurpose characteristics. However, without effective control measures sen...

    Authors: Ulfah J. Siregar, Aditya Nugroho, Hasyyati Shabrina, Fitri Indriani, Apriliya Damayanti and Deden D. Matra
    Citation: BMC Research Notes 2021 14:261

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