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  1. High-throughput custom designed genotyping arrays are a valuable resource for biologically focused research studies and increasingly for validation of variation predicted by next-generation sequencing (NGS) te...

    Authors: Elizabeth A Tindall, Desiree C Petersen, Stina Nikolaysen, Webb Miller, Stephan C Schuster and Vanessa M Hayes

    Citation: BMC Research Notes 2010 3:39

    Content type: Short Report

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  2. Chromatin adjoining the site of integration of a transgene affects expression and renders comparisons of closely related transgenes, such as those derived from a BAC deletion series retrofitted with enhancer-t...

    Authors: Pradeep K Chatterjee, Leighcraft A Shakes, Naima Stennett, Vanessa L Richardson, Tennison L Malcolm and Ken R Harewood

    Citation: BMC Research Notes 2010 3:38

    Content type: Short Report

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  3. Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral compl...

    Authors: Najla S Dar-Odeh, Wail A Hayajneh, Osama A Abu-Hammad, Huda M Hammad, Adel M Al-Wahadneh, Najwa K Bulos, Azmi M Mahafzah, Maha S Shomaf, Mohammed A El-Maaytah and Faris G Bakri

    Citation: BMC Research Notes 2010 3:37

    Content type: Short Report

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  4. Despite constant progress, cancer remains the second leading cause of death in the United States. The ability of tumors to metastasize is central to this dilemma, as many studies demonstrate successful treatme...

    Authors: John J Ryan, Benjamin L Dows, Michael V Kirk, Xueming Chen, Jeffrey R Eastman, Rodney J Dyer and Lemont B Kier

    Citation: BMC Research Notes 2010 3:36

    Content type: Hypothesis

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  5. The presence of various EPIYA tyrosine phosphorylation motifs in the CagA protein of Helicobacter pylori has been suggested to contribute to pathogenesis in adults. In this study, a unique PCR assay and sequencin...

    Authors: Hans-Jürg Monstein, Anneli Karlsson, Anna Ryberg and Kurt Borch

    Citation: BMC Research Notes 2010 3:35

    Content type: Technical Note

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  6. Chlamydia trachomatis infections are the most prevalent sexually transmitted bacterial infections in the world. There is scarce data available referring to the distribution of C. trachomatis genotypes in Argentin...

    Authors: Lucía Gallo Vaulet, Carolina Entrocassi, Ana I Corominas and Marcelo Rodríguez Fermepin

    Citation: BMC Research Notes 2010 3:34

    Content type: Short Report

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  7. High plasma cortisol levels can cause acute cognitive and neuropsychiatric dysfunction, and have been linked with delirium. CSF cortisol levels more closely reflect brain exposure to cortisol, but there are no...

    Authors: Andrew Pearson, Annick de Vries, Scott D Middleton, Fiona Gillies, Timothy O White, Ian R Armstrong, Ruth Andrew, Jonathan R Seckl and Alasdair MJ MacLullich

    Citation: BMC Research Notes 2010 3:33

    Content type: Short Report

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  8. Obstetric anal sphincter rupture (OASR) is a serious complication of delivery, which frequently results in faecal incontinence despite primary repair and has serious implications for women's health. The object...

    Authors: Sari Räisänen, Katri Vehviläinen-Julkunen, Mika Gissler and Seppo Heinonen

    Citation: BMC Research Notes 2010 3:32

    Content type: Short Report

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  9. Several lines of evidence support a role for CCL2 (monocyte chemotactic protein-1) and its receptor CCR2 in the development of atherosclerosis. The aim of the present study was to determine the association of ...

    Authors: David J Dow, Alex D McMahon, Ian C Gray, Chris J Packard and Pieter HE Groot

    Citation: BMC Research Notes 2010 3:31

    Content type: Short Report

    Published on:

  10. This study determined differences in learning, judgments of teaching and technology, and interaction when videoconferencing was used to deliver instruction on telemedicine to medical students in conditions whe...

    Authors: Craig Locatis, Eta S Berner, Glenn Hammack, Steve Smith, Richard Maisiak and Michael Ackerman

    Citation: BMC Research Notes 2010 3:30

    Content type: Short Report

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  11. Hemoglobin E beta-thalassemia (β-thalassemia/Hb E) has a variable severity, and the cost of treatment has not been well studied. The aim of this study was to analyze the societal cost of caring for children wi...

    Authors: Arthorn Riewpaiboon, Issarang Nuchprayoon, Kitti Torcharus, Kaemthong Indaratna, Montarat Thavorncharoensap and Bang-on Ubol

    Citation: BMC Research Notes 2010 3:29

    Content type: Short Report

    Published on:

  12. There is an urgent need to more accurately diagnose HIV-associated neurocognitive disorder (HAND) in Africa. Rapid screening tests for HIV-associated dementia are of limited utility due to variable sensitivity...

    Authors: Dinesh Singh, John A Joska, Karl Goodkin, Enrique Lopez, Landon Myer, Robert H Paul, Sally John and Henry Sunpath

    Citation: BMC Research Notes 2010 3:28

    Content type: Short Report

    Published on:

  13. We evaluated the quality of patient information leaflets for Trans-Rectal Ultrasound guided prostate biopsies (TRUS-Bx) in North Thames region. TRUS-Bx information leaflets were requested from 24 hospitals in ...

    Authors: Iqbal Shergill, Kishore Bahl, Muhammad Farjad, Claire Phipps and George Fowlis

    Citation: BMC Research Notes 2010 3:27

    Content type: Short Report

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  14. The process of rod photoreceptor genesis, cell fate determination and differentiation is complex and multi-factorial. Previous studies have defined a model of photoreceptor differentiation that relies on intri...

    Authors: Alison E Barnhill, Laura A Hecker, Oksana Kohutyuk, Janice E Buss, Vasant G Honavar and Heather West Greenlee

    Citation: BMC Research Notes 2010 3:25

    Content type: Short Report

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  15. The importance of non-coding RNAs (ncRNAs) as fine regulators of eukaryotic gene expression has emerged by several studies focusing on microRNAs (miRNAs). miRNAs represent a newly discovered family of non codi...

    Authors: Annalisa Rossi, Oscar F D'Urso, Graziana Gatto, Palmiro Poltronieri, Manuela Ferracin, Paolo Remondelli, Massimo Negrini, Maria G Caporaso, Stefano Bonatti and Massimo Mallardo

    Citation: BMC Research Notes 2010 3:24

    Content type: Short Report

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  16. The purpose of this study was to determine the prevalence of oral soft tissue lesions in patients and to assess their clinicopathological attributes. 3030 subjects belonging to a semi-urban district of Vidisha...

    Authors: Ravi Mehrotra, Shaji Thomas, Preeti Nair, Shruti Pandya, Mamta Singh, Niraj S Nigam and Pankaj Shukla

    Citation: BMC Research Notes 2010 3:23

    Content type: Short Report

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  17. Oxidative stress is related to several diseases, including chronic renal insufficiency. The disequilibrium in the oxidant-antioxidant balance is the result of several metabolic changes. The majority of studies...

    Authors: Marta Romeu, Rosa Nogues, Luís Marcas, Vanesa Sánchez-Martos, Miquel Mulero, Alberto Martinez-Vea, Jordi Mallol and Montserrat Giralt

    Citation: BMC Research Notes 2010 3:20

    Content type: Short Report

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  18. During grape berry ripening, the vacuoles accumulate water, sugars and secondary metabolites, causing great impact in plant productivity and wine quality. However, the molecular basis of these compartmentation...

    Authors: Natacha Fontes, Rui Silva, Céline Vignault, Fatma Lecourieux, Hernâni Gerós and Serge Delrot

    Citation: BMC Research Notes 2010 3:19

    Content type: Short Report

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  19. The Agilent microRNA microarray platform interrogates each microRNA with several copies of distinct oligonucleotide probes and integrates the results into a total gene signal (TGS), using a proprietary algorit...

    Authors: Pedro López-Romero, Manuel A González, Sergio Callejas, Ana Dopazo and Rafael A Irizarry

    Citation: BMC Research Notes 2010 3:18

    Content type: Short Report

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  20. Expression of several copies of the heat-inducible Hsp70.1Luciferase (LUC) transgene inserted at a single X chromosome locus of a bull (Bos taurus) was assessed in females after X-chromosome inactivation (XCI). F...

    Authors: Jean-Marc Lelièvre, Daniel Le Bourhis, Amandine Breton, Hélène Hayes, Jean-Luc Servely and Xavier Vignon

    Citation: BMC Research Notes 2010 3:17

    Content type: Short Report

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  21. The integration of information present in many disparate biological databases represents a major challenge in biomedical research. To define the problems and needs, and to explore strategies for database integ...

    Authors: Michael Gruenberger, Rudi Alberts, Damian Smedley, Morris Swertz, Paul Schofield and Klaus Schughart

    Citation: BMC Research Notes 2010 3:16

    Content type: Research article

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  22. Subjects with a ring scotoma can use two retinal loci, a foveal and a peripheral, for reading. Our aim was to investigate the relative use of both retinal loci as a function of the spared foveal area size and ...

    Authors: Mira Goldschmidt, Anouk Déruaz, Erika N Lorincz, Andrew R Whatham, Christophe Mermoud and Avinoam B Safran

    Citation: BMC Research Notes 2010 3:15

    Content type: Short Report

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  23. Stem cell factor (SCF) receptor c-Kit is recognized as a key signaling molecule, which transduces signals for the proliferation, differentiation and survival of stem cells. Binding of SCF to its receptor trigg...

    Authors: Soumya Pati, Gangenahalli U Gurudutta, Om P Kalra and Asok Mukhopadhyay

    Citation: BMC Research Notes 2010 3:14

    Content type: Short Report

    Published on:

  24. RNA-binding proteins of the PUF family share a conserved domain consisting of tandemly repeated 36-40 amino acid motifs (typically eight) known as Puf repeats. Proteins containing tandem repeats are often domi...

    Authors: Cristina Folgueira, Marta Martínez-Bonet and Jose M Requena

    Citation: BMC Research Notes 2010 3:13

    Content type: Short Report

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  25. 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an enigmatic enzyme specifically expressed at high levels in the vertebrate myelin sheath, whose function and physiological substrates are unknown. The ...

    Authors: Matti Myllykoski and Petri Kursula

    Citation: BMC Research Notes 2010 3:12

    Content type: Short Report

    Published on:

  26. Cardiovascular disease (CVD) remains a major cause of morbidity and a leading contributor to mortality worldwide. Over the next 2 decades, it is projected that there will be a rise in CVD mortality rates in th...

    Authors: Mahmoud U Sani, Kolawole W Wahab, Bashir O Yusuf, Maruf Gbadamosi, Omolara V Johnson and Akeem Gbadamosi

    Citation: BMC Research Notes 2010 3:11

    Content type: Short Report

    Published on:

  27. Gene-list annotations are critical for researchers to explore the complex relationships between genes and functionalities. Currently, the annotations of a gene list are usually summarized by a table or a barpl...

    Authors: Gang Feng, Pan Du, Nancy L Krett, Michael Tessel, Steven Rosen, Warren A Kibbe and Simon M Lin

    Citation: BMC Research Notes 2010 3:10

    Content type: Technical Note

    Published on:

  28. The isolation of intact RNA can be very difficult when tissues are used that contain many RNAses or that are hard to homogenize, e.g. cartilage samples. Additionally, cartilaginous tissues are characterized by...

    Authors: Anke Ruettger, Steffi Neumann, Bernd Wiederanders and René Huber

    Citation: BMC Research Notes 2010 3:7

    Content type: Technical Note

    Published on:

  29. Studies on the epidemiology of African Animal Trypanosomiasis (AAT) rarely consider the spatial dimension of disease prevalence. This problem is confounded by use of parasitological diagnostic methods of low s...

    Authors: Samuel M Thumbi, Joseph O Jung'a, Reuben O Mosi and Francis A McOdimba

    Citation: BMC Research Notes 2010 3:6

    Content type: Short Report

    Published on:

  30. The regulatory mechanisms of the expression of connective tissue growth factor/CCN family member 2 (CTGF/CCN2) in human articular chondrocytes have not been clarified. We investigated the effect of prostagland...

    Authors: Kayo Masuko, Minako Murata, Kazuo Yudoh, Hiroyuki Shimizu, Moroe Beppu, Hiroshi Nakamura and Tomohiro Kato

    Citation: BMC Research Notes 2010 3:5

    Content type: Short Report

    Published on:

  31. The extracellular deposition of aggregated amyloid β-protein is a neuropathological manifestation of Alzheimer disease and Down syndrome. The Amyloid β-protein is derived from a group of larger differentially ...

    Authors: Alexander A Vostrov, Michael J Taheny, Nerik Izkhakov and Wolfgang W Quitschke

    Citation: BMC Research Notes 2010 3:4

    Content type: Short Report

    Published on:

  32. Next generation sequencing (NGS) technologies have substantially increased the sequence output while the costs were dramatically reduced. In addition to the use in whole genome sequencing, the 454 GS-FLX platf...

    Authors: Ram Vinay Pandey, Viola Nolte and Christian Schlötterer

    Citation: BMC Research Notes 2010 3:3

    Content type: Technical Note

    Published on:

  33. Delayed maternal reporting of decreased fetal movement (DFM) is associated with adverse pregnancy outcomes. Inconsistent information on fetal activity to women during the antenatal period may result in delayed...

    Authors: Eli Saastad, Julie Victoria Holm Tveit, Vicki Flenady, Babill Stray-Pedersen, Ruth C Fretts, Per E Børdahl and J Frederik Frøen

    Citation: BMC Research Notes 2010 3:2

    Content type: Research article

    Published on:

  34. Species identification and antifungal susceptibility tests were carried out on 212 Candida isolates obtained from bloodstream infections, urinary tract infections and dialysis-associated peritonitis, from cases a...

    Authors: Ariane Bruder-Nascimento, Carlos Henrique Camargo, Maria Fátima Sugizaki, Terue Sadatsune, Augusto Cezar Montelli, Alessandro Lia Mondelli and Eduardo Bagagli

    Citation: BMC Research Notes 2010 3:1

    Content type: Short Report

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  35. To determine the ocular changes related to hypothyrodism in newly diagnosed patients without orbitopathy.

    Authors: Banu T Ozturk, Hurkan Kerimoglu, Oguz Dikbas, Hamiyet Pekel and Mustafa S Gonen

    Citation: BMC Research Notes 2009 2:266

    Content type: Short Report

    Published on:

  36. Continuing medical education (CME) is an integral part of continuing professional development and a prerequisite for good quality in health care. We aimed to describe and analyse the number of days spent in fo...

    Authors: Arja Helin-Salmivaara, Mira Kajantie, Jukka Vänskä, Hannu Halila, Taina Autti, Juha P Turunen and Amos Pasternack

    Citation: BMC Research Notes 2009 2:265

    Content type: Short Report

    Published on:

  37. Reference genes are used as internal standards to normalize mRNA abundance in quantitative real-time PCR and thereby allow a direct comparison between samples. So far most of these expression studies used huma...

    Authors: Jan Axtner and Simone Sommer

    Citation: BMC Research Notes 2009 2:264

    Content type: Project Note

    Published on:

  38. "Examinations drive students' learning." This statement refers to what is assumed to be one of the strongest relationships in education. We explored in this research how and why students differ in their approa...

    Authors: Hanan MF Al Kadri, Mohamed S Al-Moamary and Cees van der Vleuten

    Citation: BMC Research Notes 2009 2:263

    Content type: Short Report

    Published on:

  39. Bacteria that belong to the genus Sphingobacterium are Gram-negative, non-fermentative bacilli, ubiquitous in nature and rarely involved in human infections. The aims of this study were to evaluate the epidemiolo...

    Authors: Antonietta Lambiase, Fabio Rossano, Mariassunta Del Pezzo, Valeria Raia, Angela Sepe, Fabiola de Gregorio and Maria Rosaria Catania

    Citation: BMC Research Notes 2009 2:262

    Content type: Short Report

    Published on:

  40. Bovine brucellosis caused by Brucella abortus is endemic in most large commercial and smallholder cattle farms of Zimbabwe, while brucellosis in other domestic animals is rare. The diagnosis of brucellosis is mai...

    Authors: Gift Matope, Evison Bhebhe, John Bwalya Muma, Eystein Skjerve and Berit Djønne

    Citation: BMC Research Notes 2009 2:261

    Content type: Short Report

    Published on:

  41. Population-based association studies are used to identify common susceptibility variants for complex genetic traits. These studies are susceptible to confounding from unknown population substructure. Here we a...

    Authors: Jesse B Mez, John W Cole, Timothy D Howard, Leah R MacClellan, Oscar C Stine, Jeffery R O'Connell, Marcella A Wozniak, Barney J Stern, John D Sorkin, Braxton D Mitchell and Steven J Kittner

    Citation: BMC Research Notes 2009 2:260

    Content type: Short Report

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  42. Progressive loss of articular cartilage is a central hallmark in many joint disease, however, the relative importance of individual proteolytic pathways leading to cartilage erosion is at present unknown. We t...

    Authors: Bijue Wang, Pingping Chen, Anne-Christine Bay Jensen, Morten A Karsdal, Suzi H Madsen, Bodil-Cecilie Sondergaard, Qinlong Zheng and Per Qvist

    Citation: BMC Research Notes 2009 2:259

    Content type: Short Report

    Published on:

  43. The economic importance of cereals such as barley, and the demand for improved yield and quality require a better understanding of the genetic components that modulate biologically and commercially relevant tr...

    Authors: Sven Gottwald, Petra Bauer, Takao Komatsuda, Udda Lundqvist and Nils Stein

    Citation: BMC Research Notes 2009 2:258

    Content type: Research article

    Published on:

  44. Inference of gene regulatory networks (GRNs) requires accurate data, a method to simulate the expression patterns and an efficient optimization algorithm to estimate the unknown parameters. Using this approach...

    Authors: Yves Fomekong-Nanfack, Marten Postma and Jaap A Kaandorp

    Citation: BMC Research Notes 2009 2:256

    Content type: Short Report

    Published on:

  45. The Cantabrian Coast horse breeds of the Iberian Peninsula have mainly black or bay colored coats, but alleles responsible for a chestnut coat color run in these breeds and occasionally, chestnut horses are bo...

    Authors: Fernando Rendo, Mikel Iriondo, Carmen Manzano and Andone Estonba

    Citation: BMC Research Notes 2009 2:255

    Content type: Short Report

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