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  1. About 130 million people are infected with the hepatitis C virus (HCV) worldwide, but effective treatment options are not yet available. One of the most promising targets for antiviral therapy is nonstructural...

    Authors: Paola JS Provazzi, Helen A Arcuri, Isabel Maria VG de Carvalho-Mello, João Renato R Pinho, Maurício L Nogueira, Mário S Palma and Paula Rahal
    Citation: BMC Research Notes 2010 3:196
  2. The variability of maternal serum biochemical markers for Down syndrome, free β-hCG and PAPP-A can have a different impact on false-positive rates between the 10+0 and 13+6 week of gestation. The study populat...

    Authors: Dubravka Tišlarić-Medenjak, Ivana Zec, Ana-Maria Šimundić, Senka Sabolović-Rudman, Milan Kos and Željka Bukovec Megla
    Citation: BMC Research Notes 2010 3:194
  3. Routine rapid testing for Bovine Spongiform Encephalopathy (BSE) has highlighted some problems with BSE rapid test performance, the most significant being the number of initially reactive samples and the false...

    Authors: Daniela Meloni, Katia Varello, Marzia Pezzolato, Elsa Manzardo, Maria C Cavarretta, Francesco Ingravalle, Maria Caramelli and Elena Bozzetta
    Citation: BMC Research Notes 2010 3:193
  4. A complete gene-expression microarray should preferably detect all genomic sequences that can be expressed as RNA in an organism, i.e. the transcriptome. However, our knowledge of a transcriptome of any organi...

    Authors: Han Rauwerda, Mark de Jong, Wim C de Leeuw, Herman P Spaink and Timo M Breit
    Citation: BMC Research Notes 2010 3:192
  5. Numerous models, of variable quality, exist to impart the complex skills required to perform vascular anastomosis. These models differ with regard to the kinds of materials used, as well as their sizes, the ti...

    Authors: Philipe N Khalil, Axel Kleespies, Markus Rentsch, Wolfgang E Thasler, Karl-Walter Jauch and Christiane J Bruns
    Citation: BMC Research Notes 2010 3:189
  6. Trauma is a major health problem in the United Arab Emirates (UAE) as well as worldwide. Trauma registries provide large longitudinal databases for analysis and policy improvement. We aim in this paper to repo...

    Authors: Sami Shaban, Hani O Eid, Ezedin Barka and Fikri M Abu-Zidan
    Citation: BMC Research Notes 2010 3:187
  7. The presence of a mass in the nose and paranasal sinuses may seem to be a simple problem; however it raises many questions about the differential diagnosis. The aim of this study is to evaluate the clinico-pat...

    Authors: Aminu Bakari, Olushola A Afolabi, Adeyi A Adoga, Aliyu M Kodiya and Babagana M Ahmad
    Citation: BMC Research Notes 2010 3:186
  8. Polymerase chain reaction (PCR) remains a simple, flexible, and inexpensive method for enriching genomic regions of interest for next-generation sequencing. In order to utilize PCR in this context, a major cha...

    Authors: Andrew MK Brown, Ken Sin Lo, Paul Guelpa, Mélissa Beaudoin, John D Rioux, Jean-Claude Tardif, Michael S Phillips and Guillaume Lettre
    Citation: BMC Research Notes 2010 3:185
  9. Epithelial-stromal interaction provides regulatory signals that maintain correct histoarchitecture and homeostasis in the normal breast and facilitates tumor progression in breast cancer. However, research on ...

    Authors: Saevar Ingthorsson, Valgardur Sigurdsson, Agla JR Fridriksdottir, Jon G Jonasson, Jens Kjartansson, Magnus K Magnusson and Thorarinn Gudjonsson
    Citation: BMC Research Notes 2010 3:184
  10. The data produced by an Illumina flow cell with all eight lanes occupied, produces well over a terabyte worth of images with gigabytes of reads following sequence alignment. The ability to translate such reads...

    Authors: Parsa Hosseini, Arianne Tremblay, Benjamin F Matthews and Nadim W Alkharouf
    Citation: BMC Research Notes 2010 3:183
  11. The iris as a unique identifier is predicated on the assumption that the iris image does not alter. This does not consider the fact that the iris changes in response to certain external factors including medic...

    Authors: Deborah M Rankin, Bryan W Scotney, Philip J Morrow, Douglas R McDowell and Barbara K Pierscionek
    Citation: BMC Research Notes 2010 3:182
  12. Reducing the incidence of Low birth weight (LBW) neonates by at least one third between 2000 and 2010 is one of the major goals of the United Nations resolution "A World Fit for Children". This was a case-cont...

    Authors: Elhassan M Elhassan, Ameer O Abbaker, Abderahuim D Haggaz, Magid S Abubaker and Ishag Adam
    Citation: BMC Research Notes 2010 3:181
  13. A number of health benefits including improvements in acid/base balance, bone metabolism, and cardiovascular risk factors have been attributed to the intake of magnesium rich alkaline mineral water. This study...

    Authors: Richard O Day, Winston Liauw, Lynette MR Tozer, Patrick McElduff, Russell J Beckett and Kenneth M Williams
    Citation: BMC Research Notes 2010 3:180
  14. The Multiplex Ligation-dependent Probe Amplification (MLPA) is widely used for analysis of copy number variations (CNVs) in single or multiple loci. MLPA is a versatile methodology and important tool in cancer...

    Authors: Kristina Pedersen, Emilia Wiechec, Bo E Madsen, Jens Overgaard and Lise Lotte Hansen
    Citation: BMC Research Notes 2010 3:179
  15. Stable isotope probing (SIP) technique was developed to link function, structure and activity of microbial cultures metabolizing carbon and nitrogen containing substrates to synthesize their biomass. Currently...

    Authors: Ingo Fetzer, Nico Jehmlich, Carsten Vogt, Hans-Hermann Richnow, Jana Seifert, Hauke Harms, Martin von Bergen and Frank Schmidt
    Citation: BMC Research Notes 2010 3:178
  16. Health campaigns are frequently covered by printed media, but coverage is not homogeneous across different types of newspapers. Switzerland as a multilinguistic country with many newspapers offers a good field...

    Authors: Carine F Wang-Buholzer, Marta Lomazzi and Bettina Borisch
    Citation: BMC Research Notes 2010 3:177
  17. The prescribing of psychotropic medicines for the paediatric population is rapidly increasing. In attempts to curb the use of psychotropic medicine in the paediatric population, regulatory authorities have iss...

    Authors: Lise Aagaard and Ebba H Hansen
    Citation: BMC Research Notes 2010 3:176
  18. Ontology development is a rapidly growing area of research, especially in the life sciences domain. To promote collaboration and interoperability between different projects, the OBO Foundry principles require ...

    Authors: Zuoshuang Xiang, Mélanie Courtot, Ryan R Brinkman, Alan Ruttenberg and Yongqun He
    Citation: BMC Research Notes 2010 3:175
  19. The display of N-glycan carbohydrate structures is an essential part of glycoinformatics. Several tools exist for building such structures graphically, by selecting from a palette of symbols or sugar names, or el...

    Authors: Andrew G McDonald, Keith F Tipton, Corné JM Stroop and Gavin P Davey
    Citation: BMC Research Notes 2010 3:173
  20. The practical and methodological challenges inherent in online behaviour change studies are both novel and complex. We relate our experiences of estimating and managing information technology (IT) research and...

    Authors: Jim McCambridge, Orla O'Donnell, Christine Godfrey, Zarnie Khadjesari, Stuart Linke, Elizabeth Murray and Paul Wallace
    Citation: BMC Research Notes 2010 3:172
  21. The development of new microarray technologies makes custom long oligonucleotide arrays affordable for many experimental applications, notably gene expression analyses. Reliable results depend on probe design ...

    Authors: Frédérique Bidard, Sandrine Imbeaud, Nancie Reymond, Olivier Lespinet, Philippe Silar, Corinne Clavé, Hervé Delacroix, Véronique Berteaux-Lecellier and Robert Debuchy
    Citation: BMC Research Notes 2010 3:171
  22. As a first step in determining whether psychogenic stressors might be incorporated into periadolescent mouse models of stress, we evaluated whether a commonly used psychogenic stressor, exposure to red fox uri...

    Authors: Christine H Kapelewski, Jeanette M Bennett, Sonia A Cavigelli and Laura C Klein
    Citation: BMC Research Notes 2010 3:170
  23. Diabetic subjects, especially women, show high prevalence of asymptomatic bacteriuria (ASB). The aim of the present study was to evaluate the prevalence of ASB in subjects with type 2 diabetes mellitus (T2D) w...

    Authors: Athanasia Papazafiropoulou, Ioannis Daniil, Alexios Sotiropoulos, Eleni Balampani, Anthi Kokolaki, Stavros Bousboulas, Stavroula Konstantopoulou, Eystathios Skliros, Dimitra Petropoulou and Stavros Pappas
    Citation: BMC Research Notes 2010 3:169
  24. Fragaria belongs to the Rosaceae, an economically important family that includes a number of important fruit producing genera such as Malus and Prunus. Using genomic sequences from 50 Fragaria fosmids, we have ex...

    Authors: Sook Jung, Ilhyung Cho, Bryon Sosinski, Albert Abbott and Dorrie Main
    Citation: BMC Research Notes 2010 3:168
  25. Little is known about prognosis of metastatic patients after receiving a first-line treatment and failure. Our group already showed in pre-treated patients enrolled in phase I clinical trials that a performanc...

    Authors: Rhizlane Belbaraka, Olivier Trédan, Isabelle Ray-Coquard, Giselle Chvetzoff, Agathe Bajard, David Pérol, Nabil Ismaili, Mohammed Ismaili, Hassan Errihani, Thomas Bachelot and Paul Rebattu
    Citation: BMC Research Notes 2010 3:164
  26. The unbound, free concentration (Bf) of unconjugated bilirubin (UCB), and not the total UCB level, has been shown to correlate with bilirubin cytotoxicity, but the key molecular mechanisms accounting for the toxi...

    Authors: Safarina G Malik, K Astrid Irwanto, J Donald Ostrow and Claudio Tiribelli
    Citation: BMC Research Notes 2010 3:162
  27. Acquired hemophilia A (AHA) is a rare bleeding disorder caused by an autoantibody to coagulation factor (F) VIII. It is characterized by soft tissue bleeding in patients without a personal or family history of...

    Authors: Peter Collins, Francesco Baudo, Angela Huth-Kühne, Jørgen Ingerslev, Craig M Kessler, Maria E Mingot Castellano, Midori Shima, Jean St-Louis and Hervé Lévesque
    Citation: BMC Research Notes 2010 3:161
  28. Empirical support for cognitive behavioral therapy (CBT) for treating Japanese patients with major depression is lacking, therefore, a feasibility study of CBT for depression in Japanese clinical settings is u...

    Authors: Daisuke Fujisawa, Atsuo Nakagawa, Miyuki Tajima, Mitsuhiro Sado, Toshiaki Kikuchi, Motomi Hanaoka and Yutaka Ono
    Citation: BMC Research Notes 2010 3:160
  29. The order Carnivora is well represented in India, with 58 of the 250 species found globally, occurring here. However, small carnivores figure very poorly in research and conservation policies in India. This is...

    Authors: Shomita Mukherjee, Ashalakshmi CN, Chandrima Home and Uma Ramakrishnan
    Citation: BMC Research Notes 2010 3:159
  30. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, promoting an immune response to pathogens. Defects in a CRAC (Orai) channel in humans gives rise to the...

    Authors: Madeleine G Matias, Kenny M Gomolplitinant, Dorjee G Tamang and Milton H Saier Jr
    Citation: BMC Research Notes 2010 3:158
  31. Oral lichen planus (OLP) is a chronic autoimmune disease characterized by multiple clinical presentations and a relatively high prevalence in the population. This retrospective patient record study investigate...

    Authors: Mônica Ghislaine Oliveira Alves, Janete Dias Almeida, Ivan Balducci and Luiz Antonio Guimarães Cabral
    Citation: BMC Research Notes 2010 3:157
  32. Fibromyalgia (FM) is characterized by chronic, widespread muscular pain and tenderness and is generally associated with other somatic and psychological symptoms. Further, circulatory levels of proinflammatory ...

    Authors: Maria E Hernandez, Enrique Becerril, Mayra Perez, Philippe Leff, Benito Anton, Sergio Estrada, Iris Estrada, Manuel Sarasa, Enrique Serrano and Lenin Pavon
    Citation: BMC Research Notes 2010 3:156
  33. Myeloperoxidase (MPO), an important element of the microbicidal activity of neutrophils, generates hypochlorous acid (HOCl) from H2O2 and chloride, which is released into body fluids. Besides its direct microbici...

    Authors: Svenja Polzer, Melanie van Yperen, Martin Kirst, Birco Schwalbe, Heiner Schaal and Michael Schreiber
    Citation: BMC Research Notes 2010 3:155
  34. Diabetes mellitus (DM) is associated with microvascular complications, such as diabetic retinopathy (DR). DR is one of the main causes of visual loss in individuals aged 20-64 years old. This study aims to inv...

    Authors: Irini P Chatziralli, Theodoros N Sergentanis, Petros Keryttopoulos, Nikolaos Vatkalis, Antonis Agorastos and Leonidas Papazisis
    Citation: BMC Research Notes 2010 3:153
  35. In the last years, plants are being used for the production of a wide variety of biopharmaceuticals, including cytokines, and have the potential to serve as vehicles for mucosal administration of these molecul...

    Authors: Carla Sánchez-Hernández, Abel Gutiérrez-Ortega, Diana Aguilar-León, Rogelio Hernández-Pando, Miguel Gómez-Lim and Beatriz Gómez-García
    Citation: BMC Research Notes 2010 3:151
  36. From shotgun libraries used for the genomic sequencing of the phytopathogenic bacterium Xanthomonas axonopodis pv. citri (XAC), clones that were representative of the largest possible number of coding sequences (...

    Authors: Leandro M Moreira, Marcelo L de Laia, Robson F de Souza, Paulo A Zaini, Ana CR da Silva, Aline M da Silva and Jesus A Ferro
    Citation: BMC Research Notes 2010 3:150
  37. Disturbances in motor activity pattern are seen in both schizophrenia and depression. However, this activity has rarely been studied objectively. The purpose of the present study has been to study the complexi...

    Authors: Jan O Berle, Erik R Hauge, Ketil J Oedegaard, Fred Holsten and Ole B Fasmer
    Citation: BMC Research Notes 2010 3:149
  38. Banana is a nutritionally important crop across tropical and sub-tropical countries in sub-Saharan Africa, Central and South America and Asia. Although cultivars have evolved from diploid, triploid and tetrapl...

    Authors: Robert NG Miller, Marco AN Passos, Natalia NP Menezes, Manoel T Souza Jr, Marcos M do Carmo Costa, Vânia C Rennó Azevedo, Edson P Amorim, Georgios J Pappas Jr and Ana Y Ciampi
    Citation: BMC Research Notes 2010 3:148
  39. Next-generation sequencing produces high-throughput data, albeit with greater error and shorter reads than traditional Sanger sequencing methods. This complicates the detection of genomic variations, especiall...

    Authors: Hossein Khiabanian, Pieter Van Vlierberghe, Teresa Palomero, Adolfo A Ferrando and Raul Rabadan
    Citation: BMC Research Notes 2010 3:147
  40. Conjugation of small ubiquitin-related modifiers (SUMOs) is a frequent post-translational modification of proteins. SUMOs can also temporally associate with protein-targets via SUMO binding motifs (SBMs). Prot...

    Authors: Sebastian Eilebrecht, Caroline Smet-Nocca, Jean-Michel Wieruszeski and Arndt Benecke
    Citation: BMC Research Notes 2010 3:146

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