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  1. To analyze gene function in mammalian cells tetracycline inducible expression of a gene-of-interest at a specific genomic location (Flp-In T-REx™) is most attractive. However, leakiness of basal transgene expr...

    Authors: Sabine Senkel, Christoph Waldner, Gerhart U Ryffel and Heike Thomas
    Citation: BMC Research Notes 2009 2:210
  2. Bovine herpesviruses type 1 (BoHV1) and type 5 (BoHV5) are two closely related pathogens of cattle. The identity of the two viruses on the amino acid level averages 82%. Despite their high antigenetic similari...

    Authors: Evgeni Gabev, Cornel Fraefel, Mathias Ackermann and Kurt Tobler
    Citation: BMC Research Notes 2009 2:209
  3. There is little confidence in the consistency of estimation of DNA concentrations when samples move between laboratories. Evidence on this consistency is largely anecdotal. Therefore there is a need first to m...

    Authors: Jay Brown, Alexander N Donev, Charalampos Aslanidis, Pippa Bracegirdle, Katherine P Dixon, Manuela Foedinger, Rhian Gwilliam, Matthew Hardy, Thomas Illig, Xiayi Ke, Dagni Krinka, Camilla Lagerberg, Päivi Laiho, David H Lewis, Wendy McArdle, Simon Patton…
    Citation: BMC Research Notes 2009 2:208
  4. Deschampsia antarctica shows tolerance to extreme environmental factors such as low temperature, high light intensity and an increasing UV radiation as result of the Antarctic ozone layer thinning. It is very lik...

    Authors: Jaime R Sánchez-Venegas, Alejandro Navarrete, Jorge Dinamarca, León A Bravo Ramírez, Ana Gutiérrez Moraga and Manuel Gidekel
    Citation: BMC Research Notes 2009 2:207
  5. Our SigWin-detector discovers significantly enriched windows of (genomic) elements in any sequence of values (genes or other genomic elements in a DNA sequence) in a fast and reproducible way. However, since i...

    Authors: Wim C de Leeuw, Han Rauwerda, Márcia A Inda, Oskar Bruning and Timo M Breit
    Citation: BMC Research Notes 2009 2:205
  6. The reindeer lichen is the product of a mutualistic relationship between a fungus and an algae. Lichen demonstrate a remarkable capacity to tolerate dehydration. This tolerance is driven by a variety of bioche...

    Authors: Sini Junttila, Kean-Jin Lim and Stephen Rudd
    Citation: BMC Research Notes 2009 2:204
  7. BMI was increased (>25) in 22% of young healthy subjects. Increased cholesterol values (>5.0 mmol/L) were found in 23% of subjects, LDL-C (>3.0 mmol/L) in 23%, triglycerides (>1.7 mmol/L) in 11% of subjects. W...

    Authors: Jadranka Sertic, Ljiljana Juricic, Hana Ljubic, Tamara Bozina, Jasna Lovric, Jasenka Markeljevic, Bojan Jelakovic, Marijan Merkler and Zeljko Reiner
    Citation: BMC Research Notes 2009 2:203
  8. The availability of research platforms like the web tools of the National Center for Biotechnology Information (NCBI) has transformed the time-consuming task of identifying candidate genes from genetic studies...

    Authors: Rajani S Sadasivam, Gayathri Sundar, Laura K Vaughan, Murat M Tanik and Donna K Arnett
    Citation: BMC Research Notes 2009 2:201
  9. In cancer care, a GP's work is rarely defined clearly. Our aim was to assess GPs' work with cancer patients in France and in Norway, where the roles of the GP and the organization of the system are rather diff...

    Authors: Lise Demagny, Knut Holtedahl, Janine Bachimont, Tommy Thorsen, Alain Letourmy and Martine Bungener
    Citation: BMC Research Notes 2009 2:200
  10. Consolidating transcriptome data of non-human primates is essential to annotate primate genome sequences, and will facilitate research using non-human primates in the genomic era. Macaca fascicularis is a macaque...

    Authors: Naoki Osada, Makoto Hirata, Reiko Tanuma, Yutaka Suzuki, Sumio Sugano, Keiji Terao, Jun Kusuda, Yosuke Kameoka, Katsuyuki Hashimoto and Ichiro Takahashi
    Citation: BMC Research Notes 2009 2:199
  11. The Copper/Zinc superoxide dismutase (Cu/ZnSOD) gene, SOD gene, was isolated from a Deschampsia antarctica Desv. by cDNA library screening. The expression of SOD gene in the leaves of D. antarctica was determined...

    Authors: Jaime R Sánchez-Venegas, Jorge Dinamarca, Ana Gutiérrez Moraga and Manuel Gidekel
    Citation: BMC Research Notes 2009 2:198
  12. Our aim was to develop an objective computerised system for measuring different types of retinal haemorrhages in differing digital images, for use as a research tool. Despite developing various fully automated...

    Authors: Tariq Aslam, Paul Chua, Matthew Richardson, Praveen Patel and Mohammed Musadiq
    Citation: BMC Research Notes 2009 2:196
  13. The functional integration of the neuro-, endocrine- and immune-systems suggests that the transcriptome of white blood cells may reflect neuropsychiatric states, and be used as a non-invasive diagnostic indica...

    Authors: Johan H van Heerden, Ana Conesa, Dan J Stein, David Montaner, Vivienne Russell and Nicola Illing
    Citation: BMC Research Notes 2009 2:195
  14. Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also known to act as tumour suppressor genes. Increased succinate or fumarate levels as a consequen...

    Authors: Katie T Huang, Alexander Dobrovic and Stephen B Fox
    Citation: BMC Research Notes 2009 2:194
  15. Mitochondria (mt) contain their own autonomously replicating DNA, constituted as a small circular genome encoding essential subunits of the respiratory chain. Mt DNA is characterized by a genetic code which di...

    Authors: Joachim EM Jacob, Bartel Vanholme, Thomas Van Leeuwen and Godelieve Gheysen
    Citation: BMC Research Notes 2009 2:192
  16. Bub1 is a component of the spindle assembly checkpoint, a surveillance mechanism that maintains chromosome stability during M-phase. Bub1 is essential during the early stages of embryogenesis, with homozygous BUB...

    Authors: Valerie Tilston, Stephen S Taylor and David Perera
    Citation: BMC Research Notes 2009 2:190
  17. Saffron (Crocus sativus) is considered the world's most expensive spice. Used mainly as a colorant for foodstuffs, it is highly appreciated for its aromatic and flavouring properties. Since no molecular markers f...

    Authors: Angela Rubio-Moraga, Raquel Castillo-López, Lourdes Gómez-Gómez and Oussama Ahrazem
    Citation: BMC Research Notes 2009 2:189
  18. The cultivated strawberry Fragaria ×ananassa is one of the most economically-important soft-fruit species. Few structural genomic resources have been reported for Fragaria and there exists an urgent need for the ...

    Authors: Julio Bonet, Elena Lopez Girona, Daniel J Sargent, Monica C Muñoz-Torres, Amparo Monfort, Albert G Abbott, Pere Arús, David W Simpson and Jahn Davik
    Citation: BMC Research Notes 2009 2:188
  19. The rK39 strip test is reported to be simple, sensitive, specific, non-invasive and economical test. Since this method is supposed to be patient friendly, it may easily be accepted for sero-epidemiological sur...

    Authors: Dharmendra P Singh, Shyam Sundar and Tribhuban M Mohapatra
    Citation: BMC Research Notes 2009 2:187
  20. Post caesarean wound infection is not only a leading cause of prolonged hospital stay but a major cause of the widespread aversion to caesarean delivery in developing countries. In order to control and prevent...

    Authors: Oliver C Ezechi, Asuquo Edet, Hakim Akinlade, Chidinma V Gab-Okafor and Ebiere Herbertson
    Citation: BMC Research Notes 2009 2:186
  21. Though the biological process of aphid feeding is well documented, no one to date has sought to apply it as a tool to screen the biological responses to chemicals and drugs, in ecotoxicology, genotoxicology an...

    Authors: Aviv Dombrovsky, Terence Neil Ledger, Gilbert Engler and Alain Robichon
    Citation: BMC Research Notes 2009 2:185
  22. In eusocial hymenopteran insects, foraging genes, members of the cGMP-dependent protein kinase family, are considered to contribute to division of labor through behavioral caste differentiation. However, the rela...

    Authors: Yosuke Kodaira, Hajime Ohtsuki, Jun Yokoyama and Masakado Kawata
    Citation: BMC Research Notes 2009 2:184
  23. Comparative genome mapping determines the linkage between homologous genes of related taxa. It has already been used in plants to characterize agronomically important genes in lesser studied species, using inf...

    Authors: Jean-Marc Celton, David Chagné, Stuart D Tustin, Shingo Terakami, Chikako Nishitani, Toshiya Yamamoto and Susan E Gardiner
    Citation: BMC Research Notes 2009 2:182
  24. The transmissible spongiform encephalopathies (TSEs) comprise a group of fatal degenerative neurological diseases in humans and other mammals. After infection, the cellular prion protein isoform PrPC is converted...

    Authors: Michael J Taheny, Nerik Izkhakov, Alexander A Vostrov and Wolfgang W Quitschke
    Citation: BMC Research Notes 2009 2:178
  25. Fragile × syndrome is caused by loss of expression of the FMRP protein involved in the control of a large number of mRNA targets. The Drosophila ortholog dFXR interacts with a protein complex that includes Arg...

    Authors: Charlotte Madsen, Karen Grønskov, Karen Brøndum-Nielsen and Thomas G Jensen
    Citation: BMC Research Notes 2009 2:177
  26. Discrete RNA structures such as cis-acting replication elements (cre) in the coding region of RNA virus genomes create characteristic suppression of synonymous site variability (SSSV). Different phylogenetic meth...

    Authors: Matías Victoria, Rodney Colina, Marize Pereira Miagostovich, José P Leite and Juan Cristina
    Citation: BMC Research Notes 2009 2:176
  27. Zbtb7A is a proto-oncogenic transcriptional regulator that plays an important role in adipogenesis, osteogenesis and oncogenesis, but little is known about the regulation of Zbtb7A gene expression which is of ...

    Authors: Xuyu Zu, Lingling Yu, Qinsheng Sun, Feng Liu, Jue Wang, Zhenhua Xie, Ying Wang, Wei Xu and Yuyang Jiang
    Citation: BMC Research Notes 2009 2:175
  28. Neuro-imaging studies demonstrate plasticity of cortical gray matter before and after practice for some motor and cognitive tasks in adults. Other imaging studies show functional changes after practice, but th...

    Authors: Richard J Haier, Sherif Karama, Leonard Leyba and Rex E Jung
    Citation: BMC Research Notes 2009 2:174
  29. Although the Jamaica road traffic act mandates motorcycle riders to wear approved helmets, opponents suggest that the local road conditions obviate any benefits from helmet use that have been proven in Develop...

    Authors: Ivor W Crandon, Hyacinth E Harding, Shamir O Cawich, Morton AC Frankson, Georgiana Gordon-Strachan, Noel McLennon, Archibald H McDonald, Doreen Fearon-Boothe, Nicole Meeks-Aitken, Karen Watson-Jones and Kenneth C James
    Citation: BMC Research Notes 2009 2:172
  30. Guillain-Barré Syndrome (GBS), the leading cause of acute flaccid paralysis worldwide, is an autoimmune disorder involving the loss of the myelin sheaths encasing peripheral nerve axons, leading to a loss of n...

    Authors: Laura Nelson, Robert Gormley, Mark S Riddle, David R Tribble and Chad K Porter
    Citation: BMC Research Notes 2009 2:171
  31. Recent studies investigating off-line processes of consolidation in motor learning have demonstrated a sudden, short-lived improvement in performance after 5–30 minutes of post-training inactivity. Here, we in...

    Authors: Remy Schmitz, Manuel Schabus, Fabien Perrin, André Luxen, Pierre Maquet and Philippe Peigneux
    Citation: BMC Research Notes 2009 2:170
  32. Identifying the endogenous RNA induced silencing complex(RISC)-associated RNAs is essential for understanding the cellular regulatory networks by miRNAs. Recently, isolation of RISC-associated mRNAs using anti...

    Authors: Yukinobu Hayashida, Takahiro Nishibu, Kunio Inoue and Tsutomu Kurokawa
    Citation: BMC Research Notes 2009 2:169
  33. Viruses and small-genome bacteria (~2 megabases and smaller) comprise a considerable population in the biosphere and are of interest to many researchers. These genomes are now sequenced at an unprecedented rat...

    Authors: Padmanabhan Mahadevan, John F King and Donald Seto
    Citation: BMC Research Notes 2009 2:168
  34. The expression of vaccine antigens in lactic acid bacteria (LAB) is a safe and cost-effective alternative to traditional expression systems. In this study, we investigated i) the expression of Human papillomav...

    Authors: Naima G Cortes-Perez, Pascale Kharrat, Philippe Langella and Luis G Bermúdez-Humarán
    Citation: BMC Research Notes 2009 2:167
  35. Haemophilus influenzae requires a porphyrin source for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient. This porphyrin requirement may be satisfied by either heme alone, or prot...

    Authors: Daniel J Morton, Thomas W Seale, Timothy M VanWagoner, Paul W Whitby and Terrence L Stull
    Citation: BMC Research Notes 2009 2:166
  36. It was hypothesised that colorectal cancer (CRC) could be diagnosed in biopsies by measuring the combined expression of a small set of well known genes. Genes were chosen based on their role in either the brea...

    Authors: Caroline A Kerr, Robert Dunne, Barney M Hines, Michelle Zucker, Leah Cosgrove, Andrew Ruszkiewicz, Trevor Lockett and Richard Head
    Citation: BMC Research Notes 2009 2:164
  37. Venturia inaequalis is an economically-important disease of apple causing annual epidemics of scab worldwide. The pathogen is a heterothallic ascomycete with an annual cycle of sexual reproduction on infected app...

    Authors: Xiangming Xu, Tony Roberts, Dez Barbara, Nick G Harvey, Liqiang Gao and Daniel J Sargent
    Citation: BMC Research Notes 2009 2:163
  38. In view of the role of TLR2 activation in host defense against mycobacteria, the present study was conducted to examine whether TLR2 polymorphisms could account for the increased prevalence of tuberculosis in ...

    Authors: Debasis Biswas, Shailendra K Gupta, Girish Sindhwani and Abhishek Patras
    Citation: BMC Research Notes 2009 2:162

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