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  1. Hepatocellular carcinoma (HCC) is a preventable disease rather than a curable one, since there is no well-documented effective treatment modality until now, making the molecular study of this disease mandatory.

    Authors: Abdel-Rahman N Zekri, Mohamed M Hafez, Abeer A Bahnassy, Zeinab K Hassan, Tarek Mansour, Mahmoud M Kamal and Hussein M Khaled

    Citation: BMC Research Notes 2008 1:106

    Content type: Short Report

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  2. Bartonellosis due to Bartonella bacilliformis is a highly lethal endemic and sometimes epidemic infectious disease in South America, and a serious public health concern in Perú. There is limited information on th...

    Authors: Beronica Infante, Sandra Villar, Sandra Palma, Jenny Merello, Roberto Valencia, Luis Torres, Jamie Cok, Palmira Ventosilla, Ciro Manguiña, Humberto Guerra and Cesar Henriquez

    Citation: BMC Research Notes 2008 1:103

    Content type: Short Report

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  3. This paper reports the outcome of gefitinib for Chinese advanced NSCLC patients with poor performance status (PS) at the Peking Union Medical College Hospital.

    Authors: Zhong Wei, Wang Mengzhao, Zhang Li, Li Longyun and Zhang Xiaotong

    Citation: BMC Research Notes 2008 1:102

    Content type: Short Report

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  4. Depression is common among diabetic subjects. We conducted the present study to estimate the prevalence of depression in subjects with type 2 diabetes (T2D) in Greece.

    Authors: Alexios Sotiropoulos, Athanasia Papazafiropoulou, Ourania Apostolou, Anthi Kokolaki, Aristofanis Gikas and Stavros Pappas

    Citation: BMC Research Notes 2008 1:101

    Content type: Short Report

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  5. Little is known about the physiological role of the EBER1 and 2 nuclear RNAs during Epstein Barr viral infection. The EBERs are transcribed by cellular RNA Polymerase III and their strong expression results in 10

    Authors: Sebastian Eilebrecht, François-Xavier Pellay, Peter Odenwälder, Guillaume Brysbaert, Bernd-Joachim Benecke and Arndt Benecke

    Citation: BMC Research Notes 2008 1:100

    Content type: Short Report

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  6. Prions, the infectious agents that cause transmissible spongiform encephalopathies (TSEs), are relatively resistant to destruction by physical, enzymatic, and chemical treatments. Hydrolysis in boiling saturat...

    Authors: Justin J Greenlee, Eric M Nicholson, Amir N Hamir, Gary P Noyes, Mark T Holtzapple and Marcus E Kehrli Jr

    Citation: BMC Research Notes 2008 1:99

    Content type: Short Report

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  7. Echocardiography is a non-invasive, relatively cheap and useful imaging technique for the evaluation of cardiac diseases. The procedure has reliable levels of accuracy.

    Authors: Okechukwu S Ogah, Gail D Adegbite, Rufus O Akinyemi, Julius O Adesina, Albert A Alabi, Oscar I Udofia, Roseline F Ogundipe and Julius KL Osinfade

    Citation: BMC Research Notes 2008 1:98

    Content type: Short Report

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  8. SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signalling pathway mediated by phosphatidylinositol 3-kinase (PI3K) i...

    Authors: Yuichiro Nishida, Naoki Adati, Ritsuko Ozawa, Aasami Maeda, Yoshiyuki Sakaki and Tadayuki Takeda

    Citation: BMC Research Notes 2008 1:95

    Content type: Short Report

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  9. Molecular studies of Bacillus diversity in various environments have been reported. However, there have been few investigations concerning Bacillus in steel plant environments. In this study, genotypic and phenot...

    Authors: Dulcecleide B Freitas, Mariana P Reis, Cláudia I Lima-Bittencourt, Patrícia S Costa, Paulo S Assis, Edmar Chartone-Souza and Andréa MA Nascimento

    Citation: BMC Research Notes 2008 1:92

    Content type: Short Report

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  10. The function of a noncoding RNA sequence is mainly determined by its secondary structure and therefore a family of noncoding RNA sequences is much more conserved on the structural level than on the sequence le...

    Authors: Philipp N Seibel, Tobias Müller, Thomas Dandekar and Matthias Wolf

    Citation: BMC Research Notes 2008 1:91

    Content type: Short Report

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  11. In clinical practice, surgeons differentiate color changes in repaired cartilage compared with surrounding intact cartilage, but cannot quantify these color changes. Objective assessments are required. A spect...

    Authors: Koji Hattori, Kota Uematsu, Hiroaki Matsumori, Yoshihiro Dohi, Yoshinori Takakura and Hajime Ohgushi

    Citation: BMC Research Notes 2008 1:87

    Content type: Short Report

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  12. A subset of cutaneous malignant melanoma and dysplastic nevi (CMM/DN) families is linked to 1p36. To date, no CMM/DN susceptibility gene has been identified at this locus. Data from mouse studies identified ch...

    Authors: David Ng, Xiaohong R Yang, Margaret A Tucker and Alisa M Goldstein

    Citation: BMC Research Notes 2008 1:86

    Content type: Short Report

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  13. In the present pilot study we applied recently published protocols for detecting Mycobacterium tuberculosis in human remains. We screened long bones from an 18th century cemetery and skulls from the anatomical "W...

    Authors: Lutz Bachmann, Barbara Däubl, Charlotte Lindqvist, Luise Kruckenhauser, Maria Teschler-Nicola and Elisabeth Haring

    Citation: BMC Research Notes 2008 1:83

    Content type: Short Report

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  14. Although reciprocal regulation of protein phosphorylation represents a key aspect of signal transduction, a larger perspective on how these various interactions integrate to contribute towards signal processin...

    Authors: Dhiraj Kumar, Raina Dua, Ravichandran Srikanth, Shilpi Jayaswal, Zaved Siddiqui and Kanury VS Rao

    Citation: BMC Research Notes 2008 1:81

    Content type: Short Report

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  15. Image analysis of microarrays and, in particular, spot quantification and spot quality control, is one of the most important steps in statistical analysis of microarray data. Recent methods of spot quality con...

    Authors: Mikalai Yatskou, Eugene Novikov, Guillaume Vetter, Arnaud Muller, Emmanuel Barillot, Laurent Vallar and Evelyne Friederich

    Citation: BMC Research Notes 2008 1:80

    Content type: Short Report

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  16. Renal colic (RC), is one of the most severe pain patterns which is most commonly diagnosed and managed in the emergency department (ED). This study is designed to evaluate the characteristics of adult patients...

    Authors: Mustafa Serinken, Ozgur Karcioglu, Ibrahim Turkcuer, Halis Ilke Ozkan, Mustafa Kemal Keysan and Aytaç Bukiran

    Citation: BMC Research Notes 2008 1:79

    Content type: Short Report

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  17. Tartrate-resistant acid phosphatases (TRAcPs), also known as purple acid phosphatases (PAPs), are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The human enzym...

    Authors: Kieran S Hadler, Thomas Huber, A Ian Cassady, Jane Weber, Jodie Robinson, Allan Burrows, Gregory Kelly, Luke W Guddat, David A Hume, Gerhard Schenk and Jack U Flanagan

    Citation: BMC Research Notes 2008 1:78

    Content type: Short Report

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  18. To explore adolescent HIV risk perception, HIV vaccine knowledge, willingness to participate in future HIV vaccine clinical trials, and the factors that influence willingness to participate among high school s...

    Authors: Guy de Bruyn, Nokuthula Skhosana, Gavin Robertson, James A McIntyre and Glenda E Gray

    Citation: BMC Research Notes 2008 1:76

    Content type: Short Report

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  19. Coenzyme A (CoA) is an essential metabolite, synthesized from vitamin B5 by the subsequent action of five enzymes: PANK, PPCS, PPCDC, PPAT and DPCK. Mutations in Drosophila dPPCS disrupt female fecundity and in t...

    Authors: Floris Bosveld, Anil Rana, Willy Lemstra, Harm H Kampinga and Ody CM Sibon

    Citation: BMC Research Notes 2008 1:75

    Content type: Short Report

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  20. Shigellosis is one of the major causes of morbidity in children with diarrhea in Iran. The present study was undertaken to characterize apparently sporadic Shigella boydii strains isolated from pediatric patients...

    Authors: Reza Ranjbar, Caterina Mammina, Mohammad R Pourshafie and Mohammad M Soltan-Dallal

    Citation: BMC Research Notes 2008 1:74

    Content type: Short Report

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  21. Transient ischemic attack (TIA) is described as a brief episode of neurological dysfunction caused by focal brain ischemia, with clinical symptoms typically lasting less than an hour, and without evidence of a...

    Authors: Ayeesha Kamal, Farhad Khimani, Rushna Raza, Sahar Zafar, Salman Bandeali and Sayeedullah Jan

    Citation: BMC Research Notes 2008 1:73

    Content type: Project Note

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  22. Huanglongbing (HLB, previously known as citrus greening), is associated with Candidatus Liberibacter species and is a serious threat to citrus production world-wide. The pathogen is a Gram negative, unculturable,...

    Authors: Harshavardhan Doddapaneni, Huihong Liao, Hong Lin, Xianjin Bai, Xiaolong Zhao, Edwin L Civerolo, Michael Irey, Helvecio Coletta-Filho and Gerhard Pietersen

    Citation: BMC Research Notes 2008 1:72

    Content type: Short Report

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  23. Circulating endothelial cells (CEC) and endothelial precursor cells (CEP) have been suggested as markers for angiogenesis in cancer. However, CEC/CEP represent a tiny and heterogeneous cell population, renderi...

    Authors: Michael Steurer, Johann Kern, Matthias Zitt, Albert Amberger, Monika Bauer, Günther Gastl, Gerold Untergasser and Eberhard Gunsilius

    Citation: BMC Research Notes 2008 1:71

    Content type: Short Report

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  24. PCR inhibition by nucleic acid extracts is a well known yet poorly described phenomenon. Inhibition assessment generally depends on the assumption that inhibitors affect all PCR reactions to the same extent; i...

    Authors: Jim F Huggett, Tanya Novak, Jeremy A Garson, Clare Green, Stephen D Morris-Jones, Robert F Miller and Alimuddin Zumla

    Citation: BMC Research Notes 2008 1:70

    Content type: Short Report

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  25. With high levels of obesity and related illness, improving the health of the nation is a major public health concern. This study aimed to identify factors that prevent healthy eating among doctors, and that ar...

    Authors: James Winston, Carol Johnson and Sue Wilson

    Citation: BMC Research Notes 2008 1:69

    Content type: Short Report

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  26. Mier1 encodes a novel transcriptional regulator and was originally isolated as a fibroblast growth factor early response gene. Two major protein isoforms have been identified, MIER1α and β, which differ in their ...

    Authors: Tina M Blackmore, Corinne F Mercer, Gary D Paterno and Laura L Gillespie

    Citation: BMC Research Notes 2008 1:68

    Content type: Short Report

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  27. G protein-coupled receptors (GPCRs) play important physiological roles transducing extracellular signals into intracellular responses. Approximately 50% of all marketed drugs target a GPCR. There remains consi...

    Authors: Matthew N Davies, Andrew Secker, Mark Halling-Brown, David S Moss, Alex A Freitas, Jon Timmis, Edward Clark and Darren R Flower

    Citation: BMC Research Notes 2008 1:67

    Content type: Technical Note

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  28. Affymetrix GeneChips can be re-annotated at the probe-level by breaking up the original probe-sets and recomposing new probe-sets based on up-to-date genomic knowledge, such as available in Entrez Gene. This r...

    Authors: Wim C de Leeuw, Han Rauwerda, Martijs J Jonker and Timo M Breit

    Citation: BMC Research Notes 2008 1:66

    Content type: Technical Note

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  29. With the advent of increasingly efficient means to obtain genetic information, a great insurgence of data has resulted, leading to the need for methods for analyzing this data beyond that of traditional parame...

    Authors: Alison A Motsinger-Reif, Theresa J Fanelli, Anna C Davis and Marylyn D Ritchie

    Citation: BMC Research Notes 2008 1:65

    Content type: Short Report

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  30. Streptococcus pneumoniae infection starts from colonization of the host respiratory tract where interaction with host respiratory tract epithelial cells occurs. To investigate pneumococcal genes that are involved...

    Authors: Xin-Ming Song, Wayne Connor, Karsten Hokamp, Lorne A Babiuk and Andrew A Potter

    Citation: BMC Research Notes 2008 1:64

    Content type: Short Report

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  31. Chromosome location is often used as a scaffold to organize genomic information in both the living cell and molecular biological research. Thus, ever-increasing amounts of data about genomic features are store...

    Authors: Márcia A Inda, Marinus F van Batenburg, Marco Roos, Adam SZ Belloum, Dmitry Vasunin, Adianto Wibisono, Antoine HC van Kampen and Timo M Breit

    Citation: BMC Research Notes 2008 1:63

    Content type: Technical Note

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  32. There has been significant growth in the number of healthcare workers born outside the UK or recruited to the UK from countries with a high prevalence of TB, Hepatitis and other blood borne infections. Governm...

    Authors: Joanne M Alner, David Hagen, Sue Andrews, Rachel Loveday and Hugo C van Woerden

    Citation: BMC Research Notes 2008 1:62

    Content type: Short Report

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  33. Wheat, barley, and rye, of tribe Triticeae in the Poaceae, are among the most important crops worldwide but they present many challenges to genomics-aided crop improvement. Brachypodium distachyon, a close relati...

    Authors: Esteban Bortiri, Devin Coleman-Derr, Gerard R Lazo, Olin D Anderson and Yong Q Gu

    Citation: BMC Research Notes 2008 1:61

    Content type: Short Report

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  34. An abundantly growing body of literature implicates conjugation of SUMO in the regulation of many proteins and processes, yet the regulation of SUMO pathways is poorly understood. To gain insight into the play...

    Authors: Brian J Wilson

    Citation: BMC Research Notes 2008 1:60

    Content type: Correspondence

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  35. The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drug-resistant M. tuberculosis including MDR var...

    Authors: Willy Urassa, Ferdinand Mugusi, Eduardo Villamor, Gernard Msamanga, Candida Moshiro, Ronald Bosch, Elmar Saathoff and Wafaie Fawzi

    Citation: BMC Research Notes 2008 1:58

    Content type: Short Report

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  36. The human CD44 gene contains 10 variable exons (v1 to v10) that can be alternatively spliced to generate hundreds of different CD44 protein isoforms. Human CD44 variable exon v3 inclusion in the final mRNA dep...

    Authors: Elena Vela, Josep M Hilari, María Delclaux, Hugo Fernández-Bellon and Marcos Isamat

    Citation: BMC Research Notes 2008 1:57

    Content type: Short Report

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  37. Some array comparative genomic hybridisation (array CGH) platforms require a minimum of micrograms of DNA for the generation of reliable and reproducible data. For studies where there are limited amounts of ge...

    Authors: Bente A Talseth-Palmer, Nikola A Bowden, Alyssa Hill, Cliff Meldrum and Rodney J Scott

    Citation: BMC Research Notes 2008 1:56

    Content type: Short Report

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