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  1. We have analysed the distribution of post mortem DNA damage derived miscoding lesions from the datasets of seven published Neandertal specimens that have extensive cloned sequence coverage over the mitochondrial ...

    Authors: Sergi Vives, M Thomas Gilbert, Conchita Arenas, Elena Gigli, Oscar Lao and Carles Lalueza-Fox
    Citation: BMC Research Notes 2008 1:40
  2. Acupuncture is commonly used to treat chronic sinusitis, though there is little documentation on the effect. This study presents the health-related quality of life (HRQoL) outcomes in a trial comparing traditi...

    Authors: Knut Stavem, Edna Røssberg and Pål G Larsson
    Citation: BMC Research Notes 2008 1:37
  3. Electron micrographs of bacteriophage T7 reveal a tail shorter than needed to reach host cytoplasm during infection-initiating injection of a T7 DNA molecule through the tail and cell envelope. However, recent...

    Authors: Philip Serwer, Elena T Wright, Kevin W Hakala and Susan T Weintraub
    Citation: BMC Research Notes 2008 1:36
  4. The aim of this study was to evaluate a simple diagnostic test for Gilbert's syndrome (GS), which avoids hospitalization and exposure to toxic test substrates. GS is the most frequent cause of isolated unconju...

    Authors: Niels Teich, Inken Lehmann, Jonas Rosendahl, Michael Tröltzsch, Joachim Mössner and Ingolf Schiefke
    Citation: BMC Research Notes 2008 1:35
  5. Classical and atypical bovine spongiform encephalopathies (BSEs) are cattle prion diseases. Distinct bovine prion gene (PRNP) alleles have been associated with classical and atypical BSE susceptibility. However, ...

    Authors: Michael L Clawson, Michael P Heaton, John W Keele, Timothy PL Smith, Gregory P Harhay, Juergen A Richt and William W Laegreid
    Citation: BMC Research Notes 2008 1:32
  6. The Swine Leukocyte Antigen (SLA) system encodes molecules for self-nonself discrimination and is associated with immune responses and disease resistance. Three lines of pigs defined by their SLA-DRB1 alleles ...

    Authors: Maria I Nino-Soto, Razi Jafari Jozani, Byram Bridle and Bonnie A Mallard
    Citation: BMC Research Notes 2008 1:31
  7. We have created a software implementation of a published and verified method for assigning probabilities to potential phosphorylation sites on peptides using mass spectrometric data. Our tool, named PhosCalc, ...

    Authors: Daniel MacLean, Michael A Burrell, David J Studholme and Alexandra ME Jones
    Citation: BMC Research Notes 2008 1:30
  8. During pregnancy the mammary epithelium undergoes a complex developmental process which culminates in the generation of the milk-secreting epithelium. Secretory epithelial cells display lactogenic differentiat...

    Authors: Richard Jäger, Leontios Pappas and Hubert Schorle
    Citation: BMC Research Notes 2008 1:29
  9. Vigna radiata, which is classified in the family Fabaceae, is an important economic crop and a dietary staple in many developing countries. The species radiata can be further subdivided into varieties of which th...

    Authors: Noelle A Barkley, Ming L Wang, Athey G Gillaspie, Rob E Dean, Gary A Pederson and Tracie M Jenkins
    Citation: BMC Research Notes 2008 1:28
  10. Cervical cancer is increasing at 1.5% per year in Ireland with 50% mortality giving 2.2% of all cancer deaths. In the Mid-West region a pilot screening programme has begun to screen all women 25–60 years. 66% ...

    Authors: Catherine O'Connor, Helena Myles, Mortimer B O'Connor, Josephine Clancy, Ailis Ryan, Mary Traynor, Dolores McGrath and Kitty O'Sullivan
    Citation: BMC Research Notes 2008 1:24
  11. Less than half of U.S. hospitals meet guidelines for prompt treatment of ST-segment elevation myocardial infarction (STEMI). The Door-to-Balloon (D2B) Alliance is a collaborative effort of more than 900 hospit...

    Authors: Elizabeth H Bradley, Brahmajee K Nallamothu, Amy F Stern, Jason R Byrd, Emily J Cherlin, Yongfei Wang, Christina Yuan, Ingrid Nembhard, John E Brush Jr and Harlan M Krumholz
    Citation: BMC Research Notes 2008 1:23
  12. An accurate gene expression quantification using TaqMan Arrays (TA) could be limited by the low RNA quantity obtained from some clinical samples. The novel cDNA preamplification system, the TaqMan PreAmp Maste...

    Authors: Lourdes Mengual, Moisès Burset, Mercedes Marín-Aguilera, María José Ribal and Antonio Alcaraz
    Citation: BMC Research Notes 2008 1:21
  13. Alzheimer's disease (AD) is a progressive, neurodegenerative disease mostly affecting the basal forebrain, cortex and hippocampus whereas the cerebellum is relatively spared. The reason behind this region-spec...

    Authors: Sachin Patil, Deebika Balu, Joseph Melrose and Christina Chan
    Citation: BMC Research Notes 2008 1:20
  14. Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis ...

    Authors: Markus Ralser and Ivor J Benjamin
    Citation: BMC Research Notes 2008 1:19
  15. Variance-stabilizing techniques have been used for some time in the analysis of gene expression microarray data. A new adaptation, the variance-stabilizing transformation (VST), has recently been developed to ...

    Authors: Mark J Dunning, Matthew E Ritchie, Nuno L Barbosa-Morais, Simon Tavaré and Andy G Lynch
    Citation: BMC Research Notes 2008 1:18
  16. The use of methods, both sensitive and specific, for rabies diagnosis are important tools for the control and prophylaxis of the disease. Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) has been used ...

    Authors: Danielle B Araújo, Helio Langoni, Marilene F Almeida and Jane Megid
    Citation: BMC Research Notes 2008 1:17
  17. Ultrastructural and biochemical abnormalities of mitochondria have been reported in skeletal muscle biopsies of CADASIL patients with mutations in the NOTCH3 nuclear gene. Additionally, it was proposed that NOTCH...

    Authors: Khaled K Abu-Amero, Ali Hellani and Saeed Bohlega
    Citation: BMC Research Notes 2008 1:16
  18. Hepatitis delta virus (HDV) is a satellite virus of hepatitis B. During viral replication the 1700-nucleotide-long genomic RNA and its complement, the antigenomic RNA, undergo self-cleavage catalyzed by intern...

    Authors: Larissa Savochkina, Victoria Alekseenkova, Tatyana Belyanko, Nadezhda Dobrynina and Robert Beabealashvilli
    Citation: BMC Research Notes 2008 1:15
  19. A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways in...

    Authors: Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Research Notes 2008 1:14
  20. The NORE1 protein was identified in a yeast two-hybrid screen as a Ras effector that binds Ras protein in a GTP-dependent manner. NORE1A is a growth and tumour suppressor that is inactivated in a variety of ca...

    Authors: Anna Moshnikova, Sergey Kuznetsov and Andrei V Khokhlatchev
    Citation: BMC Research Notes 2008 1:13
  21. The ability of Burkholderia pseudomallei to survive in water likely contributes to its environmental persistence in endemic regions. To determine the physiological adaptations which allow B. pseudomallei to survi...

    Authors: Richard A Moore, Apichai Tuanyok and Donald E Woods
    Citation: BMC Research Notes 2008 1:11
  22. Chronic diarrhoea is one of the most debilitating consequences of HIV infection in sub-Saharan Africa and it carries a high mortality rate. We report unexpectedly low concentrations of circulating aldosterone ...

    Authors: Trevor Kaile, Isaac Zulu, Ruth Lumayi, Neil Ashman and Paul Kelly
    Citation: BMC Research Notes 2008 1:10
  23. Public health emergencies heighten several challenges in risk-communication: providing trustworthy sources of information, reaching marginalized populations, and minimizing fear and public confusion. In emerge...

    Authors: Elena Savoia, Michael A Stoto, Paul D Biddinger, Paul Campbell, Kasisomayajula Viswanath and Howard Koh
    Citation: BMC Research Notes 2008 1:6
  24. The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strateg...

    Authors: Vicente Arnau, Miguel Gallach and Ignacio Marín
    Citation: BMC Research Notes 2008 1:5
  25. The Alternative Splicing Mutation Database (ASMD) presents a collection of all known mutations inside human exons which affect splicing enhancers and silencers and cause changes in the alternative splicing pat...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov
    Citation: BMC Research Notes 2008 1:4
  26. Some mutations in the internal regions of exons occur within splicing enhancers and silencers, influencing the pattern of alternative splicing in the corresponding genes. To understand how these sequence chang...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov
    Citation: BMC Research Notes 2008 1:3
  27. In Peru, cardiovascular disease was the second most common cause of death in those aged 65 years or more in 2000. Hypertension is a major modifiable risk factor for cardiovascular disease, and if treated can s...

    Authors: Alisha R Davies, J Jaime Miranda, Robert H Gilman and Liam Smeeth
    Citation: BMC Research Notes 2008 1:2

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