Skipworth JR, Shankar A, Pereira SP: Managing acute and chronic pancreatitis. Practitioner. 2010, 254: 23-27. 22
PubMed
Google Scholar
Kloppel G, Maillet B: Development of chronic pancreatitis from acute pancreatitis: a pathogenetic concept. Zentralbl Chir. 1995, 120: 274-277.
PubMed
CAS
Google Scholar
Ahmed SA, Wray C, Rilo HL, Choe KA, Gelrud A, Howington JA, Lowy AM, Matthews JB: Chronic pancreatitis: recent advances and ongoing challenges. Curr Probl Surg. 2006, 43: 127-238. 10.1067/j.cpsurg.2005.12.004.
Article
PubMed
Google Scholar
Raimondi S, Lowenfels AB, Morselli-Labate AM, Maisonneuve P, Pezzilli R: Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection. Best Pract Res Clin Gastroenterol. 2010, 24: 349-358. 10.1016/j.bpg.2010.02.007.
Article
PubMed
Google Scholar
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin. 2011, 61: 69-90. 10.3322/caac.20107.
Article
PubMed
Google Scholar
Raptis DA, Fessas C, Belasyse-Smith P, Kurzawinski TR: Clinical presentation and waiting time targets do not affect prognosis in patients with pancreatic cancer. Surgeon. 2010, 8: 239-246. 10.1016/j.surge.2010.03.001.
Article
PubMed
Google Scholar
Lehrer RI: Immunology: Peptide gets in shape for self-defence. Nature. 2011, 469: 309-310. 10.1038/469309a.
Article
PubMed
CAS
Google Scholar
Beisswenger C, Bals R: Antimicrobial peptides in lung inflammation. Chem Immunol Allergy. 2005, 86: 55-71.
Article
PubMed
CAS
Google Scholar
Diamond G, Ryan L: Beta-defensins: what are they REALLY doing in the oral cavity?. Oral Dis. 2011, 17 (7): 628-635. 10.1111/j.1601-0825.2011.01799.x.
Article
PubMed
CAS
PubMed Central
Google Scholar
Guani-Guerra E, Santos-Mendoza T, Lugo-Reyes SO, Teran LM: Antimicrobial peptides: general overview and clinical implications in human health and disease. Clin Immunol. 2010, 135: 1-11. 10.1016/j.clim.2009.12.004.
Article
PubMed
CAS
Google Scholar
Herr C, Shaykhiev R, Bals R: The role of cathelicidin and defensins in pulmonary inflammatory diseases. Expert Opin Biol Ther. 2007, 7: 1449-1461. 10.1517/14712598.7.9.1449.
Article
PubMed
CAS
Google Scholar
Hollox EJ: Copy number variation of beta-defensins and relevance to disease. Cytogenet Genome Res. 2008, 123: 148-155. 10.1159/000184702.
Article
PubMed
CAS
Google Scholar
Paris S, Wolgin M, Kielbassa AM, Pries A, Zakrzewicz A: Gene expression of human beta-defensins in healthy and inflamed human dental pulps. J Endod. 2009, 35: 520-523. 10.1016/j.joen.2008.12.015.
Article
PubMed
Google Scholar
Hollox EJ, Armour JA, Barber JC: Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet. 2003, 73: 591-600. 10.1086/378157.
Article
PubMed
CAS
PubMed Central
Google Scholar
Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M, Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF: Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. BMC Genomics. 2004, 5: 92-10.1186/1471-2164-5-92.
Article
PubMed
PubMed Central
Google Scholar
Groth M, Szafranski K, Taudien S, Huse K, Mueller O, Rosenstiel P, Nygren AO, Schreiber S, Birkenmeier G, Platzer M: High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes. Hum Mutat. 2008, 29: 1247-1254. 10.1002/humu.20751.
Article
PubMed
CAS
Google Scholar
Groth M, Wiegand C, Szafranski K, Huse K, Kramer M, Rosenstiel P, Schreiber S, Norgauer J, Platzer M: Both copy number and sequence variations affect expression of human DEFB4. Genes Immun. 2010, 11: 458-466. 10.1038/gene.2010.19.
Article
PubMed
CAS
Google Scholar
Hardwick RJ, Machado LR, Zuccherato LW, Antolinos S, Xue Y, Shawa N, Gilman RH, Cabrera L, Berg DE, Tyler-Smith C: A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia. Hum Mutat. 2011, 32: 743-750. 10.1002/humu.21491.
Article
PubMed
CAS
PubMed Central
Google Scholar
Taudien S, Groth M, Huse K, Petzold A, Szafranski K, Hampe J, Rosenstiel P, Schreiber S, Platzer M: Haplotyping and copy number estimation of the highly polymorphic human beta-defensin locus on 8p23 by 454 amplicon sequencing. BMC Genomics. 2010, 11: 252-10.1186/1471-2164-11-252.
Article
PubMed
PubMed Central
Google Scholar
Taudien S, Szafranski K, Felder M, Groth M, Huse K, Raffaelli F, Petzold A, Zhang X, Rosenstiel P, Hampe J: Comprehensive assessment of sequence variation within the copy number variable defensin cluster on 8p23 by target enriched in-depth 454 sequencing. BMC Genomics. 2011, 12: 243-10.1186/1471-2164-12-243.
Article
PubMed
PubMed Central
Google Scholar
Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, van de Kerkhof PC, Traupe H, de Jongh G, den Heijer M: Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet. 2008, 40: 23-25. 10.1038/ng.2007.48.
Article
PubMed
CAS
PubMed Central
Google Scholar
Fredman D, White SJ, Potter S, Eichler EE, Den Dunnen JT, Brookes AJ: Complex SNP-related sequence variation in segmental genome duplications. Nat Genet. 2004, 36: 861-866. 10.1038/ng1401.
Article
PubMed
CAS
Google Scholar
Armour JA, Palla R, Zeeuwen PL, den Heijer M, Schalkwijk J, Hollox EJ: Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats. Nucleic Acids Res. 2007, 35: e19-10.1093/nar/gkl1089.
Article
PubMed
PubMed Central
Google Scholar
Deutsch S, Choudhury U, Merla G, Howald C, Sylvan A, Antonarakis SE: Detection of aneuploidies by paralogous sequence quantification. J Med Genet. 2004, 41: 908-915. 10.1136/jmg.2004.023184.
Article
PubMed
CAS
PubMed Central
Google Scholar
Lee HH, Chang JG, Lin SP, Chao HT, Yang ML, Ng HT: Rapid detection of trisomy 21 by homologous gene quantitative PCR (HGQ-PCR). Hum Genet. 1997, 99: 364-367. 10.1007/s004390050373.
Article
PubMed
CAS
Google Scholar
Schouten JP, McElgunn CJ, Waaijer R, Zwijnenburg D, Diepvens F, Pals G: Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res. 2002, 30: e57-10.1093/nar/gnf056.
Article
PubMed
PubMed Central
Google Scholar
Aldhous MC, Abu Bakar S, Prescott NJ, Palla R, Soo K, Mansfield JC, Mathew CG, Satsangi J, Armour JA: Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease. Hum Mol Genet. 2010, 19: 4930-4938. 10.1093/hmg/ddq411.
Article
PubMed
CAS
PubMed Central
Google Scholar
Perne A, Zhang X, Lehmann L, Groth M, Stuber F, Book M: Comparison of multiplex ligation-dependent probe amplification and real-time PCR accuracy for gene copy number quantification using the beta-defensin locus. Biotechniques. 2009, 47: 1023-1028. 10.2144/000113300.
Article
PubMed
CAS
Google Scholar
Chen Q, Hakimi M, Wu S, Jin Y, Cheng B, Wang H, Xie G, Ganz T, Linzmeier RM, Fang X: Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population. Anesthesiology. 2010, 112: 1428-1434. 10.1097/ALN.0b013e3181d968eb.
Article
PubMed
CAS
Google Scholar
Aldhous MC, Noble CL, Satsangi J: Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One. 2009, 4: e6285-10.1371/journal.pone.0006285.
Article
PubMed
PubMed Central
Google Scholar
Bentley RW, Pearson J, Gearry RB, Barclay ML, McKinney C, Merriman TR, Roberts RL: Association of Higher DEFB4 Genomic Copy Number With Crohn's Disease. Am J Gastroenterol. 2009, 105 (2): 354-359.
Article
PubMed
Google Scholar
Fellermann K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, Bevins CL, Reinisch W, Teml A, Schwab M, Lichter P: A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet. 2006, 79: 439-448. 10.1086/505915.
Article
PubMed
CAS
PubMed Central
Google Scholar
Huse K, Taudien S, Groth M, Rosenstiel P, Szafranski K, Hiller M, Hampe J, Junker K, Schubert J, Schreiber S: Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer. Tumour Biol. 2008, 29: 83-92. 10.1159/000135688.
Article
PubMed
CAS
Google Scholar
Greiser KH, Kluttig A, Schumann B, Kors JA, Swenne CA, Kuss O, Werdan K, Haerting J: Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study. BMC Cardiovasc Disord. 2005, 5: 33-10.1186/1471-2261-5-33.
Article
PubMed
PubMed Central
Google Scholar
Gronborg M, Bunkenborg J, Kristiansen TZ, Jensen ON, Yeo CJ, Hruban RH, Maitra A, Goggins MG, Pandey A: Comprehensive proteomic analysis of human pancreatic juice. J Proteome Res. 2004, 3: 1042-1055. 10.1021/pr0499085.
Article
PubMed
CAS
Google Scholar
Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, Dimagno EP, Andren-Sandberg A, Domellof L: Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med. 1993, 328: 1433-1437. 10.1056/NEJM199305203282001.
Article
PubMed
CAS
Google Scholar
Raimondi S, Maisonneuve P, Lowenfels AB: Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol. 2009, 6: 699-708. 10.1038/nrgastro.2009.177.
Article
PubMed
Google Scholar
Pitchumoni CS, Rubin A, Das K: Pancreatitis in inflammatory bowel diseases. J Clin Gastroenterol. 2010, 44: 246-253. 10.1097/MCG.0b013e3181cadbe1.
Article
PubMed
CAS
Google Scholar
Hollox EJ: Beta-defensins and Crohn's disease: confusion from counting copies. Am J Gastroenterol. 2010, 105: 360-362. 10.1038/ajg.2009.573.
Article
PubMed
Google Scholar
Jerrells TR, Vidlak D, Strachota JM: Alcoholic pancreatitis: mechanisms of viral infections as cofactors in the development of acute and chronic pancreatitis and fibrosis. J Leukoc Biol. 2007, 81: 430-439. 10.1189/jlb.1004622.
Article
PubMed
CAS
Google Scholar
Tiszlavicz Z, Szabolcs A, Takacs T, Farkas G, Kovacs-Nagy R, Szantai E, Sasvari-Szekely M, Mandi Y: Polymorphisms of beta defensins are associated with the risk of severe acute pancreatitis. Pancreatology. 2010, 10: 483-490. 10.1159/000276987.
Article
PubMed
CAS
Google Scholar
Farrow B, Sugiyama Y, Chen A, Uffort E, Nealon W, Mark Evers B: Inflammatory mechanisms contributing to pancreatic cancer development. Ann Surg. 2004, 239: 763-769. 10.1097/01.sla.0000128681.76786.07. discussion 769–771
Article
PubMed
PubMed Central
Google Scholar
Coussens LM, Werb Z: Inflammation and cancer. Nature. 2002, 420: 860-867. 10.1038/nature01322.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kohlgraf KG, Pingel LC, Dietrich DE, Brogden KA: Defensins as anti-inflammatory compounds and mucosal adjuvants. Future Microbiol. 2010, 5: 99-113. 10.2217/fmb.09.104.
Article
PubMed
CAS
PubMed Central
Google Scholar
Ganz T: Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003, 3: 710-720. 10.1038/nri1180.
Article
PubMed
CAS
Google Scholar