- Research note
- Open Access
Unexpected association between subclinical hearing loss and restorative sleep in a middle-aged and elderly Japanese population
BMC Research Notes volume 11, Article number: 195 (2018)
Hearing loss may be associated with certain sleep abnormalities. We recently reported that subclinical hearing loss (SHL) was more prevalent in individuals in a broad Japanese population who slept longer than 8 h; however, the underlying mechanism was unknown. Therefore, we investigated the association between SHL and self-reported restorative sleep (RS), assessed by questionnaire, in a database of 33,888 Japanese aged 40–69 years without overt or diagnosed hearing loss (20,225 men, 13,663 women).
The proportion of individuals with RS (more than half of the subjects) was significantly higher in the group with bilateral than with unilateral SHL at 4000 Hz and intact hearing; however, that was not the case at 1000 Hz, independent of age (P < 0.0001, two-way analysis of variance). Multivariate logistic regression analysis showed that bilateral SHL at 4000 Hz, but not at 1000 Hz, was significantly associated with RS. This relationship was independent of potential relevant confounders, including age, sex, and cardiometabolic risk factors. The present study extends our earlier work by revealing an unexpected association between early hearing impairment and satisfactory sleep in a middle-aged and elderly population. This association requires further confirmation regarding the possible underlying mechanism and clinical relevance.
Hearing loss is one of the most important disabilities in hampering social interaction and quality of life [1,2,3,4,5]. The degree of hearing impairment usually advances with age, but significant variation occurs among individuals [1, 6, 7]. Subclinical hearing loss (SHL) is mostly asymptomatic and underappreciated in the general population [2, 5]; thus, it tends to advance gradually, even in middle-aged people [8, 9].
Good sleep is critical for general health throughout life; however, both short and long sleep duration are associated with cardiometabolic morbidities, such as obesity and type 2 diabetes [10,11,12]. In a previous study of a medical database containing details of a broad Japanese population who underwent a health check-up in 2007 or 2008 , we found, surprisingly, that SHL at 4000 Hz was more prevalent in individuals who slept longer (≥ 8 h). In the present study, we investigated the association between SHL and self-reported restorative sleep (RS) in a different database of middle-aged and elderly Japanese people.
This cross-sectional study utilized data recorded during medical check-ups of people living or working in Saitama, a suburb of Tokyo, Japan . We reviewed the data for 62,459 individuals who underwent a health check-up at the Saitama Health Promotion Corporation in 2012. We excluded from the study 277 subjects with overt or diagnosed hearing loss (including those with ongoing treatment or past history). Older subjects aged 70 years or more (n = 677) were excluded from the main analysis: the quality of sleep can be influenced by various age-related conditions, such as cognitive and urinary tract disease [15, 16]. We also excluded younger subjects aged 20–39 years (n = 27,617) because the prevalence of SHL is very low in the young generation. After these exclusions, 33,888 apparently healthy subjects aged 40–69 years with complete data were enrolled. However, in a subsequent sub-analysis, we removed the restriction for age and conducted the same analysis (Additional file 3: Figure S1) because observed SHL might be classified into noise or other-induced hearing loss rather than age-related hearing loss (ARHL).
All anthropometric and laboratory tests were conducted in the early morning after overnight fasting. Serum parameters were measured using standard methods on Hitachi autoanalyzers (Tokyo, Japan) at the Saitama Health Promotion Corporation. HbA1c (Japan Diabetes Society [JDS]) was converted to HbA1c (National Glycohemoglobin Standardization Program [NGSP]) units using the officially certified formula: HbA1c (NGSP) (%) = 1.02 × JDS (%) + 0.25% . A hearing test with a headphone was individually conducted in a restricted quiet room or place by trained staff using an ordinary audiometer. Following several tests for decisions at each frequency, SHL was defined as a pure-tone average hearing loss of > 25 dB at high (4000 Hz) and low (1000 Hz) frequencies.
As in other studies [18, 19], RS was determined based on a positive response to the question “Do you get sufficient rest from sleep?” That was included in a questionnaire developed by Japan’s Ministry of Health, Labour and Welfare in 2008 for detecting unhealthy lifestyles . Subjects were primarily divided into three groups according to the absence or presence of SHL at 4000 Hz or 1000 Hz, unilaterally or bilaterally: intact hearing, unilateral SHL, and bilateral SHL.
Data are expressed as means ± standard deviations. We evaluated differences in continuous and categorical variables among the three SHL groups using one-way analysis of variance (ANOVA) and χ2 tests, respectively. We conducted post hoc analysis using the Bonferroni test and an additional χ2 test (P < 0.013) between two specific groups. RS was investigated using two-way ANOVA with age-group (every 10 years) as one factor and SHL condition as another. We used multivariate logistic regression models to evaluate associations between RS and SHL with or without adjustment for relevant confounders, including various cardiometabolic risk factors. Logistic regression models yielded odds ratios (ORs) and 95% confidence intervals (95% CIs). To investigate the combined effect of bilateral SHL at 4000 and 1000 Hz on RS in the logistic regression analysis, in addition to the above three groups, we divided subjects into four groups according to the presence or absence of bilateral SHL at 4000 and 1000 Hz: not bilateral at either frequency; bilateral at 1000 Hz but not at 4000 Hz; not bilateral at 1000 Hz but bilateral at 4000 Hz; and bilateral at both frequencies. We also conducted separate analyses of men and women: in our previous study, we found that unlike women, men showed a significant association with hearing loss at 4000 Hz . We performed statistical analyses using Statview, version 5.0 (SAS Institute; Cary, NC, USA). P < 0.05 was considered significant.
The subjects’ characteristics appear in Table 1. Individuals with unilateral or bilateral SHL at 4000 Hz were older than those with intact hearing and were more likely to be male. Most continuous variables and categorical parameters rose significantly with increasing SHL (all P < 0.0001, ANOVA). As shown in Fig. 1, the proportion of individuals with RS (which was more than half of subjects) was significantly higher in the group with bilateral than with unilateral SHL at 4000 Hz and intact hearing, but not at 1000 Hz (P < 0.0001 generally, two-way ANOVA). When the analysis was conducted for each age-group, a significant increase in RS was evident in subjects in their 50s and 60s (P = 0.004 and P = 0.001, respectively, one-way ANOVA). To reduce the effect of age, we categorized it every 5 years and conducted the same analysis: the results were similar, i.e., higher proportions of RS in bilateral SHL at 4000 Hz independent of age (P = 0.002 generally, one-way ANOVA, Additional file 1: Figure S1). We observed a significant rise in RS with SHL only in subjects aged 60–64 years (P = 0.01, one-way ANOVA). Notably, differences in the averages for age among the three categories in each group were all less than 1 year—even though age rose with increasing SHL in each age-group (all P < 0.0001, ANOVA, Additional file 2: Figure S1).
Logistic regression analysis showed that compared with intact hearing, bilateral SHL at 4000 Hz was significantly associated with RS: subjects with bilateral SHL at 4000 Hz were more likely to have RS. That finding remained significant even after full adjustment for confounding factors, including age, sex, smoking, alcohol consumption, current pharmacotherapy, and past history of cardiovascular disease and stroke (Model 3, Table 2). However, when subjects were categorized by sex, the statistical significance disappeared in women (Model 3, P = 0.09). The association between bilateral SHL at 1000 Hz and RS was not significant after adjustment for age and sex. Among confounding factors, habitual regular exercise and daily alcohol consumption were significantly associated with RS: ORs (95% CIs), 1.70 (1.61–1.79) and 1.25 (1.17–1.32), both P < 0.0001; however, past history of cardiovascular disease and current smoking were inversely associated with RS: 0.81 (0.70–0.92), P = 0.002 and 0.88 (0.83–0.93), P < 0.0001.
We categorized the subjects into four groups according to bilateral SHL at 4000 Hz and 1000 Hz: bilateral SHL at 4000 HL (but not bilateral SHL at 1000 Hz) and bilateral SHL at both frequencies were significantly associated with RS—even after full adjustment for confounders. After categorization by sex, the former association remained significant in men, and the latter association remained significant in women.
In a sub-analysis, we removed the age restriction for subjects and conducted the same analysis for SHL at 4000 Hz (n = 62, 182 in total, Additional file 3: Figure S1). Except for the oldest group, aged 70–79 years, the proportion of RS was highest in subjects with bilateral SHL—even with the youngest group, aged 20–29 years; however, no statistical difference was observed. In the logistic regression analysis for the whole study, compared with intact hearing, unilateral and bilateral SHL at 4000 Hz were significantly associated with RS—even after the same full adjustments for confounding factors: 1.20 (1.11–1.30) and 1.50 (1.38–1.64), respectively, both P < 0.0001 (data not shown).
This study determined that bilateral SHL (defined as > 25 dB at 4000 Hz), which may reflect hearing threshold elevation in aging, was significantly associated with RS, independent of relevant confounders, including age, sex, and cardiometabolic risk factors. In contrast to our previous study, the database used for the present study lacked data on sleep duration, ; thus, we could not confirm our previous findings using the same analysis. In the current study, RS was subjectively determined and was not validated by any confirmatory investigations; thus, this study should be considered preliminary in character. However, Matsumoto et al.  found non-RS to be significantly associated with shorter sleep duration, sleepiness, and frequent stress; subjects with RS had longer sleep duration, adequate sleep, and rare stress. Further, the prevalence of non-RS has been shown to be reduced (and RS elevated) with increasing age [18, 19]; that is consistent with our present results, indicating a significant increase of RS with age. We found RS to be associated with many factors, such as exercise, alcohol consumption, and smoking, which is also consistent with previous studies [18, 19]. Because exercise, alcohol consumption, and smoking have been associated with the quality and quantity of sleep [21, 22], the RS examined in this study probably reflects aspects of satisfactory sleep. Given that RS is likely to be reported after good sleep, our previous finding of a high prevalence of longer sleep duration in individuals with SHL  may not have reflected poor sleep quality.
Our previous study suggested that SHL is associated with longer sleep duration. In a longitudinal study, the risk of longer sleep duration (≥ 8 h) after the age of 8 years was significantly greater in subjects with SHL at 4000 Hz at baseline. However, it is not known whether SHL could be a cause of RS; that and other unquantified variables could confound the associations identified in the present study. Although RS itself may be good for general health, it could also reflect certain conditions that link to early hearing loss. In recent years, ARHL has been reportedly associated with cognitive impairment and dementia [23, 24]; those factors may also be related to longer sleep duration [25,26,27]. The auditory system involves both the ear (peripheral) and brain (central) . Taken together, these findings indicate that early hearing impairment may be associated with RS or longer sleep duration through the etiology of cognitive impairment and dementia; however, in our main analysis, we excluded older subjects aged 70–79 years. Intriguingly, we found that the proportion of RS was not highest in subjects with bilateral SHL at 4000 Hz in the oldest group, aged 70–79 years (Additional file 2: Figure S1). One plausible explanation is that the association between SHL and RS may be modified by age-related insomnia [29, 30] and common complications, such as urinary tract symptoms [16, 31].
Regular noise exposure may confound the current findings because noise-induced hearing loss begins at around 4000 Hz [32,33,34,35]. Unfortunately, hearing at frequencies beyond 4000 Hz and tinnitus were not investigated in the present study; thus, we could not differentiate between noise-induced hearing loss and ARHL. Noise exposure in the daytime elicits noise-induced hearing loss; it may increase the requirement for longer sleep duration or RS owing to the listening effort required and cognitive fatigue induced [36,37,38,39].
In conclusion, our present and previous studies suggest an unexpected potential link between early hearing impairment and good sleep; they may be preliminary observations for future multidisciplinary work. Additional larger studies are required to confirm our results and investigate the underlying mechanisms and true clinical relevance.
This was a cross-sectional study and did not allow us to conclude the causality between RS and SHL.
Detailed assessment of sleep quality, for example, by polysomnography and a specialized questionnaire as in previous studies [40, 41], and of hearing loss (particularly including other frequencies) is required to elucidate the features of RS and impaired hearing.
Investigation of brain dysfunctions, such as cognitive impairment and dementia, may also be required.
analysis of variance
age-related hearing loss
- OR (95%CI):
odds ratio (95% confidence intervals)
subclinical hearing loss
Huang Q, Tang J. Age-related hearing loss or presbycusis. Eur Arch Otorhinolaryngol. 2010;267:1179–91.
Li-Korotky HS. Age-related hearing loss: quality of care for quality of life. Gerontol. 2012;52:265–71.
Ciorba A, Bianchini C, Pelucchi S, Pastore A. The impact of hearing loss on the quality of life of elderly adults. Clin Interv Aging. 2012;7:159–63.
Lustig TA, Olson S, Forum on Aging, Disability, and Independence, Board on Health Sciences Policy, Division of Behavioral and Social Sciences and Education, Institute of Medicine, National Research Council. Hearing loss and healthy aging: workshop summary. Washington (DC): National Academies Press; 2014. https://doi.org/10.17226/18735. ISBN 978-0-309-30226-5.
Contrera KJ, Wallhagen MI, Mamo SK, Oh ES, Lin FR. Hearing loss health care for older adults. J Am Board Fam Med. 2016;29:394–403.
Fransen E, Lemkens N, Van Laer L, Van Camp G. Age-related hearing impairment (ARHI): environmental risk factors and genetic prospects. Exp Gerontol. 2003;38:353–9.
Uchida Y, Sugiura S, Sone M, Ueda H, Nakashima T. Progress and prospects in human genetic research into age-related hearing impairment. Biomed Res Int. 2014;2014:390601.
Dobie RA. The burdens of age-related and occupational noise-induced hearing loss in the United States. Ear Hear. 2008;29:565–77.
Dawes P, Fortnum H, Moore DR, et al. Hearing in middle age: a population snapshot of 40–69-year olds in the United Kingdom. Ear Hear. 2014;35:e44–51.
Gangwisch JE. Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obes Rev. 2009;10(Suppl 2):37–45.
Pack AI, Pien GW. Update on sleep and its disorders. Annu Rev Med. 2011;62:447–60.
Liu Y, Wheaton AG, Chapman DP, Croft JB. Sleep duration and chronic diseases among US adults age 45 years and older: evidence from the 2010 behavioral risk factor surveillance system. Sleep. 2013;2013(36):1421–7.
Nakajima K, Kanda E, Hosobuchi A, Suwa K. Subclinical hearing loss, longer sleep duration, and cardiometabolic risk factors in Japanese general population. Int J Otolaryngol. 2014;2014:218218.
Muneyuki T, Suwa K, Oshida H, et al. Design of the saitama cardiometabolic disease and organ impairment study (SCDOIS): a multidisciplinary observational epidemiological study. Open J Endocr Metab Dis. 2013;2:144–56.
Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM. Sleep quality and preclinical Alzheimer disease. JAMA Neurol. 2013;70:587–93.
Scovell JM, Pastuszak AW, Slawin J, Badal J, Link RE, Lipshultz LI. Impaired sleep quality is associated with more significant lower urinary tract symptoms in male shift workers. Urology. 2017;99:197–202.
Kashiwagi A, Kasuga M, Araki E, et al. International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values. J Diabetes Invest. 2012;3:39–40.
Wakasugi M, Kazama JJ, Narita I, Iseki K, Moriyama T, Yamagata K, Fujimoto S, Tsuruya K, Asahi K, et al. Association between combined lifestyle factors and non-restorative sleep in Japan: a cross-sectional study based on a Japanese health database. PLoS ONE. 2014;9(9):e108718.
Matsumoto T, Tabara Y, Murase K, Takahashi Y, Setoh K, Kawaguchi T, Muro S, Kadotani H, Kosugi S, Sekine A, Yamada R, Nakayama T, Mishima M, Matsuda F, Chin K. Combined association of clinical and lifestyle factors with non-restorative sleep: The Nagahama Study. PLoS ONE. 2017;12:e0171849.
Dote T, Nakayama S, Hayashi E, Yokoyama H. Effect of specific health checkup stratifications based on stage of change, criteria values and healthy lifestyle at a particular health checkups for three consecutive years. JJOMT. 2015;63:159–66.
Irish LA, Kline CE, Gunn HE, Buysse DJ, Hall MH. The role of sleep hygiene in promoting public health: a review of empirical evidence. Sleep Med Rev. 2015;22:23–36.
Underner M, Paquereau J, Meurice JC. Cigarette smoking and sleep disturbance. Rev Mal Respir. 2006;23:6S67–77.
Wingfield A, Peelle JE. How does hearing loss affect the brain? Aging Health. 2012;8:107–9.
Golub JS. Brain changes associated with age-related hearing loss. Curr Opin Otolaryngol Head Neck Surg. 2017;25:347–52.
Devore EE, Grodstein F, Schernhammer ES. Sleep duration in relation to cognitive function among older adults: a systematic review of observational studies. Neuroepidemiology. 2016;46:57–78.
Kim HB, Myung SK, Lee SM, Park YC, Korean Meta-Analysis (KORMA) Study Group. Longer duration of sleep and risk of cognitive decline: a meta-analysis of observational studies. Neuroepidemiology. 2016;47:171–80.
Westwood AJ, Beiser A, Jain N, Himali JJ, DeCarli C, Auerbach SH, Pase MP, Seshadri S. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. 2017;88:1172–9.
Frisina RD. Age-related hearing loss: ear and brain mechanisms. Ann N Y Acad Sci. 2009;1170:708–17.
Floyd JA, Janisse JJ, Marshall Medler S, Ager JW. Nonlinear components of age-related change in sleep initiation. Nurs Res. 2000;49:290–4.
Klerman EB, Dijk DJ. Age-related reduction in the maximal capacity for sleep–implications for insomnia. Curr Biol. 2008;18:1118–23.
Duffy JF, Scheuermaier K, Loughlin KR. Age-related sleep disruption and reduction in the circadian rhythm of urine output: contribution to nocturia? Curr Aging Sci. 2016;9:34–43.
Bergström B, Nyström B. Development of hearing loss during long-term exposure to occupational noise. A 20-year follow-up study. Scand Audiol. 1986;15:227–34.
Hong O. Hearing loss among operating engineers in American construction industry. Int Arch Occup Environ Health. 2005;78:565–74.
Mahendra Prashanth KV, Venugopalachar S. The possible influence of noise frequency components on the health of exposed industrial workers—a review. Noise Health. 2011;13:16–25.
Mostaghaci M, Mirmohammadi SJ, Mehrparvar AH, Bahaloo M, Mollasadeghi A, Davari MH. Effect of workplace noise on hearing ability in tile and ceramic industry workers in Iran: a 2-year follow-up study. Sci World J. 2013;2013:923731.
Nandi SS, Dhatrak SV. Occupational noise-induced hearing loss in India. Indian J Occup Environ Med. 2008;12:53–6.
Bess FH, Hornsby BW. Commentary: listening can be exhausting-fatigue in children and adults with hearing loss. Ear Hear. 2014;35:592–9.
Härkönen K, Kivekäs I, Rautiainen M, Kotti V, Sivonen V, Vasama JP. Sequential bilateral cochlear implantation improves working performance, quality of life, and quality of hearing. Acta Otolaryngol. 2015;135:440–6.
Liberman MC. Noise-induced hearing loss: permanent versus temporary threshold shifts and the effects of hair cell versus neuronal degeneration. Adv Exp Med Biol. 2016;875:1–7.
Drake CL, Hays RD, Morlock R, Wang F, Shikiar R, Frank L, Downey R, Roth T. Development and evaluation of a measure to assess restorative sleep. J Clin Sleep Med. 2014;10:733–41.
Tsuchiya M, Takahashi M, Miki K, Kubo T, Izawa S. Cross-sectional associations between daily rest periods during weekdays and psychological distress, non-restorative sleep, fatigue, and work performance among information technology workers. Ind Health. 2017;55:173–9.
KN designed the study and confirmed its ethicality. KS identified eligible subjects from the database and confirmed the methods for measurements. KN and EK analyzed the data, interpreted the results, and reviewed the literature. KN wrote the first draft of the manuscript. All authors read and approved the final manuscript.
We thank Dr. Takeshi Matsunobu, Department of Otolaryngology-Head and Neck Surgery, Nippon Medical School, Graduate School of Medicine for helpful suggestions. We thank Edanz Group (http://www.edanzediting.com/ac) for editing a draft of this manuscript.
The authors declare that they have no competing interests.
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All data generated or analyzed during this study are included in this published article.
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The study protocol was approved by the Ethics Committee of Kanagawa University of Human Services (No. 10-22). Written informed consent was obtained from all subjects.
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About this article
- Hearing loss
- High frequency
- Bilateral hearing loss
- Restorative sleep
- Cardiometabolic risk
- Age-related hearing loss
- Cognitive impairment