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  1. Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more var...

    Authors: Nick T Peters, Anne Catherine Miller and Darryl L Kropf

    Citation: BMC Research Notes 2009 2:106

    Content type: Short Report

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  2. Differential expression of perforin (PRF1), a gene with a pivotal role in immune surveillance, can be attributed to differential methylation of CpG sites in its promoter region. A reproducible method for quantita...

    Authors: Supraja Narasimhan, Virginia R Falkenberg, Maung M Khin and Mangalathu S Rajeevan

    Citation: BMC Research Notes 2009 2:104

    Content type: Technical Note

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  3. The Clubfoot Assessment Protocol (CAP) was developed for follow-up of children treated for clubfoot. The objective of this study was to analyze reliability and validity of the six items used in the domain CAPM...

    Authors: Hanneke Andriesse, Gunnar Hägglund and Per-Erik Isberg

    Citation: BMC Research Notes 2009 2:103

    Content type: Short Report

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  4. The human cancer-related nucleoside triphosphatase (HCR-NTPase) is overexpressed in several tumour tissues including neuroblastoma. HCR-NTPase is an enzyme exhibiting a slow in vitro activity in hydrolysing nucle...

    Authors: Markus Pasdziernik, Barbara Kaltschmidt, Christian Kaltschmidt, Claudia Klinger and Michael Kaufmann

    Citation: BMC Research Notes 2009 2:102

    Content type: Short Report

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  5. GenBank(R) is a public repository of all publicly available molecular sequence data from a range of sources. In addition to relevant metadata (e.g., sequence description, source organism and taxonomy), publica...

    Authors: Holly Miller, Catherine N Norton and Indra Neil Sarkar

    Citation: BMC Research Notes 2009 2:101

    Content type: Correspondence

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  6. A phenotype of increased muscle mass (IMM) and reduced fat, comparable to reported effects of deleterious mutations in the myostatin gene (MSTN), has been observed in the Norwegian Spælsau breed. However, the gen...

    Authors: Inger A Boman and Dag I Våge

    Citation: BMC Research Notes 2009 2:98

    Content type: Short Report

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  7. Lower respiratory tract infections are a major cause of illness and death. Such infections are common in intensive care units (ICU) and their lethality persists despite advances in diagnosis, treatment and pre...

    Authors: Virgilio Bocanegra-García, María del Rayo Camacho-Corona, Mónica Ramírez-Cabrera, Gildardo Rivera and Elvira Garza-González

    Citation: BMC Research Notes 2009 2:95

    Content type: Short Report

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  8. Germline mutations in the BRCA2 gene have been suggested to account for about 5% of familial prostate cancer; mutations have been reported in 2% of early onset (i.e., ≤ 55 years) prostate cancer cases and a segre...

    Authors: Kristina Allen-Brady, James M Farnham, Nicola J Camp, Eric Karlins, Elaine A Ostrander and Lisa A Cannon-Albright

    Citation: BMC Research Notes 2009 2:94

    Content type: Short Report

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  9. In the past, rice genome served as a good model for studies involving comparative genomics of grass species. More recently, however, Brachypodium distachyon genome has emerged as a better model system for genomes...

    Authors: Sachin Kumar, Amita Mohan, Harindra S Balyan and Pushpendra K Gupta

    Citation: BMC Research Notes 2009 2:93

    Content type: Short Report

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  10. There is a need for software scripts and modules for format parsing, data manipulation, statistical analysis and annotation especially for tasks related to marker identification from sequence data and sequence...

    Authors: B Jayashree, A BhanuPrakash, Anusha Jami, P Srinivasa Reddy, Spurthi Nayak and Rajeev K Varshney

    Citation: BMC Research Notes 2009 2:92

    Content type: Technical Note

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  11. It has been demonstrated that extracellular mRNA can be detected in the circulation. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of breast cancer patie...

    Authors: Weizhu Zhu, Wenyi Qin, Ulus Atasoy and Edward R Sauter

    Citation: BMC Research Notes 2009 2:89

    Content type: Short Report

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  12. Within-species genome diversity has been best studied in humans. The international HapMap project has revealed a tremendous amount of single-nucleotide polymorphisms (SNPs) among humans, many of which show sig...

    Authors: Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura and Hiroshi Mitani

    Citation: BMC Research Notes 2009 2:88

    Content type: Short Report

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  13. Myosin II-dependent contraction of the cytokinetic ring and primary septum formation by chitin synthase II are interdependent processes during cytokinesis in Saccharomyces cerevisiae. Hence, null mutants of myosi...

    Authors: José F Rodríguez-Quiñones and José R Rodríguez-Medina

    Citation: BMC Research Notes 2009 2:87

    Content type: Short Report

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  14. From October 2006 to February 2007, clinical specimens from 452 patients with symptoms related to respiratory tract infection in the northern region of Taiwan were collected. Real-time PCR and direct immunoflu...

    Authors: Yuan-Ming Lee, Sheng-Fan Wang, Cheng-Ming Lee, Kuan-Hsuan Chen, Yu-Jiun Chan, Wu-Tse Liu and Yi-Ming Arthur Chen

    Citation: BMC Research Notes 2009 2:86

    Content type: Short Report

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  15. The murine ghrelin gene (Ghrl), originally sequenced from stomach tissue, contains five exons and a single transcription start site in a short, 19 bp first exon (exon 0). We recently isolated several novel first ...

    Authors: Inge Seim, Shea L Carter, Adrian C Herington and Lisa K Chopin

    Citation: BMC Research Notes 2009 2:85

    Content type: Short Report

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  16. The treatment of acute acromioclavicular (AC) joint injuries depends mainly on the type of the dislocation and patient demands. This study compares the mid term outcome of two frequently performed surgical con...

    Authors: Bernd A Leidel, Volker Braunstein, Susann Pilotto, Wolf Mutschler and Chlodwig Kirchhoff

    Citation: BMC Research Notes 2009 2:84

    Content type: Short Report

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  17. Women with rheumatoid arthritis (RA) have increased morbidity and mortality due to coronary heart disease. Chronic systemic inflammation is known to accelerate atherosclerosis and increase arterial stiffness i...

    Authors: Philip W Pemberton, Yasmeen Ahmad, Helena Bodill, Daniel Lokko, Samantha L Hider, Allen P Yates, Michael G Walker, Ian Laing and Ian N Bruce

    Citation: BMC Research Notes 2009 2:83

    Content type: Short Report

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  18. We assessed NanoString's nCounter™ Analysis System for its ability to quantify gene expression of forty-eight genes in a single reaction with 100 ng of total RNA or an equivalent amount of tissue lysate. In th...

    Authors: Vladislav A Malkov, Kyle A Serikawa, Noel Balantac, James Watters, Gary Geiss, Afshin Mashadi-Hossein and Thomas Fare

    Citation: BMC Research Notes 2009 2:80

    Content type: Technical Note

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  19. Marbling defined by the amount and distribution of intramuscular fat is an economically important trait of beef cattle in Japan. We have recently reported that single nucleotide polymorphisms (SNPs) in the endoth...

    Authors: Takahisa Yamada, Seiki Sasaki, Shin Sukegawa, Sachiyo Yoshioka, Youichi Takahagi, Mitsuo Morita, Hiroshi Murakami, Fumiki Morimatsu, Tatsuo Fujita, Takeshi Miyake and Yoshiyuki Sasaki

    Citation: BMC Research Notes 2009 2:78

    Content type: Short Report

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  20. The aim of this study was to develop a simple organ score derived from the Critical Care Minimum Data Set (CCMDS) to compare with the Sequential Organ Failure Assessment (SOFA) score, a previously validated sc...

    Authors: Tim W Felton, Rebecca Sander, Mo Al-Aloul, Paul Dark and Andrew M Bentley

    Citation: BMC Research Notes 2009 2:77

    Content type: Short Report

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  21. This study investigated the nosocomial blood stream infection (BSI) in the adult ICUs in Assiut university hospitals to evaluate the rate of infection in different ICUs, causative microorganisms, antimicrobial...

    Authors: Shaaban H Ahmed, Enas A Daef, Mohammed S Badary, Mohammed A Mahmoud and Alaa A Abd-Elsayed

    Citation: BMC Research Notes 2009 2:76

    Content type: Short Report

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  22. Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder that is more frequent in males than females. Several genes on the X chromosome have been studied as cand...

    Authors: Xiaohui Xu, Keeley Brookes, Bo Sun, Nicholas Ilott and Philip Asherson

    Citation: BMC Research Notes 2009 2:71

    Content type: Short Report

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  23. Apart from simple steatosis, the non-alcoholic steatohepatitis (NASH) can progress into liver fibrosis and cirrhosis. To date, however, no widely accepted therapeutic modalities have been established against N...

    Authors: Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Masaharu Yamazaki, Tatsuhiro Tsujimoto, Hideto Kawaratani, Takemi Akahane, Yosuke Aihara and Hiroshi Fukui

    Citation: BMC Research Notes 2009 2:70

    Content type: Short Report

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  24. It can be seen from the available mollusk mitogenomes that the family Pectinidae exhibits the most variation in genome organization. In this study, comparative mitogenomic analyses were performed for three sca...

    Authors: Xiangyun Wu, Xiaodong Xu, Ziniu Yu and Xiaoyu Kong

    Citation: BMC Research Notes 2009 2:69

    Content type: Short Report

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  25. Oxygenases belong to the oxidoreductive group of enzymes (E.C. Class 1), which oxidize the substrates by transferring oxygen from molecular oxygen (O2) and utilize FAD/NADH/NADPH as the co-substrate. Oxygenases c...

    Authors: Pankaj K Arora, Manish Kumar, Archana Chauhan, Gajendra PS Raghava and Rakesh K Jain

    Citation: BMC Research Notes 2009 2:67

    Content type: Data Note

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  26. Activating mutations in the PIK3CA gene have been identified in a variety of human malignancies and are commonly detected in hotspot codons located in the helical and kinase domains in exons 9 and 20. Existing me...

    Authors: Carolyn D Hurst, Tahlita CM Zuiverloon, Christian Hafner, Ellen C Zwarthoff and Margaret A Knowles

    Citation: BMC Research Notes 2009 2:66

    Content type: Technical Note

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  27. Cell-specific expression of a subset of Enhancer of split (E(spl)-C) genes in proneural clusters is mediated by synergistic interactions between bHLH A (b asic H elix-L oop-H elix A ctivator) and Notch-signalling...

    Authors: John W Cave, Li Xia and Michael A Caudy

    Citation: BMC Research Notes 2009 2:65

    Content type: Short Report

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  28. Baculovirus expression vector system (BEVS) has become a standard in recombinant protein production and virus-like particle preparation for numerous applications.

    Authors: Hanna-Riikka Kärkkäinen, Hanna P Lesch, Antti I Määttä, Pyry I Toivanen, Anssi J Mähönen, Miia M Roschier, Kari J Airenne, Olli H Laitinen and Seppo Ylä-Herttuala

    Citation: BMC Research Notes 2009 2:63

    Content type: Technical Note

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  29. The purpose of this report is to assess the safety and efficacy of single lower pole access for multiple and branched renal calculi. A prospective non randomized clinical study included 26 patients with comple...

    Authors: Mahmoud M Shalaby, Medhat A Abdalla, Hassan A Aboul-Ella, Abdel-Monem A El-haggagy and Alaa A Abd-Elsayed

    Citation: BMC Research Notes 2009 2:62

    Content type: Short Report

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  30. Dermatophytes are a group of closely related keratinophilic fungi that can invade keratinized humans and animals tissues such as skin, hair and nails causing dermatophytosis. They are an important cause of sup...

    Authors: Jaya Garg, Ragini Tilak, Atul Garg, Pradyot Prakash, Anil Kumar Gulati and Gopal Nath

    Citation: BMC Research Notes 2009 2:60

    Content type: Short Report

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  31. The Runt DNA binding domain (Runx) defines a metazoan family of sequence-specific transcription factors with essential roles in animal ontogeny and stem cell based development. Depending on cis-regulatory context...

    Authors: Anthony J Robertson, Claire Larroux, Bernard M Degnan and James A Coffman

    Citation: BMC Research Notes 2009 2:59

    Content type: Short Report

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  32. Fluorescent proteins such as GFP (Green Fluorescent Protein) and DsRED (Discosoma sp.Red Fluorescent Protein) are often used as reporter molecules for transgene expression in Drosophila and other species. We h...

    Authors: Dhruv Grover, Junsheng Yang, Daniel Ford, Simon Tavaré and John Tower

    Citation: BMC Research Notes 2009 2:58

    Content type: Short Report

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