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  1. Cervical cancer is increasing at 1.5% per year in Ireland with 50% mortality giving 2.2% of all cancer deaths. In the Mid-West region a pilot screening programme has begun to screen all women 25–60 years. 66% ...

    Authors: Catherine O'Connor, Helena Myles, Mortimer B O'Connor, Josephine Clancy, Ailis Ryan, Mary Traynor, Dolores McGrath and Kitty O'Sullivan

    Citation: BMC Research Notes 2008 1:24

    Content type: Short Report

    Published on:

  2. Less than half of U.S. hospitals meet guidelines for prompt treatment of ST-segment elevation myocardial infarction (STEMI). The Door-to-Balloon (D2B) Alliance is a collaborative effort of more than 900 hospit...

    Authors: Elizabeth H Bradley, Brahmajee K Nallamothu, Amy F Stern, Jason R Byrd, Emily J Cherlin, Yongfei Wang, Christina Yuan, Ingrid Nembhard, John E Brush Jr and Harlan M Krumholz

    Citation: BMC Research Notes 2008 1:23

    Content type: Short Report

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  3. An accurate gene expression quantification using TaqMan Arrays (TA) could be limited by the low RNA quantity obtained from some clinical samples. The novel cDNA preamplification system, the TaqMan PreAmp Maste...

    Authors: Lourdes Mengual, Moisès Burset, Mercedes Marín-Aguilera, María José Ribal and Antonio Alcaraz

    Citation: BMC Research Notes 2008 1:21

    Content type: Technical Note

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  4. Alzheimer's disease (AD) is a progressive, neurodegenerative disease mostly affecting the basal forebrain, cortex and hippocampus whereas the cerebellum is relatively spared. The reason behind this region-spec...

    Authors: Sachin Patil, Deebika Balu, Joseph Melrose and Christina Chan

    Citation: BMC Research Notes 2008 1:20

    Content type: Short Report

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  5. Recently, Schulz and colleagues have contributed to the ongoing controversy on the unproven role of oxidative stress in the aging process in their well-performed study 'Glucose restriction extends Caenorhabditis ...

    Authors: Markus Ralser and Ivor J Benjamin

    Citation: BMC Research Notes 2008 1:19

    Content type: Correspondence

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  6. Variance-stabilizing techniques have been used for some time in the analysis of gene expression microarray data. A new adaptation, the variance-stabilizing transformation (VST), has recently been developed to ...

    Authors: Mark J Dunning, Matthew E Ritchie, Nuno L Barbosa-Morais, Simon Tavaré and Andy G Lynch

    Citation: BMC Research Notes 2008 1:18

    Content type: Short Report

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  7. The use of methods, both sensitive and specific, for rabies diagnosis are important tools for the control and prophylaxis of the disease. Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) has been used ...

    Authors: Danielle B Araújo, Helio Langoni, Marilene F Almeida and Jane Megid

    Citation: BMC Research Notes 2008 1:17

    Content type: Short Report

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  8. Ultrastructural and biochemical abnormalities of mitochondria have been reported in skeletal muscle biopsies of CADASIL patients with mutations in the NOTCH3 nuclear gene. Additionally, it was proposed that NOTCH...

    Authors: Khaled K Abu-Amero, Ali Hellani and Saeed Bohlega

    Citation: BMC Research Notes 2008 1:16

    Content type: Short Report

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  9. Hepatitis delta virus (HDV) is a satellite virus of hepatitis B. During viral replication the 1700-nucleotide-long genomic RNA and its complement, the antigenomic RNA, undergo self-cleavage catalyzed by intern...

    Authors: Larissa Savochkina, Victoria Alekseenkova, Tatyana Belyanko, Nadezhda Dobrynina and Robert Beabealashvilli

    Citation: BMC Research Notes 2008 1:15

    Content type: Short Report

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  10. A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways in...

    Authors: Hongdo Do, Benjamin Solomon, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic

    Citation: BMC Research Notes 2008 1:14

    Content type: Short Report

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  11. The NORE1 protein was identified in a yeast two-hybrid screen as a Ras effector that binds Ras protein in a GTP-dependent manner. NORE1A is a growth and tumour suppressor that is inactivated in a variety of ca...

    Authors: Anna Moshnikova, Sergey Kuznetsov and Andrei V Khokhlatchev

    Citation: BMC Research Notes 2008 1:13

    Content type: Short Report

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  12. The ability of Burkholderia pseudomallei to survive in water likely contributes to its environmental persistence in endemic regions. To determine the physiological adaptations which allow B. pseudomallei to survi...

    Authors: Richard A Moore, Apichai Tuanyok and Donald E Woods

    Citation: BMC Research Notes 2008 1:11

    Content type: Short Report

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  13. Chronic diarrhoea is one of the most debilitating consequences of HIV infection in sub-Saharan Africa and it carries a high mortality rate. We report unexpectedly low concentrations of circulating aldosterone ...

    Authors: Trevor Kaile, Isaac Zulu, Ruth Lumayi, Neil Ashman and Paul Kelly

    Citation: BMC Research Notes 2008 1:10

    Content type: Short Report

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  14. Public health emergencies heighten several challenges in risk-communication: providing trustworthy sources of information, reaching marginalized populations, and minimizing fear and public confusion. In emerge...

    Authors: Elena Savoia, Michael A Stoto, Paul D Biddinger, Paul Campbell, Kasisomayajula Viswanath and Howard Koh

    Citation: BMC Research Notes 2008 1:6

    Content type: Short Report

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  15. The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strateg...

    Authors: Vicente Arnau, Miguel Gallach and Ignacio Marín

    Citation: BMC Research Notes 2008 1:5

    Content type: Technical Note

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  16. The Alternative Splicing Mutation Database (ASMD) presents a collection of all known mutations inside human exons which affect splicing enhancers and silencers and cause changes in the alternative splicing pat...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov

    Citation: BMC Research Notes 2008 1:4

    Content type: Technical Note

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  17. Some mutations in the internal regions of exons occur within splicing enhancers and silencers, influencing the pattern of alternative splicing in the corresponding genes. To understand how these sequence chang...

    Authors: Jason M Bechtel, Preeti Rajesh, Irina Ilikchyan, Ying Deng, Pankaj K Mishra, Qi Wang, Xiaochun Wu, Kirill A Afonin, William E Grose, Ye Wang, Sadik Khuder and Alexei Fedorov

    Citation: BMC Research Notes 2008 1:3

    Content type: Data Note

    Published on:

  18. In Peru, cardiovascular disease was the second most common cause of death in those aged 65 years or more in 2000. Hypertension is a major modifiable risk factor for cardiovascular disease, and if treated can s...

    Authors: Alisha R Davies, J Jaime Miranda, Robert H Gilman and Liam Smeeth

    Citation: BMC Research Notes 2008 1:2

    Content type: Short Report

    Published on:

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