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  1. Non-alcoholic steatohepatitis (NASH) has become a global medical problem. Currently, there is no approved pharmacologic treatment for this condition. Previous studies have suggested that in the pathogenesis of...

    Authors: Rasoul Akbari, Hamid Yaghooti, Mohammad Taha Jalali, Laya Sadat Khorsandi and Narges Mohammadtaghvaei
    Citation: BMC Research Notes 2022 15:315
  2. Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more sid...

    Authors: Sadia Afrin, Ahmed Hossain and Shelina Begum
    Citation: BMC Research Notes 2022 15:314
  3. Antimalarial chemoprophylaxis for high risk groups in endemic areas of Southeast Asia has the potential to reduce malaria transmission and accelerate elimination. However, the optimal choice of medication and ...

    Authors: Joel Tarning, Lorenz von Seidlein, Arjen M. Dondorp, Nicholas J. White and Richard J. Maude
    Citation: BMC Research Notes 2022 15:313
  4. Breast cancer is the leading cause of death among women in many countries. Numerous factors serve as oncogenes or tumor suppressors in breast cancer. The large family of Tripartite-motif (TRIM) proteins with ~...

    Authors: Mohammad Reza Roshanazadeh, Maryam Adelipour, Arash Sanaei, Hadi Chenane and Mojtaba Rashidi
    Citation: BMC Research Notes 2022 15:312
  5. The transition from school to the workforce is important for concrete future planning. During this period, people are more likely to experience psychological health problems, such as anxiety and feelings of ho...

    Authors: Sumin Lee, Ryota Kobayashi, Mami Oda, Yoshihide Noritake and Ken’ichiro Nakashima
    Citation: BMC Research Notes 2022 15:311
  6. Engineering bone in 3D is important for both regenerative medicine purposes and for the development of accurate in vitro models of bone tissue. The changing material stiffness of bone tissue had not yet been m...

    Authors: Deniz Bakkalci, Auxtine Micalet, Rawiya Al Hosni, Emad Moeendarbary and Umber Cheema
    Citation: BMC Research Notes 2022 15:310
  7. In the past 5 years, we captured the perspectives from a broad array of research stakeholders to better understand the impact that current approaches to success and research assessment may have on the integrit...

    Authors: Noémie Aubert Bonn, Raymond G. De Vries and Wim Pinxten
    Citation: BMC Research Notes 2022 15:309
  8. Gait parameters can measure risks of falling and mortality and identify early stages of frailty. The use of walking aid changes gait parameters. The aim of this study was to describe differences in gait parame...

    Authors: Eva Ekvall Hansson, Yara Akar, Tingting Liu, Cong Wang and Agneta Malmgren Fänge
    Citation: BMC Research Notes 2022 15:308
  9. Familiarity with the unique tradition and experience of Swedish midwives during the more than 300 years in which midwife-led care has contributed to one of the lowest maternal and neonatal mortality and morbid...

    Authors: Helena Lindgren and Kerstin Erlandsson
    Citation: BMC Research Notes 2022 15:306
  10. Patient-Reported Experience Measures (PREMs) provide valuable patient feedback on quality of care and have been associated with clinical outcomes. We aimed to test the reliability of a modified adult trauma ca...

    Authors: Matthew Yeung, Brent E. Hagel, Niklas Bobrovitz, Thomas H. Stelfox and Natalie L. Yanchar
    Citation: BMC Research Notes 2022 15:304
  11. This study was performed in Razi Hospital, Rasht, Iran, between March 2016 and August 2018 on a population of chronic obstructive pulmonary disease (COPD) patients (56 as COPD exacerbation group and 56 as COPD...

    Authors: Behrang Motamed, Ali Alavi Foumani, Azita Tangestaninezhad, Mohammad Almasi, Niloofar Faraji and Alireza Jafarinezhad
    Citation: BMC Research Notes 2022 15:326
  12. The current study aimed to translate the Australian Type 2 Diabetes Risk Assessment tool (AUSDRISK) into the Arabic language and evaluate the reliability and validity of the resultant Arabic version among Egyp...

    Authors: Hassan Farag Mohamed Farag, Eman Anwar Sultan, Ehab Elrewany and Basem Farouk Abdel-Aziz
    Citation: BMC Research Notes 2022 15:303
  13. Proponents of open science often refer to issues pertaining to research integrity and vice versa. In this commentary, we argue that concepts such as responsible research practices, transparency, and open scien...

    Authors: Tamarinde Haven, Gowri Gopalakrishna, Joeri Tijdink, Dorien van der Schot and Lex Bouter
    Citation: BMC Research Notes 2022 15:302
  14. Our aim was to assess the feasibility and preliminary results of implementing a telehealth system, Alice Agora, as a tool for optimizing health delivery in a new primary care-based health system.

    Authors: Vinícius Ynoe de Moraes, César Biselli Ferreira, Camila Kaory Kawagoe, Fernanda Gushken, Guilherme Azevedo and Mário Ferretti Filho
    Citation: BMC Research Notes 2022 15:301
  15. The usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To evaluate their relevance on CVR assessment in non-diabetic hypertensi...

    Authors: Jan René Nkeck, Chemgne Marie Ida, Valerie Ndobo Koe, Antonin Wilson Ndjitoyap Ndam, Yondo Ndedi Claudine Jessica, Eko Ondoa Manuella, Boukeu Yonta Charelle, Zouague Zalbi Corine, Ntyam Abena Andrée, Falmata Amazia, Jériel Pascal Nkeck, Esther Astrid Mbono Samba and Vicky Jocelyne Ama Moor
    Citation: BMC Research Notes 2022 15:300
  16. Atrial Fibrillation (A-fib) is an abnormal heartbeat condition in which the heart races and beats in an uncontrollable way. It is observed that the presence of increased epicardial fat/fatty tissue in the atri...

    Authors: Deepa Deepa, Yashbir Singh, Wathiq Mansoor, Weichih Hu, Rahul Paul and Gunnar E. Carlsson
    Citation: BMC Research Notes 2022 15:299
  17. This study adapted Improving Cancer Patients’ Insurance Choices (I Can PIC), an intervention to help cancer patients navigate health insurance decisions and care costs. The original intervention improved knowledg...

    Authors: Miles E. Charles, Lindsay M. Kuroki, Ana A. Baumann, Rachel G. Tabak, Aimee James, Krista Cooksey and Mary C. Politi
    Citation: BMC Research Notes 2022 15:298
  18. The accessibility of acute care services is currently under pressure, and one way to improve services is better integration. Adequate methodology will be required to provide for a clear and accessible evaluati...

    Authors: Rosa Naomi Minderhout, Mattijs E. Numans, Hedwig M. M. Vos and Marc A. Bruijnzeels
    Citation: BMC Research Notes 2022 15:296
  19. This study aimed to investigate the effect of heat inactivation and chemical bulklysis on SARS-CoV-2 detection.

    Authors: Dereje Leta, Gadissa Gutema, Gebremedhin Gebremichael Hagos, Regasa Diriba, Gutema Bulti, Tolawak Sura, Desta Ayana, Dawit Chala, Boki Lenjiso, Jaleta Bulti, Saro Abdella and Habteyes Hailu Tola
    Citation: BMC Research Notes 2022 15:295
  20. Some prognostic factors have affected the functional outcomes of patients with anorectal malformations (ARM) after definitive surgery, including the associated anomalies. Moreover, the anal position index (API...

    Authors: Ririd Tri Pitaka, Aditya Rifqi Fauzi, Akhmad Makhmudi and Gunadi
    Citation: BMC Research Notes 2022 15:294
  21. Diabetic foot infection (DFI) represents a major healthcare burden, for which treatment is challenging owing to the pathophysiological alterations intrinsic to diabetes and the alarming increase of antimicrobi...

    Authors: Ana Isabel MENDES, Maria João PEIXOTO, Alexandra Pinto MARQUES, Jorge PEDROSA and Alexandra Gabriel FRAGA
    Citation: BMC Research Notes 2022 15:293
  22. Cases of thrombosis have been reported after administration of SARS-CoV-2 vaccines, with controversial results relating to Oxford-AstraZeneca’s ChAdOx1-S. Despite such cases being rare, they still raised conce...

    Authors: George Krashias, Anna Pafiti, Elie Deeba, Christina Christodoulou, Marios Pantzaris and Anastasia Lambrianides
    Citation: BMC Research Notes 2022 15:292
  23. There is great interest in developing tobacco plants containing minimal amounts of the addictive compound nicotine. Quinolate phosphoribosyltransferase (QPT) is an important enzyme both for primary (NAD produc...

    Authors: William A. Smith, Yuki Matsuba and Ralph E. Dewey
    Citation: BMC Research Notes 2022 15:291
  24. Staphylococcus aureus nasal carriage screening among hemodialysis patients is not standard practice in Thailand, because of data lacking regarding prevalence and correlation with subsequent infection. We aimed to...

    Authors: Tanyanop Techasupaboon, Vasin Vasikasin, Narittaya Varothai, Navee Raknaisil and Worapong Nasomsong
    Citation: BMC Research Notes 2022 15:290
  25. How self-rated health (SRH) varies when the response on SRH is recorded from the respondent herself (adolescent girl) and her mother on her behalf. This study examines the prevalence of SRH among adolescent gi...

    Authors: Ratna Patel and Dhananjay W. Bansod
    Citation: BMC Research Notes 2022 15:289
  26. To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil in Japanese men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) tr...

    Authors: Daisuke Gotoh, Kazumasa Torimoto, Yosuke Morizawa, Shunta Hori, Yasushi Nakai, Makito Miyake and Kiyohide Fujimoto
    Citation: BMC Research Notes 2022 15:288
  27. Use of dried blood spots (DBS) for detection of hepatitis B virus (HBV) markers of infection has the potential to facilitate diagnosis of HBV infection especially in resource-limited countries. The aim of this...

    Authors: Minami Kikuchi, Patrick Lindstrom, Alexandra Tejada-Strop, Tonya Mixson-Hayden, Saleem Kamili and Motoji Sawabe
    Citation: BMC Research Notes 2022 15:287
  28. Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has ...

    Authors: Mohammad Kamalabadi-Farahani, Amir Atashi, Zahra Jabbarpour and Seyed Sajjad Aghayan
    Citation: BMC Research Notes 2022 15:286
  29. Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients. Dietary imbalance between these PUFAs, in particular high in n-6 PUFAs and low in n-3 PUFAs (n-6high/n-3low), is common...

    Authors: Nobuyuki Sakayori, Masanori Katakura, Susumu Setogawa, Makoto Sugita and Kazuto Kobayashi
    Citation: BMC Research Notes 2022 15:285
  30. There are conflicting data regarding the relationship between Parkinson’s disease (PD) and the atherosclerotic process. This study aimed to compare endothelial function in patients with PD and matched controls...

    Authors: Branislav Kollár, Andrej Blaho, Katarína Valovičová, Michal Poddaný, Peter Valkovič, Igor Straka, Peter Turčáni and Pavel Šiarnik
    Citation: BMC Research Notes 2022 15:284
  31. The outbreak of the novel coronavirus disease 2019 (COVID-19) is still affecting African countries. The pandemic presents challenges on how to measure governmental, and community responses to the crisis. Beyon...

    Authors: Chelsea Mbeke Kilonzo, Mark Wamalwa, Solange Youdom Whegang and Henri E. Z. Tonnang
    Citation: BMC Research Notes 2022 15:283
  32. Crayfish plague disease, caused by the oomycete pathogen Aphanomyces astaci represents one of the greatest risks for the biodiversity of the freshwater crayfish. This data article covers the de novo transcriptome...

    Authors: Ljudevit Luka Boštjančić, Caterina Francesconi, Christelle Rutz, Lucien Hoffbeck, Laetitia Poidevin, Arnaud Kress, Japo Jussila, Jenny Makkonen, Barbara Feldmeyer, Miklós Bálint, Klaus Schwenk, Odile Lecompte and Kathrin Theissinger
    Citation: BMC Research Notes 2022 15:281

    The Research article to this article has been published in BMC Genomics 2022 23:600

  33. Causal mutations for major genes that underlie a broad range of morphological traits are often located within exons of genes that then affect protein functions. Non-model organism genetic studies are not easy ...

    Authors: Nathalie Iannuccelli, Julien Sarry, Yvon Billon, Patrick Aymard, Virginie Helies, Cédric Cabau, Cécile Donnadieu and Julie Demars
    Citation: BMC Research Notes 2022 15:282
  34. Due to gaps in the literature, we developed a systematic method to assess multimorbidity using national surveys. The objectives of this study were thus to identify methods used to define and measure multimorbi...

    Authors: Rifqah Abeeda Roomaney, Brian van Wyk and Victoria Pillay-van Wyk
    Citation: BMC Research Notes 2022 15:280
  35. Authors: Sosuke Kageyama, Atsuhiro Nakagawa, Tomohiro Kawaguchi, Kiyonobu Ohtani, Toshiki Endo, Manabu Kyan, Tetsuya Kusunoki, Yoshiteru Shimoda, Shin-Ichiro Osawa, Masayuki Kanamori, Kuniyasu Niizuma and Teiji Tominaga
    Citation: BMC Research Notes 2022 15:279

    The original article was published in BMC Research Notes 2022 15:85

  36. While essential oils have many applications in medicine, not many studies have been done in the past to address issues of active targeting, enhancing bioavailability and reducing toxicity at higher concentrati...

    Authors: Nasla Shakya, S. Budha Chettri, Susan Joshi and Annada Rajbhandary
    Citation: BMC Research Notes 2022 15:278
  37. As a progressive chronic condition, osteoarthritis (OA) causes substantial pain and impairment. Secrete proinflammatory cytokines are essential mediators involved in the pathophysiology of OA. In this regard, ...

    Authors: Alireza Pishgahi, Majid Zamani, Amir Mehdizadeh, Leila Roshangar, Milad Afkham-Daghdaghan, Behzad Pourabbas and Mehdi Yousefi
    Citation: BMC Research Notes 2022 15:277
  38. Microbial infections and mosquito-borne diseases such as malaria, with 627 k deaths in 2020, are still major public health challenges.

    Authors: Mahmoud Osanloo, Samira Firooziyan, Abbas Abdollahi, Shekoufeh Hatami, Amene Nematollahi, Narges Elahi and Elham Zarenezhad
    Citation: BMC Research Notes 2022 15:276
  39. Chronic multisymptom illness (CMI) is an idiopathic disease affecting thousands of U.S. Veterans exposed to open-air burn pits emitting aerosolized particulate matter (PM) while serving in Central and Southwes...

    Authors: Janeen H. Trembley, Simon W. So, Joshua P. Nixon, Elizabeth C. Bowdridge, Krista L. Garner, Julie Griffith, Kevin J. Engles, Thomas P. Batchelor, William T. Goldsmith, Julie M. Tomáška, Salik Hussain, Timothy R. Nurkiewicz and Tammy A. Butterick
    Citation: BMC Research Notes 2022 15:275
  40. This research sought to explore health care providers’ (HCPs) experiences of delivering the first US Food and Drug Administration (FDA) and European Commission (EC) approved peanut oral immunotherapy (peanut O...

    Authors: Aikaterini Anagnostou, Claire Lawrence, Stephen A. Tilles, Susan Laubach, Sarah M. Donelson, Mohamed Yassine and Anna Nowak-Wegrzyn
    Citation: BMC Research Notes 2022 15:273
  41. Osteoporosis is a common skeletal disorder attributed to age and is defined as a systematic degradation of bone mass and the microarchitecture leading to bone fractures. Exosomes have been reported in almost a...

    Authors: Mohammad Hasan Omidvar, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Roza Motavalli, Mehdi Jafarpoor, Sanam Dolati, Majid Ahmadi, Amir Mehdizadeh, Alireza Khabbazi, Mehrzad Hajialilo and Mehdi Yousefi
    Citation: BMC Research Notes 2022 15:272
  42. To perform a molecular screening to detect infections by the mayaro virus and possible coinfections with Chikungunya during an outbreak in the state of Tocantins/Brazil in 2017.

    Authors: Robson dos Santos Souza Marinho, Rodrigo Lopes Sanz Duro, Débora Bellini Caldeira, Juliana Galinskas, Mânlio Tasso Oliveira Mota, James Hunter, Maria da Aparecida Rodrigues Teles, Flávio Augusto de Pádua Milagres, Ricardo Sobhie Diaz, Fernando Shinji Kawakubo and Shirley Vasconcelos Komninakis
    Citation: BMC Research Notes 2022 15:271
  43. Increasing the reproducibility and trustworthiness of biomedical research requires engaging stakeholders from all levels in an institutional setting. The QUEST Center for Responsible Research aims to develop a...

    Authors: Natascha Drude, Lorena Martinez-Gamboa, Tamarinde Haven, Constance Holman, Martin Holst, Silke Kniffert, Sarah McCann, Torsten Rackoll, Robert Schulz and Sarah Weschke
    Citation: BMC Research Notes 2022 15:270
  44. The COVID-19 pandemic in Australia disrupted usual clinical training placements for naturopathic students. An innovative, remote Telehealth clinic was developed and implemented. This pilot study evaluates stud...

    Authors: Tracelee Shew, Catherine Smith, Greg Connolly and Craig S. McLachlan
    Citation: BMC Research Notes 2022 15:269
  45. This paper proposes three iterative methods of order three, six and seven respectively for solving non-linear equations using the modified homotopy perturbation technique coupled with system of equations. This...

    Authors: Srinivasarao Thota and P. Shanmugasundaram
    Citation: BMC Research Notes 2022 15:267

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