Forooghian F, Das B: Anti-angiogenic effects of ribonucleic acid interference targeting vascular endothelial growth factor and hypoxia- inducible factor-1alpha. Am J Ophthalmol. 2007, 144: 761-768.
Article
PubMed
CAS
Google Scholar
Brusselmans K, Bono F, Collen D, Herbert JM, Carmeliet P, Dewerchin M: A novel role for vascular endothelial growth factor as an autocrine survival factor for embryonic stem cells during hypoxia. J Biol Chem. 2005, 280: 3493-3499.
Article
PubMed
CAS
Google Scholar
Winkler BS, Boulton ME, Gottsch JD, Sternberg P: Oxidative damage and age-related macular degeneration. Mol Vis. 1999, 5: 32-
PubMed
CAS
PubMed Central
Google Scholar
Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT: Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol. 1997, 81: 154-162.
Article
PubMed
CAS
PubMed Central
Google Scholar
Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kasier PK, Chung CY, Kim RY, MARINA study group: Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006, 355: 1419-1431.
Article
PubMed
CAS
Google Scholar
Kaiser PK, Brown DM, Zhang K, Hudson HL, Holz FG, Shapiro H, Schneider S, Acharya NR: Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol. 2007, 144: 850-857.
Article
PubMed
CAS
Google Scholar
Kramer I, Lipp HP: Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer. J Clin Pharm Ther. 2007, 32: 1-14.
Article
PubMed
CAS
Google Scholar
Avery RL, Pieramici DJ, Rabena MD, Castellarin AA, Nasir MA, Giust MJ: Intravitrealbevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology. 2006, 113: 363-372. e365
Article
PubMed
Google Scholar
Moreno SF, Paloma JB: Therapeutic anti-VEGF in age-related macular degeneration: Ranibizumab and Bevacizumab controversy. Br J Ophthalmol. 2008, 92: 866-867.
PubMed
Google Scholar
Klettner A, Roider J: Comparison ofbevacizumab, ranibizumab, and pegaptanib in vitro: Efficiency and possible additional pathways. Invest Ophthalmol Vis Sci. 2008, 49: 4523-4527.
Article
PubMed
Google Scholar
Spitzer MS, Wallenfels-Thilo B, Sierra A, Yoeruek E, Peters S, Henke-Fahle S, Bartz-Schmidt KU, Szurman P, Tuebingen Bevacizumab Study Group: Antiproliferative and cytotoxic properties of bevacizumab on different ocular cells. Br J Ophthalmol. 2006, 90: 1316-1321.
Article
PubMed
CAS
PubMed Central
Google Scholar
Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL, Jaffe GJ, CATT Research Group: Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 2011, 364: 1897-1908.
Article
PubMed
CAS
Google Scholar
Chakravarthy U, Harding SP, Rogers CA, Downes SM, Lotery AJ, Wordsworth S, Reeves BC, IVAN Study Investigators: Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. Ophthalmology. 2012, 119 (7): 1399-1411.
Article
PubMed
Google Scholar
Fernando NH, Hurwitz HI: Targeted therapy of colorectal cancer: clinical experience with bevacizumab. Oncologist. 2004, 9 (Suppl 1): 11-18.
Article
PubMed
CAS
Google Scholar
European Medicines Agency Avastin assessment history, initial marketing authorization documents: Avastin EPAR scientific discussion: European Medicines Agency Avastin assessment history, initial marketing authorization documents: Avastin EPAR scientific discussion. Available athttp://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000582/human_med_000663.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d125. Accessed July 2012
Chen Y, Wiesmann C, Fuh G, Li B, Christinger HW, McKay P, de Vos AM, Lowman HB: Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J Mol Biol. 1999, 293: 865-881.
Article
PubMed
CAS
Google Scholar
Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, de-Vos AM: VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure. 1998, 6: 1153-1167.
Article
PubMed
CAS
Google Scholar
Baca M, Presta LG, O'Connor SJ, Wells JA: Antibody humanization using monovalent phage display. J Biol Chem. 1997, 272: 10678-10684.
Article
PubMed
CAS
Google Scholar
Ferrara N, Damico L, Shams N, Lowman H, Kim R: Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006, 26: 859-870.
Article
PubMed
Google Scholar
Meyer CH, Holzl FG: Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab. Eye (Lond). 2011, 25 (6): 661-672.
Article
CAS
Google Scholar
Klettner A, Möhle F, Roider J: Intracellular bevacizumab reduces phagocytotic uptake in RPE cells. Graefes Arch Clin Exp Ophthalmol. 2010, 248 (6): 819-824.
Article
PubMed
CAS
Google Scholar
Klettner A, Roider J: Constitutive and oxidative-stress-induced expression of VEGF in the RPE are differently regulated by different Mitogen-activated protein kinases. Graefes Arch Clin Exp Ophthalmol. 2009, 247: 1487-1492.
Article
PubMed
Google Scholar
Deissler HL, Deissler H, Lang GE: Actions of bevacizumab and ranibizumab on microvascular retinal endothelial cells: similarities and differences. Br J Ophthalmol. 2012, 96 (7): 1023-1028.
Article
PubMed
PubMed Central
Google Scholar
Bian ZM, Elner SG, Elner VM: Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells. Exp Eye Res. 2007, 84: 812-822.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kunchithapautham K, Rohrer B: Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem. 2011, 286: 23717-23724.
Article
PubMed
CAS
PubMed Central
Google Scholar
SAB biosciences RT [2] Profiler PCR Array assay (Qiagen).http://www.sabiosciences.com/rt_pcr_product/HTML/PAHS-091A.html,
Perotti V, Baldassari P, Bersani I, Molla A, Vegetti C, Tassi E, Dal Col J, Dolcetti R, Anichini A, Mortarini R: NFATc2 is a potential therapeutic target in human melanoma. J Invest Dermatol. 2012, 132 (11): 2652-2660.
Article
PubMed
CAS
Google Scholar
Endo A, Nagashima K, Kurose H, Mochizuki S, Matsuda M, Mochizuki N: Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. J Biol Chem. 2002, 277: 23747-23754.
Article
PubMed
CAS
Google Scholar
Matsumoto T, Claesson-Welsh L: VEGF receptor signal transduction. Sci STKE. 2001, RE 21
Google Scholar
Chae JK, Kim I, Lim ST, Chung MJ, Kim WH, Kim HG, Ko JK, Koy GY: Co administration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization. Arterioscler Thromb Vasc Biol. 2000, 20: 2573-2578.
Article
PubMed
CAS
Google Scholar
Saint-Geniez M, Maharaj ASR, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D’Amore PA: Endogenous VEGF is required for visual function: Evidence for a survival role on Müller cells and photoreceptors. PLoS One. 2008, 3: e3554-
Article
PubMed
PubMed Central
Google Scholar
Klettner A, Westhues D, Lassen J, Bartsch S, Roider J: Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway. Mol Vis. 2013, 19: 281-291.
PubMed
CAS
PubMed Central
Google Scholar
Adamis AP, Shima DT, Tolentino MJ, Gragoudas ES, Ferrara N, Folkman J, D'Amore PA, Miller JW: Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate. Arch Ophthalmol. 1996, 114: 66-71.
Article
PubMed
CAS
Google Scholar
Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michauda NA, Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michauda NA, Li W, Connolly E, O'Neill CA, Miller JW: Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol. 2002, 120: 338-346.
Article
PubMed
CAS
Google Scholar
Rakic JM, Lambert V, Devy L, Luttun A, Carmeliet P, Claes C, Nguyen L, Foidart JM, Noël A, Munaut C: Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003, 44: 3186-3193.
Article
PubMed
Google Scholar
Wells JA, Murthy R, Chibber R, Nunn A, Molinatti PA, Kohner EM, Gregor ZJ: Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinalneovascularisation. Br J Ophthalmol. 1996, 80: 363-366.
Article
PubMed
CAS
PubMed Central
Google Scholar
Adamis AP, Miller JW, Bernal MT, D’Amico DJ, Folkman J, Yeo TK, Yeo KT: Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994, 118: 445-450.
Article
PubMed
CAS
Google Scholar