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  1. Portal mesenchymal cells induce the epithelial differentiation of the bile ducts in the developing liver via one of the Delta-Notch signaling components, JAGGED1. Although this differential induction is crucia...

    Authors: Teppei Nishino, Masaharu Yoshihara, Takahiro Nakayama, Takaho Tsuchiya, Saeko Tahara, Haruka Ozaki and Satoru Takahashi
    Citation: BMC Research Notes 2022 15:172
  2. The detection and monitoring of DNA methylation status in circulating tumor cell DNA (ctDNA) provides critical insights into cancer diagnosis and progression. The methylation status of the Dickkopf-related pro...

    Authors: Kenji Araki, Ai Kurosawa and Hiromi Kumon
    Citation: BMC Research Notes 2022 15:169
  3. The mesoderm-specific transcript (Mest) is an imprinted gene that is transcribed from the paternal allele. It is a marker of adipose tissue expansion; however, it is uncertain whether Mest expression promotes or ...

    Authors: Yoshito Kadota, Takashige Kawakami, Masao Sato and Shinya Suzuki
    Citation: BMC Research Notes 2022 15:164
  4. The increasing spread of severe acute respiratory syndrome coronavirus-2 has prompted Canada to take unprecedented measures. The objective of this study was to examine the impact of the implemented public heal...

    Authors: Laila Aboulatta, Kaarina Kowalec, Joseph Delaney, Silvia Alessi-Severini, Christine Leong, Jamie Falk and Sherif Eltonsy
    Citation: BMC Research Notes 2022 15:162
  5. Research examining the age of diagnosis of autism spectrum disorder (ASD) and its influencing factors mostly originate from developed Western countries, providing little to no systematic information about the ...

    Authors: Fahad M. Alnemary, Faisal M. Alnemary, Gabriela Simon-Cereijido, Hesham M. Aldhalaan, Anthony Hernandez, Ahmed Alyahya and Shuliweeh Alenezi
    Citation: BMC Research Notes 2022 15:161
  6. The objective of this study was to identify the diagnostic performance of video capsule endoscopy (VCE) among patients presenting with iron deficiency anaemia (IDA) and negative bidirectional endoscopy to a ga...

    Authors: Maddison Furner, Robyn Nagel and Janani Pinidiyapathirage
    Citation: BMC Research Notes 2022 15:160
  7. We present a database on Brazilian spatial, demographic, and socioeconomic characteristics from 1996 to 2020. This database aims for integration and harmonization with epidemiological data from two major studi...

    Authors: Ronaldo Fernandes Santos Alves, Patricia de Moraes Mello Boccolini, Lais Ribeiro Baroni, Laís de Almeida Relvas-Brandt, Raquel de Abreu Junqueira Gritz and Cristiano Siqueira Boccolini
    Citation: BMC Research Notes 2022 15:159
  8. The advent of new techniques such as video-assisted thoracoscopic surgery (VATS) for the removal of lung segments leads to compression of the surgical specimen, with the possible dissemination of neoplastic ce...

    Authors: Carlos Andrés Latorre Noguera, Agnaldo José Lopes, Ivan Mathias Filho, Claudio Higa, Rodolfo Acatauassú Nunes, Carlos Eduardo Teixeira Lima and Eduardo Haruo Saito
    Citation: BMC Research Notes 2022 15:158
  9. ‘Integrative and Conjugative Elements’ (ICEs) and ‘Integrative and Mobilizable Elements’ (IMEs) are two classes of mobile genetic elements that are complex to detect and delineate. Therefore, they are yet poor...

    Authors: Gérard Guédon, Julie Lao, Sophie Payot, Thomas Lacroix, Hélène Chiapello and Nathalie Leblond-Bourget
    Citation: BMC Research Notes 2022 15:157
  10. It has been shown that variable compared to fixed task prioritization during dual task practice more effectively improves motor (i.e., postural control) and cognitive (i.e., memory) performance in older adults...

    Authors: Thomas Muehlbauer, Hagen Voigt, Dennis Brueckner and Rainer Beurskens
    Citation: BMC Research Notes 2022 15:156
  11. The mosquito transmitted dengue virus (DENV) the causative agent of dengue fever (DF) remains a significant public health burden in many countries. Thailand, along with many countries in Asia and elsewhere, ha...

    Authors: Thippayawan Ratanakomol, Sittiruk Roytrakul, Nitwara Wikan and Duncan R. Smith
    Citation: BMC Research Notes 2022 15:154
  12. Doppler echocardiographic aortic valve peak velocity and peak pressure gradient assessment across the aortic valve (AV) is the mainstay for diagnosing aortic stenosis. Four-dimensional flow cardiovascular magn...

    Authors: Ciaran Grafton-Clarke, Paul Njoku, Jean-Paul Aben, Leon Ledoux, Liang Zhong, Jos Westenberg, Andrew Swift, Gareth Archer, James Wild, Rod Hose, Marcus Flather, Vassilios S. Vassiliou and Pankaj Garg
    Citation: BMC Research Notes 2022 15:151
  13. Green synthesized iron(III) oxide (Fe3O4) nanoparticles are gaining appeal in targeted drug delivery systems because of their low cost, fast processing and nontoxicity. However, there is no known research work un...

    Authors: Henry Fenekansi Kiwumulo, Haruna Muwonge, Charles Ibingira, Michael Lubwama, John Baptist Kirabira and Robert Tamale Ssekitoleko
    Citation: BMC Research Notes 2022 15:149
  14. The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to...

    Authors: Kok-Siong Poon, Izz Irfan B. Imran, Silvester Kheng-Han Chew, Patrice Tan and Karen Mei-Ling Tan
    Citation: BMC Research Notes 2022 15:148
  15. Main malaria diagnosis is based on microscopic examination combined with rapid diagnostic tests. Both methods have low sensitivity and specificity. Loop-mediated isothermal amplification techniques have shown ...

    Authors: Alexandra Martín-Ramírez, Marta Lanza, Shamilah Hisam, Ana Perez-Ayala and José M. Rubio
    Citation: BMC Research Notes 2022 15:147
  16. Mitral Valve Prolapse (MVP) is a common valvular abnormality accounting for 2% of the population. There is a reported association between pes planus (PP) and MVP in some syndromes such as Marfan. However, this...

    Authors: Antoine AbdelMassih, Rafeef Hozaien, Fady Mishriky, Mark Michael, Mostafa AmanAllah, Nada Ali, Nadine ElGamal, Omar Medhat, Mona Kamel, Rasha Helmy, Mai Sarhan, Hams Attalla, Omneya Dawoud, Athar Marwan and Mohamed Ghobashy
    Citation: BMC Research Notes 2022 15:145
  17. SARS-CoV-2 is the cause of COVID-19, the rapidly spreading pandemic. When SARS-CoV-2 enters the target cells in the respiratory system, the spike glycoprotein binds to a cellular receptor angiotensin convertin...

    Authors: Makoto Nogami, Tomoaki Hoshi, Yoko Toukairin, Tomomi Arai and Tadashi Nishio
    Citation: BMC Research Notes 2022 15:144
  18. People experiencing homelessness often encounter progressive illness(es) earlier and are at increased risk of mortality compared to the housed population. There are limited resources available to serve this po...

    Authors: Cait Vihvelin, Viraji Rupasinghe, Jean Hughes, Jeff Karabanow and Lori E. Weeks
    Citation: BMC Research Notes 2022 15:142
  19. The last decade has seen renewed concern within the scientific community over the reproducibility and transparency of research findings. This paper outlines some of the various responsibilities of stakeholders...

    Authors: Thomas Rhys Evans, Madeleine Pownall, Elizabeth Collins, Emma L. Henderson, Jade S. Pickering, Aoife O’Mahony, Mirela Zaneva, Matt Jaquiery and Tsvetomira Dumbalska
    Citation: BMC Research Notes 2022 15:141
  20. This study was to explore the most appropriate radiomics modeling method to predict the progression-free survival of EGFR-TKI treatment in advanced non-small cell lung cancer with EGFR mutations. Different mac...

    Authors: Jian-man Zhu, Lei Sun, Linjing Wang, Tong-Chong Zhou, Yawei Yuan, Xin Zhen and Zhi-Wei Liao
    Citation: BMC Research Notes 2022 15:140
  21. Hypertrophic cardiomyopathy (HCM) is a common genetic disease with diverse morphology, symptoms, and prognosis. Hypertrophied myocardium metabolism has not been explored in detail. We assessed the association ...

    Authors: Keitaro Akita, Kenji Kikushima, Takenori Ikoma, Ariful Islam, Tomohito Sato, Taisei Yamamoto, Tomoaki Kahyo, Mitsutoshi Setou and Yuichiro Maekawa
    Citation: BMC Research Notes 2022 15:139
  22. Himetobi P virus (HiPV) is an insect virus belonging to the genus Cripavirus in the Dicistroviridae family within the Picornavirales order. Himetobi P strain. Sh.Moghaddam is the first study reported, was isolate...

    Authors: Mohammad Reza Rezapanah, Zahra Ziafati Kafi, Iradj Ashrafi Tamai, Naser Sadri, Ali Hojabr Rajeoni, Fahimeh Jamiri and Arash GhalyanchiLangeroudi
    Citation: BMC Research Notes 2022 15:138
  23. Canine dirofilariasis is a mosquito borne zoonotic filarial parasitic disease caused by Dirofilaria species. In Sri Lanka, human dirofilariasis is endemic and well documented. Even though canine dirofilariasis is...

    Authors: Randima Dasanayake, Thivya Balendran, Dhilma Atapattu and Devika Iddawela
    Citation: BMC Research Notes 2022 15:137
  24. These data were collected to generate a novel reference metagenome for the sponge Halichondria panicea and its microbiome for subsequent differential expression analyses.

    Authors: Brian W. Strehlow, Astrid Schuster, Warren R. Francis and Donald E. Canfield
    Citation: BMC Research Notes 2022 15:135
  25. Since 2017, an increasing number of opioid overdoses in Oslo, Norway, has been categorized as involving unspecified opioids, as noted in the patient records by the doctor treating the patient. In this study we...

    Authors: Zahra Zeineb Iqbal, Thanh Mai Thi Nguyen, Mette Brekke and Odd Martin Vallersnes
    Citation: BMC Research Notes 2022 15:134
  26. Elizabethkingia meningoseptica is a multidrug resistance strain which primarily causes meningitis in neonates and immunocompromised patients. Being a nosocomial infection causing agent, less information is availa...

    Authors: Neha Girdhar, Nilima Kumari and A. Krishnamachari
    Citation: BMC Research Notes 2022 15:133
  27. This paper reports HIV prevalence, incidence, progress towards the UNAIDS (90-90-90) targets, and HIV drug resistance among adolescents living with HIV in South Africa. We conducted secondary analyses using da...

    Authors: Naidoo Inbarani, Takatshana Sinovuyo, Sewpaul Ronel, Jooste Sean, Siyanai Zhou, Maseko Goitseone, Moyo Sizulu, Zuma Khangelani, Mabaso Musawenkosi and Nompumelelo Zungu
    Citation: BMC Research Notes 2022 15:132
  28. The present study investigates if symptoms of COVID-19 contagion in different social contexts (cohabitants, family, acquaintances, and others) are associated with university students' own self-reported symptom...

    Authors: Claes Andersson, Marcus Bendtsen, Olof Molander, Lilian Granlund, Naira Topooco, Karin Engström, Petra Lindfors and Anne H. Berman
    Citation: BMC Research Notes 2022 15:131
  29. The actual impact of the pandemic on COVID-19 specific mortality is still unclear due to the variability in access to diagnostic tools. This study aimed to estimate the excess all-cause mortality in Iran until...

    Authors: Seyed Amir Ahmad Safavi-Naini, Yeganeh Farsi, Walid Q. Alali, Ali Solhpour and Mohamad Amin Pourhoseingholi
    Citation: BMC Research Notes 2022 15:130
  30. Insulin-like growth factor (IGF)-1 participates in modulating immunity and inflammation. Its bioactivity is controlled by six IGF-binding proteins (IGFBP-1 to IGFBP-6). In particular, the IGFBP-3 level is repo...

    Authors: Hanna Lee, Young Sun Suh, Sang-Il Lee, Yun-Hong Cheon, Mingyo Kim, Hae Sook Noh and Hyun-Ok Kim
    Citation: BMC Research Notes 2022 15:128
  31. Journal peer review regulates the flow of ideas through an academic discipline and thus has the power to shape what a research community knows, actively investigates, and recommends to policymakers and the wid...

    Authors: Alexandru Marcoci, Ans Vercammen, Martin Bush, Daniel G. Hamilton, Anca Hanea, Victoria Hemming, Bonnie C. Wintle, Mark Burgman and Fiona Fidler
    Citation: BMC Research Notes 2022 15:127
  32. ‘Candidatus Liberibacter asiaticus’ (CLas) is associated with the devastating citrus ‘greening’ disease. All attempts to achieve axenic growth and complete Koch’s postulates with CLas have failed to date, at best...

    Authors: Lulu Cai, Mukesh Jain, Alejandra Munoz-Bodnar, Jose C. Huguet-Tapia and Dean W. Gabriel
    Citation: BMC Research Notes 2022 15:125
  33. To design and construct a new synthetic nanobody library using a structure-based approach that seeks to maintain high protein stability and increase the number of functional variants within the combinatorial s...

    Authors: Ernesto Moreno, Mario S. Valdés-Tresanco, Andrea Molina-Zapata and Oliberto Sánchez-Ramos
    Citation: BMC Research Notes 2022 15:124
  34. The aim of this study is to determine the metabolic impact of a nutrition education program on metabolic parameters and the presence of metabolic syndrome (MetS).

    Authors: Quintí Foguet-Boreu, Mireia Vilamala-Orra, Cristina Vaqué-Crusellas, Pere Roura-Poch, Montse Assens Tauste, Judit Bori Vila, Jose Manuel Santos-López and Ruben del Río Sáez
    Citation: BMC Research Notes 2022 15:122
  35. How do birds navigate their way? It is one of the interesting question about homing pigeons, however the genetic of navigation has reminded as a puzzle. Optic lobe, olfactory bulb, hippocampus and cere were co...

    Authors: Hamed Kharrati-Koopaee, Ali Esmailizadeh and Fatemeh Sabahi
    Citation: BMC Research Notes 2022 15:121
  36. Due to the increase of type 2 diabetes (T2D), the number of patients in treatment with multiple anti-diabetic agents is increased. According to the recent recommendation of treatment guidelines, sodium-glucose...

    Authors: Makoto Fujiwara, Masaru Shimizu, Yuko Maejima and Kenju Shimomura
    Citation: BMC Research Notes 2022 15:120
  37. A clinical trial carried out in patients hospitalized for clinical and surgical conditions. This study evaluated the effectiveness of text messaging interventions (TM) versus telephone counseling (TC) to promo...

    Authors: Lígia Menezes do Amaral, Telmo Mota Ronzani, Erica Cruvinel, Kimber Richter, Rafaela de Oliveira Andrade, Isabella Oliveira Lanzieri, Ângela Caroline Dias Albino Destro de Macêdo and Isabel Cristina Gonçalves Leite
    Citation: BMC Research Notes 2022 15:119
  38. It remains unclear that the relationship between sprint and/or endurance performance and salivary immunological factors and stress hormones in athletes. The aim of this study was to investigate if salivary imm...

    Authors: Masataka Uchida, Tadashi Suga, Masafumi Terada and Tadao Isaka
    Citation: BMC Research Notes 2022 15:118

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